
NATURE . COM {
}
Title:
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells | Nature
Description:
Increased salt concentrations are shown to induce murine and human TH17 cells by a mechanism that depends on activation of p38/MAPK, NFAT5 and SGK1; mice kept on a high-salt diet develop a more severe experimental autoimmune encephalomyelitis due to increased induction of TH17 cells. Two independent groups have come to the same surprising conclusion: that increased salt concentrations promote autoimmune disease by stimulating the production of interleukin-17-producing helper T (TH17) cells from CD4+ T cells. Chuan Wu et al. show that increases in salt concentrations induce serum glucocorticoid kinase 1 (SGK1) in T cells and enhance TH17 differentiation in vitro and in vivo in mice. Markus Kleinewietfeld et al. find that salt induces murine and human TH17 cells by a mechanism dependent on activation of SGK1 and the p38 MAP kinase/NFAT5 pathway. Mice on a high-salt diet develop a more severe experimental autoimmune encephalomyelitis, a model for brain inflammation, owing to high numbers of infiltrating TH17 cells. These studies raise the possibility that high salt intake might trigger tissue inflammation and autoimmune disease in humans. A further paper from Nir Yosef et al. presents a global view of the gene networks regulating TH17 cell differentiation. There has been a marked increase in the incidence of autoimmune diseases in the past half-century. Although the underlying genetic basis of this class of diseases has recently been elucidated, implicating predominantly immune-response genes1, changes in environmental factors must ultimately be driving this increase. The newly identified population of interleukin (IL)-17-producing CD4+ helper T cells (TH17 cells) has a pivotal role in autoimmune diseases2. Pathogenic IL-23-dependent TH17 cells have been shown to be critical for the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, and genetic risk factors associated with multiple sclerosis are related to the IL-23–TH17 pathway1,2. However, little is known about the environmental factors that directly influence TH17 cells. Here we show that increased salt (sodium chloride, NaCl) concentrations found locally under physiological conditions in vivo markedly boost the induction of murine and human TH17 cells. High-salt conditions activate the p38/MAPK pathway involving nuclear factor of activated T cells 5 (NFAT5; also called TONEBP) and serum/glucocorticoid-regulated kinase 1 (SGK1) during cytokine-induced TH17 polarization. Gene silencing or chemical inhibition of p38/MAPK, NFAT5 or SGK1 abrogates the high-salt-induced TH17 cell development. The TH17 cells generated under high-salt conditions display a highly pathogenic and stable phenotype characterized by the upregulation of the pro-inflammatory cytokines GM-CSF, TNF-α and IL-2. Moreover, mice fed with a high-salt diet develop a more severe form of EAE, in line with augmented central nervous system infiltrating and peripherally induced antigen-specific TH17 cells. Thus, increased dietary salt intake might represent an environmental risk factor for the development of autoimmune diseases through the induction of pathogenic TH17 cells.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Science
- Education
- Health & Fitness
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.
Keywords {🔍}
article, google, scholar, nature, cells, cas, autoimmune, data, kinase, cell, access, research, salt, human, ads, content, diseases, development, usa, disease, sgk, gene, manuscript, center, cookies, pathogenic, kleinewietfeld, david, hafler, mice, immunol, sci, university, germany, analysed, privacy, information, sodium, induction, markus, factors, multiple, sclerosis, pathway, highsalt, open, proc, natl, acad, differentiation,
Topics {✒️}
nature portfolio permissions reprints privacy policy accession number gse42569 lentiviral rnai library editing advertising pro-inflammatory cytokines gm-csf glucocorticoid-inducible protein kinase p38/map kinase pathway social media clinical research center german research foundation high-salt diet develop experimental autoimmune encephalomyelitis α1-adrenergic receptor autoantibodies glucocorticoid-regulated kinase-1 antagonist high-salt conditions activate high-salt conditions display myelin oligodendrocyte glycoprotein-specific serum/glucocorticoid-regulated kinase 1 p38 mapk-dependent pathway inherited salt-losing tubulopathies nature genet population-wide sodium reduction cardiovascular research nature med nature immunol cell-mediated immune mechanisms clinical research cytokine-induced th17 polarization salt-sensitive hypertension monica springerlink instant access nature 476 nature 454 nature 484 nature 467 nature 496 nature content rubbing salt osmotic stress responses gene expression permissions central nervous system microarray data sets high salt intake renin-angiotensin system cell development hypertonic stress regulates environmental risk factor
Questions {❓}
- Increased Intestinal Permeability: An Avenue for the Development of Autoimmune Disease?
Schema {🗺️}
WebPage:
mainEntity:
headline:Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
description:Increased salt concentrations are shown to induce murine and human TH17 cells by a mechanism that depends on activation of p38/MAPK, NFAT5 and SGK1; mice kept on a high-salt diet develop a more severe experimental autoimmune encephalomyelitis due to increased induction of TH17 cells. Two independent groups have come to the same surprising conclusion: that increased salt concentrations promote autoimmune disease by stimulating the production of interleukin-17-producing helper T (TH17) cells from CD4+ T cells. Chuan Wu et al. show that increases in salt concentrations induce serum glucocorticoid kinase 1 (SGK1) in T cells and enhance TH17 differentiation in vitro and in vivo in mice. Markus Kleinewietfeld et al. find that salt induces murine and human TH17 cells by a mechanism dependent on activation of SGK1 and the p38 MAP kinase/NFAT5 pathway. Mice on a high-salt diet develop a more severe experimental autoimmune encephalomyelitis, a model for brain inflammation, owing to high numbers of infiltrating TH17 cells. These studies raise the possibility that high salt intake might trigger tissue inflammation and autoimmune disease in humans. A further paper from Nir Yosef et al. presents a global view of the gene networks regulating TH17 cell differentiation. There has been a marked increase in the incidence of autoimmune diseases in the past half-century. Although the underlying genetic basis of this class of diseases has recently been elucidated, implicating predominantly immune-response genes1, changes in environmental factors must ultimately be driving this increase. The newly identified population of interleukin (IL)-17-producing CD4+ helper T cells (TH17 cells) has a pivotal role in autoimmune diseases2. Pathogenic IL-23-dependent TH17 cells have been shown to be critical for the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, and genetic risk factors associated with multiple sclerosis are related to the IL-23âTH17 pathway1,2. However, little is known about the environmental factors that directly influence TH17 cells. Here we show that increased salt (sodium chloride, NaCl) concentrations found locally under physiological conditions in vivo markedly boost the induction of murine and human TH17 cells. High-salt conditions activate the p38/MAPK pathway involving nuclear factor of activated T cells 5 (NFAT5; also called TONEBP) and serum/glucocorticoid-regulated kinase 1 (SGK1) during cytokine-induced TH17 polarization. Gene silencing or chemical inhibition of p38/MAPK, NFAT5 or SGK1 abrogates the high-salt-induced TH17 cell development. The TH17 cells generated under high-salt conditions display a highly pathogenic and stable phenotype characterized by the upregulation of the pro-inflammatory cytokines GM-CSF, TNF-α and IL-2. Moreover, mice fed with a high-salt diet develop a more severe form of EAE, in line with augmented central nervous system infiltrating and peripherally induced antigen-specific TH17 cells. Thus, increased dietary salt intake might represent an environmental risk factor for the development of autoimmune diseases through the induction of pathogenic TH17 cells.
datePublished:2013-03-06T00:00:00Z
dateModified:2013-03-06T00:00:00Z
pageStart:518
pageEnd:522
sameAs:https://doi.org/10.1038/nature11868
keywords:
Autoimmunity
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig4_HTML.jpg
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:496
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Markus Kleinewietfeld
affiliation:
name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
address:
name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
type:PostalAddress
type:Organization
name:Broad Institute of MIT and Harvard, 7 Cambridge Center
address:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Arndt Manzel
affiliation:
name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
address:
name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
type:PostalAddress
type:Organization
name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150
address:
name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150, Bochum, Germany
type:PostalAddress
type:Organization
type:Person
name:Jens Titze
affiliation:
name:Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA
address:
name:Division of Clinical Pharmacology, Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA,
type:PostalAddress
type:Organization
name:University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
address:
name:Interdisciplinary Center for Clinical Research and Department for Nephrology and Hypertension, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
type:PostalAddress
type:Organization
type:Person
name:Heda Kvakan
affiliation:
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
address:
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
type:PostalAddress
type:Organization
name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany
address:
name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany,
type:PostalAddress
type:Organization
type:Person
name:Nir Yosef
affiliation:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center
address:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Ralf A. Linker
affiliation:
name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
address:
name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
type:PostalAddress
type:Organization
type:Person
name:Dominik N. Muller
affiliation:
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
address:
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
type:PostalAddress
type:Organization
name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
address:
name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
type:PostalAddress
type:Organization
type:Person
name:David A. Hafler
affiliation:
name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
address:
name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
type:PostalAddress
type:Organization
name:Broad Institute of MIT and Harvard, 7 Cambridge Center
address:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
description:Increased salt concentrations are shown to induce murine and human TH17 cells by a mechanism that depends on activation of p38/MAPK, NFAT5 and SGK1; mice kept on a high-salt diet develop a more severe experimental autoimmune encephalomyelitis due to increased induction of TH17 cells. Two independent groups have come to the same surprising conclusion: that increased salt concentrations promote autoimmune disease by stimulating the production of interleukin-17-producing helper T (TH17) cells from CD4+ T cells. Chuan Wu et al. show that increases in salt concentrations induce serum glucocorticoid kinase 1 (SGK1) in T cells and enhance TH17 differentiation in vitro and in vivo in mice. Markus Kleinewietfeld et al. find that salt induces murine and human TH17 cells by a mechanism dependent on activation of SGK1 and the p38 MAP kinase/NFAT5 pathway. Mice on a high-salt diet develop a more severe experimental autoimmune encephalomyelitis, a model for brain inflammation, owing to high numbers of infiltrating TH17 cells. These studies raise the possibility that high salt intake might trigger tissue inflammation and autoimmune disease in humans. A further paper from Nir Yosef et al. presents a global view of the gene networks regulating TH17 cell differentiation. There has been a marked increase in the incidence of autoimmune diseases in the past half-century. Although the underlying genetic basis of this class of diseases has recently been elucidated, implicating predominantly immune-response genes1, changes in environmental factors must ultimately be driving this increase. The newly identified population of interleukin (IL)-17-producing CD4+ helper T cells (TH17 cells) has a pivotal role in autoimmune diseases2. Pathogenic IL-23-dependent TH17 cells have been shown to be critical for the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, and genetic risk factors associated with multiple sclerosis are related to the IL-23âTH17 pathway1,2. However, little is known about the environmental factors that directly influence TH17 cells. Here we show that increased salt (sodium chloride, NaCl) concentrations found locally under physiological conditions in vivo markedly boost the induction of murine and human TH17 cells. High-salt conditions activate the p38/MAPK pathway involving nuclear factor of activated T cells 5 (NFAT5; also called TONEBP) and serum/glucocorticoid-regulated kinase 1 (SGK1) during cytokine-induced TH17 polarization. Gene silencing or chemical inhibition of p38/MAPK, NFAT5 or SGK1 abrogates the high-salt-induced TH17 cell development. The TH17 cells generated under high-salt conditions display a highly pathogenic and stable phenotype characterized by the upregulation of the pro-inflammatory cytokines GM-CSF, TNF-α and IL-2. Moreover, mice fed with a high-salt diet develop a more severe form of EAE, in line with augmented central nervous system infiltrating and peripherally induced antigen-specific TH17 cells. Thus, increased dietary salt intake might represent an environmental risk factor for the development of autoimmune diseases through the induction of pathogenic TH17 cells.
datePublished:2013-03-06T00:00:00Z
dateModified:2013-03-06T00:00:00Z
pageStart:518
pageEnd:522
sameAs:https://doi.org/10.1038/nature11868
keywords:
Autoimmunity
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig4_HTML.jpg
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:496
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Markus Kleinewietfeld
affiliation:
name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
address:
name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
type:PostalAddress
type:Organization
name:Broad Institute of MIT and Harvard, 7 Cambridge Center
address:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Arndt Manzel
affiliation:
name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
address:
name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
type:PostalAddress
type:Organization
name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150
address:
name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150, Bochum, Germany
type:PostalAddress
type:Organization
type:Person
name:Jens Titze
affiliation:
name:Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA
address:
name:Division of Clinical Pharmacology, Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA,
type:PostalAddress
type:Organization
name:University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
address:
name:Interdisciplinary Center for Clinical Research and Department for Nephrology and Hypertension, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
type:PostalAddress
type:Organization
type:Person
name:Heda Kvakan
affiliation:
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
address:
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
type:PostalAddress
type:Organization
name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany
address:
name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany,
type:PostalAddress
type:Organization
type:Person
name:Nir Yosef
affiliation:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center
address:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Ralf A. Linker
affiliation:
name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
address:
name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
type:PostalAddress
type:Organization
type:Person
name:Dominik N. Muller
affiliation:
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
address:
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
type:PostalAddress
type:Organization
name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
address:
name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
type:PostalAddress
type:Organization
type:Person
name:David A. Hafler
affiliation:
name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
address:
name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
type:PostalAddress
type:Organization
name:Broad Institute of MIT and Harvard, 7 Cambridge Center
address:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:496
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
address:
name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
type:PostalAddress
name:Broad Institute of MIT and Harvard, 7 Cambridge Center
address:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
type:PostalAddress
name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
address:
name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
type:PostalAddress
name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150
address:
name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150, Bochum, Germany
type:PostalAddress
name:Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA
address:
name:Division of Clinical Pharmacology, Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA,
type:PostalAddress
name:University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
address:
name:Interdisciplinary Center for Clinical Research and Department for Nephrology and Hypertension, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
type:PostalAddress
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
address:
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
type:PostalAddress
name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany
address:
name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany,
type:PostalAddress
name:Broad Institute of MIT and Harvard, 7 Cambridge Center
address:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
type:PostalAddress
name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
address:
name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
type:PostalAddress
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
address:
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
type:PostalAddress
name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
address:
name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
type:PostalAddress
name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
address:
name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
type:PostalAddress
name:Broad Institute of MIT and Harvard, 7 Cambridge Center
address:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Markus Kleinewietfeld
affiliation:
name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
address:
name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
type:PostalAddress
type:Organization
name:Broad Institute of MIT and Harvard, 7 Cambridge Center
address:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
name:Arndt Manzel
affiliation:
name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
address:
name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
type:PostalAddress
type:Organization
name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150
address:
name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150, Bochum, Germany
type:PostalAddress
type:Organization
name:Jens Titze
affiliation:
name:Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA
address:
name:Division of Clinical Pharmacology, Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA,
type:PostalAddress
type:Organization
name:University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
address:
name:Interdisciplinary Center for Clinical Research and Department for Nephrology and Hypertension, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
type:PostalAddress
type:Organization
name:Heda Kvakan
affiliation:
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
address:
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
type:PostalAddress
type:Organization
name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany
address:
name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany,
type:PostalAddress
type:Organization
name:Nir Yosef
affiliation:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center
address:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
type:PostalAddress
type:Organization
name:Ralf A. Linker
affiliation:
name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
address:
name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
type:PostalAddress
type:Organization
name:Dominik N. Muller
affiliation:
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
address:
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
type:PostalAddress
type:Organization
name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
address:
name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
type:PostalAddress
type:Organization
name:David A. Hafler
affiliation:
name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
address:
name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
type:PostalAddress
type:Organization
name:Broad Institute of MIT and Harvard, 7 Cambridge Center
address:
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150, Bochum, Germany
name:Division of Clinical Pharmacology, Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA,
name:Interdisciplinary Center for Clinical Research and Department for Nephrology and Hypertension, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany,
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(119)
- Get to know https://link.springer.com/article/10.1038/nature11868?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle's earnings
- What's the income of http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE42569?
- Income figures for https://doi.org/10.1146%2Fannurev.immunol.021908.132710
- Financial intake of http://scholar.google.com/scholar_lookup?&title=IL-17%20and%20Th17%20Cells&journal=Annu.%20Rev.%20Immunol.&doi=10.1146%2Fannurev.immunol.021908.132710&volume=27&pages=485-517&publication_year=2009&author=Korn%2CT&author=Bettelli%2CE&author=Oukka%2CM&author=Kuchroo%2CVK
- How much does https://doi.org/10.1002%2Fana.21141 bring in each month?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Environmental%20risk%20factors%20for%20multiple%20sclerosis.%20Part%20II%3A%20Noninfectious%20factors&journal=Ann.%20Neurol.&doi=10.1002%2Fana.21141&volume=61&pages=504-513&publication_year=2007&author=Ascherio%2CA&author=Munger%2CKL
- https://doi.org/10.3945%2Fan.110.1002 income
- How much does http://scholar.google.com/scholar_lookup?&title=Institute%20of%20Medicine.%202010.%20Strategies%20to%20reduce%20sodium%20intake%20in%20the%20United%20States.%20Washington%2C%20DC%3A%20The%20National%20Academies%20Press&journal=Adv.%20Nutr.&doi=10.3945%2Fan.110.1002&volume=1&pages=49-50&publication_year=2010&author=McGuire%2CS gross monthly?
- How much does https://doi.org/10.1161%2FCIR.0b013e31820d0793 earn?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=The%20importance%20of%20population-wide%20sodium%20reduction%20as%20a%20means%20to%20prevent%20cardiovascular%20disease%20and%20stroke%3A%20a%20call%20to%20action%20from%20the%20American%20Heart%20Association&journal=Circulation&doi=10.1161%2FCIR.0b013e31820d0793&volume=123&pages=1138-1143&publication_year=2011&author=Appel%2CLJ
- Find out how much https://doi.org/10.1093%2Fije%2Fdyp139 earns monthly
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Salt%20intakes%20around%20the%20world%3A%20implications%20for%20public%20health&journal=Int.%20J.%20Epidemiol.&doi=10.1093%2Fije%2Fdyp139&volume=38&pages=791-813&publication_year=2009&author=Brown%2CIJ&author=Tzoulaki%2CI&author=Candeias%2CV&author=Elliott%2CP produce monthly?
- How much cash flow does https://doi.org/10.1038%2Fnm.1960 have monthly?
- Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Macrophages%20regulate%20salt-dependent%20volume%20and%20blood%20pressure%20by%20a%20vascular%20endothelial%20growth%20factor-C-dependent%20buffering%20mechanism&journal=Nature%20Med.&doi=10.1038%2Fnm.1960&volume=15&pages=545-552&publication_year=2009&author=Machnik%2CA
- What's the total monthly financial gain of https://doi.org/10.1073%2Fpnas.0903958106?
- Check the income stats for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009PNAS..10614948P
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Blocking%20angiotensin-converting%20enzyme%20induces%20potent%20regulatory%20T%20cells%20and%20modulates%20TH1-%20and%20TH17-mediated%20autoimmunity&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0903958106&volume=106&pages=14948-14953&publication_year=2009&author=Platten%2CM
- https://doi.org/10.1073%2Fpnas.0903602106's total income per month
- Income figures for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009PNAS..10614942S
- How much does http://scholar.google.com/scholar_lookup?&title=Role%20of%20the%20renin-angiotensin%20system%20in%20autoimmune%20inflammation%20of%20the%20central%20nervous%20system&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0903602106&volume=106&pages=14942-14947&publication_year=2009&author=Stegbauer%2CJ generate monthly?
- What's the total monthly financial gain of https://doi.org/10.1038%2Fnature07021?
- How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2008Natur.454..350Y bring in each month?
- Get to know http://scholar.google.com/scholar_lookup?&title=IL-21%20and%20TGF-%CE%B2%20are%20required%20for%20differentiation%20of%20human%20TH17%20cells&journal=Nature&doi=10.1038%2Fnature07021&volume=454&pages=350-352&publication_year=2008&author=Yang%2CL's earnings
- Learn about the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8055665
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Hypertonic%20saline%20enhances%20cellular%20immune%20function&journal=Circ.%20Shock&volume=42&pages=190-196&publication_year=1994&author=Junger%2CWG&author=Liu%2CFC&author=Loomis%2CWH&author=Hoyt%2CDB bring in?
- How much cash flow does https://doi.org/10.1038%2Fnature10957 have monthly?
- Discover the revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2012Natur.484..514Z
- See how much http://scholar.google.com/scholar_lookup?&title=Pathogen-induced%20human%20TH17%20cells%20produce%20IFN-%CE%B3%20or%20IL-10%20and%20are%20regulated%20by%20IL-1%CE%B2&journal=Nature&doi=10.1038%2Fnature10957&volume=484&pages=514-518&publication_year=2012&author=Zielinski%2CCE makes per month
- How much does https://doi.org/10.1016%2Fj.coi.2009.03.001 net monthly?
- http://scholar.google.com/scholar_lookup?&title=Transcriptional%20regulatory%20networks%20in%20Th17%20cell%20differentiation&journal=Curr.%20Opin.%20Immunol.&doi=10.1016%2Fj.coi.2009.03.001&volume=21&pages=146-152&publication_year=2009&author=Zhou%2CL&author=Littman%2CDR income
- Check the income stats for https://doi.org/10.1038%2Fnature09447
- Financial intake of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2010Natur.467..967G
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Generation%20of%20pathogenic%20TH17%20cells%20in%20the%20absence%20of%20TGF-%CE%B2%20signalling&journal=Nature&doi=10.1038%2Fnature09447&volume=467&pages=967-971&publication_year=2010&author=Ghoreschi%2CK
- How much does https://doi.org/10.1038%2Fni.2027 earn?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=ROR%CE%B3t%20drives%20production%20of%20the%20cytokine%20GM-CSF%20in%20helper%20T%20cells%2C%20which%20is%20essential%20for%20the%20effector%20phase%20of%20autoimmune%20neuroinflammation&journal=Nature%20Immunol.&doi=10.1038%2Fni.2027&volume=12&pages=560-567&publication_year=2011&author=Codarri%2CL?
- Get to know https://doi.org/10.1038%2Fni.2031's earnings
- What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=The%20encephalitogenicity%20of%20TH17%20cells%20is%20dependent%20on%20IL-1-%20and%20IL-23-induced%20production%20of%20the%20cytokine%20GM-CSF&journal=Nature%20Immunol.&doi=10.1038%2Fni.2031&volume=12&pages=568-575&publication_year=2011&author=El-Behi%2CM?
- What's the monthly income of https://doi.org/10.1038%2Fni.1716?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=C%E2%80%93C%20chemokine%20receptor%206-regulated%20entry%20of%20TH-17%20cells%20into%20the%20CNS%20through%20the%20choroid%20plexus%20is%20required%20for%20the%20initiation%20of%20EAE&journal=Nature%20Immunol.&doi=10.1038%2Fni.1716&volume=10&pages=514-523&publication_year=2009&author=Reboldi%2CA?
- Check the income stats for https://doi.org/10.1016%2Fj.immuni.2010.09.009
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=MicroRNA-155%20promotes%20autoimmune%20inflammation%20by%20enhancing%20inflammatory%20T%20cell%20development&journal=Immunity&doi=10.1016%2Fj.immuni.2010.09.009&volume=33&pages=607-619&publication_year=2010&author=O%E2%80%99Connell%2CRM
- Financial intake of https://doi.org/10.1073%2Fpnas.92.26.12230
- How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1995PNAS...9212230S pull in?
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Osmotic%20regulation%20of%20cytokine%20synthesis%20in%20vitro&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.92.26.12230&volume=92&pages=12230-12234&publication_year=1995&author=Shapiro%2CL&author=Dinarello%2CCA?
- What's the financial gain of https://doi.org/10.1073%2Fpnas.0403139101?
- How much income does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2004PNAS..10110673G have?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=NFAT5%2FTonEBP%20mutant%20mice%20define%20osmotic%20stress%20as%20a%20critical%20feature%20of%20the%20lymphoid%20microenvironment&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0403139101&volume=101&pages=10673-10678&publication_year=2004&author=Go%2CWY&author=Liu%2CX&author=Roti%2CMA&author=Liu%2CF&author=Ho%2CSN
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19211510 generate monthly?
- What's the financial outcome of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856329?
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=Brx%20mediates%20the%20response%20of%20lymphocytes%20to%20osmotic%20stress%20through%20the%20activation%20of%20NFAT5&journal=Sci.%20Signal.&volume=2&publication_year=2009&author=Kino%2CT
- How much income is https://doi.org/10.1172%2FJCI35314 earning monthly?
- How much income is http://scholar.google.com/scholar_lookup?&title=Tonicity-dependent%20induction%20of%20Sgk1%20expression%20has%20a%20potential%20role%20in%20dehydration-induced%20natriuresis%20in%20rodents&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI35314&volume=119&pages=1647-1658&publication_year=2009&author=Chen%2CS earning monthly?
- https://doi.org/10.1093%2Fnar%2Fgks038 income
- http://scholar.google.com/scholar_lookup?&title=Transcriptional%20regulation%20of%20gene%20expression%20during%20osmotic%20stress%20responses%20by%20the%20mammalian%20target%20of%20rapamycin&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgks038&volume=40&pages=4368-4384&publication_year=2012&author=Ortells%2CMC's revenue stream
- How much revenue does https://doi.org/10.1189%2Fjlb.0410211 bring in?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Hypertonic%20stress%20regulates%20T%20cell%20function%20via%20pannexin-1%20hemichannels%20and%20P2X%20receptors&journal=J.%20Leukoc.%20Biol.&doi=10.1189%2Fjlb.0410211&volume=88&pages=1181-1189&publication_year=2010&author=Woehrle%2CT?
- How much does https://doi.org/10.1073%2Fpnas.94.9.4440 rake in every month?
- How much profit does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1997PNAS...94.4440W make?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Cloning%20and%20characterization%20of%20a%20putative%20human%20serine%2Fthreonine%20protein%20kinase%20transcriptionally%20modified%20during%20anisotonic%20and%20isotonic%20alterations%20of%20cell%20volume&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.94.9.4440&volume=94&pages=4440-4445&publication_year=1997&author=Waldegger%2CS&author=Barth%2CP&author=Raber%2CG&author=Lang%2CF?
- How much revenue does https://doi.org/10.1074%2Fjbc.M002076200 generate?
- How much does http://scholar.google.com/scholar_lookup?&title=Hyperosmotic%20stress%20stimulates%20promoter%20activity%20and%20regulates%20cellular%20utilization%20of%20the%20serum-%20and%20glucocorticoid-inducible%20protein%20kinase%20%28Sgk%29%20by%20a%20p38%20MAPK-dependent%20pathway&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M002076200&volume=275&pages=25262-25272&publication_year=2000&author=Bell%2CLM earn?
- How much does https://doi.org/10.1016%2FS0016-5085%2899%2970011-9 earn?
- How much income does http://scholar.google.com/scholar_lookup?&title=h-sgk%20serine-threonine%20protein%20kinase%20gene%20as%20transcriptional%20target%20of%20transforming%20growth%20factor%20%CE%B2%20in%20human%20intestine&journal=Gastroenterology&doi=10.1016%2FS0016-5085%2899%2970011-9&volume=116&pages=1081-1088&publication_year=1999&author=Waldegger%2CS have?
- Get to know https://doi.org/10.1128%2FMCB.13.4.2031's earnings
- Get to know http://scholar.google.com/scholar_lookup?&title=Characterization%20of%20sgk%2C%20a%20novel%20member%20of%20the%20serine%2Fthreonine%20protein%20kinase%20gene%20family%20which%20is%20transcriptionally%20induced%20by%20glucocorticoids%20and%20serum&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.13.4.2031&volume=13&pages=2031-2040&publication_year=1993&author=Webster%2CMK&author=Goya%2CL&author=Ge%2CY&author=Maiyar%2CAC&author=Firestone%2CGL's earnings
- https://doi.org/10.1159%2F000016351's revenue stream
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=h-sgk%20serine-threonine%20protein%20kinase%20as%20transcriptional%20target%20of%20p38%2FMAP%20kinase%20pathway%20in%20HepG2%20human%20hepatoma%20cells&journal=Cell.%20Physiol.%20Biochem.&doi=10.1159%2F000016351&volume=10&pages=203-208&publication_year=2000&author=Waldegger%2CS&author=Gabrysch%2CS&author=Barth%2CP&author=Fillon%2CS&author=Lang%2CF?
- What's https://doi.org/10.1158%2F0008-5472.CAN-08-1047's gross income?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Development%20of%20a%20small-molecule%20serum-%20and%20glucocorticoid-regulated%20kinase-1%20antagonist%20and%20its%20evaluation%20as%20a%20prostate%20cancer%20therapeutic&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-08-1047&volume=68&pages=7475-7483&publication_year=2008&author=Sherk%2CAB generate?
- https://doi.org/10.1016%2Fj.cell.2006.01.040 income
- How much does http://scholar.google.com/scholar_lookup?&title=A%20lentiviral%20RNAi%20library%20for%20human%20and%20mouse%20genes%20applied%20to%20an%20arrayed%20viral%20high-content%20screen&journal=Cell&doi=10.1016%2Fj.cell.2006.01.040&volume=124&pages=1283-1298&publication_year=2006&author=Moffat%2CJ rake in every month?
- How much revenue does https://doi.org/10.4049%2Fjimmunol.0902443 generate?
- How much does http://scholar.google.com/scholar_lookup?&title=RNA%20interference%20screen%20in%20primary%20human%20T%20cells%20reveals%20FLT3%20as%20a%20modulator%20of%20IL-10%20levels&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.0902443&volume=184&pages=685-693&publication_year=2010&author=Astier%2CAL earn?
- What's the total monthly financial gain of https://doi.org/10.1038%2Fng0506-500?
- How much does http://scholar.google.com/scholar_lookup?&title=GenePattern%202.0&journal=Nature%20Genet.&doi=10.1038%2Fng0506-500&volume=38&pages=500-501&publication_year=2006&author=Reich%2CM generate monthly?
- How much does https://doi.org/10.1093%2Fbiostatistics%2F4.2.249 pull in?
- What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Exploration%2C%20normalization%2C%20and%20summaries%20of%20high%20density%20oligonucleotide%20array%20probe%20level%20data&journal=Biostatistics&doi=10.1093%2Fbiostatistics%2F4.2.249&volume=4&pages=249-264&publication_year=2003&author=Irizarry%2CRA?
- What's the income generated by https://doi.org/10.1371%2Fjournal.pone.0003742 each month?
- How much profit does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2008PLoSO...3.3742W generate?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Potential%20relevance%20of%20%CE%B11-adrenergic%20receptor%20autoantibodies%20in%20refractory%20hypertension&journal=PLoS%20ONE&doi=10.1371%2Fjournal.pone.0003742&volume=3&publication_year=2008&author=Wenzel%2CK?
- See how much https://doi.org/10.1182%2Fblood-2011-02-336552 makes per month
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Activation%20of%20p38%20MAPK%20in%20CD4%20T%20cells%20controls%20IL-17%20production%20and%20autoimmune%20encephalomyelitis&journal=Blood&doi=10.1182%2Fblood-2011-02-336552&volume=118&pages=3290-3300&publication_year=2011&author=Noubade%2CR
- What's the monthly income of https://doi.org/10.1101%2Fgad.1306705?
- http://scholar.google.com/scholar_lookup?&title=p38%20MAP%20kinase%20inhibition%20enables%20proliferation%20of%20adult%20mammalian%20cardiomyocytes&journal=Genes%20Dev.&doi=10.1101%2Fgad.1306705&volume=19&pages=1175-1187&publication_year=2005&author=Engel%2CFB's total income per month
- How much cash flow does https://doi.org/10.1084%2Fjem.20021603 have monthly?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Myelin%20oligodendrocyte%20glycoprotein-specific%20T%20cell%20receptor%20transgenic%20mice%20develop%20spontaneous%20autoimmune%20optic%20neuritis&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20021603&volume=197&pages=1073-1081&publication_year=2003&author=Bettelli%2CE
- How much does https://citation-needed.springer.com/v2/references/10.1038/nature11868?format=refman&flavour=references generate monthly?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Markus%20Kleinewietfeld gross monthly?
- Discover the revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Markus%20Kleinewietfeld%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Get to know https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Arndt%20Manzel's earnings
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Arndt%20Manzel%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earn?
- Explore the financials of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jens%20Titze
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jens%20Titze%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en rake in every month?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Heda%20Kvakan pull in?
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Heda%20Kvakan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's revenue stream
- How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Nir%20Yosef make?
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Nir%20Yosef%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en produce monthly?
- How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ralf%20A.%20Linker generate?
- What's the financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ralf%20A.%20Linker%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much cash flow does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dominik%20N.%20Muller have monthly?
- Learn about the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Dominik%20N.%20Muller%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What's the total monthly financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=David%20A.%20Hafler?
- What are the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22David%20A.%20Hafler%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Revenue of https://static-content.springer.com/esm/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_BFnature11868_MOESM5_ESM.pdf
- How much revenue does https://static-content.springer.com/esm/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_BFnature11868_MOESM1_ESM.ppt bring in?
- https://static-content.springer.com/esm/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_BFnature11868_MOESM2_ESM.ppt's financial summary
- Find out how much https://static-content.springer.com/esm/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_BFnature11868_MOESM3_ESM.ppt earns monthly
- How much money does https://static-content.springer.com/esm/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_BFnature11868_MOESM4_ESM.ppt make?
- How much money does https://s100.copyright.com/AppDispatchServlet?title=Sodium%20chloride%20drives%20autoimmune%20disease%20by%20the%20induction%20of%20pathogenic%20TH17%20cells&author=Markus%20Kleinewietfeld%20et%20al&contentID=10.1038%2Fnature11868©right=Springer%20Nature%20Limited&publication=0028-0836&publicationDate=2013-03-06&publisherName=SpringerNature&orderBeanReset=true generate?
- What's https://citation-needed.springer.com/v2/references/10.1038/nature11868?format=refman&flavour=citation's gross income?
- How much profit does https://doi.org/10.1186/s12964-023-01381-0 make?
- How much money does https://doi.org/10.1038/s41593-023-01497-z make?
- How much revenue does https://doi.org/10.1038/s41577-024-00994-x bring in?
- How much does https://doi.org/10.1038/s41598-024-51279-1 make?
- Get to know https://doi.org/10.1007/s12403-023-00578-5's earnings
- How profitable is https://www.protocols.io/?
- How much profit does https://www.natureindex.com/ generate?
- How profitable is http://www.naturechina.com?
- Income figures for https://www.natureasia.com/ja-jp
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Foundation
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref