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nature portfolio permissions reprints privacy policy advertising genome-wide crispr–cas9 screens genome-wide crispr-cas9 screen social media nature identify gasdermin acute lung injury fr/espript/cgi-bin/espript atp-based cell viability research nlrp1-dependent pyroptosis leads lfn–bsak-induced gsdmd cleavage crispr-cas9-mediated targeting del castillo velasco-herrera nature biotechnol crispr-cas9-mdiated targeting lfn–bsak-triggered pyroptosis nature immunol reverse-transcription pcr analyses inflammasome-mediated caspase-1 autoprocessing lfn–bsak-induced pyroptosis prolonged lfn–bsak treatment overexpression-activated inflammatory caspases inflammasome-mediated immunity/diseases pan-caspase inhibitor zvad author correspondence bacterial-infection-activated caspase-1 macrophages drives orchitis gsdmd-deficient cell lines nature 477 nature 513 nature 514 nature 479 nature 505 nature 490 nature 526 nature t3ss-deficient mutant strains lps electroporation-induced pyroptosis caspase-1-mediated caspase-3/7 cleavage t3ss-deficient δsipd mutant boosts anti-tumor immunity gsdmd-deficient cells resisted interleukin-1β release springerlink instant access anti-tubulin blots serving tlr4-independent endotoxic shock n-terminal cleavage product

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      headline:Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
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