NATURE . COM {}

Matching Content Categories {📚}

• Telecommunications
• Science
• Education

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$63,100 per month
Our estimates place Nature.com's monthly online earnings from display ads at $42,042 to $115,616.

Keywords {🔍}

article, pubmed, google, scholar, cas, nature, cell, cancer, akt, pml, suppressor, nuclear, pten, access, tumor, content, tumour, pier, paolo, pandolfi, prostate, regulation, cookies, function, data, transcription, pakt, mice, suppression, ads, privacy, information, trotman, ppa, sci, central, essential, alimonti, scaglioni, cordoncardo, human, tumorigenesis, leads, phosphatase, multiple, genet, biol, science, protein, ppp,

Topics {✒️}

nature portfolio privacy policy permissions reprints nature cell biol advertising pkb/akt-dependent cell survival social media embryonic development p53-dependent cellular senescence subscribe nature nature genet pml-ii regulates erk high cancer susceptibility nature 436 nature nature 441 author information authors pier paolo pandolfi pier paolo scaglioni p53-dependent apoptosis springerlink instant access author contributions author correspondence permissions information akt signal activation expected tumor suppressor tumour suppressor pml sloan-kettering institute tumor suppressor pten ovarian follicle activation competing financial interests personal data stress-dependent regulation pten tumour suppressor1 privacy suppresses tumor growth metastatic prostate cancer prostate cancer cells pml nuclear bodies permissions proto-oncogene akt pi3k–akt pathway directly dephosphorylates akt pten-deficient tumorigenesis data protection data analysis akt phosphatase pp2a accumulate nuclear pakt cordon-cardo prostate-specific deletion

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Identification of a tumour suppressor network opposing nuclear Akt function
         description:The proto-oncogene AKT (also known as PKB) is activated in many human cancers, mostly owing to loss of the PTEN tumour suppressor1. In such tumours, AKT becomes enriched at cell membranes where it is activated by phosphorylation. Yet many targets inhibited by phosphorylated AKT (for example, the FOXO transcription factors) are nuclear; it has remained unclear how relevant nuclear phosphorylated AKT (pAKT) function is for tumorigenesis. Here we show that the PMLtumour suppressor prevents cancer by inactivating pAKT inside the nucleus. We find in a mouse model that Pml loss markedly accelerates tumour onset, incidence and progression in Pten-heterozygous mutants, and leads to female sterility with features that recapitulate the phenotype of Foxo3a knockout mice2. We show that Pml deficiency on its own leads to tumorigenesis in the prostate, a tissue that is exquisitely sensitive to pAkt levels, and demonstrate that Pml specifically recruits the Akt phosphatase PP2a as well as pAkt into Pml nuclear bodies. Notably, we find that Pml-null cells are impaired in PP2a phosphatase activity towards Akt, and thus accumulate nuclear pAkt. As a consequence, the progressive reduction in Pml dose leads to inactivation of Foxo3a-mediated transcription of proapoptotic Bim and the cell cycle inhibitor p27kip1. Our results demonstrate that Pml orchestrates a nuclear tumour suppressor network for inactivation of nuclear pAkt, and thus highlight the importance of AKT compartmentalization in human cancer pathogenesis and treatment.
         datePublished:2006-05-07T00:00:00Z
         dateModified:2006-05-07T00:00:00Z
         pageStart:523
         pageEnd:527
         sameAs:https://doi.org/10.1038/nature04809
         keywords:
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig4_HTML.jpg
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:441
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Lloyd C. Trotman
               affiliation:
                     name:Cancer Biology and Genetics Program
                     address:
                        name:Cancer Biology and Genetics Program,
                        type:PostalAddress
                     type:Organization
                     name:Department of Pathology
                     address:
                        name:Department of Pathology,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Andrea Alimonti
               affiliation:
                     name:Cancer Biology and Genetics Program
                     address:
                        name:Cancer Biology and Genetics Program,
                        type:PostalAddress
                     type:Organization
                     name:Department of Pathology
                     address:
                        name:Department of Pathology,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pier Paolo Scaglioni
               affiliation:
                     name:Cancer Biology and Genetics Program
                     address:
                        name:Cancer Biology and Genetics Program,
                        type:PostalAddress
                     type:Organization
                     name:Department of Medicine
                     address:
                        name:Department of Medicine,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jason A. Koutcher
               affiliation:
                     name:Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute
                     address:
                        name:Departments of Medicine, Radiology and Medical Physics, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Carlos Cordon-Cardo
               affiliation:
                     name:Department of Pathology
                     address:
                        name:Department of Pathology,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pier Paolo Pandolfi
               affiliation:
                     name:Cancer Biology and Genetics Program
                     address:
                        name:Cancer Biology and Genetics Program,
                        type:PostalAddress
                     type:Organization
                     name:Department of Pathology
                     address:
                        name:Department of Pathology,
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Identification of a tumour suppressor network opposing nuclear Akt function
      description:The proto-oncogene AKT (also known as PKB) is activated in many human cancers, mostly owing to loss of the PTEN tumour suppressor1. In such tumours, AKT becomes enriched at cell membranes where it is activated by phosphorylation. Yet many targets inhibited by phosphorylated AKT (for example, the FOXO transcription factors) are nuclear; it has remained unclear how relevant nuclear phosphorylated AKT (pAKT) function is for tumorigenesis. Here we show that the PMLtumour suppressor prevents cancer by inactivating pAKT inside the nucleus. We find in a mouse model that Pml loss markedly accelerates tumour onset, incidence and progression in Pten-heterozygous mutants, and leads to female sterility with features that recapitulate the phenotype of Foxo3a knockout mice2. We show that Pml deficiency on its own leads to tumorigenesis in the prostate, a tissue that is exquisitely sensitive to pAkt levels, and demonstrate that Pml specifically recruits the Akt phosphatase PP2a as well as pAkt into Pml nuclear bodies. Notably, we find that Pml-null cells are impaired in PP2a phosphatase activity towards Akt, and thus accumulate nuclear pAkt. As a consequence, the progressive reduction in Pml dose leads to inactivation of Foxo3a-mediated transcription of proapoptotic Bim and the cell cycle inhibitor p27kip1. Our results demonstrate that Pml orchestrates a nuclear tumour suppressor network for inactivation of nuclear pAkt, and thus highlight the importance of AKT compartmentalization in human cancer pathogenesis and treatment.
      datePublished:2006-05-07T00:00:00Z
      dateModified:2006-05-07T00:00:00Z
      pageStart:523
      pageEnd:527
      sameAs:https://doi.org/10.1038/nature04809
      keywords:
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig4_HTML.jpg
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:441
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Lloyd C. Trotman
            affiliation:
                  name:Cancer Biology and Genetics Program
                  address:
                     name:Cancer Biology and Genetics Program,
                     type:PostalAddress
                  type:Organization
                  name:Department of Pathology
                  address:
                     name:Department of Pathology,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andrea Alimonti
            affiliation:
                  name:Cancer Biology and Genetics Program
                  address:
                     name:Cancer Biology and Genetics Program,
                     type:PostalAddress
                  type:Organization
                  name:Department of Pathology
                  address:
                     name:Department of Pathology,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pier Paolo Scaglioni
            affiliation:
                  name:Cancer Biology and Genetics Program
                  address:
                     name:Cancer Biology and Genetics Program,
                     type:PostalAddress
                  type:Organization
                  name:Department of Medicine
                  address:
                     name:Department of Medicine,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jason A. Koutcher
            affiliation:
                  name:Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute
                  address:
                     name:Departments of Medicine, Radiology and Medical Physics, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carlos Cordon-Cardo
            affiliation:
                  name:Department of Pathology
                  address:
                     name:Department of Pathology,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pier Paolo Pandolfi
            affiliation:
                  name:Cancer Biology and Genetics Program
                  address:
                     name:Cancer Biology and Genetics Program,
                     type:PostalAddress
                  type:Organization
                  name:Department of Pathology
                  address:
                     name:Department of Pathology,
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:441
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Cancer Biology and Genetics Program
      address:
         name:Cancer Biology and Genetics Program,
         type:PostalAddress
      name:Department of Pathology
      address:
         name:Department of Pathology,
         type:PostalAddress
      name:Cancer Biology and Genetics Program
      address:
         name:Cancer Biology and Genetics Program,
         type:PostalAddress
      name:Department of Pathology
      address:
         name:Department of Pathology,
         type:PostalAddress
      name:Cancer Biology and Genetics Program
      address:
         name:Cancer Biology and Genetics Program,
         type:PostalAddress
      name:Department of Medicine
      address:
         name:Department of Medicine,
         type:PostalAddress
      name:Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute
      address:
         name:Departments of Medicine, Radiology and Medical Physics, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, New York, USA
         type:PostalAddress
      name:Department of Pathology
      address:
         name:Department of Pathology,
         type:PostalAddress
      name:Cancer Biology and Genetics Program
      address:
         name:Cancer Biology and Genetics Program,
         type:PostalAddress
      name:Department of Pathology
      address:
         name:Department of Pathology,
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Lloyd C. Trotman
      affiliation:
            name:Cancer Biology and Genetics Program
            address:
               name:Cancer Biology and Genetics Program,
               type:PostalAddress
            type:Organization
            name:Department of Pathology
            address:
               name:Department of Pathology,
               type:PostalAddress
            type:Organization
      name:Andrea Alimonti
      affiliation:
            name:Cancer Biology and Genetics Program
            address:
               name:Cancer Biology and Genetics Program,
               type:PostalAddress
            type:Organization
            name:Department of Pathology
            address:
               name:Department of Pathology,
               type:PostalAddress
            type:Organization
      name:Pier Paolo Scaglioni
      affiliation:
            name:Cancer Biology and Genetics Program
            address:
               name:Cancer Biology and Genetics Program,
               type:PostalAddress
            type:Organization
            name:Department of Medicine
            address:
               name:Department of Medicine,
               type:PostalAddress
            type:Organization
      name:Jason A. Koutcher
      affiliation:
            name:Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute
            address:
               name:Departments of Medicine, Radiology and Medical Physics, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, New York, USA
               type:PostalAddress
            type:Organization
      name:Carlos Cordon-Cardo
      affiliation:
            name:Department of Pathology
            address:
               name:Department of Pathology,
               type:PostalAddress
            type:Organization
      name:Pier Paolo Pandolfi
      affiliation:
            name:Cancer Biology and Genetics Program
            address:
               name:Cancer Biology and Genetics Program,
               type:PostalAddress
            type:Organization
            name:Department of Pathology
            address:
               name:Department of Pathology,
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Cancer Biology and Genetics Program,
      name:Department of Pathology,
      name:Cancer Biology and Genetics Program,
      name:Department of Pathology,
      name:Cancer Biology and Genetics Program,
      name:Department of Medicine,
      name:Departments of Medicine, Radiology and Medical Physics, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, New York, USA
      name:Department of Pathology,
      name:Cancer Biology and Genetics Program,
      name:Department of Pathology,
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/Nature
• https://twitter.com/nature

External Links {🔗}(126)

• Learn about the earnings of https://link.springer.com/article/10.1038/nature04809?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle
• How profitable is https://doi.org/10.1016%2FS1535-6108%2803%2900248-4?
• What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14585353?
• Find out how much http://scholar.google.com/scholar_lookup?&title=Targeting%20the%20PI3K%E2%80%93Akt%20pathway%20in%20human%20cancer%3A%20rationale%20and%20promise&journal=Cancer%20Cell&doi=10.1016%2FS1535-6108%2803%2900248-4&volume=4&pages=257-262&publication_year=2003&author=Luo%2CJ&author=Manning%2CBD&author=Cantley%2CLC earns monthly
• Financial intake of https://doi.org/10.1016%2Fj.molmed.2003.09.003
• Revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14604822
• What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=FoxO3a%20eggs%20on%20fertility%20and%20aging&journal=Trends%20Mol.%20Med.&doi=10.1016%2Fj.molmed.2003.09.003&volume=9&pages=464-467&publication_year=2003&author=Brenkman%2CAB&author=Burgering%2CBM?
• What's the financial intake of https://doi.org/10.1016%2FS0092-8674%2802%2900626-8?
• Check the income stats for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11832207
• How much does http://scholar.google.com/scholar_lookup?&title=The%20role%20of%20PML%20in%20tumor%20suppression&journal=Cell&doi=10.1016%2FS0092-8674%2802%2900626-8&volume=108&pages=165-170&publication_year=2002&author=Salomoni%2CP&author=Pandolfi%2CPP generate monthly?
• https://doi.org/10.1093%2Fjnci%2Fdjh043 income
• What's http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14970276's gross income?
• How much profit does http://scholar.google.com/scholar_lookup?&title=Loss%20of%20the%20tumour%20suppressor%20PML%20in%20human%20cancers%20of%20multiple%20histologic%20origins&journal=J.%20Natl%20Cancer%20Inst.&doi=10.1093%2Fjnci%2Fdjh043&volume=96&pages=269-279&publication_year=2004&author=Gurrieri%2CC make?
• Earnings of https://doi.org/10.1158%2F0008-5472.CAN-2401-2
• Earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15126336
• Financial intake of http://scholar.google.com/scholar_lookup?&title=Frequent%20inactivation%20of%20PTEN%20by%20promoter%20hypermethylation%20in%20microsatellite%20instability-high%20sporadic%20colorectal%20cancers&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-2401-2&volume=64&pages=3014-3021&publication_year=2004&author=Goel%2CA
• Discover the revenue of https://doi.org/10.1016%2Fj.eururo.2004.01.012
• Discover the revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15149739
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=Molecular%20mechanisms%20of%20prostate%20cancer&journal=Eur.%20Urol.&doi=10.1016%2Fj.eururo.2004.01.012&volume=45&pages=683-691&publication_year=2004&author=Porkka%2CKP&author=Visakorpi%2CT
• Get to know https://doi.org/10.1038%2F1235's earnings
• What's the profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9697695?
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=Pten%20is%20essential%20for%20embryonic%20development%20and%20tumour%20suppression&journal=Nature%20Genet.&doi=10.1038%2F1235&volume=19&pages=348-355&publication_year=1998&author=Di%20Cristofano%2CA&author=Pesce%2CB&author=Cordon-Cardo%2CC&author=Pandolfi%2CPP is on a monthly basis
• What's the income generated by https://doi.org/10.1073%2Fpnas.96.4.1563 each month?
• What's the financial gain of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1999PNAS...96.1563P?
• How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9990064 generate?
• Financial intake of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC15517
• How much profit does http://scholar.google.com/scholar_lookup?&title=Mutation%20of%20Pten%2FMmac1%20in%20mice%20causes%20neoplasia%20in%20multiple%20organ%20systems&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.96.4.1563&volume=96&pages=1563-1568&publication_year=1999&author=Podsypanina%2CK make?
• Explore the financials of https://doi.org/10.1016%2FS0960-9822%2807%2900488-5
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9799734 bring in each month?
• Income figures for http://scholar.google.com/scholar_lookup?&title=High%20cancer%20susceptibility%20and%20embryonic%20lethality%20associated%20with%20mutation%20of%20the%20PTEN%20tumor%20suppressor%20gene%20in%20mice&journal=Curr.%20Biol.&doi=10.1016%2FS0960-9822%2807%2900488-5&volume=8&pages=1169-1178&publication_year=1998&author=Suzuki%2CA
• How much does https://doi.org/10.1126%2Fscience.285.5436.2122 gross monthly?
• How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10497129 make?
• How much does http://scholar.google.com/scholar_lookup?&title=Impaired%20Fas%20response%20and%20autoimmunity%20in%20Pten%2B%2F-%20mice&journal=Science&doi=10.1126%2Fscience.285.5436.2122&volume=285&pages=2122-2125&publication_year=1999&author=Di%20Cristofano%2CA pull in?
• What's the monthly income of https://doi.org/10.1371%2Fjournal.pbio.0000059?
• How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14691534 make?
• What's http://www.ncbi.nlm.nih.gov/pmc/articles/PMC270016's gross income?
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=Pten%20dose%20dictates%20cancer%20progression%20in%20the%20prostate&journal=PLoS%20Biol.&doi=10.1371%2Fjournal.pbio.0000059&volume=1&publication_year=2003&author=Trotman%2CLC
• What's the financial outcome of https://doi.org/10.1016%2FS1535-6108%2803%2900215-0?
• What's the financial outcome of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14522255?
• How much does http://scholar.google.com/scholar_lookup?&title=Prostate-specific%20deletion%20of%20the%20murine%20Pten%20tumor%20suppressor%20gene%20leads%20to%20metastatic%20prostate%20cancer&journal=Cancer%20Cell&doi=10.1016%2FS1535-6108%2803%2900215-0&volume=4&pages=209-221&publication_year=2003&author=Wang%2CS pull in?
• What's the total monthly financial gain of https://doi.org/10.1038%2F84879?
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11175795 income
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Pten%20and%20p27KIP1%20cooperate%20in%20prostate%20cancer%20tumor%20suppression%20in%20the%20mouse&journal=Nature%20Genet.&doi=10.1038%2F84879&volume=27&pages=222-224&publication_year=2001&author=Di%20Cristofano%2CA&author=De%20Acetis%2CM&author=Koff%2CA&author=Cordon-Cardo%2CC&author=Pandolfi%2CPP generate?
• What are the earnings of https://doi.org/10.1146%2Fannurev.biochem.70.1.247?
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11395408 gross monthly?
• What's the income generated by http://scholar.google.com/scholar_lookup?&title=PTEN%20and%20myotubularin%3A%20novel%20phosphoinositide%20phosphatases&journal=Annu.%20Rev.%20Biochem.&doi=10.1146%2Fannurev.biochem.70.1.247&volume=70&pages=247-279&publication_year=2001&author=Maehama%2CT&author=Taylor%2CGS&author=Dixon%2CJE each month?
• How much money does https://doi.org/10.1016%2FS0092-8674%2800%2981780-8 generate?
• How much cash flow does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9778245 have monthly?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Negative%20regulation%20of%20PKB%2FAkt-dependent%20cell%20survival%20by%20the%20tumor%20suppressor%20PTEN&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981780-8&volume=95&pages=29-39&publication_year=1998&author=Stambolic%2CV bring in?
• How much income does https://doi.org/10.1126%2Fscience.1106148 have?
• How much income does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2005Sci...307.1098S have?
• What's the profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15718470?
• http://scholar.google.com/scholar_lookup?&title=Phosphorylation%20and%20regulation%20of%20Akt%2FPKB%20by%20the%20rictor%E2%80%93mTOR%20complex&journal=Science&doi=10.1126%2Fscience.1106148&volume=307&pages=1098-1101&publication_year=2005&author=Sarbassov%2CDD&author=Guertin%2CDA&author=Ali%2CSM&author=Sabatini%2CDM's financial summary
• How much does https://doi.org/10.1016%2Fj.tibs.2004.03.006 pull in?
• What is the monthly revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15130559?
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Advances%20in%20protein%20kinase%20B%20signalling%3A%20AKTion%20on%20multiple%20fronts&journal=Trends%20Biochem.%20Sci.&doi=10.1016%2Fj.tibs.2004.03.006&volume=29&pages=233-242&publication_year=2004&author=Brazil%2CDP&author=Yang%2CZZ&author=Hemmings%2CBA?
• How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12621150 make?
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=The%20many%20forks%20in%20FOXO%27s%20road&journal=Sci.%20STKE&volume=2003&publication_year=2003&author=Tran%2CH&author=Brunet%2CA&author=Griffith%2CEC&author=Greenberg%2CME?
• Discover the revenue of https://doi.org/10.1016%2FS0092-8674%2800%2980595-4
• What's the monthly income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10102273?
• Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Akt%20promotes%20cell%20survival%20by%20phosphorylating%20and%20inhibiting%20a%20Forkhead%20transcription%20factor&journal=Cell&doi=10.1016%2FS0092-8674%2800%2980595-4&volume=96&pages=857-868&publication_year=1999&author=Brunet%2CA
• What's the monthly money flow for https://doi.org/10.1126%2Fscience.1086336?
• Discover the revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2003Sci...301..215C
• What's the monthly money flow for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12855809?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Suppression%20of%20ovarian%20follicle%20activation%20in%20mice%20by%20the%20transcription%20factor%20Foxo3a&journal=Science&doi=10.1126%2Fscience.1086336&volume=301&pages=215-218&publication_year=2003&author=Castrillon%2CDH&author=Miao%2CL&author=Kollipara%2CR&author=Horner%2CJW&author=DePinho%2CRA generate?
• What's the monthly income of https://doi.org/10.1073%2Fpnas.0400093101?
• Explore the financials of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2004PNAS..101.2975H
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14978268 income
• What's http://www.ncbi.nlm.nih.gov/pmc/articles/PMC365730's gross income?
• How much does http://scholar.google.com/scholar_lookup?&title=Disruption%20of%20forkhead%20transcription%20factor%20%28FOXO%29%20family%20members%20in%20mice%20reveals%20their%20functional%20diversification&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0400093101&volume=101&pages=2975-2980&publication_year=2004&author=Hosaka%2CT make?
• How much does https://doi.org/10.1016%2FS0968-0004%2899%2901375-4 bring in each month?
• Find out how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10322434 earns monthly
• How much does http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20protein%20kinase%20cascades%20by%20protein%20phosphatase%202A&journal=Trends%20Biochem.%20Sci.&doi=10.1016%2FS0968-0004%2899%2901375-4&volume=24&pages=186-191&publication_year=1999&author=Millward%2CTA&author=Zolnierowicz%2CS&author=Hemmings%2CBA pull in monthly?
• How much money does https://doi.org/10.1016%2Fj.molcel.2005.03.008 make?
• What is the monthly revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15808505?
• How much does http://scholar.google.com/scholar_lookup?&title=PHLPP%3A%20a%20phosphatase%20that%20directly%20dephosphorylates%20Akt%2C%20promotes%20apoptosis%2C%20and%20suppresses%20tumor%20growth&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2005.03.008&volume=18&pages=13-24&publication_year=2005&author=Gao%2CT&author=Furnari%2CF&author=Newton%2CAC pull in monthly?
• What is the monthly revenue of https://doi.org/10.1016%2Fj.gde.2004.12.004?
• Financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15661531
• Financial intake of http://scholar.google.com/scholar_lookup?&title=PP2A%3A%20the%20expected%20tumor%20suppressor&journal=Curr.%20Opin.%20Genet.%20Dev.&doi=10.1016%2Fj.gde.2004.12.004&volume=15&pages=34-41&publication_year=2005&author=Janssens%2CV&author=Goris%2CJ&author=Van%20Hoof%2CC
• How much profit does https://doi.org/10.1128%2FMCB.23.24.9389-9404.2003 make?
• Monthly income for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14645548
• What's the financial outcome of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC309640?
• How much profit does http://scholar.google.com/scholar_lookup?&title=Caveolin-1%20maintains%20activated%20Akt%20in%20prostate%20cancer%20cells%20through%20scaffolding%20domain%20binding%20site%20interactions%20with%20and%20inhibition%20of%20serine%2Fthreonine%20protein%20phosphatases%20PP1%20and%20PP2A&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.23.24.9389-9404.2003&volume=23&pages=9389-9404&publication_year=2003&author=Li%2CL&author=Ren%2CCH&author=Tahir%2CSA&author=Ren%2CC&author=Thompson%2CTC make?
• How much cash flow does https://doi.org/10.1016%2FS0092-8674%2800%2981683-9 have monthly?
• What's the monthly income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10647931?
• What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=The%20hallmarks%20of%20cancer&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981683-9&volume=100&pages=57-70&publication_year=2000&author=Hanahan%2CD&author=Weinberg%2CRA?
• Check the income stats for https://doi.org/10.1038%2Fnature03918
• How much revenue does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2005Natur.436..725C bring in?
• Earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16079851
• What is the earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939938?
• What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Crucial%20role%20of%20p53-dependent%20cellular%20senescence%20in%20suppression%20of%20Pten-deficient%20tumorigenesis&journal=Nature&doi=10.1038%2Fnature03918&volume=436&pages=725-730&publication_year=2005&author=Chen%2CZ?
• How much revenue does https://doi.org/10.1038%2F3073 generate?
• Financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9806545
• How much profit does http://scholar.google.com/scholar_lookup?&title=PML%20is%20essential%20for%20multiple%20apoptotic%20pathways&journal=Nature%20Genet.&doi=10.1038%2F3073&volume=20&pages=266-272&publication_year=1998&author=Wang%2CZG generate?
• How much does https://doi.org/10.1038%2F35036365 earn?
• Earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11025664
• How much revenue does http://scholar.google.com/scholar_lookup?&title=The%20function%20of%20PML%20in%20p53-dependent%20apoptosis&journal=Nature%20Cell%20Biol.&doi=10.1038%2F35036365&volume=2&pages=730-736&publication_year=2000&author=Guo%2CA bring in?
• Learn about the earnings of https://doi.org/10.1126%2Fscience.1094637
• See how much http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2004Sci...303.2011B makes per month
• Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14976264's earnings
• What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Stress-dependent%20regulation%20of%20FOXO%20transcription%20factors%20by%20the%20SIRT1%20deacetylase&journal=Science&doi=10.1126%2Fscience.1094637&volume=303&pages=2011-2015&publication_year=2004&author=Brunet%2CA?
• Get to know https://citation-needed.springer.com/v2/references/10.1038/nature04809?format=refman&flavour=references's earnings
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Lloyd%20C.%20Trotman rake in every month?
• Income figures for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Lloyd%20C.%20Trotman%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Andrea%20Alimonti
• How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Andrea%20Alimonti%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Pier%20Paolo%20Scaglioni net monthly?
• How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Pier%20Paolo%20Scaglioni%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jason%20A.%20Koutcher earn?
• What's https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jason%20A.%20Koutcher%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's gross income?
• Income figures for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Carlos%20Cordon-Cardo
• How profitable is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Carlos%20Cordon-Cardo%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What's the financial outcome of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Pier%20Paolo%20Pandolfi?
• What's the financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Pier%20Paolo%20Pandolfi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What's the revenue for https://static-content.springer.com/esm/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_BFnature04809_MOESM1_ESM.pdf?
• What's the profit of https://s100.copyright.com/AppDispatchServlet?title=Identification%20of%20a%20tumour%20suppressor%20network%20opposing%20nuclear%20Akt%20function&author=Lloyd%20C.%20Trotman%20et%20al&contentID=10.1038%2Fnature04809©right=Springer%20Nature%20Limited&publication=0028-0836&publicationDate=2006-05-07&publisherName=SpringerNature&orderBeanReset=true?
• Income figures for https://citation-needed.springer.com/v2/references/10.1038/nature04809?format=refman&flavour=citation
• How much money does https://doi.org/10.1038/s41419-022-05491-4 make?
• How much does https://doi.org/10.1186/s12964-021-00756-5 gross monthly?
• Get to know https://doi.org/10.1038/s41366-018-0167-1's earnings
• How much revenue does https://doi.org/10.1186/s13578-018-0204-8 bring in?
• https://doi.org/10.1038/s41419-018-0559-0's revenue stream
• How much profit does https://www.protocols.io/ generate?
• Get to know https://www.natureindex.com/'s earnings
• How much does http://www.naturechina.com rake in every month?
• See how much https://www.natureasia.com/ja-jp makes per month

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref