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The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression | Nature Cell Biology
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The Snail family of transcription factors has previously been implicated in the differentiation of epithelial cells into mesenchymal cells (epithelial–mesenchymal transitions) during embryonic development. Epithelial–mesenchymal transitions are also determinants of the progression of carcinomas, occurring concomitantly with the cellular acquisition of migratory properties following downregulation of expression of the adhesion protein E-cadherin. Here we show that mouse Snail is a strong repressor of transcription of the E-cadherin gene. Epithelial cells that ectopically express Snail adopt a fibroblastoid phenotype and acquire tumorigenic and invasive properties. Endogenous Snail protein is present in invasive mouse and human carcinoma cell lines and tumours in which E-cadherin expression has been lost. Therefore, the same molecules are used to trigger epithelial–mesenchymal transitions during embryonic development and in tumour progression. Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs.
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nature portfolio gsf research centre permissions reprints privacy policy advertising nature 392 nature promote epithelial-mesenchymal transition social media trigger epithelial–mesenchymal transitions e-cadherin invasion-suppressor gene specific anti-invasive drugs stable cell-cell contacts increased cell-substratum adhesion pre-malignant skin tumors epstein-barr virus infection adhesion protein e-cadherin repressing e-cadherin expression epithelial–mesenchymal transitions epithelial-mesenchymal transitions e-cadherin promoter constructs ddr2-regulated arginase activity human e-cadherin gene dna-binding site repertoire e-cadherin gene expression personal data springerlink instant access cell biology data protection permissions zinc finger gene human cell lines human carcinoma cells epithelial gene expression epithelio-mesenchymal transformation e-pal element epithelium-mesenchyme transition e-cadherin gene endogenous snail protein e-cadherin promoter dominant negative mutant mouse skin carcinogenesis privacy drosophila snail gene e-cadherin expression e-cadherin transfection e-cadherin complexes mouse gene homologous issue learn trophoblast giant cells
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headline:The transcription factor Snail controls epithelialâmesenchymal transitions by repressing E-cadherin expression
description:The Snail family of transcription factors has previously been implicated in the differentiation of epithelial cells into mesenchymal cells (epithelialâmesenchymal transitions) during embryonic development. Epithelialâmesenchymal transitions are also determinants of the progression of carcinomas, occurring concomitantly with the cellular acquisition of migratory properties following downregulation of expression of the adhesion protein E-cadherin. Here we show that mouse Snail is a strong repressor of transcription of the E-cadherin gene. Epithelial cells that ectopically express Snail adopt a fibroblastoid phenotype and acquire tumorigenic and invasive properties. Endogenous Snail protein is present in invasive mouse and human carcinoma cell lines and tumours in which E-cadherin expression has been lost. Therefore, the same molecules are used to trigger epithelialâmesenchymal transitions during embryonic development and in tumour progression. Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs.
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headline:The transcription factor Snail controls epithelialâmesenchymal transitions by repressing E-cadherin expression
description:The Snail family of transcription factors has previously been implicated in the differentiation of epithelial cells into mesenchymal cells (epithelialâmesenchymal transitions) during embryonic development. Epithelialâmesenchymal transitions are also determinants of the progression of carcinomas, occurring concomitantly with the cellular acquisition of migratory properties following downregulation of expression of the adhesion protein E-cadherin. Here we show that mouse Snail is a strong repressor of transcription of the E-cadherin gene. Epithelial cells that ectopically express Snail adopt a fibroblastoid phenotype and acquire tumorigenic and invasive properties. Endogenous Snail protein is present in invasive mouse and human carcinoma cell lines and tumours in which E-cadherin expression has been lost. Therefore, the same molecules are used to trigger epithelialâmesenchymal transitions during embryonic development and in tumour progression. Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs.
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