NATURE . COM {}

Matching Content Categories {📚}

• Education
• Science
• Video & Online Content

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,798,980 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$539,300 per month
Estimations show Nature.com's display ad online revenue falls between $359,553 and $988,772 per month.

Keywords {🔍}

cas, dna, cleavage, target, crrna, fret, article, fig, conformational, binding, google, scholar, tracrrna, casgrna, nature, rloop, conformation, complex, grnas, inactive, supplementary, singlemolecule, data, activity, min, time, nuclease, structure, state, casgrnadna, efficiency, states, crisprcas, sequences, end, pamdistal, ads, structural, kim, genome, results, open, guide, endonuclease, active, apocas, rna, fluorescence, formation, strand,

Topics {✒️}

nature portfolio privacy policy rna-related solutions national research foundation rna-programmed genome editing advertising short-lived open conformation γ=δ iacceptor/δ idonor=1 social media efficient genome editing research 0/ reprints nature 471 nature 507 nature 513 nature 527 nature ni-nta agarose beads single-molecule fluorescence spectroscopy seong keun kim rna-guided endonuclease utilizing genome editing water-immersion objective lens temperature-dependent circular dichroism open conformation resulted increased-fidelity spcas9 variants rna-directed adaptive immunity crrna–dna r-loop structure trans-encoded small rna single rna-guided cas9 single-molecule fret data synchronous single-molecule measurement watson–crick base pairing cas9 rna-guided endonuclease peltier-type temperature controller initiate large-scale conformational r-loop structure based entire rna–dna heteroduplex dna double-helix structures single-molecule time traces prevent urea-mediated denaturation author cas9–grna–dna ternary complex rna–dna base pairing single-molecule fret analysis single-molecule fret measurements pam-proximal bound complex home-built idl pre-incubation temperature increases permissions

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Structural roles of guide RNAs in the nuclease activity of Cas9 endonuclease
         description:The type II CRISPR-associated protein Cas9 recognizes and cleaves target DNA with the help of two guide RNAs (gRNAs; tracrRNA and crRNA). However, the detailed mechanisms and kinetics of these gRNAs in the Cas9 nuclease activity are unclear. Here, we investigate the structural roles of gRNAs in the CRISPR-Cas9 system by single-molecule spectroscopy and reveal a new conformation of inactive Cas9 that is thermodynamically more preferable than active apo-Cas9. We find that tracrRNA prevents Cas9 from changing into the inactive form and leads to the Cas9:gRNA complex. For the Cas9:gRNA complex, we identify sub-conformations of the RNA–DNA heteroduplex during R-loop expansion. Our single-molecule study indicates that the kinetics of the sub-conformations is controlled by the complementarity between crRNA and target DNA. We conclude that both tracrRNA and crRNA regulate the conformations and kinetics of the Cas9 complex, which are crucial in the DNA cleavage activity of the CRISPR-Cas9 system. In bacteria, CRISPR-Cas9 identifies and cleaves the target DNA with the assistance of a tracrRNA and a crRNA. Here the authors use single-molecule spectroscopy to investigate conformational changes and show that the tracrRNA keeps Cas9 in a functionally active form.
         datePublished:2016-11-02T00:00:00Z
         dateModified:2016-11-02T00:00:00Z
         pageStart:1
         pageEnd:8
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/ncomms13350
         keywords:
            Biological fluorescence
            CRISPR-Cas9 genome editing
            Enzyme mechanisms
            Structural biology
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Figa_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig5_HTML.jpg
         isPartOf:
            name:Nature Communications
            issn:
               2041-1723
            volumeNumber:7
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Youngbin Lim
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:So Young Bak
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Keewon Sung
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Euihwan Jeong
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Seung Hwan Lee
               affiliation:
                     name:Center for Genome Engineering, Institute for Basic Science
                     address:
                        name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jin-Soo Kim
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:Center for Genome Engineering, Institute for Basic Science
                     address:
                        name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sangsu Bae
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:Center for Genome Engineering, Institute for Basic Science
                     address:
                        name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea
                     address:
                        name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea,
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Seong Keun Kim
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Structural roles of guide RNAs in the nuclease activity of Cas9 endonuclease
      description:The type II CRISPR-associated protein Cas9 recognizes and cleaves target DNA with the help of two guide RNAs (gRNAs; tracrRNA and crRNA). However, the detailed mechanisms and kinetics of these gRNAs in the Cas9 nuclease activity are unclear. Here, we investigate the structural roles of gRNAs in the CRISPR-Cas9 system by single-molecule spectroscopy and reveal a new conformation of inactive Cas9 that is thermodynamically more preferable than active apo-Cas9. We find that tracrRNA prevents Cas9 from changing into the inactive form and leads to the Cas9:gRNA complex. For the Cas9:gRNA complex, we identify sub-conformations of the RNA–DNA heteroduplex during R-loop expansion. Our single-molecule study indicates that the kinetics of the sub-conformations is controlled by the complementarity between crRNA and target DNA. We conclude that both tracrRNA and crRNA regulate the conformations and kinetics of the Cas9 complex, which are crucial in the DNA cleavage activity of the CRISPR-Cas9 system. In bacteria, CRISPR-Cas9 identifies and cleaves the target DNA with the assistance of a tracrRNA and a crRNA. Here the authors use single-molecule spectroscopy to investigate conformational changes and show that the tracrRNA keeps Cas9 in a functionally active form.
      datePublished:2016-11-02T00:00:00Z
      dateModified:2016-11-02T00:00:00Z
      pageStart:1
      pageEnd:8
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/ncomms13350
      keywords:
         Biological fluorescence
         CRISPR-Cas9 genome editing
         Enzyme mechanisms
         Structural biology
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Figa_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_Article_BFncomms13350_Fig5_HTML.jpg
      isPartOf:
         name:Nature Communications
         issn:
            2041-1723
         volumeNumber:7
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Youngbin Lim
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:So Young Bak
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Keewon Sung
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Euihwan Jeong
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Seung Hwan Lee
            affiliation:
                  name:Center for Genome Engineering, Institute for Basic Science
                  address:
                     name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jin-Soo Kim
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Center for Genome Engineering, Institute for Basic Science
                  address:
                     name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sangsu Bae
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Center for Genome Engineering, Institute for Basic Science
                  address:
                     name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea
                  address:
                     name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea,
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Seong Keun Kim
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Nature Communications
      issn:
         2041-1723
      volumeNumber:7
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Seoul National University
      address:
         name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Center for Genome Engineering, Institute for Basic Science
      address:
         name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Center for Genome Engineering, Institute for Basic Science
      address:
         name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Center for Genome Engineering, Institute for Basic Science
      address:
         name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
         type:PostalAddress
      name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea
      address:
         name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea,
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Youngbin Lim
      affiliation:
            name:Seoul National University
            address:
               name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:So Young Bak
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Keewon Sung
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Euihwan Jeong
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Seung Hwan Lee
      affiliation:
            name:Center for Genome Engineering, Institute for Basic Science
            address:
               name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Jin-Soo Kim
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:Center for Genome Engineering, Institute for Basic Science
            address:
               name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Sangsu Bae
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:Center for Genome Engineering, Institute for Basic Science
            address:
               name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea
            address:
               name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea,
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Seong Keun Kim
      affiliation:
            name:Seoul National University
            address:
               name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
      name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
      name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
      name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
      name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
      name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
      name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
      name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea
      name:Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea
      name:Present address: Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea,
      name:Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Republic of Korea
      name:Department of Chemistry, Seoul National University, Seoul, Republic of Korea

Social Networks {👍}(2)

• https://www.facebook.com/NatureCommunications
• https://twitter.com/NatureComms

External Links {🔗}(102)

• Check the income stats for https://cplc.illinois.edu/software
• What's the total monthly financial gain of https://doi.org/10.1046%2Fj.1365-2958.2002.02839.x?
• http://scholar.google.com/scholar_lookup?&title=Identification%20of%20genes%20that%20are%20associated%20with%20DNA%20repeats%20in%20prokaryotes&journal=Mol.%20Microbiol.&doi=10.1046%2Fj.1365-2958.2002.02839.x&volume=43&pages=1565-1575&publication_year=2002&author=Jansen%2CR&author=van%20Embden%2CJDA&author=Gaastra%2CW&author=Schouls%2CLM's revenue stream
• What's the monthly income of https://doi.org/10.1099%2Fmic.0.28048-0?
• Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Clustered%20regularly%20interspaced%20short%20palindrome%20repeats%20%28CRISPRs%29%20have%20spacers%20of%20extrachromosomal%20origin&journal=Microbiology&doi=10.1099%2Fmic.0.28048-0&volume=151&pages=2551-2561&publication_year=2005&author=Bolotin%2CA&author=Quinquis%2CB&author=Sorokin%2CA&author=Ehrlich%2CSD
• What's the financial gain of https://doi.org/10.1038%2Fnrg2749?
• What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=CRISPR%20interference%3A%20RNA-directed%20adaptive%20immunity%20in%20bacteria%20and%20archaea&journal=Nat.%20Rev.%20Genet.&doi=10.1038%2Fnrg2749&volume=11&pages=181-190&publication_year=2010&author=Marraffini%2CLA&author=Sontheimer%2CEJ?
• How much cash flow does https://doi.org/10.1126%2Fscience.1138140 have monthly?
• How much money does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2007Sci...315.1709B make?
• What are the total earnings of http://scholar.google.com/scholar_lookup?&title=CRISPR%20provides%20acquired%20resistance%20against%20viruses%20in%20prokaryotes&journal=Science&doi=10.1126%2Fscience.1138140&volume=315&pages=1709-1712&publication_year=2007&author=Barrangou%2CR?
• See how much https://doi.org/10.1038%2Fnature09886 makes per month
• How much profit does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2011Natur.471..602D make?
• http://scholar.google.com/scholar_lookup?&title=CRISPR%20RNA%20maturation%20by%20trans-encoded%20small%20RNA%20and%20host%20factor%20RNase%20III&journal=Nature&doi=10.1038%2Fnature09886&volume=471&pages=602-607&publication_year=2011&author=Deltcheva%2CE income
• How much does https://doi.org/10.1038%2Fnrg3686 net monthly?
• How profitable is http://scholar.google.com/scholar_lookup?&title=A%20guide%20to%20genome%20engineering%20with%20programmable%20nucleases&journal=Nat.%20Rev.%20Genet.&doi=10.1038%2Fnrg3686&volume=15&pages=321-334&publication_year=2014&author=Kim%2CH&author=Kim%2CJS?
• How much does https://doi.org/10.1038%2Fnrmicro2577 pull in monthly?
• How much money does http://scholar.google.com/scholar_lookup?&title=Evolution%20and%20classification%20of%20the%20CRISPR-Cas%20systems&journal=Nat.%20Rev.%20Microbiol.&doi=10.1038%2Fnrmicro2577&volume=9&pages=467-477&publication_year=2011&author=Makarova%2CKS make?
• How much does https://doi.org/10.1099%2Fmic.0.023960-0 generate monthly?
• What's http://scholar.google.com/scholar_lookup?&title=Short%20motif%20sequences%20determine%20the%20targets%20of%20the%20prokaryotic%20CRISPR%20defence%20system&journal=Microbiology&doi=10.1099%2Fmic.0.023960-0&volume=155&pages=733-740&publication_year=2009&author=Mojica%2CFJM&author=Diez-Villasenor%2CC&author=Garcia-Martinez%2CJ&author=Almendros%2CC's gross income?
• How much money does https://doi.org/10.1128%2FJB.01412-07 make?
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Phage%20response%20to%20CRISPR-encoded%20resistance%20in%20Streptococcus%20thermophilus&journal=J.%20Bacteriol.&doi=10.1128%2FJB.01412-07&volume=190&pages=1390-1400&publication_year=2008&author=Deveau%2CH
• What's the financial outcome of https://doi.org/10.1126%2Fscience.1225829?
• What's the revenue for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2012Sci...337..816J?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=A%20programmable%20dual-RNA-guided%20DNA%20endonuclease%20in%20adaptive%20bacterial%20immunity&journal=Science&doi=10.1126%2Fscience.1225829&volume=337&pages=816-821&publication_year=2012&author=Jinek%2CM?
• Find out how much https://doi.org/10.1126%2Fscience.1231143 earns monthly
• What's http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2013Sci...339..819C's gross income?
• How much money does http://scholar.google.com/scholar_lookup?&title=Multiplex%20genome%20engineering%20using%20CRISPR%2FCas%20systems&journal=Science&doi=10.1126%2Fscience.1231143&volume=339&pages=819-823&publication_year=2013&author=Cong%2CL make?
• Get to know what's the income of https://doi.org/10.7554%2FeLife.00471
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=RNA-programmed%20genome%20editing%20in%20human%20cells&journal=Elife&doi=10.7554%2FeLife.00471&volume=2&publication_year=2013&author=Jinek%2CM is on a monthly basis
• https://doi.org/10.1038%2Fnbt.2507 income
• What are the earnings of http://scholar.google.com/scholar_lookup?&title=Targeted%20genome%20engineering%20in%20human%20cells%20with%20the%20Cas9%20RNA-guided%20endonuclease&journal=Nat.%20Biotechnol.&doi=10.1038%2Fnbt.2507&volume=31&pages=230-232&publication_year=2013&author=Cho%2CSW&author=Kim%2CS&author=Kim%2CJM&author=Kim%2CJS?
• How much does https://doi.org/10.1126%2Fscience.1232033 rake in every month?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2013Sci...339..823M bring in each month?
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=RNA-guided%20human%20genome%20engineering%20via%20Cas9&journal=Science&doi=10.1126%2Fscience.1232033&volume=339&pages=823-826&publication_year=2013&author=Mali%2CP
• How much does https://doi.org/10.1038%2Fnature13011 pull in?
• How much cash flow does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2014Natur.507...62S have monthly?
• How much does http://scholar.google.com/scholar_lookup?&title=DNA%20interrogation%20by%20the%20CRISPR%20RNA-guided%20endonuclease%20Cas9&journal=Nature&doi=10.1038%2Fnature13011&volume=507&pages=62-67&publication_year=2014&author=Sternberg%2CSH&author=Redding%2CS&author=Jinek%2CM&author=Greene%2CEC&author=Doudna%2CJA generate monthly?
• How much does https://doi.org/10.1038%2Fnature13579 pull in?
• How much income does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2014Natur.513..569A have?
• http://scholar.google.com/scholar_lookup?&title=Structural%20basis%20of%20PAM-dependent%20target%20DNA%20recognition%20by%20the%20Cas9%20endonuclease&journal=Nature&doi=10.1038%2Fnature13579&volume=513&pages=569-573&publication_year=2014&author=Anders%2CC&author=Niewoehner%2CO&author=Duerst%2CA&author=Jinek%2CM's total income per month
• What is the earnings of https://doi.org/10.1016%2Fj.cell.2014.02.001?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Crystal%20structure%20of%20Cas9%20in%20complex%20with%20guide%20RNA%20and%20target%20DNA&journal=Cell&doi=10.1016%2Fj.cell.2014.02.001&volume=156&pages=935-949&publication_year=2014&author=Nishimasu%2CH bring in?
• How much cash flow does https://doi.org/10.1126%2Fscience.aab1452 have monthly?
• Learn how profitable http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2015Sci...348.1477J is on a monthly basis
• What's the income of http://scholar.google.com/scholar_lookup?&title=Structural%20biology.%20A%20Cas9-guide%20RNA%20complex%20preorganized%20for%20target%20DNA%20recognition&journal=Science&doi=10.1126%2Fscience.aab1452&volume=348&pages=1477-1481&publication_year=2015&author=Jiang%2CF&author=Zhou%2CK&author=Ma%2CL&author=Gressel%2CS&author=Doudna%2CJA?
• How much cash flow does https://doi.org/10.1126%2Fscience.1247997 have monthly?
• Revenue of http://scholar.google.com/scholar_lookup?&title=Structures%20of%20Cas9%20endonucleases%20reveal%20RNA-mediated%20conformational%20activation&journal=Science&doi=10.1126%2Fscience.1247997&volume=343&publication_year=2014&author=Jinek%2CM
• What's the financial outcome of https://doi.org/10.1126%2Fscience.aad8282?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2016Sci...351..867J bring in each month?
• Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Structures%20of%20a%20CRISPR-Cas9%20R-loop%20complex%20primed%20for%20DNA%20cleavage&journal=Science&doi=10.1126%2Fscience.aad8282&volume=351&pages=867-871&publication_year=2016&author=Jiang%2CF
• How much does https://doi.org/10.1038%2Fnbt.2808 rake in every month?
• How much does http://scholar.google.com/scholar_lookup?&title=Improving%20CRISPR-Cas%20nuclease%20specificity%20using%20truncated%20guide%20RNAs&journal=Nat.%20Biotechnol.&doi=10.1038%2Fnbt.2808&volume=32&pages=279-284&publication_year=2014&author=Fu%2CYF&author=Sander%2CJD&author=Reyon%2CD&author=Cascio%2CVM&author=Joung%2CJK generate monthly?
• What's the revenue for https://doi.org/10.1126%2Fscience.aad5227?
• What's the financial intake of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2016Sci...351...84S?
• How profitable is http://scholar.google.com/scholar_lookup?&title=Rationally%20engineered%20Cas9%20nucleases%20with%20improved%20specificity&journal=Science&doi=10.1126%2Fscience.aad5227&volume=351&pages=84-88&publication_year=2016&author=Slaymaker%2CIM?
• Earnings of https://doi.org/10.1038%2Fnbt.2889
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Genome-wide%20binding%20of%20the%20CRISPR%20endonuclease%20Cas9%20in%20mammalian%20cells&journal=Nat.%20Biotechnol.&doi=10.1038%2Fnbt.2889&volume=32&pages=670-676&publication_year=2014&author=Wu%2CXB bring in?
• What's the income of https://doi.org/10.1073%2Fpnas.1402597111?
• Discover the revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2014PNAS..111.9798S
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=Direct%20observation%20of%20R-loop%20formation%20by%20single%20RNA-guided%20Cas9%20and%20Cascade%20effector%20complexes&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.1402597111&volume=111&pages=9798-9803&publication_year=2014&author=Szczelkun%2CMD is on a monthly basis
• https://doi.org/10.1038%2Fnature15544 income
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2015Natur.527..110S make?
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=Conformational%20control%20of%20DNA%20target%20cleavage%20by%20CRISPR-Cas9&journal=Nature&doi=10.1038%2Fnature15544&volume=527&pages=110-113&publication_year=2015&author=Sternberg%2CSH&author=LaFrance%2CB&author=Kaplan%2CM&author=Doudna%2CJA
• How much income is https://doi.org/10.1038%2Fnmeth.1208 earning monthly?
• See how much http://scholar.google.com/scholar_lookup?&title=A%20practical%20guide%20to%20single-molecule%20FRET&journal=Nat.%20Methods&doi=10.1038%2Fnmeth.1208&volume=5&pages=507-516&publication_year=2008&author=Roy%2CR&author=Hohng%2CS&author=Ha%2CT makes per month
• How much money does https://doi.org/10.1021%2Fnn301895c make?
• How much does http://scholar.google.com/scholar_lookup?&title=Enzymatic%20oxygen%20scavenging%20for%20photostability%20without%20pH%20drop%20in%20single-molecule%20experiments&journal=ACS%20Nano&doi=10.1021%2Fnn301895c&volume=6&pages=6364-6369&publication_year=2012&author=Swoboda%2CM pull in?
• How much money does https://doi.org/10.1016%2Fj.bpj.2009.09.031 make?
• What's the financial outcome of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009BpJ....97.3196B?
• Revenue of http://scholar.google.com/scholar_lookup?&title=Learning%20rates%20and%20states%20from%20biophysical%20time%20series%3A%20a%20Bayesian%20approach%20to%20model%20selection%20and%20single-molecule%20FRET%20data&journal=Biophys.%20J.&doi=10.1016%2Fj.bpj.2009.09.031&volume=97&pages=3196-3205&publication_year=2009&author=Bronson%2CJE&author=Fei%2CJY&author=Hofman%2CJM&author=Gonzalez%2CRL&author=Wiggins%2CCH
• What is the earnings of https://citation-needed.springer.com/v2/references/10.1038/ncomms13350?format=refman&flavour=references?
• See how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Youngbin%20Lim makes per month
• Income figures for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Youngbin%20Lim%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• Get to know what's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=So%20Young%20Bak
• Get to know https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22So%20Young%20Bak%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's earnings
• What is the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Keewon%20Sung?
• How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Keewon%20Sung%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
• Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Euihwan%20Jeong
• How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Euihwan%20Jeong%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Seung%20Hwan%20Lee pull in monthly?
• How profitable is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Seung%20Hwan%20Lee%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Check the income stats for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jin-Soo%20Kim
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jin-Soo%20Kim%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sangsu%20Bae
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sangsu%20Bae%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earn?
• How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Seong%20Keun%20Kim have?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Seong%20Keun%20Kim%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en net monthly?
• What's the total monthly financial gain of https://static-content.springer.com/esm/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_BFncomms13350_MOESM1164_ESM.pdf?
• What's the financial outcome of https://static-content.springer.com/esm/art%3A10.1038%2Fncomms13350/MediaObjects/41467_2016_BFncomms13350_MOESM1165_ESM.pdf?
• How profitable is http://creativecommons.org/licenses/by/4.0/?
• What are the total earnings of https://s100.copyright.com/AppDispatchServlet?title=Structural%20roles%20of%20guide%20RNAs%20in%20the%20nuclease%20activity%20of%20Cas9%20endonuclease&author=Youngbin%20Lim%20et%20al&contentID=10.1038%2Fncomms13350©right=The%20Author%28s%29&publication=2041-1723&publicationDate=2016-11-02&publisherName=SpringerNature&orderBeanReset=true&oa=CC%20BY?
• How much does https://crossmark.crossref.org/dialog/?doi=10.1038/ncomms13350 generate monthly?
• What's the total monthly financial gain of https://citation-needed.springer.com/v2/references/10.1038/ncomms13350?format=refman&flavour=citation?
• How profitable is https://doi.org/10.1038/s41467-023-41393-5?
• What are the total earnings of https://doi.org/10.1186/s12967-022-03738-4?
• https://doi.org/10.1038/s41467-022-29604-x's revenue stream
• How much income does https://doi.org/10.1038/s41598-021-93685-9 have?
• https://doi.org/10.1007/s10142-021-00782-z's financial summary
• How much revenue does https://www.protocols.io/ produce monthly?
• What's the financial outcome of https://www.natureindex.com/?
• How much does http://www.naturechina.com generate monthly?
• Revenue of https://www.natureasia.com/ja-jp

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref