
NATURE . COM {
}
Title:
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins | Nature
Description:
The aryl hydrocarbon receptor (AHR) is a transcription factor best known for mediating the toxicity of aromatic hydrocarbons such as dioxin: its activation leads to the production of detoxification enzymes. AHR has been intensely studied in relation to toxicology and cancer research, but no mechanistic connection to the immune system was known. Now two groups report a role for AHR in maintaining the balance between two T-lymphocyte populations β the Treg and TH17 cells β that are part of the immune regulation system dealing with tolerance of self-antigens and pathogen clearance. Both groups also show that AHR affects the severity of experimental autoimmune encephalitis, a mouse model of multiple sclerosis. This work raises the possibility that stimulation of AHR by environmental factors could be involved in the development of autoimmune disease, and point to AHR as a possible drug target for immunomodulation. Activation of the aryl hydrocarbon receptor with the ligand FICZ regulates IL-22 expression in TH17 cells. The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor best known for mediating the toxicity of dioxin1. Environmental factors are believed to contribute to the increased prevalence of autoimmune diseases, many of which are due to the activity of TH17 T cells, a new helper T-cell subset characterized by the production of the cytokine IL-17. Here we show that in the CD4+ T-cell lineage of mice AHR expression is restricted to the TH17 cell subset and its ligation results in the production of the TH17 cytokine interleukin (IL)-22. AHR is also expressed in human TH17 cells. Activation of AHR by a high-affinity ligand during TH17 cell development markedly increases the proportion of TH17 T cells and their production of cytokines. CD4+ T cells from AHR-deficient mice can develop TH17 cell responses, but when confronted with AHR ligand fail to produce IL-22 and do not show enhanced TH17 cell development. AHR activation during induction of experimental autoimmune encephalomyelitis causes accelerated onset and increased pathology in wild-type mice, but not AHR-deficient mice. AHR ligands may therefore represent co-factors in the development of autoimmune diseases.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {π}
- Science
- Education
- Health & Fitness
Content Management System {π}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {π}
What is the average monthly size of nature.com audience?
π Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {πΈ}
Display Ads {π―}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {π°}
Display Ads {π―}
$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.
Keywords {π}
article, google, scholar, cas, nature, receptor, cells, ahr, research, aryl, hydrocarbon, autoimmune, cell, immunol, content, interleukin, development, access, mice, cookies, human, activation, inflammation, privacy, information, environmental, factor, experimental, encephalomyelitis, data, march, veldhoen, hirota, westendorf, stockinger, production, show, immune, bradfield, sci, ads, system, med, author, supplementary, advertising, subscribe, autoimmunity, toxins, astrid,
Topics {βοΈ}
nature portfolio permissions reprints privacy policy biological services advertising receptor-dependent protein-dna interactions anti-il-17a auto-vaccine social media nature med nature immunol cell-mediated murine hepatitis nature 445 nature 453 nature author information authors dioxin-responsive transcriptional enhancer cd4+ t-cell lineage medical research cell-derived inducible factor ligand-dependent transcription factor 8-tetrachlorodibenzo-p-dioxin generates personal data ccr6-expressing th17 cells infection research cancer research pollution research dioxin-binding ah receptor springerlink instant access permissions author contributions author correspondence ahr-deficient mouse strain nf-ΞΊb-deficient mice data protection aryl hydrocarbon receptor experimental medicine unit th17 cell subset research privacy experimental autoimmune encephalomyelitis induces autoimmune inflammation immune system impairment nf-ΞΊb interactions pah-induced metabolic human th17 cells 8-tetrachlorodibenzo-p-dioxin hepatocyte-stimulating factor therapeutic lymphocyte depletion mrc national institute t-lymphocyte populations
Schema {πΊοΈ}
WebPage:
mainEntity:
headline:The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
description:The aryl hydrocarbon receptor (AHR) is a transcription factor best known for mediating the toxicity of aromatic hydrocarbons such as dioxin: its activation leads to the production of detoxification enzymes. AHR has been intensely studied in relation to toxicology and cancer research, but no mechanistic connection to the immune system was known. Now two groups report a role for AHR in maintaining the balance between two T-lymphocyte populations Γ’ΒΒ the Treg and TH17 cells Γ’ΒΒ that are part of the immune regulation system dealing with tolerance of self-antigens and pathogen clearance. Both groups also show that AHR affects the severity of experimental autoimmune encephalitis, a mouse model of multiple sclerosis. This work raises the possibility that stimulation of AHR by environmental factors could be involved in the development of autoimmune disease, and point to AHR as a possible drug target for immunomodulation. Activation of the aryl hydrocarbon receptor with the ligand FICZ regulates IL-22 expression in TH17 cells. The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor best known for mediating the toxicity of dioxin1. Environmental factors are believed to contribute to the increased prevalence of autoimmune diseases, many of which are due to the activity of TH17 T cells, a new helper T-cell subset characterized by the production of the cytokine IL-17. Here we show that in the CD4+ T-cell lineage of mice AHR expression is restricted to the TH17 cell subset and its ligation results in the production of the TH17 cytokine interleukin (IL)-22. AHR is also expressed in human TH17 cells. Activation of AHR by a high-affinity ligand during TH17 cell development markedly increases the proportion of TH17 T cells and their production of cytokines. CD4+ T cells from AHR-deficient mice can develop TH17 cell responses, but when confronted with AHR ligand fail to produce IL-22 and do not show enhanced TH17 cell development. AHR activation during induction of experimental autoimmune encephalomyelitis causes accelerated onset and increased pathology in wild-type mice, but not AHR-deficient mice. AHR ligands may therefore represent co-factors in the development of autoimmune diseases.
datePublished:2008-03-23T00:00:00Z
dateModified:2008-03-23T00:00:00Z
pageStart:106
pageEnd:109
sameAs:https://doi.org/10.1038/nature06881
keywords:
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature06881/MediaObjects/41586_2008_Article_BFnature06881_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature06881/MediaObjects/41586_2008_Article_BFnature06881_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature06881/MediaObjects/41586_2008_Article_BFnature06881_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature06881/MediaObjects/41586_2008_Article_BFnature06881_Fig4_HTML.jpg
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:453
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Marc Veldhoen
affiliation:
name:MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
address:
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
type:PostalAddress
type:Organization
type:Person
name:Keiji Hirota
affiliation:
name:MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
address:
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
type:PostalAddress
type:Organization
type:Person
name:Astrid M. Westendorf
affiliation:
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany
address:
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany ,
type:PostalAddress
type:Organization
name:Helmholtz Center for Infection Research
address:
name:Helmholtz Center for Infection Research, D-38124 Braunschweig, Germany
type:PostalAddress
type:Organization
type:Person
name:Jan Buer
affiliation:
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany
address:
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany ,
type:PostalAddress
type:Organization
type:Person
name:Laure Dumoutier
affiliation:
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain
address:
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain, B-1200 Brussels, Belgium
type:PostalAddress
type:Organization
type:Person
name:Jean-Christophe Renauld
affiliation:
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain
address:
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain, B-1200 Brussels, Belgium
type:PostalAddress
type:Organization
type:Person
name:Brigitta Stockinger
affiliation:
name:MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
address:
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
description:The aryl hydrocarbon receptor (AHR) is a transcription factor best known for mediating the toxicity of aromatic hydrocarbons such as dioxin: its activation leads to the production of detoxification enzymes. AHR has been intensely studied in relation to toxicology and cancer research, but no mechanistic connection to the immune system was known. Now two groups report a role for AHR in maintaining the balance between two T-lymphocyte populations Γ’ΒΒ the Treg and TH17 cells Γ’ΒΒ that are part of the immune regulation system dealing with tolerance of self-antigens and pathogen clearance. Both groups also show that AHR affects the severity of experimental autoimmune encephalitis, a mouse model of multiple sclerosis. This work raises the possibility that stimulation of AHR by environmental factors could be involved in the development of autoimmune disease, and point to AHR as a possible drug target for immunomodulation. Activation of the aryl hydrocarbon receptor with the ligand FICZ regulates IL-22 expression in TH17 cells. The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor best known for mediating the toxicity of dioxin1. Environmental factors are believed to contribute to the increased prevalence of autoimmune diseases, many of which are due to the activity of TH17 T cells, a new helper T-cell subset characterized by the production of the cytokine IL-17. Here we show that in the CD4+ T-cell lineage of mice AHR expression is restricted to the TH17 cell subset and its ligation results in the production of the TH17 cytokine interleukin (IL)-22. AHR is also expressed in human TH17 cells. Activation of AHR by a high-affinity ligand during TH17 cell development markedly increases the proportion of TH17 T cells and their production of cytokines. CD4+ T cells from AHR-deficient mice can develop TH17 cell responses, but when confronted with AHR ligand fail to produce IL-22 and do not show enhanced TH17 cell development. AHR activation during induction of experimental autoimmune encephalomyelitis causes accelerated onset and increased pathology in wild-type mice, but not AHR-deficient mice. AHR ligands may therefore represent co-factors in the development of autoimmune diseases.
datePublished:2008-03-23T00:00:00Z
dateModified:2008-03-23T00:00:00Z
pageStart:106
pageEnd:109
sameAs:https://doi.org/10.1038/nature06881
keywords:
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature06881/MediaObjects/41586_2008_Article_BFnature06881_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature06881/MediaObjects/41586_2008_Article_BFnature06881_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature06881/MediaObjects/41586_2008_Article_BFnature06881_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature06881/MediaObjects/41586_2008_Article_BFnature06881_Fig4_HTML.jpg
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:453
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Marc Veldhoen
affiliation:
name:MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
address:
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
type:PostalAddress
type:Organization
type:Person
name:Keiji Hirota
affiliation:
name:MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
address:
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
type:PostalAddress
type:Organization
type:Person
name:Astrid M. Westendorf
affiliation:
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany
address:
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany ,
type:PostalAddress
type:Organization
name:Helmholtz Center for Infection Research
address:
name:Helmholtz Center for Infection Research, D-38124 Braunschweig, Germany
type:PostalAddress
type:Organization
type:Person
name:Jan Buer
affiliation:
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany
address:
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany ,
type:PostalAddress
type:Organization
type:Person
name:Laure Dumoutier
affiliation:
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain
address:
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain, B-1200 Brussels, Belgium
type:PostalAddress
type:Organization
type:Person
name:Jean-Christophe Renauld
affiliation:
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain
address:
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain, B-1200 Brussels, Belgium
type:PostalAddress
type:Organization
type:Person
name:Brigitta Stockinger
affiliation:
name:MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
address:
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:453
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
address:
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
type:PostalAddress
name:MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
address:
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
type:PostalAddress
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany
address:
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany ,
type:PostalAddress
name:Helmholtz Center for Infection Research
address:
name:Helmholtz Center for Infection Research, D-38124 Braunschweig, Germany
type:PostalAddress
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany
address:
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany ,
type:PostalAddress
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain
address:
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain, B-1200 Brussels, Belgium
type:PostalAddress
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain
address:
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain, B-1200 Brussels, Belgium
type:PostalAddress
name:MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
address:
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Marc Veldhoen
affiliation:
name:MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
address:
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
type:PostalAddress
type:Organization
name:Keiji Hirota
affiliation:
name:MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
address:
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
type:PostalAddress
type:Organization
name:Astrid M. Westendorf
affiliation:
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany
address:
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany ,
type:PostalAddress
type:Organization
name:Helmholtz Center for Infection Research
address:
name:Helmholtz Center for Infection Research, D-38124 Braunschweig, Germany
type:PostalAddress
type:Organization
name:Jan Buer
affiliation:
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany
address:
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany ,
type:PostalAddress
type:Organization
name:Laure Dumoutier
affiliation:
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain
address:
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain, B-1200 Brussels, Belgium
type:PostalAddress
type:Organization
name:Jean-Christophe Renauld
affiliation:
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain
address:
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain, B-1200 Brussels, Belgium
type:PostalAddress
type:Organization
name:Brigitta Stockinger
affiliation:
name:MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
address:
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany ,
name:Helmholtz Center for Infection Research, D-38124 Braunschweig, Germany
name: Institute for Medical Microbiology, University Hospital Essen, D-45122, Germany ,
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain, B-1200 Brussels, Belgium
name:Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Universite Catholique de Louvain, B-1200 Brussels, Belgium
name:Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK,
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {π}(92)
- Financial intake of https://link.springer.com/article/10.1038/nature06881?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle
- How much profit is https://doi.org/10.1146%2Fannurev.cellbio.12.1.55 making per month?
- How much money does http://scholar.google.com/scholar_lookup?&title=Ah%20receptor%20signaling%20pathways&journal=Annu.%20Rev.%20Cell%20Dev.%20Biol.&doi=10.1146%2Fannurev.cellbio.12.1.55&volume=12&pages=55-89&publication_year=1996&author=Schmidt%2CJV&author=Bradfield%2CCA make?
- How much profit is https://doi.org/10.1016%2Fj.bcp.2006.01.007 making per month?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Regulating%20the%20regulator%3A%20factors%20that%20control%20levels%20and%20activity%20of%20the%20aryl%20hydrocarbon%20receptor&journal=Biochem.%20Pharmacol.&doi=10.1016%2Fj.bcp.2006.01.007&volume=72&pages=267-279&publication_year=2006&author=Harper%2CPA&author=Riddick%2CDS&author=Okey%2CAB?
- https://doi.org/10.1073%2Fpnas.93.13.6731's total income per month
- How much revenue does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1996PNAS...93.6731S produce monthly?
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=Characterization%20of%20a%20murine%20Ahr%20null%20allele%3A%20involvement%20of%20the%20Ah%20receptor%20in%20hepatic%20growth%20and%20development&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.93.13.6731&volume=93&pages=6731-6736&publication_year=1996&author=Schmidt%2CJV&author=Su%2CGH&author=Reddy%2CJK&author=Simon%2CMC&author=Bradfield%2CCA?
- How much does https://doi.org/10.1126%2Fscience.7732381 earn?
- How much income does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1995Sci...268..722F have?
- How much does http://scholar.google.com/scholar_lookup?&title=Immune%20system%20impairment%20and%20hepatic%20fibrosis%20in%20mice%20lacking%20the%20dioxin-binding%20Ah%20receptor&journal=Science&doi=10.1126%2Fscience.7732381&volume=268&pages=722-726&publication_year=1995&author=Fernandez-Salguero%2CP bring in each month?
- What's the income of https://doi.org/10.1046%2Fj.1365-2443.1997.1490345.x?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=Loss%20of%20teratogenic%20response%20to%202%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin%20%28TCDD%29%20in%20mice%20lacking%20the%20Ah%20%28dioxin%29%20receptor&journal=Genes%20Cells&doi=10.1046%2Fj.1365-2443.1997.1490345.x&volume=2&pages=645-654&publication_year=1997&author=Mimura%2CJ
- https://doi.org/10.1016%2Fj.cell.2006.07.035's financial summary
- Profit of http://scholar.google.com/scholar_lookup?&title=The%20orphan%20nuclear%20receptor%20ROR%CE%B3t%20directs%20the%20differentiation%20program%20of%20proinflammatory%20IL-17%2B%20T%20helper%20cells&journal=Cell&doi=10.1016%2Fj.cell.2006.07.035&volume=126&pages=1121-1133&publication_year=2006&author=Ivanov%2CII
- How much profit does https://doi.org/10.1073%2Fpnas.170291697 generate?
- What's the income generated by http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2000PNAS...9710144D each month?
- http://scholar.google.com/scholar_lookup?&title=Human%20interleukin-10-related%20T%20cell-derived%20inducible%20factor%3A%20molecular%20cloning%20and%20functional%20characterization%20as%20an%20hepatocyte-stimulating%20factor&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.170291697&volume=97&pages=10144-10149&publication_year=2000&author=Dumoutier%2CL&author=Van%20Roost%2CE&author=Colau%2CD&author=Renauld%2CJC's financial summary
- How much money does https://doi.org/10.1038%2Fnature05505 generate?
- See how much http://scholar.google.com/scholar_lookup?&title=Interleukin-22%2C%20a%20TH17%20cytokine%2C%20mediates%20IL-23-induced%20dermal%20inflammation%20and%20acanthosis&journal=Nature&doi=10.1038%2Fnature05505&volume=445&pages=648-651&publication_year=2007&author=Zheng%2CY makes per month
- Explore the financials of https://doi.org/10.1084%2Fjem.20061308
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Interleukin%20%28IL%29-22%20and%20IL-17%20are%20coexpressed%20by%20Th17%20cells%20and%20cooperatively%20enhance%20expression%20of%20antimicrobial%20peptides&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20061308&volume=203&pages=2271-2279&publication_year=2006&author=Liang%2CSC?
- Get to know https://doi.org/10.4049%2Fjimmunol.174.6.3695's earnings
- Profit of http://scholar.google.com/scholar_lookup?&title=IL-22%20inhibits%20epidermal%20differentiation%20and%20induces%20proinflammatory%20gene%20expression%20and%20migration%20of%20human%20keratinocytes&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.174.6.3695&volume=174&pages=3695-3702&publication_year=2005&author=Boniface%2CK
- How much revenue does https://doi.org/10.1002%2Fhep.20184 bring in?
- What's http://scholar.google.com/scholar_lookup?&title=Interleukin%2022%20%28IL-22%29%20plays%20a%20protective%20role%20in%20T%20cell-mediated%20murine%20hepatitis%3A%20IL-22%20is%20a%20survival%20factor%20for%20hepatocytes%20via%20STAT3%20activation&journal=Hepatology&doi=10.1002%2Fhep.20184&volume=39&pages=1332-1342&publication_year=2004&author=Radaeva%2CS&author=Sun%2CR&author=Pan%2CHN&author=Hong%2CF&author=Gao%2CB's gross income?
- https://doi.org/10.1016%2Fj.immuni.2007.07.023 income
- How much profit does http://scholar.google.com/scholar_lookup?&title=Interleukin-22%20but%20not%20interleukin-17%20provides%20protection%20to%20hepatocytes%20during%20acute%20liver%20inflammation&journal=Immunity&doi=10.1016%2Fj.immuni.2007.07.023&volume=27&pages=647-659&publication_year=2007&author=Zenewicz%2CLA make?
- How much profit does https://doi.org/10.1515%2FBC.2006.143 generate?
- How much does http://scholar.google.com/scholar_lookup?&title=The%20aryl%20hydrocarbon%20receptor%20and%20light&journal=Biol.%20Chem.&doi=10.1515%2FBC.2006.143&volume=387&pages=1149-1157&publication_year=2006&author=Rannug%2CA&author=Fritsche%2CE generate monthly?
- How much profit is https://doi.org/10.1084%2Fjem.20071397 making per month?
- Get to know http://scholar.google.com/scholar_lookup?&title=Preferential%20recruitment%20of%20CCR6-expressing%20Th17%20cells%20to%20inflamed%20joints%20via%20CCL20%20in%20rheumatoid%20arthritis%20and%20its%20animal%20model&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20071397&volume=204&pages=2803-2812&publication_year=2007&author=Hirota%2CK's earnings
- https://doi.org/10.1038%2Fni1467 income
- How much does http://scholar.google.com/scholar_lookup?&title=Surface%20phenotype%20and%20antigenic%20specificity%20of%20human%20interleukin%2017-producing%20T%20helper%20memory%20cells&journal=Nature%20Immunol.&doi=10.1038%2Fni1467&volume=8&pages=639-646&publication_year=2007&author=Acosta-Rodriguez%2CEV pull in monthly?
- How much revenue does https://doi.org/10.1016%2FS1567-5769%2801%2900179-5 produce monthly?
- Revenue of http://scholar.google.com/scholar_lookup?&title=Recent%20advances%20in%20understanding%20the%20mechanisms%20of%20TCDD%20immunotoxicity&journal=Int.%20Immunopharmacol.&doi=10.1016%2FS1567-5769%2801%2900179-5&volume=2&pages=277-291&publication_year=2002&author=Kerkvliet%2CNI
- How much income does https://doi.org/10.4049%2Fjimmunol.175.7.4184 have?
- How much does http://scholar.google.com/scholar_lookup?&title=Cutting%20edge%3A%20activation%20of%20the%20aryl%20hydrocarbon%20receptor%20by%202%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin%20generates%20a%20population%20of%20CD4%2BCD25%2Bcells%20with%20characteristics%20of%20regulatory%20T%20cells&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.175.7.4184&volume=175&pages=4184-4188&publication_year=2005&author=Funatake%2CCJ&author=Marshall%2CNB&author=Steppan%2CLB&author=Mourich%2CDV&author=Kerkvliet%2CNI net monthly?
- How much does https://doi.org/10.4049%2Fjimmunol.176.7.4125 make?
- See how much http://scholar.google.com/scholar_lookup?&title=CD4%2B%20regulatory%20T%20cells%20are%20spared%20from%20deletion%20by%20antilymphocyte%20serum%2C%20a%20polyclonal%20anti-T%20cell%20antibody&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.176.7.4125&volume=176&pages=4125-4132&publication_year=2006&author=Minamimura%2CK&author=Gao%2CW&author=Maki%2CT makes per month
- How much money does https://doi.org/10.1002%2Feji.200535075 make?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Lymphocyte%20homeostasis%20following%20therapeutic%20lymphocyte%20depletion%20in%20multiple%20sclerosis&journal=Eur.%20J.%20Immunol.&doi=10.1002%2Feji.200535075&volume=35&pages=3332-3342&publication_year=2005&author=Cox%2CAL?
- How much cash flow does https://doi.org/10.1021%2Ftx7001965 have monthly?
- What's http://scholar.google.com/scholar_lookup?&title=The%20search%20for%20endogenous%20activators%20of%20the%20aryl%20hydrocarbon%20receptor&journal=Chem.%20Res.%20Toxicol.&doi=10.1021%2Ftx7001965&volume=21&pages=102-116&publication_year=2007&author=Nguyen%2CLP&author=Bradfield%2CCA's gross income?
- What's the financial intake of https://doi.org/10.1046%2Fj.1523-1747.2000.00876.x?
- http://scholar.google.com/scholar_lookup?&title=Ultraviolet-B%20exposure%20of%20human%20skin%20induces%20cytochromes%20P450%201A1%20and%201B1&journal=J.%20Invest.%20Dermatol.&doi=10.1046%2Fj.1523-1747.2000.00876.x&volume=114&pages=328-333&publication_year=2000&author=Katiyar%2CSK&author=Matsui%2CMS&author=Mukhtar%2CH's total income per month
- What's the profit of https://doi.org/10.1002%2Feji.200636662?
- How much profit is http://scholar.google.com/scholar_lookup?&title=Development%20of%20an%20anti-IL-17A%20auto-vaccine%20that%20prevents%20experimental%20auto-immune%20encephalomyelitis&journal=Eur.%20J.%20Immunol.&doi=10.1002%2Feji.200636662&volume=36&pages=2868-2874&publication_year=2006&author=Uyttenhove%2CC&author=Van%20Snick%2CJ making per month?
- Earnings of https://doi.org/10.1084%2Fjem.20041257
- How much revenue does http://scholar.google.com/scholar_lookup?&title=IL-23%20drives%20a%20pathogenic%20T%20cell%20population%20that%20induces%20autoimmune%20inflammation&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.20041257&volume=201&pages=233-240&publication_year=2005&author=Langrish%2CCL produce monthly?
- How much does https://doi.org/10.1038%2Fnm1651 make?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Human%20TH17%20lymphocytes%20promote%20blood-brain%20barrier%20disruption%20and%20central%20nervous%20system%20inflammation&journal=Nature%20Med.&doi=10.1038%2Fnm1651&volume=13&pages=1173-1175&publication_year=2007&author=Kebir%2CH bring in?
- https://doi.org/10.4049%2Fjimmunol.179.12.8098's financial summary
- How much does http://scholar.google.com/scholar_lookup?&title=IL-22%20is%20expressed%20by%20Th17%20cells%20in%20an%20IL-23-dependent%20fashion%2C%20but%20not%20required%20for%20the%20development%20of%20autoimmune%20encephalomyelitis&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.179.12.8098&volume=179&pages=8098-8104&publication_year=2007&author=Kreymborg%2CK earn?
- Get to know https://doi.org/10.1093%2Ftoxsci%2Fkfm096's earnings
- How much income does http://scholar.google.com/scholar_lookup?&title=An%20aryl%20hydrocarbon%20receptor%20odyssey%20to%20the%20shores%20of%20toxicology%3A%20the%20Deichmann%20lecture%2C%20International%20Congress%20of%20Toxicology-XI&journal=Toxicol.%20Sci.&doi=10.1093%2Ftoxsci%2Fkfm096&volume=98&pages=5-38&publication_year=2007&author=Okey%2CAB have?
- What's the income of https://doi.org/10.1016%2FS0009-2797%2802%2900068-6?
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=Ah%20receptor%20and%20NF-%CE%BAB%20interactions%3A%20mechanisms%20and%20physiological%20implications&journal=Chem.%20Biol.%20Interact.&doi=10.1016%2FS0009-2797%2802%2900068-6&volume=141&pages=97-115&publication_year=2002&author=Tian%2CY&author=Rabson%2CAB&author=Gallo%2CMA is on a monthly basis
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10453042's total income per month
- How much income does http://scholar.google.com/scholar_lookup?&title=Experimental%20autoimmune%20encephalomyelitis%20in%20NF-%CE%BAB-deficient%20mice%3A%20roles%20of%20NF-%CE%BAB%20in%20the%20activation%20and%20differentiation%20of%20autoreactive%20T%20cells&journal=J.%20Immunol.&volume=163&pages=2937-2943&publication_year=1999&author=Hilliard%2CB&author=Samoilova%2CEB&author=Liu%2CTS&author=Rostami%2CA&author=Chen%2CY have?
- How much revenue does https://doi.org/10.1073%2Fpnas.85.8.2528 bring in?
- http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1988PNAS...85.2528D's revenue stream
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Inducible%2C%20receptor-dependent%20protein-DNA%20interactions%20at%20a%20dioxin-responsive%20transcriptional%20enhancer&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.85.8.2528&volume=85&pages=2528-2532&publication_year=1988&author=Denison%2CMS&author=Fisher%2CJM&author=Whitlock%2CJP?
- What's the income of https://doi.org/10.1038%2Fni1391?
- How much income is http://scholar.google.com/scholar_lookup?&title=Signals%20mediated%20by%20transforming%20growth%20factor-%CE%B2%20initiate%20autoimmune%20encephalomyelitis%2C%20but%20chronic%20inflammation%20is%20needed%20to%20sustain%20disease&journal=Nature%20Immunol.&doi=10.1038%2Fni1391&volume=7&pages=1151-1156&publication_year=2006&author=Veldhoen%2CM&author=Hocking%2CRJ&author=Flavell%2CRA&author=Stockinger%2CB earning monthly?
- How much does https://citation-needed.springer.com/v2/references/10.1038/nature06881?format=refman&flavour=references rake in every month?
- What's the financial outcome of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Marc%20Veldhoen?
- Financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Marc%20Veldhoen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What's the income generated by https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Keiji%20Hirota each month?
- What's the profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Keiji%20Hirota%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Astrid%20M.%20Westendorf generate?
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Astrid%20M.%20Westendorf%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's total income per month
- How much profit is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jan%20Buer making per month?
- What's the financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jan%20Buer%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Laure%20Dumoutier
- How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Laure%20Dumoutier%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jean-Christophe%20Renauld's financial summary
- Find out how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jean-Christophe%20Renauld%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earns monthly
- Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Brigitta%20Stockinger
- How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Brigitta%20Stockinger%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
- What are the earnings of https://static-content.springer.com/esm/art%3A10.1038%2Fnature06881/MediaObjects/41586_2008_BFnature06881_MOESM243_ESM.pdf?
- How much money does https://s100.copyright.com/AppDispatchServlet?title=The%20aryl%20hydrocarbon%20receptor%20links%20TH17-cell-mediated%20autoimmunity%20to%20environmental%20toxins&author=Marc%20Veldhoen%20et%20al&contentID=10.1038%2Fnature06881©right=Springer%20Nature%20Limited&publication=0028-0836&publicationDate=2008-03-23&publisherName=SpringerNature&orderBeanReset=true generate?
- How much cash flow does https://citation-needed.springer.com/v2/references/10.1038/nature06881?format=refman&flavour=citation have monthly?
- What's the monthly money flow for https://doi.org/10.1007/s12026-022-09325-5?
- Learn how profitable https://doi.org/10.1038/s41598-022-20164-0 is on a monthly basis
- How much does https://doi.org/10.1007/s11356-022-23091-9 pull in monthly?
- How much money does https://doi.org/10.1186/s43166-021-00076-z generate?
- What's the monthly income of https://doi.org/10.1186/s10020-021-00353-9?
- How much does https://www.protocols.io/ bring in each month?
- How much does https://www.natureindex.com/ rake in every month?
- What's the financial outcome of http://www.naturechina.com?
- See how much https://www.natureasia.com/ja-jp makes per month
Analytics and Tracking {π}
- Google Tag Manager
Libraries {π}
- Prism.js
- Zoom.js
Emails and Hosting {βοΈ}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {π¦}
- Crossref