NATURE . COM {}

Matching Content Categories {📚}

• Education
• Science
• Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 41,362,249 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$521,200 per month
Our estimates place Nature.com's monthly online earnings from display ads at $347,485 to $955,583.

Keywords {🔍}

article, cas, google, scholar, nature, cytokine, autoimmune, interleukin, immunol, access, inflammation, content, brain, encephalomyelitis, research, factor, cells, mice, experimental, cell, cookies, information, receptor, usa, supplementary, privacy, critical, daniel, cua, chen, expression, central, role, ads, dnax, author, function, data, heterodimeric, immune, subunit, disease, open, development, references, exp, med, nervous, system, department,

Topics {✒️}

nature portfolio permissions reprints privacy policy schering-plough research institute alloantigen-reactive th1 development advertising advertisement nature social media nature 407 nature 421 nature t-cell-dependent immune dnax research gene-targeted mice lacking author correspondence il-12 prevent superantigen-induced personal data end-stage effector cytokine springerlink instant access data protection development supplementary figure legends interferon-γ response experimental autoimmune encephalomyelitis t-lymphocyte entry biological activities similar privacy central nervous system autoimmune disease models autoimmune demyelinating disease mac-1+ myelopoiesis induced th17 cell heterogeneity experimental autoimmune encephalitis mice lacking expression competing financial interests il-12-deficient mice trends cell biol permissions regulate autoimmune responses ifn-γ plays cytokine receptor subunit blood-brain barrier european economic area transgenic mice10 suggest institutional subscriptions read familial mediterranean fever ubiquitous transgenic expression cxc chemokine lungkine mount sinai school mistaken identity wendy

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
         description:Interleukin-12 (IL-12) is a heterodimeric molecule composed of p35 and p40 subunits. Analyses in vitro have defined IL-12 as an important factor for the differentiation of naive T cells into T-helper type 1 CD4+ lymphocytes secreting interferon-γ (refs 1, 2). Similarly, numerous studies3,4,5,6,7 have concluded that IL-12 is essential for T-cell-dependent immune and inflammatory responses in vivo, primarily through the use of IL-12 p40 gene-targeted mice and neutralizing antibodies against p40. The cytokine IL-23, which comprises the p40 subunit of IL-12 but a different p19 subunit8, is produced predominantly by macrophages and dendritic cells, and shows activity on memory T cells. Evidence from studies of IL-23 receptor expression9 and IL-23 overexpression in transgenic mice10 suggest, however, that IL-23 may also affect macrophage function directly. Here we show, by using gene-targeted mice lacking only IL-23 and cytokine replacement studies, that the perceived central role for IL-12 in autoimmune inflammation, specifically in the brain, has been misinterpreted and that IL-23, and not IL-12, is the critical factor in this response. In addition, we show that IL-23, unlike IL-12, acts more broadly as an end-stage effector cytokine through direct actions on macrophages.
         datePublished:
         dateModified:
         pageStart:744
         pageEnd:748
         sameAs:https://doi.org/10.1038/nature01355
         keywords:
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature01355/MediaObjects/41586_2003_Article_BFnature01355_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature01355/MediaObjects/41586_2003_Article_BFnature01355_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature01355/MediaObjects/41586_2003_Article_BFnature01355_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature01355/MediaObjects/41586_2003_Article_BFnature01355_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature01355/MediaObjects/41586_2003_Article_BFnature01355_Fig5_HTML.jpg
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:421
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Daniel J. Cua
               affiliation:
                     name:DNAX Research Inc.
                     address:
                        name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Jonathan Sherlock
               affiliation:
                     name:DNAX Research Inc.
                     address:
                        name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yi Chen
               affiliation:
                     name:DNAX Research Inc.
                     address:
                        name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Craig A. Murphy
               affiliation:
                     name:DNAX Research Inc.
                     address:
                        name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Barbara Joyce
               affiliation:
                     name:DNAX Research Inc.
                     address:
                        name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Brian Seymour
               affiliation:
                     name:DNAX Research Inc.
                     address:
                        name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Linda Lucian
               affiliation:
                     name:DNAX Research Inc.
                     address:
                        name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wayne To
               affiliation:
                     name:DNAX Research Inc.
                     address:
                        name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sylvia Kwan
               affiliation:
                     name:DNAX Research Inc.
                     address:
                        name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Tatyana Churakova
               affiliation:
                     name:DNAX Research Inc.
                     address:
                        name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sandra Zurawski
               affiliation:
                     name:DNAX Research Inc.
                     address:
                        name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Maria Wiekowski
               affiliation:
                     name:Schering-Plough Research Institute
                     address:
                        name:Department of Immunology, Schering-Plough Research Institute, Kenilworth, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sergio A. Lira
               affiliation:
                     name:Schering-Plough Research Institute
                     address:
                        name:Department of Immunology, Schering-Plough Research Institute, Kenilworth, USA
                        type:PostalAddress
                     type:Organization
                     name:Immunobiology Center, Mount Sinai School of Medicine
                     address:
                        name:Immunobiology Center, Mount Sinai School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daniel Gorman
               affiliation:
                     name:DNAX Research Inc.
                     address:
                        name:Department of Genomics, DNAX Research Inc., Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Robert A. Kastelein
               affiliation:
                     name:DNAX Research Inc.
                     address:
                        name:Department of Genomics, DNAX Research Inc., Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jonathon D. Sedgwick
               affiliation:
                     name:DNAX Research Inc.
                     address:
                        name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
      description:Interleukin-12 (IL-12) is a heterodimeric molecule composed of p35 and p40 subunits. Analyses in vitro have defined IL-12 as an important factor for the differentiation of naive T cells into T-helper type 1 CD4+ lymphocytes secreting interferon-γ (refs 1, 2). Similarly, numerous studies3,4,5,6,7 have concluded that IL-12 is essential for T-cell-dependent immune and inflammatory responses in vivo, primarily through the use of IL-12 p40 gene-targeted mice and neutralizing antibodies against p40. The cytokine IL-23, which comprises the p40 subunit of IL-12 but a different p19 subunit8, is produced predominantly by macrophages and dendritic cells, and shows activity on memory T cells. Evidence from studies of IL-23 receptor expression9 and IL-23 overexpression in transgenic mice10 suggest, however, that IL-23 may also affect macrophage function directly. Here we show, by using gene-targeted mice lacking only IL-23 and cytokine replacement studies, that the perceived central role for IL-12 in autoimmune inflammation, specifically in the brain, has been misinterpreted and that IL-23, and not IL-12, is the critical factor in this response. In addition, we show that IL-23, unlike IL-12, acts more broadly as an end-stage effector cytokine through direct actions on macrophages.
      datePublished:
      dateModified:
      pageStart:744
      pageEnd:748
      sameAs:https://doi.org/10.1038/nature01355
      keywords:
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature01355/MediaObjects/41586_2003_Article_BFnature01355_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature01355/MediaObjects/41586_2003_Article_BFnature01355_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature01355/MediaObjects/41586_2003_Article_BFnature01355_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature01355/MediaObjects/41586_2003_Article_BFnature01355_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature01355/MediaObjects/41586_2003_Article_BFnature01355_Fig5_HTML.jpg
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:421
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Daniel J. Cua
            affiliation:
                  name:DNAX Research Inc.
                  address:
                     name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Jonathan Sherlock
            affiliation:
                  name:DNAX Research Inc.
                  address:
                     name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yi Chen
            affiliation:
                  name:DNAX Research Inc.
                  address:
                     name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Craig A. Murphy
            affiliation:
                  name:DNAX Research Inc.
                  address:
                     name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Barbara Joyce
            affiliation:
                  name:DNAX Research Inc.
                  address:
                     name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Brian Seymour
            affiliation:
                  name:DNAX Research Inc.
                  address:
                     name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Linda Lucian
            affiliation:
                  name:DNAX Research Inc.
                  address:
                     name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wayne To
            affiliation:
                  name:DNAX Research Inc.
                  address:
                     name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sylvia Kwan
            affiliation:
                  name:DNAX Research Inc.
                  address:
                     name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tatyana Churakova
            affiliation:
                  name:DNAX Research Inc.
                  address:
                     name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sandra Zurawski
            affiliation:
                  name:DNAX Research Inc.
                  address:
                     name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Maria Wiekowski
            affiliation:
                  name:Schering-Plough Research Institute
                  address:
                     name:Department of Immunology, Schering-Plough Research Institute, Kenilworth, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sergio A. Lira
            affiliation:
                  name:Schering-Plough Research Institute
                  address:
                     name:Department of Immunology, Schering-Plough Research Institute, Kenilworth, USA
                     type:PostalAddress
                  type:Organization
                  name:Immunobiology Center, Mount Sinai School of Medicine
                  address:
                     name:Immunobiology Center, Mount Sinai School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel Gorman
            affiliation:
                  name:DNAX Research Inc.
                  address:
                     name:Department of Genomics, DNAX Research Inc., Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Robert A. Kastelein
            affiliation:
                  name:DNAX Research Inc.
                  address:
                     name:Department of Genomics, DNAX Research Inc., Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jonathon D. Sedgwick
            affiliation:
                  name:DNAX Research Inc.
                  address:
                     name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:421
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:DNAX Research Inc.
      address:
         name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
         type:PostalAddress
      name:DNAX Research Inc.
      address:
         name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
         type:PostalAddress
      name:DNAX Research Inc.
      address:
         name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
         type:PostalAddress
      name:DNAX Research Inc.
      address:
         name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
         type:PostalAddress
      name:DNAX Research Inc.
      address:
         name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
         type:PostalAddress
      name:DNAX Research Inc.
      address:
         name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
         type:PostalAddress
      name:DNAX Research Inc.
      address:
         name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
         type:PostalAddress
      name:DNAX Research Inc.
      address:
         name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
         type:PostalAddress
      name:DNAX Research Inc.
      address:
         name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
         type:PostalAddress
      name:DNAX Research Inc.
      address:
         name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
         type:PostalAddress
      name:DNAX Research Inc.
      address:
         name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
         type:PostalAddress
      name:Schering-Plough Research Institute
      address:
         name:Department of Immunology, Schering-Plough Research Institute, Kenilworth, USA
         type:PostalAddress
      name:Schering-Plough Research Institute
      address:
         name:Department of Immunology, Schering-Plough Research Institute, Kenilworth, USA
         type:PostalAddress
      name:Immunobiology Center, Mount Sinai School of Medicine
      address:
         name:Immunobiology Center, Mount Sinai School of Medicine, New York, USA
         type:PostalAddress
      name:DNAX Research Inc.
      address:
         name:Department of Genomics, DNAX Research Inc., Palo Alto, USA
         type:PostalAddress
      name:DNAX Research Inc.
      address:
         name:Department of Genomics, DNAX Research Inc., Palo Alto, USA
         type:PostalAddress
      name:DNAX Research Inc.
      address:
         name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Daniel J. Cua
      affiliation:
            name:DNAX Research Inc.
            address:
               name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jonathan Sherlock
      affiliation:
            name:DNAX Research Inc.
            address:
               name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Yi Chen
      affiliation:
            name:DNAX Research Inc.
            address:
               name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Craig A. Murphy
      affiliation:
            name:DNAX Research Inc.
            address:
               name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Barbara Joyce
      affiliation:
            name:DNAX Research Inc.
            address:
               name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Brian Seymour
      affiliation:
            name:DNAX Research Inc.
            address:
               name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Linda Lucian
      affiliation:
            name:DNAX Research Inc.
            address:
               name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Wayne To
      affiliation:
            name:DNAX Research Inc.
            address:
               name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Sylvia Kwan
      affiliation:
            name:DNAX Research Inc.
            address:
               name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Tatyana Churakova
      affiliation:
            name:DNAX Research Inc.
            address:
               name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Sandra Zurawski
      affiliation:
            name:DNAX Research Inc.
            address:
               name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Maria Wiekowski
      affiliation:
            name:Schering-Plough Research Institute
            address:
               name:Department of Immunology, Schering-Plough Research Institute, Kenilworth, USA
               type:PostalAddress
            type:Organization
      name:Sergio A. Lira
      affiliation:
            name:Schering-Plough Research Institute
            address:
               name:Department of Immunology, Schering-Plough Research Institute, Kenilworth, USA
               type:PostalAddress
            type:Organization
            name:Immunobiology Center, Mount Sinai School of Medicine
            address:
               name:Immunobiology Center, Mount Sinai School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      name:Daniel Gorman
      affiliation:
            name:DNAX Research Inc.
            address:
               name:Department of Genomics, DNAX Research Inc., Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Robert A. Kastelein
      affiliation:
            name:DNAX Research Inc.
            address:
               name:Department of Genomics, DNAX Research Inc., Palo Alto, USA
               type:PostalAddress
            type:Organization
      name:Jonathon D. Sedgwick
      affiliation:
            name:DNAX Research Inc.
            address:
               name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
      name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
      name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
      name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
      name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
      name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
      name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
      name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
      name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
      name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
      name:Department of Protein and Antibody Technology, DNAX Research Inc., Palo Alto, USA
      name:Department of Immunology, Schering-Plough Research Institute, Kenilworth, USA
      name:Department of Immunology, Schering-Plough Research Institute, Kenilworth, USA
      name:Immunobiology Center, Mount Sinai School of Medicine, New York, USA
      name:Department of Genomics, DNAX Research Inc., Palo Alto, USA
      name:Department of Genomics, DNAX Research Inc., Palo Alto, USA
      name:Department of Immunology, DNAX Research Inc., Palo Alto, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/Nature
• https://twitter.com/nature

External Links {🔗}(108)

• How much does https://link.springer.com/article/10.1038/nature01355?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle pull in monthly?
• How much profit does https://doi.org/10.1084%2Fjem.170.3.827 make?
• How much profit does http://scholar.google.com/scholar_lookup?&title=Identification%20and%20purification%20of%20natural%20killer%20cell%20stimulatory%20factor%20%28NKSF%29%2C%20a%20cytokine%20with%20multiple%20biologic%20effects%20on%20human%20lymphocytes&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.170.3.827&volume=170&pages=827-845&publication_year=1989&author=Kobayashi%2CM make?
• https://doi.org/10.1016%2F0955-2235%2892%2990016-B's revenue stream
• Find out how much http://scholar.google.com/scholar_lookup?&title=Natural%20killer%20cell%20stimulatory%20factor%20%28NKSF%29%20or%20interleukin-12%20is%20a%20key%20regulator%20of%20immune%20response%20and%20inflammation&journal=Prog.%20Growth%20Factor%20Res.&doi=10.1016%2F0955-2235%2892%2990016-B&volume=4&pages=355-368&publication_year=1992&author=Trinchieri%2CG earns monthly
• https://doi.org/10.1084%2Fjem.181.1.381 income
• See how much http://scholar.google.com/scholar_lookup?&title=Prevention%20of%20experimental%20autoimmune%20encephalomyelitis%20by%20antibodies%20against%20interleukin%2012&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.181.1.381&volume=181&pages=381-386&publication_year=1995&author=Leonard%2CJP&author=Waldburger%2CKE&author=Goldman%2CSJ makes per month
• How much revenue does https://doi.org/10.1016%2F0165-5728%2895%2900100-G generate?
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Cytokine%20production%20in%20the%20central%20nervous%20system%20of%20Lewis%20rats%20with%20experimental%20autoimmune%20encephalomyelitis%3A%20dynamics%20of%20mRNA%20expression%20for%20interleukin-10%2C%20interleukin-12%2C%20cytolysin%2C%20tumour%20necrosis%20factor%20%CE%B1%20and%20tumour%20necrosis%20factor%20%CE%B2&journal=J.%20Neuroimmunol.&doi=10.1016%2F0165-5728%2895%2900100-G&volume=61&pages=205-212&publication_year=1995&author=Issazadeh%2CS&author=Ljungdahl%2CA&author=Hojeberg%2CB&author=Mustafa%2CM&author=Olsson%2CT?
• Check the income stats for https://doi.org/10.1111%2Fj.1749-6632.1996.tb52671.x
• Learn about the earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1996NYASA.795..216L
• Revenue of http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20experimental%20autoimmune%20encephalomyelitis%20by%20interleukin-12&journal=Ann.%20NY%20Acad.%20Sci.&doi=10.1111%2Fj.1749-6632.1996.tb52671.x&volume=795&pages=216-226&publication_year=1996&author=Leonard%2CJP&author=Waldburger%2CKE&author=Goldman%2CSJ
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=Antibodies%20against%20IL-12%20prevent%20superantigen-induced%20and%20spontaneous%20relapses%20of%20experimental%20autoimmune%20encephalomyelitis&journal=J.%20Immunol.&volume=161&pages=5097-5104&publication_year=1998&author=Constantinescu%2CCS is on a monthly basis
• How much does https://doi.org/10.1084%2Fjem.187.4.537 earn?
• How much money does http://scholar.google.com/scholar_lookup?&title=An%20interleukin%20%28IL%29-10%2FIL-12%20immunoregulatory%20circuit%20controls%20susceptibility%20to%20autoimmune%20disease&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.187.4.537&volume=187&pages=537-546&publication_year=1998&author=Segal%2CBM&author=Dwyer%2CBK&author=Shevach%2CEM make?
• What's the income generated by https://doi.org/10.1016%2FS1074-7613%2800%2900070-4 each month?
• What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Novel%20p19%20protein%20engages%20IL-12p40%20to%20form%20a%20cytokine%2C%20IL-23%2C%20with%20biological%20activities%20similar%20as%20well%20as%20distinct%20from%20IL-12&journal=Immunity&doi=10.1016%2FS1074-7613%2800%2900070-4&volume=13&pages=715-725&publication_year=2000&author=Oppmann%2CB?
• How much revenue does https://doi.org/10.4049%2Fjimmunol.168.11.5699 produce monthly?
• How much does http://scholar.google.com/scholar_lookup?&title=A%20receptor%20for%20the%20heterodimeric%20cytokine%20IL-23%20is%20composed%20of%20IL-12R%CE%B21%20and%20a%20novel%20cytokine%20receptor%20subunit%2C%20IL-23R&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.168.11.5699&volume=168&pages=5699-5708&publication_year=2002&author=Parham%2CC pull in?
• What's the income of https://doi.org/10.4049%2Fjimmunol.166.12.7563?
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Ubiquitous%20transgenic%20expression%20of%20the%20IL-23%20subunit%20p19%20induces%20multiorgan%20inflammation%2C%20runting%2C%20infertility%2C%20and%20premature%20death&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.166.12.7563&volume=166&pages=7563-7570&publication_year=2001&author=Wiekowski%2CMT
• https://doi.org/10.4049%2Fjimmunol.166.1.602 income
• Income figures for http://scholar.google.com/scholar_lookup?&title=Central%20nervous%20system%20expression%20of%20IL-10%20inhibits%20autoimmune%20encephalomyelitis&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.166.1.602&volume=166&pages=602-608&publication_year=2001&author=Cua%2CDJ&author=Hutchins%2CB&author=LaFace%2CDM&author=Stohlman%2CSA&author=Coffman%2CRL
• How much revenue does https://doi.org/10.1016%2FS0962-8924%2800%2901856-0 generate?
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=The%20molecular%20basis%20of%20T%20helper%201%20and%20T%20helper%202%20cell%20differentiation&journal=Trends%20Cell%20Biol.&doi=10.1016%2FS0962-8924%2800%2901856-0&volume=10&pages=542-550&publication_year=2000&author=O%27Garra%2CA&author=Arai%2CN have monthly?
• What's the financial gain of https://doi.org/10.1006%2Fclin.1998.4540?
• How much does http://scholar.google.com/scholar_lookup?&title=IL-12%20in%20autoimmunity&journal=Clin.%20Immunol.%20Immunopathol.&doi=10.1006%2Fclin.1998.4540&volume=88&pages=4-13&publication_year=1998&author=Caspi%2CRR bring in each month?
• https://doi.org/10.1016%2FS0952-7915%2899%2900035-7's financial summary
• What's the income generated by http://scholar.google.com/scholar_lookup?&title=Cytokines%20that%20regulate%20autoimmune%20responses&journal=Curr.%20Opin.%20Immunol.&doi=10.1016%2FS0952-7915%2899%2900035-7&volume=11&pages=670-676&publication_year=1999&author=Falcone%2CM&author=Sarvetnick%2CN each month?
• Earnings of http://scholar.google.com/scholar_lookup?&title=IFN-%CE%B3%20plays%20a%20critical%20down-regulatory%20role%20in%20the%20induction%20and%20effector%20phase%20of%20myelin%20oligodendrocyte%20glycoprotein-induced%20autoimmune%20encephalomyelitis&journal=J.%20Immunol.&volume=157&pages=3223-3227&publication_year=1996&author=Willenborg%2CDO&author=Fordham%2CS&author=Bernard%2CCC&author=Cowden%2CWB&author=Ramshaw%2CIA
• How much does https://doi.org/10.1084%2Fjem.192.1.123 make?
• Revenue of http://scholar.google.com/scholar_lookup?&title=Failure%20to%20suppress%20the%20expansion%20of%20the%20activated%20CD4%20T%20cell%20population%20in%20interferon%20%CE%B3-deficient%20mice%20leads%20to%20exacerbation%20of%20experimental%20autoimmune%20encephalomyelitis&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.192.1.123&volume=192&pages=123-128&publication_year=2000&author=Chu%2CCQ&author=Wittmer%2CS&author=Dalton%2CDK
• What's the revenue for https://doi.org/10.1016%2FS1471-4906%2801%2901937-8?
• Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Mac-1%2B%20myelopoiesis%20induced%20by%20CFA%3A%20a%20clue%20to%20the%20paradoxical%20effects%20of%20IFN-%CE%B3%20in%20autoimmune%20disease%20models&journal=Trends%20Immunol.&doi=10.1016%2FS1471-4906%2801%2901937-8&volume=22&pages=367-371&publication_year=2001&author=Matthys%2CP&author=Vermeire%2CK&author=Billiau%2CA
• How much does https://doi.org/10.1002%2Fjnr.490280213 gross monthly?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=T-lymphocyte%20entry%20into%20the%20central%20nervous%20system&journal=J.%20Neurosci.%20Res.&doi=10.1002%2Fjnr.490280213&volume=28&pages=254-260&publication_year=1991&author=Hickey%2CWF&author=Hsu%2CBL&author=Kimura%2CH produce monthly?
• How much profit is https://doi.org/10.1073%2Fpnas.88.16.7438 making per month?
• How much money does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1991PNAS...88.7438S generate?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Isolation%20and%20direct%20characterization%20of%20resident%20microglial%20cells%20from%20the%20normal%20and%20inflamed%20central%20nervous%20system&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.88.16.7438&volume=88&pages=7438-7442&publication_year=1991&author=Sedgwick%2CJD?
• Revenue of http://stke.sciencemag.org/
• What is the monthly revenue of https://doi.org/10.1126%2Fscience.1074900?
• How much revenue does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2002Sci...297.2063N produce monthly?
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=Critical%20role%20for%20STAT4%20activation%20by%20type%201%20interferons%20in%20the%20interferon-%CE%B3%20response%20to%20viral%20infection&journal=Science&doi=10.1126%2Fscience.1074900&volume=297&pages=2063-2066&publication_year=2002&author=Nguyen%2CKB
• How much income does https://doi.org/10.1126%2Fscience.1062960 have?
• What's the financial outcome of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2001Sci...294.1731C?
• How much does http://scholar.google.com/scholar_lookup?&title=The%20influence%20of%20the%20proinflammatory%20cytokine%2C%20osteopontin%2C%20on%20autoimmune%20demyelinating%20disease&journal=Science&doi=10.1126%2Fscience.1062960&volume=294&pages=1731-1735&publication_year=2001&author=Chabas%2CD rake in every month?
• What are the total earnings of https://doi.org/10.1038%2F35038103?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2000Natur.407..916C bring in each month?
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Development%20of%20Th1-type%20immune%20responses%20requires%20the%20type%20I%20cytokine%20receptor%20TCCR&journal=Nature&doi=10.1038%2F35038103&volume=407&pages=916-920&publication_year=2000&author=Chen%2CQ?
• How much revenue does https://doi.org/10.1016%2FS1074-7613%2802%2900324-2 produce monthly?
• How much does http://scholar.google.com/scholar_lookup?&title=IL-27%2C%20a%20heterodimeric%20cytokine%20composed%20of%20EBI3%20and%20p28%20protein%2C%20induces%20proliferation%20of%20naive%20CD4%2B%20T%20cells&journal=Immunity&doi=10.1016%2FS1074-7613%2802%2900324-2&volume=16&pages=779-790&publication_year=2002&author=Pflanz%2CS net monthly?
• How much does https://doi.org/10.4049%2Fjimmunol.167.12.6957 gross monthly?
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=A%20protective%20and%20agonistic%20function%20of%20IL-12p40%20in%20mycobacterial%20infection&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.167.12.6957&volume=167&pages=6957-6966&publication_year=2001&author=Holscher%2CC have monthly?
• How much profit does http://scholar.google.com/scholar_lookup?&title=Alloantigen-reactive%20Th1%20development%20in%20IL-12-deficient%20mice&journal=J.%20Immunol.&volume=160&pages=1132-1138&publication_year=1998&author=Piccotti%2CJR generate?
• https://doi.org/10.1172%2FJCI0215751's revenue stream
• Monthly income for http://scholar.google.com/scholar_lookup?&title=Experimental%20autoimmune%20encephalitis%20and%20inflammation%20in%20the%20absence%20of%20interleukin-12&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI0215751&volume=110&pages=493-497&publication_year=2002&author=Becher%2CB&author=Durell%2CBG&author=Noelle%2CRJ
• What's the monthly income of https://doi.org/10.4049%2Fjimmunol.166.5.3362?
• How much does http://scholar.google.com/scholar_lookup?&title=Impaired%20pulmonary%20host%20defense%20in%20mice%20lacking%20expression%20of%20the%20CXC%20chemokine%20lungkine&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.166.5.3362&volume=166&pages=3362-3368&publication_year=2001&author=Chen%2CSC pull in?
• What's the monthly money flow for https://doi.org/10.1111%2Fj.1750-3639.1991.tb00646.x?
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Migration%20of%20hematogenous%20cells%20through%20the%20blood-brain%20barrier%20and%20the%20initiation%20of%20CNS%20inflammation&journal=Brain%20Pathol.&doi=10.1111%2Fj.1750-3639.1991.tb00646.x&volume=1&pages=97-105&publication_year=1991&author=Hickey%2CWF?
• How much does https://citation-needed.springer.com/v2/references/10.1038/nature01355?format=refman&flavour=references rake in every month?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Daniel%20J.%20Cua gross monthly?
• What's the financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Daniel%20J.%20Cua%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What's the financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jonathan%20Sherlock?
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jonathan%20Sherlock%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en produce monthly?
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Yi%20Chen's total income per month
• What's the profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Yi%20Chen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Craig%20A.%20Murphy generate?
• Discover the revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Craig%20A.%20Murphy%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Barbara%20Joyce have?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Barbara%20Joyce%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Brian%20Seymour rake in every month?
• What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Brian%20Seymour%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What's the revenue for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Linda%20Lucian?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Linda%20Lucian%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in each month?
• What are the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Wayne%20To?
• Get to know https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Wayne%20To%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's earnings
• What's the financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sylvia%20Kwan?
• What are the total earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sylvia%20Kwan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Tatyana%20Churakova gross monthly?
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Tatyana%20Churakova%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sandra%20Zurawski's total income per month
• How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sandra%20Zurawski%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• How much cash flow does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Maria%20Wiekowski have monthly?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Maria%20Wiekowski%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sergio%20A.%20Lira earn?
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sergio%20A.%20Lira%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• Check the income stats for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Daniel%20Gorman
• Earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Daniel%20Gorman%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• See how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Robert%20A.%20Kastelein makes per month
• What's the profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Robert%20A.%20Kastelein%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jonathon%20D.%20Sedgwick generate?
• What's the monthly money flow for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jonathon%20D.%20Sedgwick%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much money does https://static-content.springer.com/esm/art%3A10.1038%2Fnature01355/MediaObjects/41586_2003_BFnature01355_MOESM1_ESM.pdf make?
• What's the financial intake of https://static-content.springer.com/esm/art%3A10.1038%2Fnature01355/MediaObjects/41586_2003_BFnature01355_MOESM2_ESM.pdf?
• Find out how much https://static-content.springer.com/esm/art%3A10.1038%2Fnature01355/MediaObjects/41586_2003_BFnature01355_MOESM3_ESM.doc earns monthly
• Discover the revenue of https://static-content.springer.com/esm/art%3A10.1038%2Fnature01355/MediaObjects/41586_2003_BFnature01355_MOESM4_ESM.doc
• What is the monthly revenue of https://s100.copyright.com/AppDispatchServlet?title=Interleukin-23%20rather%20than%20interleukin-12%20is%20the%20critical%20cytokine%20for%20autoimmune%20inflammation%20of%20the%20brain&author=Daniel%20J.%20Cua%20et%20al&contentID=10.1038%2Fnature01355©right=Macmillan%20Magazines%20Ltd.&publication=0028-0836&publicationDate=2003-02-13&publisherName=SpringerNature&orderBeanReset=true?
• How much profit does https://citation-needed.springer.com/v2/references/10.1038/nature01355?format=refman&flavour=citation generate?
• Income figures for https://doi.org/10.1186/s12964-024-01509-w
• Get to know https://doi.org/10.1186/s13041-024-01077-7's earnings
• https://doi.org/10.1007/s00204-023-03628-8's financial summary
• Revenue of https://doi.org/10.1186/s40168-023-01486-1
• Get to know what's the income of https://doi.org/10.1038/s41590-022-01387-9
• Get to know what's the income of https://www.protocols.io/
• What is the earnings of https://www.natureindex.com/?
• What are the earnings of http://www.naturechina.com?
• How much does https://www.natureasia.com/ja-jp earn?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref