Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Schema
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers
  15. CDN Services

We are analyzing https://www.nature.com/articles/ncb3390.

Title:
F-actin dismantling through a redox-driven synergy between Mical and cofilin | Nature Cell Biology
Description:
Numerous cellular functions depend on actin filament (F-actin) disassembly. The best-characterized disassembly proteins, the ADF (actin-depolymerizing factor)/cofilins (encoded by the twinstar gene in Drosophila), sever filaments and recycle monomers to promote actin assembly. Cofilin is also a relatively weak actin disassembler, posing questions about mechanisms of cellular F-actin destabilization. Here we uncover a key link to targeted F-actin disassembly by finding that F-actin is efficiently dismantled through a post-translational-mediated synergism between cofilin and the actin-oxidizing enzyme Mical. We find that Mical-mediated oxidation of actin improves cofilin binding to filaments, where their combined effect dramatically accelerates F-actin disassembly compared with either effector alone. This synergism is also necessary and sufficient for F-actin disassembly in vivo, magnifying the effects of both Mical and cofilin on cellular remodelling, axon guidance and Semaphorin–Plexin repulsion. Mical and cofilin, therefore, form a redox-dependent synergistic pair that promotes F-actin instability by rapidly dismantling F-actin and generating post-translationally modified actin that has altered assembly properties. Grintsevich et al. discover that the redox enzyme Mical oxidizes F-actin to promote binding of the F-actin-severing protein cofilin, and that the synergy of Mical and cofilin is necessary and sufficient for F-actin disassembly in Drosophila.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Telecommunications
  • Science

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
Estimations show Nature.com's display ad online revenue falls between $42,042 and $115,616 per month.

Keywords {🔍}

actin, cofilin, article, google, scholar, cas, mical, factin, cell, supplementary, severing, fig, micaloxidized, filaments, biol, nature, oxidation, copolymer, conditions, disassembly, red, drosophila, unoxidized, data, terman, note, time, nadph, subtilisin, experiments, oxactin, shown, binding, met, boxes, mol, nat, skeletal, yeast, presence, antibody, residue, fluorescence, compared, axon, access, cytoskeleton, human, independent, enhanced,

Topics {✒️}

nature portfolio semaphorin/plexin-mediated f-actin/cellular remodeling permissions reprints mical-oxidized anp-cross-linked f-actin privacy policy hem-derived cajal-retzius cells mical-oxidized cross-linked f-actin advertising open circles cross-linked q41c f-actin semaphorin/plexin/mical-dependent effects q41c f-actin cross-linking nature 463 nature yeast cofilin-kck-cy5-maleimide social media plexin-mediated axonal repulsion ox-actin—mical-oxidized g-actin 2d [upper middle 2d [lower middle rabbit skeletal actin-alexa488se cofilin-mediated f-actin severing cellular f-actin destabilization post-translational-mediated synergism redox-dependent synergistic pair q41c actin cross-linking promotes f-actin instability inducing f-actin disassembly1 actin-oxidizing enzyme mical rapidly dismantling f-actin reverses mical-mediated oxidation regulate f-actin disassembly targeted f-actin disassembly modulating f-actin disassembly impair f-actin assembly regulate f-actin dynamics f-actin disassembly factor q41c-xl f-actin wild-type met44 antibodies mical-oxidized f-actin semaphorin–plexin repulsion characterized mical-oxidized actin purified mical-oxidized actin semaphorin-dependent manner7 drosophila ovary development anp-modified actin skeletal f-actin curved drosophila bristle ruei-jiun hung & jonathan permissions

Schema {🗺️}

WebPage:
      mainEntity:
         headline:F-actin dismantling through a redox-driven synergy between Mical and cofilin
         description:Numerous cellular functions depend on actin filament (F-actin) disassembly. The best-characterized disassembly proteins, the ADF (actin-depolymerizing factor)/cofilins (encoded by the twinstar gene in Drosophila), sever filaments and recycle monomers to promote actin assembly. Cofilin is also a relatively weak actin disassembler, posing questions about mechanisms of cellular F-actin destabilization. Here we uncover a key link to targeted F-actin disassembly by finding that F-actin is efficiently dismantled through a post-translational-mediated synergism between cofilin and the actin-oxidizing enzyme Mical. We find that Mical-mediated oxidation of actin improves cofilin binding to filaments, where their combined effect dramatically accelerates F-actin disassembly compared with either effector alone. This synergism is also necessary and sufficient for F-actin disassembly in vivo, magnifying the effects of both Mical and cofilin on cellular remodelling, axon guidance and Semaphorin–Plexin repulsion. Mical and cofilin, therefore, form a redox-dependent synergistic pair that promotes F-actin instability by rapidly dismantling F-actin and generating post-translationally modified actin that has altered assembly properties. Grintsevich et al. discover that the redox enzyme Mical oxidizes F-actin to promote binding of the F-actin-severing protein cofilin, and that the synergy of Mical and cofilin is necessary and sufficient for F-actin disassembly in Drosophila.
         datePublished:2016-07-25T00:00:00Z
         dateModified:2016-07-25T00:00:00Z
         pageStart:876
         pageEnd:885
         sameAs:https://doi.org/10.1038/ncb3390
         keywords:
            Actin
            Post-translational modifications
            Life Sciences
            general
            Cell Biology
            Cancer Research
            Developmental Biology
            Stem Cells
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncb3390/MediaObjects/41556_2016_Article_BFncb3390_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncb3390/MediaObjects/41556_2016_Article_BFncb3390_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncb3390/MediaObjects/41556_2016_Article_BFncb3390_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncb3390/MediaObjects/41556_2016_Article_BFncb3390_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncb3390/MediaObjects/41556_2016_Article_BFncb3390_Fig5_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncb3390/MediaObjects/41556_2016_Article_BFncb3390_Fig6_HTML.jpg
         isPartOf:
            name:Nature Cell Biology
            issn:
               1476-4679
               1465-7392
            volumeNumber:18
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Elena E. Grintsevich
               affiliation:
                     name:University of California-Los Angeles
                     address:
                        name:Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California 90095, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hunkar Gizem Yesilyurt
               affiliation:
                     name:The University of Texas Southwestern Medical Center
                     address:
                        name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shannon K. Rich
               affiliation:
                     name:The University of Texas Southwestern Medical Center
                     address:
                        name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ruei-Jiun Hung
               affiliation:
                     name:The University of Texas Southwestern Medical Center
                     address:
                        name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jonathan R. Terman
               affiliation:
                     name:The University of Texas Southwestern Medical Center
                     address:
                        name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Emil Reisler
               affiliation:
                     name:University of California-Los Angeles
                     address:
                        name:Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California 90095, USA
                        type:PostalAddress
                     type:Organization
                     name:Molecular Biology Institute, University of California-Los Angeles
                     address:
                        name:Molecular Biology Institute, University of California-Los Angeles, Los Angeles, California 90095, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:F-actin dismantling through a redox-driven synergy between Mical and cofilin
      description:Numerous cellular functions depend on actin filament (F-actin) disassembly. The best-characterized disassembly proteins, the ADF (actin-depolymerizing factor)/cofilins (encoded by the twinstar gene in Drosophila), sever filaments and recycle monomers to promote actin assembly. Cofilin is also a relatively weak actin disassembler, posing questions about mechanisms of cellular F-actin destabilization. Here we uncover a key link to targeted F-actin disassembly by finding that F-actin is efficiently dismantled through a post-translational-mediated synergism between cofilin and the actin-oxidizing enzyme Mical. We find that Mical-mediated oxidation of actin improves cofilin binding to filaments, where their combined effect dramatically accelerates F-actin disassembly compared with either effector alone. This synergism is also necessary and sufficient for F-actin disassembly in vivo, magnifying the effects of both Mical and cofilin on cellular remodelling, axon guidance and Semaphorin–Plexin repulsion. Mical and cofilin, therefore, form a redox-dependent synergistic pair that promotes F-actin instability by rapidly dismantling F-actin and generating post-translationally modified actin that has altered assembly properties. Grintsevich et al. discover that the redox enzyme Mical oxidizes F-actin to promote binding of the F-actin-severing protein cofilin, and that the synergy of Mical and cofilin is necessary and sufficient for F-actin disassembly in Drosophila.
      datePublished:2016-07-25T00:00:00Z
      dateModified:2016-07-25T00:00:00Z
      pageStart:876
      pageEnd:885
      sameAs:https://doi.org/10.1038/ncb3390
      keywords:
         Actin
         Post-translational modifications
         Life Sciences
         general
         Cell Biology
         Cancer Research
         Developmental Biology
         Stem Cells
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncb3390/MediaObjects/41556_2016_Article_BFncb3390_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncb3390/MediaObjects/41556_2016_Article_BFncb3390_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncb3390/MediaObjects/41556_2016_Article_BFncb3390_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncb3390/MediaObjects/41556_2016_Article_BFncb3390_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncb3390/MediaObjects/41556_2016_Article_BFncb3390_Fig5_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncb3390/MediaObjects/41556_2016_Article_BFncb3390_Fig6_HTML.jpg
      isPartOf:
         name:Nature Cell Biology
         issn:
            1476-4679
            1465-7392
         volumeNumber:18
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Elena E. Grintsevich
            affiliation:
                  name:University of California-Los Angeles
                  address:
                     name:Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California 90095, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hunkar Gizem Yesilyurt
            affiliation:
                  name:The University of Texas Southwestern Medical Center
                  address:
                     name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shannon K. Rich
            affiliation:
                  name:The University of Texas Southwestern Medical Center
                  address:
                     name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ruei-Jiun Hung
            affiliation:
                  name:The University of Texas Southwestern Medical Center
                  address:
                     name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jonathan R. Terman
            affiliation:
                  name:The University of Texas Southwestern Medical Center
                  address:
                     name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Emil Reisler
            affiliation:
                  name:University of California-Los Angeles
                  address:
                     name:Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California 90095, USA
                     type:PostalAddress
                  type:Organization
                  name:Molecular Biology Institute, University of California-Los Angeles
                  address:
                     name:Molecular Biology Institute, University of California-Los Angeles, Los Angeles, California 90095, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Cell Biology
      issn:
         1476-4679
         1465-7392
      volumeNumber:18
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of California-Los Angeles
      address:
         name:Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California 90095, USA
         type:PostalAddress
      name:The University of Texas Southwestern Medical Center
      address:
         name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
         type:PostalAddress
      name:The University of Texas Southwestern Medical Center
      address:
         name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
         type:PostalAddress
      name:The University of Texas Southwestern Medical Center
      address:
         name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
         type:PostalAddress
      name:The University of Texas Southwestern Medical Center
      address:
         name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
         type:PostalAddress
      name:University of California-Los Angeles
      address:
         name:Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California 90095, USA
         type:PostalAddress
      name:Molecular Biology Institute, University of California-Los Angeles
      address:
         name:Molecular Biology Institute, University of California-Los Angeles, Los Angeles, California 90095, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Elena E. Grintsevich
      affiliation:
            name:University of California-Los Angeles
            address:
               name:Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California 90095, USA
               type:PostalAddress
            type:Organization
      name:Hunkar Gizem Yesilyurt
      affiliation:
            name:The University of Texas Southwestern Medical Center
            address:
               name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
               type:PostalAddress
            type:Organization
      name:Shannon K. Rich
      affiliation:
            name:The University of Texas Southwestern Medical Center
            address:
               name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
               type:PostalAddress
            type:Organization
      name:Ruei-Jiun Hung
      affiliation:
            name:The University of Texas Southwestern Medical Center
            address:
               name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
               type:PostalAddress
            type:Organization
      name:Jonathan R. Terman
      affiliation:
            name:The University of Texas Southwestern Medical Center
            address:
               name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Emil Reisler
      affiliation:
            name:University of California-Los Angeles
            address:
               name:Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California 90095, USA
               type:PostalAddress
            type:Organization
            name:Molecular Biology Institute, University of California-Los Angeles
            address:
               name:Molecular Biology Institute, University of California-Los Angeles, Los Angeles, California 90095, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California 90095, USA
      name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
      name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
      name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
      name:Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
      name:Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California 90095, USA
      name:Molecular Biology Institute, University of California-Los Angeles, Los Angeles, California 90095, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(1)

External Links {🔗}(165)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

5.36s.