NATURE . COM {}

Matching Content Categories {📚}

• Science
• Education
• Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$63,100 per month
Estimations show Nature.com's display ad online revenue falls between $42,042 and $115,616 per month.

Keywords {🔍}

article, google, scholar, nature, cells, cas, autoimmune, data, kinase, cell, access, research, salt, human, ads, content, diseases, development, usa, disease, sgk, gene, manuscript, center, cookies, pathogenic, kleinewietfeld, david, hafler, mice, immunol, sci, university, germany, analysed, privacy, information, sodium, induction, markus, factors, multiple, sclerosis, pathway, highsalt, open, proc, natl, acad, differentiation,

Topics {✒️}

nature portfolio permissions reprints privacy policy accession number gse42569 lentiviral rnai library editing advertising pro-inflammatory cytokines gm-csf glucocorticoid-inducible protein kinase p38/map kinase pathway social media clinical research center german research foundation high-salt diet develop experimental autoimmune encephalomyelitis α1-adrenergic receptor autoantibodies glucocorticoid-regulated kinase-1 antagonist high-salt conditions activate high-salt conditions display myelin oligodendrocyte glycoprotein-specific serum/glucocorticoid-regulated kinase 1 p38 mapk-dependent pathway inherited salt-losing tubulopathies nature genet population-wide sodium reduction cardiovascular research nature med nature immunol cell-mediated immune mechanisms clinical research cytokine-induced th17 polarization salt-sensitive hypertension monica springerlink instant access nature 476 nature 454 nature 484 nature 467 nature 496 nature content rubbing salt osmotic stress responses gene expression permissions central nervous system microarray data sets high salt intake renin-angiotensin system cell development hypertonic stress regulates environmental risk factor

Questions {❓}

• Increased Intestinal Permeability: An Avenue for the Development of Autoimmune Disease?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
         description:Increased salt concentrations are shown to induce murine and human TH17 cells by a mechanism that depends on activation of p38/MAPK, NFAT5 and SGK1; mice kept on a high-salt diet develop a more severe experimental autoimmune encephalomyelitis due to increased induction of TH17 cells. Two independent groups have come to the same surprising conclusion: that increased salt concentrations promote autoimmune disease by stimulating the production of interleukin-17-producing helper T (TH17) cells from CD4+ T cells. Chuan Wu et al. show that increases in salt concentrations induce serum glucocorticoid kinase 1 (SGK1) in T cells and enhance TH17 differentiation in vitro and in vivo in mice. Markus Kleinewietfeld et al. find that salt induces murine and human TH17 cells by a mechanism dependent on activation of SGK1 and the p38 MAP kinase/NFAT5 pathway. Mice on a high-salt diet develop a more severe experimental autoimmune encephalomyelitis, a model for brain inflammation, owing to high numbers of infiltrating TH17 cells. These studies raise the possibility that high salt intake might trigger tissue inflammation and autoimmune disease in humans. A further paper from Nir Yosef et al. presents a global view of the gene networks regulating TH17 cell differentiation. There has been a marked increase in the incidence of autoimmune diseases in the past half-century. Although the underlying genetic basis of this class of diseases has recently been elucidated, implicating predominantly immune-response genes1, changes in environmental factors must ultimately be driving this increase. The newly identified population of interleukin (IL)-17-producing CD4+ helper T cells (TH17 cells) has a pivotal role in autoimmune diseases2. Pathogenic IL-23-dependent TH17 cells have been shown to be critical for the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, and genetic risk factors associated with multiple sclerosis are related to the IL-23–TH17 pathway1,2. However, little is known about the environmental factors that directly influence TH17 cells. Here we show that increased salt (sodium chloride, NaCl) concentrations found locally under physiological conditions in vivo markedly boost the induction of murine and human TH17 cells. High-salt conditions activate the p38/MAPK pathway involving nuclear factor of activated T cells 5 (NFAT5; also called TONEBP) and serum/glucocorticoid-regulated kinase 1 (SGK1) during cytokine-induced TH17 polarization. Gene silencing or chemical inhibition of p38/MAPK, NFAT5 or SGK1 abrogates the high-salt-induced TH17 cell development. The TH17 cells generated under high-salt conditions display a highly pathogenic and stable phenotype characterized by the upregulation of the pro-inflammatory cytokines GM-CSF, TNF-α and IL-2. Moreover, mice fed with a high-salt diet develop a more severe form of EAE, in line with augmented central nervous system infiltrating and peripherally induced antigen-specific TH17 cells. Thus, increased dietary salt intake might represent an environmental risk factor for the development of autoimmune diseases through the induction of pathogenic TH17 cells.
         datePublished:2013-03-06T00:00:00Z
         dateModified:2013-03-06T00:00:00Z
         pageStart:518
         pageEnd:522
         sameAs:https://doi.org/10.1038/nature11868
         keywords:
            Autoimmunity
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig4_HTML.jpg
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:496
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Markus Kleinewietfeld
               affiliation:
                     name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
                     address:
                        name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
                        type:PostalAddress
                     type:Organization
                     name:Broad Institute of MIT and Harvard, 7 Cambridge Center
                     address:
                        name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Arndt Manzel
               affiliation:
                     name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
                     address:
                        name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
                        type:PostalAddress
                     type:Organization
                     name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150
                     address:
                        name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150, Bochum, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jens Titze
               affiliation:
                     name:Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA
                     address:
                        name:Division of Clinical Pharmacology, Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA,
                        type:PostalAddress
                     type:Organization
                     name:University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
                     address:
                        name:Interdisciplinary Center for Clinical Research and Department for Nephrology and Hypertension, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Heda Kvakan
               affiliation:
                     name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
                     address:
                        name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
                        type:PostalAddress
                     type:Organization
                     name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany
                     address:
                        name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nir Yosef
               affiliation:
                     name:Broad Institute of MIT and Harvard, 7 Cambridge Center
                     address:
                        name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ralf A. Linker
               affiliation:
                     name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
                     address:
                        name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Dominik N. Muller
               affiliation:
                     name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
                     address:
                        name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
                        type:PostalAddress
                     type:Organization
                     name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
                     address:
                        name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:David A. Hafler
               affiliation:
                     name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
                     address:
                        name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
                        type:PostalAddress
                     type:Organization
                     name:Broad Institute of MIT and Harvard, 7 Cambridge Center
                     address:
                        name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
      description:Increased salt concentrations are shown to induce murine and human TH17 cells by a mechanism that depends on activation of p38/MAPK, NFAT5 and SGK1; mice kept on a high-salt diet develop a more severe experimental autoimmune encephalomyelitis due to increased induction of TH17 cells. Two independent groups have come to the same surprising conclusion: that increased salt concentrations promote autoimmune disease by stimulating the production of interleukin-17-producing helper T (TH17) cells from CD4+ T cells. Chuan Wu et al. show that increases in salt concentrations induce serum glucocorticoid kinase 1 (SGK1) in T cells and enhance TH17 differentiation in vitro and in vivo in mice. Markus Kleinewietfeld et al. find that salt induces murine and human TH17 cells by a mechanism dependent on activation of SGK1 and the p38 MAP kinase/NFAT5 pathway. Mice on a high-salt diet develop a more severe experimental autoimmune encephalomyelitis, a model for brain inflammation, owing to high numbers of infiltrating TH17 cells. These studies raise the possibility that high salt intake might trigger tissue inflammation and autoimmune disease in humans. A further paper from Nir Yosef et al. presents a global view of the gene networks regulating TH17 cell differentiation. There has been a marked increase in the incidence of autoimmune diseases in the past half-century. Although the underlying genetic basis of this class of diseases has recently been elucidated, implicating predominantly immune-response genes1, changes in environmental factors must ultimately be driving this increase. The newly identified population of interleukin (IL)-17-producing CD4+ helper T cells (TH17 cells) has a pivotal role in autoimmune diseases2. Pathogenic IL-23-dependent TH17 cells have been shown to be critical for the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, and genetic risk factors associated with multiple sclerosis are related to the IL-23–TH17 pathway1,2. However, little is known about the environmental factors that directly influence TH17 cells. Here we show that increased salt (sodium chloride, NaCl) concentrations found locally under physiological conditions in vivo markedly boost the induction of murine and human TH17 cells. High-salt conditions activate the p38/MAPK pathway involving nuclear factor of activated T cells 5 (NFAT5; also called TONEBP) and serum/glucocorticoid-regulated kinase 1 (SGK1) during cytokine-induced TH17 polarization. Gene silencing or chemical inhibition of p38/MAPK, NFAT5 or SGK1 abrogates the high-salt-induced TH17 cell development. The TH17 cells generated under high-salt conditions display a highly pathogenic and stable phenotype characterized by the upregulation of the pro-inflammatory cytokines GM-CSF, TNF-α and IL-2. Moreover, mice fed with a high-salt diet develop a more severe form of EAE, in line with augmented central nervous system infiltrating and peripherally induced antigen-specific TH17 cells. Thus, increased dietary salt intake might represent an environmental risk factor for the development of autoimmune diseases through the induction of pathogenic TH17 cells.
      datePublished:2013-03-06T00:00:00Z
      dateModified:2013-03-06T00:00:00Z
      pageStart:518
      pageEnd:522
      sameAs:https://doi.org/10.1038/nature11868
      keywords:
         Autoimmunity
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_Article_BFnature11868_Fig4_HTML.jpg
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:496
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Markus Kleinewietfeld
            affiliation:
                  name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
                  address:
                     name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
                     type:PostalAddress
                  type:Organization
                  name:Broad Institute of MIT and Harvard, 7 Cambridge Center
                  address:
                     name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Arndt Manzel
            affiliation:
                  name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
                  address:
                     name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
                     type:PostalAddress
                  type:Organization
                  name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150
                  address:
                     name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150, Bochum, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jens Titze
            affiliation:
                  name:Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA
                  address:
                     name:Division of Clinical Pharmacology, Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA,
                     type:PostalAddress
                  type:Organization
                  name:University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
                  address:
                     name:Interdisciplinary Center for Clinical Research and Department for Nephrology and Hypertension, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Heda Kvakan
            affiliation:
                  name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
                  address:
                     name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
                     type:PostalAddress
                  type:Organization
                  name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany
                  address:
                     name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nir Yosef
            affiliation:
                  name:Broad Institute of MIT and Harvard, 7 Cambridge Center
                  address:
                     name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ralf A. Linker
            affiliation:
                  name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
                  address:
                     name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dominik N. Muller
            affiliation:
                  name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
                  address:
                     name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
                     type:PostalAddress
                  type:Organization
                  name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
                  address:
                     name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David A. Hafler
            affiliation:
                  name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
                  address:
                     name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
                     type:PostalAddress
                  type:Organization
                  name:Broad Institute of MIT and Harvard, 7 Cambridge Center
                  address:
                     name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:496
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
      address:
         name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
         type:PostalAddress
      name:Broad Institute of MIT and Harvard, 7 Cambridge Center
      address:
         name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
         type:PostalAddress
      name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
      address:
         name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
         type:PostalAddress
      name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150
      address:
         name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150, Bochum, Germany
         type:PostalAddress
      name:Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA
      address:
         name:Division of Clinical Pharmacology, Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA,
         type:PostalAddress
      name:University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
      address:
         name:Interdisciplinary Center for Clinical Research and Department for Nephrology and Hypertension, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
         type:PostalAddress
      name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
      address:
         name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
         type:PostalAddress
      name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany
      address:
         name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany,
         type:PostalAddress
      name:Broad Institute of MIT and Harvard, 7 Cambridge Center
      address:
         name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
         type:PostalAddress
      name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
      address:
         name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
         type:PostalAddress
      name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
      address:
         name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
         type:PostalAddress
      name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
      address:
         name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
         type:PostalAddress
      name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
      address:
         name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
         type:PostalAddress
      name:Broad Institute of MIT and Harvard, 7 Cambridge Center
      address:
         name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Markus Kleinewietfeld
      affiliation:
            name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
            address:
               name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
               type:PostalAddress
            type:Organization
            name:Broad Institute of MIT and Harvard, 7 Cambridge Center
            address:
               name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Arndt Manzel
      affiliation:
            name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
            address:
               name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
               type:PostalAddress
            type:Organization
            name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150
            address:
               name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150, Bochum, Germany
               type:PostalAddress
            type:Organization
      name:Jens Titze
      affiliation:
            name:Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA
            address:
               name:Division of Clinical Pharmacology, Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA,
               type:PostalAddress
            type:Organization
            name:University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
            address:
               name:Interdisciplinary Center for Clinical Research and Department for Nephrology and Hypertension, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
               type:PostalAddress
            type:Organization
      name:Heda Kvakan
      affiliation:
            name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
            address:
               name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
               type:PostalAddress
            type:Organization
            name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany
            address:
               name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany,
               type:PostalAddress
            type:Organization
      name:Nir Yosef
      affiliation:
            name:Broad Institute of MIT and Harvard, 7 Cambridge Center
            address:
               name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Ralf A. Linker
      affiliation:
            name:University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
            address:
               name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
               type:PostalAddress
            type:Organization
      name:Dominik N. Muller
      affiliation:
            name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany
            address:
               name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
               type:PostalAddress
            type:Organization
            name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany
            address:
               name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
               type:PostalAddress
            type:Organization
      name:David A. Hafler
      affiliation:
            name:Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA
            address:
               name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
               type:PostalAddress
            type:Organization
            name:Broad Institute of MIT and Harvard, 7 Cambridge Center
            address:
               name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
      name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
      name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
      name:International Graduate School of Neuroscience, Ruhr-University Bochum, Universitätsstr. 150, Bochum, Germany
      name:Division of Clinical Pharmacology, Vanderbilt University, 2213 Garland Avenue, Nashville, Tennessee 37232, USA,
      name:Interdisciplinary Center for Clinical Research and Department for Nephrology and Hypertension, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
      name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
      name:Helios Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany,
      name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
      name:Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany,
      name:Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Lindenberger Weg 80, 13125 Berlin, Germany,
      name:Nikolaus-Fiebiger-Center for Molecular Medicine, University of Erlangen-Nuremberg, Glückstr. 6, 91054 Erlangen, Germany,
      name:Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA,
      name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/Nature
• https://twitter.com/nature

External Links {🔗}(119)

• How much revenue does https://link.springer.com/article/10.1038/nature11868?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle bring in?
• What's the profit of http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE42569?
• What's the income generated by https://doi.org/10.1146%2Fannurev.immunol.021908.132710 each month?
• What's http://scholar.google.com/scholar_lookup?&title=IL-17%20and%20Th17%20Cells&journal=Annu.%20Rev.%20Immunol.&doi=10.1146%2Fannurev.immunol.021908.132710&volume=27&pages=485-517&publication_year=2009&author=Korn%2CT&author=Bettelli%2CE&author=Oukka%2CM&author=Kuchroo%2CVK's gross income?
• What's the income generated by https://doi.org/10.1002%2Fana.21141 each month?
• How much does http://scholar.google.com/scholar_lookup?&title=Environmental%20risk%20factors%20for%20multiple%20sclerosis.%20Part%20II%3A%20Noninfectious%20factors&journal=Ann.%20Neurol.&doi=10.1002%2Fana.21141&volume=61&pages=504-513&publication_year=2007&author=Ascherio%2CA&author=Munger%2CKL rake in every month?
• https://doi.org/10.3945%2Fan.110.1002's financial summary
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Institute%20of%20Medicine.%202010.%20Strategies%20to%20reduce%20sodium%20intake%20in%20the%20United%20States.%20Washington%2C%20DC%3A%20The%20National%20Academies%20Press&journal=Adv.%20Nutr.&doi=10.3945%2Fan.110.1002&volume=1&pages=49-50&publication_year=2010&author=McGuire%2CS bring in?
• Income figures for https://doi.org/10.1161%2FCIR.0b013e31820d0793
• How much does http://scholar.google.com/scholar_lookup?&title=The%20importance%20of%20population-wide%20sodium%20reduction%20as%20a%20means%20to%20prevent%20cardiovascular%20disease%20and%20stroke%3A%20a%20call%20to%20action%20from%20the%20American%20Heart%20Association&journal=Circulation&doi=10.1161%2FCIR.0b013e31820d0793&volume=123&pages=1138-1143&publication_year=2011&author=Appel%2CLJ gross monthly?
• How much income does https://doi.org/10.1093%2Fije%2Fdyp139 have?
• How profitable is http://scholar.google.com/scholar_lookup?&title=Salt%20intakes%20around%20the%20world%3A%20implications%20for%20public%20health&journal=Int.%20J.%20Epidemiol.&doi=10.1093%2Fije%2Fdyp139&volume=38&pages=791-813&publication_year=2009&author=Brown%2CIJ&author=Tzoulaki%2CI&author=Candeias%2CV&author=Elliott%2CP?
• Get to know https://doi.org/10.1038%2Fnm.1960's earnings
• How much does http://scholar.google.com/scholar_lookup?&title=Macrophages%20regulate%20salt-dependent%20volume%20and%20blood%20pressure%20by%20a%20vascular%20endothelial%20growth%20factor-C-dependent%20buffering%20mechanism&journal=Nature%20Med.&doi=10.1038%2Fnm.1960&volume=15&pages=545-552&publication_year=2009&author=Machnik%2CA gross monthly?
• How much income is https://doi.org/10.1073%2Fpnas.0903958106 earning monthly?
• Find out how much http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009PNAS..10614948P earns monthly
• What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Blocking%20angiotensin-converting%20enzyme%20induces%20potent%20regulatory%20T%20cells%20and%20modulates%20TH1-%20and%20TH17-mediated%20autoimmunity&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0903958106&volume=106&pages=14948-14953&publication_year=2009&author=Platten%2CM?
• How much does https://doi.org/10.1073%2Fpnas.0903602106 gross monthly?
• What's http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009PNAS..10614942S's gross income?
• http://scholar.google.com/scholar_lookup?&title=Role%20of%20the%20renin-angiotensin%20system%20in%20autoimmune%20inflammation%20of%20the%20central%20nervous%20system&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0903602106&volume=106&pages=14942-14947&publication_year=2009&author=Stegbauer%2CJ's financial summary
• What's the income generated by https://doi.org/10.1038%2Fnature07021 each month?
• What's the income of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2008Natur.454..350Y?
• What's the monthly income of http://scholar.google.com/scholar_lookup?&title=IL-21%20and%20TGF-%CE%B2%20are%20required%20for%20differentiation%20of%20human%20TH17%20cells&journal=Nature&doi=10.1038%2Fnature07021&volume=454&pages=350-352&publication_year=2008&author=Yang%2CL?
• Earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8055665
• How much does http://scholar.google.com/scholar_lookup?&title=Hypertonic%20saline%20enhances%20cellular%20immune%20function&journal=Circ.%20Shock&volume=42&pages=190-196&publication_year=1994&author=Junger%2CWG&author=Liu%2CFC&author=Loomis%2CWH&author=Hoyt%2CDB earn?
• What's the profit of https://doi.org/10.1038%2Fnature10957?
• How much profit is http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2012Natur.484..514Z making per month?
• How much profit does http://scholar.google.com/scholar_lookup?&title=Pathogen-induced%20human%20TH17%20cells%20produce%20IFN-%CE%B3%20or%20IL-10%20and%20are%20regulated%20by%20IL-1%CE%B2&journal=Nature&doi=10.1038%2Fnature10957&volume=484&pages=514-518&publication_year=2012&author=Zielinski%2CCE make?
• What are the earnings of https://doi.org/10.1016%2Fj.coi.2009.03.001?
• What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Transcriptional%20regulatory%20networks%20in%20Th17%20cell%20differentiation&journal=Curr.%20Opin.%20Immunol.&doi=10.1016%2Fj.coi.2009.03.001&volume=21&pages=146-152&publication_year=2009&author=Zhou%2CL&author=Littman%2CDR?
• Financial intake of https://doi.org/10.1038%2Fnature09447
• What are the earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2010Natur.467..967G?
• http://scholar.google.com/scholar_lookup?&title=Generation%20of%20pathogenic%20TH17%20cells%20in%20the%20absence%20of%20TGF-%CE%B2%20signalling&journal=Nature&doi=10.1038%2Fnature09447&volume=467&pages=967-971&publication_year=2010&author=Ghoreschi%2CK's financial summary
• What's the profit of https://doi.org/10.1038%2Fni.2027?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=ROR%CE%B3t%20drives%20production%20of%20the%20cytokine%20GM-CSF%20in%20helper%20T%20cells%2C%20which%20is%20essential%20for%20the%20effector%20phase%20of%20autoimmune%20neuroinflammation&journal=Nature%20Immunol.&doi=10.1038%2Fni.2027&volume=12&pages=560-567&publication_year=2011&author=Codarri%2CL generate?
• What's the revenue for https://doi.org/10.1038%2Fni.2031?
• How much does http://scholar.google.com/scholar_lookup?&title=The%20encephalitogenicity%20of%20TH17%20cells%20is%20dependent%20on%20IL-1-%20and%20IL-23-induced%20production%20of%20the%20cytokine%20GM-CSF&journal=Nature%20Immunol.&doi=10.1038%2Fni.2031&volume=12&pages=568-575&publication_year=2011&author=El-Behi%2CM bring in each month?
• What's the financial outcome of https://doi.org/10.1038%2Fni.1716?
• How much does http://scholar.google.com/scholar_lookup?&title=C%E2%80%93C%20chemokine%20receptor%206-regulated%20entry%20of%20TH-17%20cells%20into%20the%20CNS%20through%20the%20choroid%20plexus%20is%20required%20for%20the%20initiation%20of%20EAE&journal=Nature%20Immunol.&doi=10.1038%2Fni.1716&volume=10&pages=514-523&publication_year=2009&author=Reboldi%2CA pull in monthly?
• How much profit is https://doi.org/10.1016%2Fj.immuni.2010.09.009 making per month?
• Profit of http://scholar.google.com/scholar_lookup?&title=MicroRNA-155%20promotes%20autoimmune%20inflammation%20by%20enhancing%20inflammatory%20T%20cell%20development&journal=Immunity&doi=10.1016%2Fj.immuni.2010.09.009&volume=33&pages=607-619&publication_year=2010&author=O%E2%80%99Connell%2CRM
• What is the monthly revenue of https://doi.org/10.1073%2Fpnas.92.26.12230?
• How much revenue does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1995PNAS...9212230S produce monthly?
• What's the income generated by http://scholar.google.com/scholar_lookup?&title=Osmotic%20regulation%20of%20cytokine%20synthesis%20in%20vitro&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.92.26.12230&volume=92&pages=12230-12234&publication_year=1995&author=Shapiro%2CL&author=Dinarello%2CCA each month?
• How much money does https://doi.org/10.1073%2Fpnas.0403139101 make?
• What's the financial intake of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2004PNAS..10110673G?
• How much does http://scholar.google.com/scholar_lookup?&title=NFAT5%2FTonEBP%20mutant%20mice%20define%20osmotic%20stress%20as%20a%20critical%20feature%20of%20the%20lymphoid%20microenvironment&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0403139101&volume=101&pages=10673-10678&publication_year=2004&author=Go%2CWY&author=Liu%2CX&author=Roti%2CMA&author=Liu%2CF&author=Ho%2CSN gross monthly?
• How much profit is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19211510 making per month?
• What's the income generated by http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856329 each month?
• Profit of http://scholar.google.com/scholar_lookup?&title=Brx%20mediates%20the%20response%20of%20lymphocytes%20to%20osmotic%20stress%20through%20the%20activation%20of%20NFAT5&journal=Sci.%20Signal.&volume=2&publication_year=2009&author=Kino%2CT
• How much does https://doi.org/10.1172%2FJCI35314 generate monthly?
• How much does http://scholar.google.com/scholar_lookup?&title=Tonicity-dependent%20induction%20of%20Sgk1%20expression%20has%20a%20potential%20role%20in%20dehydration-induced%20natriuresis%20in%20rodents&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI35314&volume=119&pages=1647-1658&publication_year=2009&author=Chen%2CS rake in every month?
• How much money does https://doi.org/10.1093%2Fnar%2Fgks038 generate?
• What's http://scholar.google.com/scholar_lookup?&title=Transcriptional%20regulation%20of%20gene%20expression%20during%20osmotic%20stress%20responses%20by%20the%20mammalian%20target%20of%20rapamycin&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgks038&volume=40&pages=4368-4384&publication_year=2012&author=Ortells%2CMC's gross income?
• How much does https://doi.org/10.1189%2Fjlb.0410211 rake in every month?
• See how much http://scholar.google.com/scholar_lookup?&title=Hypertonic%20stress%20regulates%20T%20cell%20function%20via%20pannexin-1%20hemichannels%20and%20P2X%20receptors&journal=J.%20Leukoc.%20Biol.&doi=10.1189%2Fjlb.0410211&volume=88&pages=1181-1189&publication_year=2010&author=Woehrle%2CT makes per month
• Learn about the earnings of https://doi.org/10.1073%2Fpnas.94.9.4440
• Learn how profitable http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1997PNAS...94.4440W is on a monthly basis
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=Cloning%20and%20characterization%20of%20a%20putative%20human%20serine%2Fthreonine%20protein%20kinase%20transcriptionally%20modified%20during%20anisotonic%20and%20isotonic%20alterations%20of%20cell%20volume&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.94.9.4440&volume=94&pages=4440-4445&publication_year=1997&author=Waldegger%2CS&author=Barth%2CP&author=Raber%2CG&author=Lang%2CF have monthly?
• What's the monthly money flow for https://doi.org/10.1074%2Fjbc.M002076200?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Hyperosmotic%20stress%20stimulates%20promoter%20activity%20and%20regulates%20cellular%20utilization%20of%20the%20serum-%20and%20glucocorticoid-inducible%20protein%20kinase%20%28Sgk%29%20by%20a%20p38%20MAPK-dependent%20pathway&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M002076200&volume=275&pages=25262-25272&publication_year=2000&author=Bell%2CLM?
• What's the financial intake of https://doi.org/10.1016%2FS0016-5085%2899%2970011-9?
• How much does http://scholar.google.com/scholar_lookup?&title=h-sgk%20serine-threonine%20protein%20kinase%20gene%20as%20transcriptional%20target%20of%20transforming%20growth%20factor%20%CE%B2%20in%20human%20intestine&journal=Gastroenterology&doi=10.1016%2FS0016-5085%2899%2970011-9&volume=116&pages=1081-1088&publication_year=1999&author=Waldegger%2CS pull in?
• What are the earnings of https://doi.org/10.1128%2FMCB.13.4.2031?
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Characterization%20of%20sgk%2C%20a%20novel%20member%20of%20the%20serine%2Fthreonine%20protein%20kinase%20gene%20family%20which%20is%20transcriptionally%20induced%20by%20glucocorticoids%20and%20serum&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.13.4.2031&volume=13&pages=2031-2040&publication_year=1993&author=Webster%2CMK&author=Goya%2CL&author=Ge%2CY&author=Maiyar%2CAC&author=Firestone%2CGL?
• How much money does https://doi.org/10.1159%2F000016351 generate?
• What's the income of http://scholar.google.com/scholar_lookup?&title=h-sgk%20serine-threonine%20protein%20kinase%20as%20transcriptional%20target%20of%20p38%2FMAP%20kinase%20pathway%20in%20HepG2%20human%20hepatoma%20cells&journal=Cell.%20Physiol.%20Biochem.&doi=10.1159%2F000016351&volume=10&pages=203-208&publication_year=2000&author=Waldegger%2CS&author=Gabrysch%2CS&author=Barth%2CP&author=Fillon%2CS&author=Lang%2CF?
• Find out how much https://doi.org/10.1158%2F0008-5472.CAN-08-1047 earns monthly
• How much does http://scholar.google.com/scholar_lookup?&title=Development%20of%20a%20small-molecule%20serum-%20and%20glucocorticoid-regulated%20kinase-1%20antagonist%20and%20its%20evaluation%20as%20a%20prostate%20cancer%20therapeutic&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-08-1047&volume=68&pages=7475-7483&publication_year=2008&author=Sherk%2CAB rake in every month?
• What's the income of https://doi.org/10.1016%2Fj.cell.2006.01.040?
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=A%20lentiviral%20RNAi%20library%20for%20human%20and%20mouse%20genes%20applied%20to%20an%20arrayed%20viral%20high-content%20screen&journal=Cell&doi=10.1016%2Fj.cell.2006.01.040&volume=124&pages=1283-1298&publication_year=2006&author=Moffat%2CJ
• What are the earnings of https://doi.org/10.4049%2Fjimmunol.0902443?
• What's the profit of http://scholar.google.com/scholar_lookup?&title=RNA%20interference%20screen%20in%20primary%20human%20T%20cells%20reveals%20FLT3%20as%20a%20modulator%20of%20IL-10%20levels&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.0902443&volume=184&pages=685-693&publication_year=2010&author=Astier%2CAL?
• How much profit does https://doi.org/10.1038%2Fng0506-500 make?
• How much does http://scholar.google.com/scholar_lookup?&title=GenePattern%202.0&journal=Nature%20Genet.&doi=10.1038%2Fng0506-500&volume=38&pages=500-501&publication_year=2006&author=Reich%2CM earn?
• What's https://doi.org/10.1093%2Fbiostatistics%2F4.2.249's gross income?
• How much does http://scholar.google.com/scholar_lookup?&title=Exploration%2C%20normalization%2C%20and%20summaries%20of%20high%20density%20oligonucleotide%20array%20probe%20level%20data&journal=Biostatistics&doi=10.1093%2Fbiostatistics%2F4.2.249&volume=4&pages=249-264&publication_year=2003&author=Irizarry%2CRA bring in each month?
• How much does https://doi.org/10.1371%2Fjournal.pone.0003742 make?
• How much cash flow does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2008PLoSO...3.3742W have monthly?
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Potential%20relevance%20of%20%CE%B11-adrenergic%20receptor%20autoantibodies%20in%20refractory%20hypertension&journal=PLoS%20ONE&doi=10.1371%2Fjournal.pone.0003742&volume=3&publication_year=2008&author=Wenzel%2CK
• Profit of https://doi.org/10.1182%2Fblood-2011-02-336552
• How much profit does http://scholar.google.com/scholar_lookup?&title=Activation%20of%20p38%20MAPK%20in%20CD4%20T%20cells%20controls%20IL-17%20production%20and%20autoimmune%20encephalomyelitis&journal=Blood&doi=10.1182%2Fblood-2011-02-336552&volume=118&pages=3290-3300&publication_year=2011&author=Noubade%2CR generate?
• What's the revenue for https://doi.org/10.1101%2Fgad.1306705?
• How much does http://scholar.google.com/scholar_lookup?&title=p38%20MAP%20kinase%20inhibition%20enables%20proliferation%20of%20adult%20mammalian%20cardiomyocytes&journal=Genes%20Dev.&doi=10.1101%2Fgad.1306705&volume=19&pages=1175-1187&publication_year=2005&author=Engel%2CFB pull in monthly?
• Monthly income for https://doi.org/10.1084%2Fjem.20021603
• What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Myelin%20oligodendrocyte%20glycoprotein-specific%20T%20cell%20receptor%20transgenic%20mice%20develop%20spontaneous%20autoimmune%20optic%20neuritis&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20021603&volume=197&pages=1073-1081&publication_year=2003&author=Bettelli%2CE?
• Discover the revenue of https://citation-needed.springer.com/v2/references/10.1038/nature11868?format=refman&flavour=references
• Learn about the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Markus%20Kleinewietfeld
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Markus%20Kleinewietfeld%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en gross monthly?
• Profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Arndt%20Manzel
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Arndt%20Manzel%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en net monthly?
• How profitable is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jens%20Titze?
• What's the monthly money flow for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jens%20Titze%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Find out how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Heda%20Kvakan earns monthly
• How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Heda%20Kvakan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
• What are the total earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Nir%20Yosef?
• What are the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Nir%20Yosef%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ralf%20A.%20Linker
• Find out how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ralf%20A.%20Linker%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earns monthly
• Explore the financials of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dominik%20N.%20Muller
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Dominik%20N.%20Muller%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en produce monthly?
• How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=David%20A.%20Hafler have?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22David%20A.%20Hafler%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in?
• How much revenue does https://static-content.springer.com/esm/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_BFnature11868_MOESM5_ESM.pdf bring in?
• What's the income of https://static-content.springer.com/esm/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_BFnature11868_MOESM1_ESM.ppt?
• https://static-content.springer.com/esm/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_BFnature11868_MOESM2_ESM.ppt's revenue stream
• What's the financial intake of https://static-content.springer.com/esm/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_BFnature11868_MOESM3_ESM.ppt?
• What's the income generated by https://static-content.springer.com/esm/art%3A10.1038%2Fnature11868/MediaObjects/41586_2013_BFnature11868_MOESM4_ESM.ppt each month?
• How much does https://s100.copyright.com/AppDispatchServlet?title=Sodium%20chloride%20drives%20autoimmune%20disease%20by%20the%20induction%20of%20pathogenic%20TH17%20cells&author=Markus%20Kleinewietfeld%20et%20al&contentID=10.1038%2Fnature11868©right=Springer%20Nature%20Limited&publication=0028-0836&publicationDate=2013-03-06&publisherName=SpringerNature&orderBeanReset=true earn?
• Get to know https://citation-needed.springer.com/v2/references/10.1038/nature11868?format=refman&flavour=citation's earnings
• How much income is https://doi.org/10.1186/s12964-023-01381-0 earning monthly?
• How much does https://doi.org/10.1038/s41593-023-01497-z earn?
• Earnings of https://doi.org/10.1038/s41577-024-00994-x
• How much does https://doi.org/10.1038/s41598-024-51279-1 make?
• How much revenue does https://doi.org/10.1007/s12403-023-00578-5 produce monthly?
• How much revenue does https://www.protocols.io/ produce monthly?
• How much does https://www.natureindex.com/ rake in every month?
• How much does http://www.naturechina.com earn?
• How profitable is https://www.natureasia.com/ja-jp?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Foundation
• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref