NATURE . COM {}

Matching Content Categories {📚}

• Telecommunications
• Science
• Education

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 41,362,249 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$521,200 per month
Our estimates place Nature.com's monthly online earnings from display ads at $347,485 to $955,583.

Keywords {🔍}

article, pubmed, google, scholar, cas, nature, cell, cancer, akt, pml, suppressor, nuclear, pten, access, tumor, content, tumour, pier, paolo, pandolfi, prostate, regulation, cookies, function, data, transcription, pakt, mice, suppression, ads, privacy, information, trotman, ppa, sci, central, essential, alimonti, scaglioni, cordoncardo, human, tumorigenesis, leads, phosphatase, multiple, genet, biol, science, protein, ppp,

Topics {✒️}

nature portfolio privacy policy permissions reprints nature cell biol advertising pkb/akt-dependent cell survival social media embryonic development p53-dependent cellular senescence subscribe nature nature genet pml-ii regulates erk high cancer susceptibility nature 436 nature nature 441 author information authors pier paolo pandolfi pier paolo scaglioni p53-dependent apoptosis springerlink instant access author contributions author correspondence permissions information akt signal activation expected tumor suppressor tumour suppressor pml sloan-kettering institute tumor suppressor pten ovarian follicle activation competing financial interests personal data stress-dependent regulation pten tumour suppressor1 privacy suppresses tumor growth metastatic prostate cancer prostate cancer cells pml nuclear bodies permissions proto-oncogene akt pi3k–akt pathway directly dephosphorylates akt pten-deficient tumorigenesis data protection data analysis akt phosphatase pp2a accumulate nuclear pakt cordon-cardo prostate-specific deletion

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Identification of a tumour suppressor network opposing nuclear Akt function
         description:The proto-oncogene AKT (also known as PKB) is activated in many human cancers, mostly owing to loss of the PTEN tumour suppressor1. In such tumours, AKT becomes enriched at cell membranes where it is activated by phosphorylation. Yet many targets inhibited by phosphorylated AKT (for example, the FOXO transcription factors) are nuclear; it has remained unclear how relevant nuclear phosphorylated AKT (pAKT) function is for tumorigenesis. Here we show that the PMLtumour suppressor prevents cancer by inactivating pAKT inside the nucleus. We find in a mouse model that Pml loss markedly accelerates tumour onset, incidence and progression in Pten-heterozygous mutants, and leads to female sterility with features that recapitulate the phenotype of Foxo3a knockout mice2. We show that Pml deficiency on its own leads to tumorigenesis in the prostate, a tissue that is exquisitely sensitive to pAkt levels, and demonstrate that Pml specifically recruits the Akt phosphatase PP2a as well as pAkt into Pml nuclear bodies. Notably, we find that Pml-null cells are impaired in PP2a phosphatase activity towards Akt, and thus accumulate nuclear pAkt. As a consequence, the progressive reduction in Pml dose leads to inactivation of Foxo3a-mediated transcription of proapoptotic Bim and the cell cycle inhibitor p27kip1. Our results demonstrate that Pml orchestrates a nuclear tumour suppressor network for inactivation of nuclear pAkt, and thus highlight the importance of AKT compartmentalization in human cancer pathogenesis and treatment.
         datePublished:2006-05-07T00:00:00Z
         dateModified:2006-05-07T00:00:00Z
         pageStart:523
         pageEnd:527
         sameAs:https://doi.org/10.1038/nature04809
         keywords:
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig4_HTML.jpg
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:441
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Lloyd C. Trotman
               affiliation:
                     name:Cancer Biology and Genetics Program
                     address:
                        name:Cancer Biology and Genetics Program,
                        type:PostalAddress
                     type:Organization
                     name:Department of Pathology
                     address:
                        name:Department of Pathology,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Andrea Alimonti
               affiliation:
                     name:Cancer Biology and Genetics Program
                     address:
                        name:Cancer Biology and Genetics Program,
                        type:PostalAddress
                     type:Organization
                     name:Department of Pathology
                     address:
                        name:Department of Pathology,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pier Paolo Scaglioni
               affiliation:
                     name:Cancer Biology and Genetics Program
                     address:
                        name:Cancer Biology and Genetics Program,
                        type:PostalAddress
                     type:Organization
                     name:Department of Medicine
                     address:
                        name:Department of Medicine,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jason A. Koutcher
               affiliation:
                     name:Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute
                     address:
                        name:Departments of Medicine, Radiology and Medical Physics, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Carlos Cordon-Cardo
               affiliation:
                     name:Department of Pathology
                     address:
                        name:Department of Pathology,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pier Paolo Pandolfi
               affiliation:
                     name:Cancer Biology and Genetics Program
                     address:
                        name:Cancer Biology and Genetics Program,
                        type:PostalAddress
                     type:Organization
                     name:Department of Pathology
                     address:
                        name:Department of Pathology,
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Identification of a tumour suppressor network opposing nuclear Akt function
      description:The proto-oncogene AKT (also known as PKB) is activated in many human cancers, mostly owing to loss of the PTEN tumour suppressor1. In such tumours, AKT becomes enriched at cell membranes where it is activated by phosphorylation. Yet many targets inhibited by phosphorylated AKT (for example, the FOXO transcription factors) are nuclear; it has remained unclear how relevant nuclear phosphorylated AKT (pAKT) function is for tumorigenesis. Here we show that the PMLtumour suppressor prevents cancer by inactivating pAKT inside the nucleus. We find in a mouse model that Pml loss markedly accelerates tumour onset, incidence and progression in Pten-heterozygous mutants, and leads to female sterility with features that recapitulate the phenotype of Foxo3a knockout mice2. We show that Pml deficiency on its own leads to tumorigenesis in the prostate, a tissue that is exquisitely sensitive to pAkt levels, and demonstrate that Pml specifically recruits the Akt phosphatase PP2a as well as pAkt into Pml nuclear bodies. Notably, we find that Pml-null cells are impaired in PP2a phosphatase activity towards Akt, and thus accumulate nuclear pAkt. As a consequence, the progressive reduction in Pml dose leads to inactivation of Foxo3a-mediated transcription of proapoptotic Bim and the cell cycle inhibitor p27kip1. Our results demonstrate that Pml orchestrates a nuclear tumour suppressor network for inactivation of nuclear pAkt, and thus highlight the importance of AKT compartmentalization in human cancer pathogenesis and treatment.
      datePublished:2006-05-07T00:00:00Z
      dateModified:2006-05-07T00:00:00Z
      pageStart:523
      pageEnd:527
      sameAs:https://doi.org/10.1038/nature04809
      keywords:
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_Article_BFnature04809_Fig4_HTML.jpg
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:441
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Lloyd C. Trotman
            affiliation:
                  name:Cancer Biology and Genetics Program
                  address:
                     name:Cancer Biology and Genetics Program,
                     type:PostalAddress
                  type:Organization
                  name:Department of Pathology
                  address:
                     name:Department of Pathology,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andrea Alimonti
            affiliation:
                  name:Cancer Biology and Genetics Program
                  address:
                     name:Cancer Biology and Genetics Program,
                     type:PostalAddress
                  type:Organization
                  name:Department of Pathology
                  address:
                     name:Department of Pathology,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pier Paolo Scaglioni
            affiliation:
                  name:Cancer Biology and Genetics Program
                  address:
                     name:Cancer Biology and Genetics Program,
                     type:PostalAddress
                  type:Organization
                  name:Department of Medicine
                  address:
                     name:Department of Medicine,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jason A. Koutcher
            affiliation:
                  name:Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute
                  address:
                     name:Departments of Medicine, Radiology and Medical Physics, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carlos Cordon-Cardo
            affiliation:
                  name:Department of Pathology
                  address:
                     name:Department of Pathology,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pier Paolo Pandolfi
            affiliation:
                  name:Cancer Biology and Genetics Program
                  address:
                     name:Cancer Biology and Genetics Program,
                     type:PostalAddress
                  type:Organization
                  name:Department of Pathology
                  address:
                     name:Department of Pathology,
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:441
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Cancer Biology and Genetics Program
      address:
         name:Cancer Biology and Genetics Program,
         type:PostalAddress
      name:Department of Pathology
      address:
         name:Department of Pathology,
         type:PostalAddress
      name:Cancer Biology and Genetics Program
      address:
         name:Cancer Biology and Genetics Program,
         type:PostalAddress
      name:Department of Pathology
      address:
         name:Department of Pathology,
         type:PostalAddress
      name:Cancer Biology and Genetics Program
      address:
         name:Cancer Biology and Genetics Program,
         type:PostalAddress
      name:Department of Medicine
      address:
         name:Department of Medicine,
         type:PostalAddress
      name:Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute
      address:
         name:Departments of Medicine, Radiology and Medical Physics, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, New York, USA
         type:PostalAddress
      name:Department of Pathology
      address:
         name:Department of Pathology,
         type:PostalAddress
      name:Cancer Biology and Genetics Program
      address:
         name:Cancer Biology and Genetics Program,
         type:PostalAddress
      name:Department of Pathology
      address:
         name:Department of Pathology,
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Lloyd C. Trotman
      affiliation:
            name:Cancer Biology and Genetics Program
            address:
               name:Cancer Biology and Genetics Program,
               type:PostalAddress
            type:Organization
            name:Department of Pathology
            address:
               name:Department of Pathology,
               type:PostalAddress
            type:Organization
      name:Andrea Alimonti
      affiliation:
            name:Cancer Biology and Genetics Program
            address:
               name:Cancer Biology and Genetics Program,
               type:PostalAddress
            type:Organization
            name:Department of Pathology
            address:
               name:Department of Pathology,
               type:PostalAddress
            type:Organization
      name:Pier Paolo Scaglioni
      affiliation:
            name:Cancer Biology and Genetics Program
            address:
               name:Cancer Biology and Genetics Program,
               type:PostalAddress
            type:Organization
            name:Department of Medicine
            address:
               name:Department of Medicine,
               type:PostalAddress
            type:Organization
      name:Jason A. Koutcher
      affiliation:
            name:Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute
            address:
               name:Departments of Medicine, Radiology and Medical Physics, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, New York, USA
               type:PostalAddress
            type:Organization
      name:Carlos Cordon-Cardo
      affiliation:
            name:Department of Pathology
            address:
               name:Department of Pathology,
               type:PostalAddress
            type:Organization
      name:Pier Paolo Pandolfi
      affiliation:
            name:Cancer Biology and Genetics Program
            address:
               name:Cancer Biology and Genetics Program,
               type:PostalAddress
            type:Organization
            name:Department of Pathology
            address:
               name:Department of Pathology,
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Cancer Biology and Genetics Program,
      name:Department of Pathology,
      name:Cancer Biology and Genetics Program,
      name:Department of Pathology,
      name:Cancer Biology and Genetics Program,
      name:Department of Medicine,
      name:Departments of Medicine, Radiology and Medical Physics, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, New York, USA
      name:Department of Pathology,
      name:Cancer Biology and Genetics Program,
      name:Department of Pathology,
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/Nature
• https://twitter.com/nature

External Links {🔗}(126)

• See how much https://link.springer.com/article/10.1038/nature04809?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle makes per month
• What's the income generated by https://doi.org/10.1016%2FS1535-6108%2803%2900248-4 each month?
• How much income is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14585353 earning monthly?
• Income figures for http://scholar.google.com/scholar_lookup?&title=Targeting%20the%20PI3K%E2%80%93Akt%20pathway%20in%20human%20cancer%3A%20rationale%20and%20promise&journal=Cancer%20Cell&doi=10.1016%2FS1535-6108%2803%2900248-4&volume=4&pages=257-262&publication_year=2003&author=Luo%2CJ&author=Manning%2CBD&author=Cantley%2CLC
• Get to know what's the income of https://doi.org/10.1016%2Fj.molmed.2003.09.003
• What's the income generated by http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14604822 each month?
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=FoxO3a%20eggs%20on%20fertility%20and%20aging&journal=Trends%20Mol.%20Med.&doi=10.1016%2Fj.molmed.2003.09.003&volume=9&pages=464-467&publication_year=2003&author=Brenkman%2CAB&author=Burgering%2CBM have monthly?
• Check the income stats for https://doi.org/10.1016%2FS0092-8674%2802%2900626-8
• Earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11832207
• How much revenue does http://scholar.google.com/scholar_lookup?&title=The%20role%20of%20PML%20in%20tumor%20suppression&journal=Cell&doi=10.1016%2FS0092-8674%2802%2900626-8&volume=108&pages=165-170&publication_year=2002&author=Salomoni%2CP&author=Pandolfi%2CPP generate?
• How much profit is https://doi.org/10.1093%2Fjnci%2Fdjh043 making per month?
• Find out how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14970276 earns monthly
• How much does http://scholar.google.com/scholar_lookup?&title=Loss%20of%20the%20tumour%20suppressor%20PML%20in%20human%20cancers%20of%20multiple%20histologic%20origins&journal=J.%20Natl%20Cancer%20Inst.&doi=10.1093%2Fjnci%2Fdjh043&volume=96&pages=269-279&publication_year=2004&author=Gurrieri%2CC bring in each month?
• What is the earnings of https://doi.org/10.1158%2F0008-5472.CAN-2401-2?
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15126336's total income per month
• http://scholar.google.com/scholar_lookup?&title=Frequent%20inactivation%20of%20PTEN%20by%20promoter%20hypermethylation%20in%20microsatellite%20instability-high%20sporadic%20colorectal%20cancers&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-2401-2&volume=64&pages=3014-3021&publication_year=2004&author=Goel%2CA's financial summary
• Check the income stats for https://doi.org/10.1016%2Fj.eururo.2004.01.012
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15149739 rake in every month?
• Profit of http://scholar.google.com/scholar_lookup?&title=Molecular%20mechanisms%20of%20prostate%20cancer&journal=Eur.%20Urol.&doi=10.1016%2Fj.eururo.2004.01.012&volume=45&pages=683-691&publication_year=2004&author=Porkka%2CKP&author=Visakorpi%2CT
• https://doi.org/10.1038%2F1235 income
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9697695 make?
• How much does http://scholar.google.com/scholar_lookup?&title=Pten%20is%20essential%20for%20embryonic%20development%20and%20tumour%20suppression&journal=Nature%20Genet.&doi=10.1038%2F1235&volume=19&pages=348-355&publication_year=1998&author=Di%20Cristofano%2CA&author=Pesce%2CB&author=Cordon-Cardo%2CC&author=Pandolfi%2CPP net monthly?
• How much income does https://doi.org/10.1073%2Fpnas.96.4.1563 have?
• How much income is http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1999PNAS...96.1563P earning monthly?
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9990064 rake in every month?
• How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC15517 earn?
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=Mutation%20of%20Pten%2FMmac1%20in%20mice%20causes%20neoplasia%20in%20multiple%20organ%20systems&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.96.4.1563&volume=96&pages=1563-1568&publication_year=1999&author=Podsypanina%2CK have monthly?
• What are the total earnings of https://doi.org/10.1016%2FS0960-9822%2807%2900488-5?
• How much income is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9799734 earning monthly?
• Financial intake of http://scholar.google.com/scholar_lookup?&title=High%20cancer%20susceptibility%20and%20embryonic%20lethality%20associated%20with%20mutation%20of%20the%20PTEN%20tumor%20suppressor%20gene%20in%20mice&journal=Curr.%20Biol.&doi=10.1016%2FS0960-9822%2807%2900488-5&volume=8&pages=1169-1178&publication_year=1998&author=Suzuki%2CA
• How much does https://doi.org/10.1126%2Fscience.285.5436.2122 make?
• What's the income generated by http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10497129 each month?
• What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Impaired%20Fas%20response%20and%20autoimmunity%20in%20Pten%2B%2F-%20mice&journal=Science&doi=10.1126%2Fscience.285.5436.2122&volume=285&pages=2122-2125&publication_year=1999&author=Di%20Cristofano%2CA?
• How much revenue does https://doi.org/10.1371%2Fjournal.pbio.0000059 generate?
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14691534 pull in?
• What's the income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC270016?
• How much does http://scholar.google.com/scholar_lookup?&title=Pten%20dose%20dictates%20cancer%20progression%20in%20the%20prostate&journal=PLoS%20Biol.&doi=10.1371%2Fjournal.pbio.0000059&volume=1&publication_year=2003&author=Trotman%2CLC pull in?
• What's the total monthly financial gain of https://doi.org/10.1016%2FS1535-6108%2803%2900215-0?
• What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14522255?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Prostate-specific%20deletion%20of%20the%20murine%20Pten%20tumor%20suppressor%20gene%20leads%20to%20metastatic%20prostate%20cancer&journal=Cancer%20Cell&doi=10.1016%2FS1535-6108%2803%2900215-0&volume=4&pages=209-221&publication_year=2003&author=Wang%2CS?
• Discover the revenue of https://doi.org/10.1038%2F84879
• What's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11175795?
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=Pten%20and%20p27KIP1%20cooperate%20in%20prostate%20cancer%20tumor%20suppression%20in%20the%20mouse&journal=Nature%20Genet.&doi=10.1038%2F84879&volume=27&pages=222-224&publication_year=2001&author=Di%20Cristofano%2CA&author=De%20Acetis%2CM&author=Koff%2CA&author=Cordon-Cardo%2CC&author=Pandolfi%2CPP have monthly?
• What's https://doi.org/10.1146%2Fannurev.biochem.70.1.247's gross income?
• Monthly income for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11395408
• What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=PTEN%20and%20myotubularin%3A%20novel%20phosphoinositide%20phosphatases&journal=Annu.%20Rev.%20Biochem.&doi=10.1146%2Fannurev.biochem.70.1.247&volume=70&pages=247-279&publication_year=2001&author=Maehama%2CT&author=Taylor%2CGS&author=Dixon%2CJE?
• What's https://doi.org/10.1016%2FS0092-8674%2800%2981780-8's gross income?
• What's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9778245?
• What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Negative%20regulation%20of%20PKB%2FAkt-dependent%20cell%20survival%20by%20the%20tumor%20suppressor%20PTEN&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981780-8&volume=95&pages=29-39&publication_year=1998&author=Stambolic%2CV?
• Explore the financials of https://doi.org/10.1126%2Fscience.1106148
• http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2005Sci...307.1098S's revenue stream
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15718470 generate monthly?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Phosphorylation%20and%20regulation%20of%20Akt%2FPKB%20by%20the%20rictor%E2%80%93mTOR%20complex&journal=Science&doi=10.1126%2Fscience.1106148&volume=307&pages=1098-1101&publication_year=2005&author=Sarbassov%2CDD&author=Guertin%2CDA&author=Ali%2CSM&author=Sabatini%2CDM?
• How much revenue does https://doi.org/10.1016%2Fj.tibs.2004.03.006 bring in?
• How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15130559 generate?
• What's the income of http://scholar.google.com/scholar_lookup?&title=Advances%20in%20protein%20kinase%20B%20signalling%3A%20AKTion%20on%20multiple%20fronts&journal=Trends%20Biochem.%20Sci.&doi=10.1016%2Fj.tibs.2004.03.006&volume=29&pages=233-242&publication_year=2004&author=Brazil%2CDP&author=Yang%2CZZ&author=Hemmings%2CBA?
• What's the financial outcome of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12621150?
• How much does http://scholar.google.com/scholar_lookup?&title=The%20many%20forks%20in%20FOXO%27s%20road&journal=Sci.%20STKE&volume=2003&publication_year=2003&author=Tran%2CH&author=Brunet%2CA&author=Griffith%2CEC&author=Greenberg%2CME pull in monthly?
• https://doi.org/10.1016%2FS0092-8674%2800%2980595-4's total income per month
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10102273 rake in every month?
• What's the revenue for http://scholar.google.com/scholar_lookup?&title=Akt%20promotes%20cell%20survival%20by%20phosphorylating%20and%20inhibiting%20a%20Forkhead%20transcription%20factor&journal=Cell&doi=10.1016%2FS0092-8674%2800%2980595-4&volume=96&pages=857-868&publication_year=1999&author=Brunet%2CA?
• How much money does https://doi.org/10.1126%2Fscience.1086336 generate?
• Get to know http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2003Sci...301..215C's earnings
• Get to know what's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12855809
• Income figures for http://scholar.google.com/scholar_lookup?&title=Suppression%20of%20ovarian%20follicle%20activation%20in%20mice%20by%20the%20transcription%20factor%20Foxo3a&journal=Science&doi=10.1126%2Fscience.1086336&volume=301&pages=215-218&publication_year=2003&author=Castrillon%2CDH&author=Miao%2CL&author=Kollipara%2CR&author=Horner%2CJW&author=DePinho%2CRA
• How much money does https://doi.org/10.1073%2Fpnas.0400093101 make?
• How much profit does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2004PNAS..101.2975H generate?
• What's the financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14978268?
• How profitable is http://www.ncbi.nlm.nih.gov/pmc/articles/PMC365730?
• What's http://scholar.google.com/scholar_lookup?&title=Disruption%20of%20forkhead%20transcription%20factor%20%28FOXO%29%20family%20members%20in%20mice%20reveals%20their%20functional%20diversification&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0400093101&volume=101&pages=2975-2980&publication_year=2004&author=Hosaka%2CT's gross income?
• What is the monthly revenue of https://doi.org/10.1016%2FS0968-0004%2899%2901375-4?
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10322434's total income per month
• What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20protein%20kinase%20cascades%20by%20protein%20phosphatase%202A&journal=Trends%20Biochem.%20Sci.&doi=10.1016%2FS0968-0004%2899%2901375-4&volume=24&pages=186-191&publication_year=1999&author=Millward%2CTA&author=Zolnierowicz%2CS&author=Hemmings%2CBA?
• How much profit does https://doi.org/10.1016%2Fj.molcel.2005.03.008 generate?
• How much income is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15808505 earning monthly?
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=PHLPP%3A%20a%20phosphatase%20that%20directly%20dephosphorylates%20Akt%2C%20promotes%20apoptosis%2C%20and%20suppresses%20tumor%20growth&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2005.03.008&volume=18&pages=13-24&publication_year=2005&author=Gao%2CT&author=Furnari%2CF&author=Newton%2CAC?
• Financial intake of https://doi.org/10.1016%2Fj.gde.2004.12.004
• What's the income generated by http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15661531 each month?
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=PP2A%3A%20the%20expected%20tumor%20suppressor&journal=Curr.%20Opin.%20Genet.%20Dev.&doi=10.1016%2Fj.gde.2004.12.004&volume=15&pages=34-41&publication_year=2005&author=Janssens%2CV&author=Goris%2CJ&author=Van%20Hoof%2CC
• How much does https://doi.org/10.1128%2FMCB.23.24.9389-9404.2003 earn?
• Discover the revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14645548
• How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC309640 generate monthly?
• How much does http://scholar.google.com/scholar_lookup?&title=Caveolin-1%20maintains%20activated%20Akt%20in%20prostate%20cancer%20cells%20through%20scaffolding%20domain%20binding%20site%20interactions%20with%20and%20inhibition%20of%20serine%2Fthreonine%20protein%20phosphatases%20PP1%20and%20PP2A&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.23.24.9389-9404.2003&volume=23&pages=9389-9404&publication_year=2003&author=Li%2CL&author=Ren%2CCH&author=Tahir%2CSA&author=Ren%2CC&author=Thompson%2CTC generate monthly?
• How much does https://doi.org/10.1016%2FS0092-8674%2800%2981683-9 make?
• What's the financial gain of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10647931?
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=The%20hallmarks%20of%20cancer&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981683-9&volume=100&pages=57-70&publication_year=2000&author=Hanahan%2CD&author=Weinberg%2CRA is on a monthly basis
• How much profit does https://doi.org/10.1038%2Fnature03918 generate?
• What is the monthly revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2005Natur.436..725C?
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16079851 income
• How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939938 generate monthly?
• http://scholar.google.com/scholar_lookup?&title=Crucial%20role%20of%20p53-dependent%20cellular%20senescence%20in%20suppression%20of%20Pten-deficient%20tumorigenesis&journal=Nature&doi=10.1038%2Fnature03918&volume=436&pages=725-730&publication_year=2005&author=Chen%2CZ's revenue stream
• Monthly income for https://doi.org/10.1038%2F3073
• Financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9806545
• Revenue of http://scholar.google.com/scholar_lookup?&title=PML%20is%20essential%20for%20multiple%20apoptotic%20pathways&journal=Nature%20Genet.&doi=10.1038%2F3073&volume=20&pages=266-272&publication_year=1998&author=Wang%2CZG
• Income figures for https://doi.org/10.1038%2F35036365
• Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11025664's earnings
• Income figures for http://scholar.google.com/scholar_lookup?&title=The%20function%20of%20PML%20in%20p53-dependent%20apoptosis&journal=Nature%20Cell%20Biol.&doi=10.1038%2F35036365&volume=2&pages=730-736&publication_year=2000&author=Guo%2CA
• What's the financial outcome of https://doi.org/10.1126%2Fscience.1094637?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2004Sci...303.2011B make?
• See how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14976264 makes per month
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=Stress-dependent%20regulation%20of%20FOXO%20transcription%20factors%20by%20the%20SIRT1%20deacetylase&journal=Science&doi=10.1126%2Fscience.1094637&volume=303&pages=2011-2015&publication_year=2004&author=Brunet%2CA
• How much does https://citation-needed.springer.com/v2/references/10.1038/nature04809?format=refman&flavour=references earn?
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Lloyd%20C.%20Trotman's total income per month
• Discover the revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Lloyd%20C.%20Trotman%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Andrea%20Alimonti gross monthly?
• What is the monthly revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Andrea%20Alimonti%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Pier%20Paolo%20Scaglioni generate monthly?
• Income figures for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Pier%20Paolo%20Scaglioni%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• See how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jason%20A.%20Koutcher makes per month
• What's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jason%20A.%20Koutcher%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Carlos%20Cordon-Cardo generate?
• What's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Carlos%20Cordon-Cardo%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Pier%20Paolo%20Pandolfi generate?
• What's https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Pier%20Paolo%20Pandolfi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's gross income?
• Learn how profitable https://static-content.springer.com/esm/art%3A10.1038%2Fnature04809/MediaObjects/41586_2006_BFnature04809_MOESM1_ESM.pdf is on a monthly basis
• What's the financial gain of https://s100.copyright.com/AppDispatchServlet?title=Identification%20of%20a%20tumour%20suppressor%20network%20opposing%20nuclear%20Akt%20function&author=Lloyd%20C.%20Trotman%20et%20al&contentID=10.1038%2Fnature04809©right=Springer%20Nature%20Limited&publication=0028-0836&publicationDate=2006-05-07&publisherName=SpringerNature&orderBeanReset=true?
• How much does https://citation-needed.springer.com/v2/references/10.1038/nature04809?format=refman&flavour=citation earn?
• What's https://doi.org/10.1038/s41419-022-05491-4's gross income?
• How much money does https://doi.org/10.1186/s12964-021-00756-5 generate?
• What's the profit of https://doi.org/10.1038/s41366-018-0167-1?
• What's the total monthly financial gain of https://doi.org/10.1186/s13578-018-0204-8?
• How much does https://doi.org/10.1038/s41419-018-0559-0 pull in?
• Financial intake of https://www.protocols.io/
• What's the income generated by https://www.natureindex.com/ each month?
• See how much http://www.naturechina.com makes per month
• How much money does https://www.natureasia.com/ja-jp make?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref