NATURE . COM {}

Matching Content Categories {📚}

• Science
• Health & Fitness
• Fitness & Wellness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$63,100 per month
According to our algorithms, Nature.com's monthly online income from display advertising ranges from $42,042 to $115,616.

Keywords {🔍}

article, muscle, cas, google, scholar, nature, skeletal, coactivator, type, access, cell, mitochondrial, content, transcriptional, expression, biol, pgcα, fibre, fibres, mice, slow, cookies, biogenesis, physiol, pgc, usa, medical, texas, privacy, data, gene, peroxisome, receptor, open, mol, department, function, formation, lin, olson, proteins, transgenic, kinase, mef, calcineurin, proliferatoractivated, regulates, control, pathway, center,

Topics {✒️}

peroxisome-proliferator-activated receptor-γ nature portfolio permissions reprints privacy policy fast-fibre-type-specific regulatory elements advertising muscle development social media nature 413 nature 418 nature author information authors fibre-type-specific promoters fibre-type-specific transcription regulates mitochondrial biogenesis metachromatic dye-atpase method insulin-sensitive glucose transporter pgc-1α transgenic mice author correspondence calcineurin-dependent pathway pgc-1α activates transcription activator pgc-1α drives activates mitochondrial biogenesis springerlink instant access fibre-type determination exercise-regulated mitochondrial slow-twitch muscle fibres cardiac muscle expression content muscle regulator multiple calcium-regulated signals permissions muscle creatine kinase personal data thermogenic coactivator pgc-1 coactivator pgc-1 cooperates cold-inducible coactivator fibre type conversion transcriptional coactivator pgc-1 mitochondrial content transgenic mice driven generating transgenic mice data protection nuclear receptors linked skeletal muscle slow chen-yu zhang privacy myocyte enhancer factor-2 skeletal muscle elizabeth nuclear signalling networks myoglobin-mutant mice

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
         description:The biochemical basis for the regulation of fibre-type determination in skeletal muscle is not well understood. In addition to the expression of particular myofibrillar proteins, type I (slow-twitch) fibres are much higher in mitochondrial content and are more dependent on oxidative metabolism than type II (fast-twitch) fibres1. We have previously identified a transcriptional co-activator, peroxisome-proliferator-activated receptor-γ co-activator-1 (PGC-1α), which is expressed in several tissues including brown fat and skeletal muscle, and that activates mitochondrial biogenesis and oxidative metabolism2,3,4. We show here that PGC-1α is expressed preferentially in muscle enriched in type I fibres. When PGC-1α is expressed at physiological levels in transgenic mice driven by a muscle creatine kinase (MCK) promoter, a fibre type conversion is observed: muscles normally rich in type II fibres are redder and activate genes of mitochondrial oxidative metabolism. Notably, putative type II muscles from PGC-1α transgenic mice also express proteins characteristic of type I fibres, such as troponin I (slow) and myoglobin, and show a much greater resistance to electrically stimulated fatigue. Using fibre-type-specific promoters, we show in cultured muscle cells that PGC-1α activates transcription in cooperation with Mef2 proteins and serves as a target for calcineurin signalling, which has been implicated in slow fibre gene expression. These data indicate that PGC-1α is a principal factor regulating muscle fibre type determination.
         datePublished:
         dateModified:
         pageStart:797
         pageEnd:801
         sameAs:https://doi.org/10.1038/nature00904
         keywords:
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature00904/MediaObjects/41586_2002_Article_BFnature00904_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature00904/MediaObjects/41586_2002_Article_BFnature00904_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature00904/MediaObjects/41586_2002_Article_BFnature00904_Fig3_HTML.jpg
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:418
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Jiandie Lin
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hai Wu
               affiliation:
                     name:University of Texas Southwestern Medical Center
                     address:
                        name:Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Paul T. Tarr
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chen-Yu Zhang
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zhidan Wu
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Olivier Boss
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Laura F. Michael
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pere Puigserver
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eiji Isotani
               affiliation:
                     name:University of Texas Southwestern Medical Center
                     address:
                        name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eric N. Olson
               affiliation:
                     name:University of Texas Southwestern Medical Center
                     address:
                        name:Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bradford B. Lowell
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rhonda Bassel-Duby
               affiliation:
                     name:University of Texas Southwestern Medical Center
                     address:
                        name:Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bruce M. Spiegelman
               affiliation:
                     name:Harvard Medical School
                     address:
                        name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
      description:The biochemical basis for the regulation of fibre-type determination in skeletal muscle is not well understood. In addition to the expression of particular myofibrillar proteins, type I (slow-twitch) fibres are much higher in mitochondrial content and are more dependent on oxidative metabolism than type II (fast-twitch) fibres1. We have previously identified a transcriptional co-activator, peroxisome-proliferator-activated receptor-γ co-activator-1 (PGC-1α), which is expressed in several tissues including brown fat and skeletal muscle, and that activates mitochondrial biogenesis and oxidative metabolism2,3,4. We show here that PGC-1α is expressed preferentially in muscle enriched in type I fibres. When PGC-1α is expressed at physiological levels in transgenic mice driven by a muscle creatine kinase (MCK) promoter, a fibre type conversion is observed: muscles normally rich in type II fibres are redder and activate genes of mitochondrial oxidative metabolism. Notably, putative type II muscles from PGC-1α transgenic mice also express proteins characteristic of type I fibres, such as troponin I (slow) and myoglobin, and show a much greater resistance to electrically stimulated fatigue. Using fibre-type-specific promoters, we show in cultured muscle cells that PGC-1α activates transcription in cooperation with Mef2 proteins and serves as a target for calcineurin signalling, which has been implicated in slow fibre gene expression. These data indicate that PGC-1α is a principal factor regulating muscle fibre type determination.
      datePublished:
      dateModified:
      pageStart:797
      pageEnd:801
      sameAs:https://doi.org/10.1038/nature00904
      keywords:
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature00904/MediaObjects/41586_2002_Article_BFnature00904_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature00904/MediaObjects/41586_2002_Article_BFnature00904_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature00904/MediaObjects/41586_2002_Article_BFnature00904_Fig3_HTML.jpg
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:418
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jiandie Lin
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hai Wu
            affiliation:
                  name:University of Texas Southwestern Medical Center
                  address:
                     name:Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Paul T. Tarr
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chen-Yu Zhang
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zhidan Wu
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Olivier Boss
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Laura F. Michael
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pere Puigserver
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eiji Isotani
            affiliation:
                  name:University of Texas Southwestern Medical Center
                  address:
                     name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eric N. Olson
            affiliation:
                  name:University of Texas Southwestern Medical Center
                  address:
                     name:Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bradford B. Lowell
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rhonda Bassel-Duby
            affiliation:
                  name:University of Texas Southwestern Medical Center
                  address:
                     name:Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bruce M. Spiegelman
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:418
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Harvard Medical School
      address:
         name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:University of Texas Southwestern Medical Center
      address:
         name:Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:University of Texas Southwestern Medical Center
      address:
         name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of Texas Southwestern Medical Center
      address:
         name:Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:University of Texas Southwestern Medical Center
      address:
         name:Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Jiandie Lin
      affiliation:
            name:Harvard Medical School
            address:
               name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Hai Wu
      affiliation:
            name:University of Texas Southwestern Medical Center
            address:
               name:Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Paul T. Tarr
      affiliation:
            name:Harvard Medical School
            address:
               name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Chen-Yu Zhang
      affiliation:
            name:Harvard Medical School
            address:
               name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Zhidan Wu
      affiliation:
            name:Harvard Medical School
            address:
               name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Olivier Boss
      affiliation:
            name:Harvard Medical School
            address:
               name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Laura F. Michael
      affiliation:
            name:Harvard Medical School
            address:
               name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Pere Puigserver
      affiliation:
            name:Harvard Medical School
            address:
               name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Eiji Isotani
      affiliation:
            name:University of Texas Southwestern Medical Center
            address:
               name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Eric N. Olson
      affiliation:
            name:University of Texas Southwestern Medical Center
            address:
               name:Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Bradford B. Lowell
      affiliation:
            name:Harvard Medical School
            address:
               name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Rhonda Bassel-Duby
      affiliation:
            name:University of Texas Southwestern Medical Center
            address:
               name:Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Bruce M. Spiegelman
      affiliation:
            name:Harvard Medical School
            address:
               name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
      name:Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
      name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
      name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
      name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
      name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
      name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
      name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
      name:Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
      name:Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/Nature
• https://twitter.com/nature

External Links {🔗}(93)

• How much does https://link.springer.com/article/10.1038/nature00904?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle make?
• How much does https://doi.org/10.1152%2Fphysrev.2000.80.3.1215 bring in each month?
• What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Calcium%20ion%20in%20skeletal%20muscle%3A%20its%20crucial%20role%20for%20muscle%20function%2C%20plasticity%2C%20and%20disease&journal=Physiol.%20Rev.&doi=10.1152%2Fphysrev.2000.80.3.1215&volume=80&pages=1215-1265&publication_year=2000&author=Berchtold%2CMW&author=Brinkmeier%2CH&author=Muntener%2CM?
• Learn about the earnings of https://doi.org/10.1016%2FS0092-8674%2800%2981410-5
• How much does http://scholar.google.com/scholar_lookup?&title=A%20cold-inducible%20coactivator%20of%20nuclear%20receptors%20linked%20to%20adaptive%20thermogenesis&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981410-5&volume=92&pages=829-839&publication_year=1998&author=Puigserver%2CP pull in monthly?
• Revenue of https://doi.org/10.1016%2FS0092-8674%2800%2980611-X
• How much does http://scholar.google.com/scholar_lookup?&title=Mechanisms%20controlling%20mitochondrial%20biogenesis%20and%20respiration%20through%20the%20thermogenic%20coactivator%20PGC-1&journal=Cell&doi=10.1016%2FS0092-8674%2800%2980611-X&volume=98&pages=115-124&publication_year=1999&author=Wu%2CZ earn?
• How much money does https://doi.org/10.1128%2FMCB.20.5.1868-1876.2000 generate?
• Earnings of http://scholar.google.com/scholar_lookup?&title=The%20coactivator%20PGC-1%20cooperates%20with%20peroxisome%20proliferator-activated%20receptor%20%CE%B1%20in%20transcriptional%20control%20of%20nuclear%20genes%20encoding%20mitochondrial%20fatty%20acid%20oxidation%20enzymes&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.20.5.1868-1876.2000&volume=20&pages=1868-1876&publication_year=2000&author=Vega%2CRB&author=Huss%2CJM&author=Kelly%2CDP
• How much money does https://doi.org/10.1152%2Fphysrev.1991.71.2.541 generate?
• What's http://scholar.google.com/scholar_lookup?&title=Molecular%20and%20cellular%20adaptation%20of%20muscle%20in%20response%20to%20exercise%3A%20perspectives%20of%20various%20models&journal=Physiol.%20Rev.&doi=10.1152%2Fphysrev.1991.71.2.541&volume=71&pages=541-585&publication_year=1991&author=Booth%2CFW&author=Thomason%2CDB's gross income?
• Find out how much https://doi.org/10.1152%2Fjappl.2001.90.3.1137 earns monthly
• What is the earnings of http://scholar.google.com/scholar_lookup?&title=Contractile%20activity-induced%20mitochondrial%20biogenesis%20in%20skeletal%20muscle&journal=J.%20Appl.%20Physiol.&doi=10.1152%2Fjappl.2001.90.3.1137&volume=90&pages=1137-1157&publication_year=2001&author=Hood%2CDA?
• How much profit does https://doi.org/10.1152%2Fjappl.1972.33.3.312 make?
• How much does http://scholar.google.com/scholar_lookup?&title=Enzyme%20activity%20and%20fibre%20composition%20in%20skeletal%20muscle%20of%20untrained%20and%20trained%20men&journal=J.%20Appl.%20Physiol.&doi=10.1152%2Fjappl.1972.33.3.312&volume=33&pages=312-319&publication_year=1972&author=Gollnick%2CPD gross monthly?
• How much revenue does https://doi.org/10.1002%2F%28SICI%291097-4598%28199611%2919%3A11%3C1469%3A%3AAID-MUS11%3E3.0.CO%3B2-O produce monthly?
• Income figures for http://scholar.google.com/scholar_lookup?&title=Fast-to-slow%20transformation%20in%20stimulated%20rat%20muscle&journal=Muscle%20Nerve&doi=10.1002%2F%28SICI%291097-4598%28199611%2919%3A11%3C1469%3A%3AAID-MUS11%3E3.0.CO%3B2-O&volume=19&pages=1469-1475&publication_year=1996&author=Jarvis%2CJC
• Income figures for https://doi.org/10.1101%2Fgad.12.16.2499
• What are the earnings of http://scholar.google.com/scholar_lookup?&title=A%20calcineurin-dependent%20transcriptional%20pathway%20controls%20skeletal%20muscle%20fibre%20type&journal=Genes%20Dev.&doi=10.1101%2Fgad.12.16.2499&volume=12&pages=2499-2509&publication_year=1998&author=Chin%2CER?
• How much profit is https://doi.org/10.1074%2Fjbc.275.7.4545 making per month?
• What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Stimulation%20of%20slow%20skeletal%20muscle%20fibre%20gene%20expression%20by%20calcineurin%20in%20vivo&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.275.7.4545&volume=275&pages=4545-4548&publication_year=2000&author=Naya%2CFJ?
• What's the financial intake of https://doi.org/10.1074%2Fjbc.M000430200?
• What is the earnings of http://scholar.google.com/scholar_lookup?&title=Calcineurin%20co-regulates%20contractile%20and%20metabolic%20components%20of%20slow%20muscle%20phenotype&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M000430200&volume=275&pages=19653-19660&publication_year=2000&author=Bigard%2CX?
• Profit of https://doi.org/10.1002%2F%28SICI%291521-1878%28200006%2922%3A6%3C510%3A%3AAID-BIES4%3E3.0.CO%3B2-1
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Remodeling%20muscles%20with%20calcineurin&journal=Bioassays&doi=10.1002%2F%28SICI%291521-1878%28200006%2922%3A6%3C510%3A%3AAID-BIES4%3E3.0.CO%3B2-1&volume=22&pages=510-519&publication_year=2000&author=Olson%2CEN&author=Williams%2CRS
• How much does https://doi.org/10.1172%2FJCI10268 earn?
• How profitable is http://scholar.google.com/scholar_lookup?&title=Peroxisome%20proliferator-activated%20receptor%20%CE%B3%20coactivator-1%20promotes%20cardiac%20mitochondrial%20biogenesis&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI10268&volume=106&pages=847-856&publication_year=2000&author=Lehman%2CJJ?
• Revenue of https://doi.org/10.1038%2F35093050
• Profit of http://scholar.google.com/scholar_lookup?&title=Control%20of%20hepatic%20gluconeogenesis%20through%20the%20transcriptional%20coactivator%20PGC-1&journal=Nature&doi=10.1038%2F35093050&volume=413&pages=131-138&publication_year=2001&author=Yoon%2CJC
• What are the total earnings of https://doi.org/10.1006%2Fgeno.1999.5977?
• What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Human%20peroxisome%20proliferator%20activated%20receptor%20gamma%20coactivator%201%20%28PPARGC1%29%20gene%3A%20cDNA%20sequence%2C%20genomic%20organization%2C%20chromosomal%20localization%2C%20and%20tissue%20expression&journal=Genomics&doi=10.1006%2Fgeno.1999.5977&volume=62&pages=98-102&publication_year=1999&author=Esterbauer%2CH?
• How much does https://doi.org/10.1074%2Fjbc.C100631200 pull in monthly?
• How much money does http://scholar.google.com/scholar_lookup?&title=PGC-1%CE%B2%3A%20a%20novel%20PGC-1%20related%20transcription%20coactivator%20associated%20with%20host%20cell%20factor&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.C100631200&volume=277&pages=1645-1648&publication_year=2002&author=Lin%2CJ make?
• Earnings of https://doi.org/10.1128%2FMCB.9.8.3393
• What's the revenue for http://scholar.google.com/scholar_lookup?&title=Muscle%20creatine%20kinase%20sequence%20elements%20regulating%20skeletal%20and%20cardiac%20muscle%20expression%20in%20transgenic%20mice&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.9.8.3393&volume=9&pages=3393-3399&publication_year=1989&author=Johnson%2CJE&author=Wold%2CBJ&author=Hauschka%2CSD?
• How much income does https://doi.org/10.3109%2F10520299009105613 have?
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=A%20metachromatic%20dye-ATPase%20method%20for%20the%20simultaneous%20identification%20of%20skeletal%20muscle%20fibre%20types%20I%2C%20IIA%2C%20IIB%20and%20IIC&journal=Stain%20Technol.&doi=10.3109%2F10520299009105613&volume=65&pages=231-241&publication_year=1990&author=Ogilvie%2CRW&author=Feeback%2CDL have monthly?
• Get to know what's the income of https://doi.org/10.1152%2Fajpcell.2001.281.5.C1487
• How much income is http://scholar.google.com/scholar_lookup?&title=Functional%20and%20molecular%20adaptations%20in%20skeletal%20muscle%20of%20myoglobin-mutant%20mice&journal=Am.%20J.%20Physiol.%20Cell%20Physiol.&doi=10.1152%2Fajpcell.2001.281.5.C1487&volume=281&pages=C1487-C1494&publication_year=2001&author=Grange%2CRW earning monthly?
• What's the financial outcome of https://doi.org/10.1093%2Femboj%2F19.9.1963?
• How much does http://scholar.google.com/scholar_lookup?&title=MEF2%20responds%20to%20multiple%20calcium-regulated%20signals%20in%20the%20control%20of%20skeletal%20muscle%20fibre%20type&journal=EMBO%20J.&doi=10.1093%2Femboj%2F19.9.1963&volume=19&pages=1963-1973&publication_year=2000&author=Wu%2CH pull in?
• Find out how much https://doi.org/10.1093%2Femboj%2F20.22.6414 earns monthly
• Get to know http://scholar.google.com/scholar_lookup?&title=Activation%20of%20MEF2%20by%20muscle%20activity%20is%20mediated%20through%20a%20calcineurin-dependent%20pathway&journal=EMBO%20J.&doi=10.1093%2Femboj%2F20.22.6414&volume=20&pages=6414-6423&publication_year=2001&author=Wu%2CH's earnings
• What's the revenue for https://doi.org/10.1128%2FMCB.19.1.515?
• What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Fibre-type-specific%20transcription%20of%20the%20troponin%20I%20slow%20gene%20is%20regulated%20by%20multiple%20elements&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.19.1.515&volume=19&pages=515-525&publication_year=1999&author=Calvo%2CS?
• What's the income of https://doi.org/10.1146%2Fannurev.cellbio.14.1.167?
• How much does http://scholar.google.com/scholar_lookup?&title=Transcriptional%20control%20of%20muscle%20development%20by%20myocyte%20enhancer%20factor-2%20%28MEF2%29%20proteins&journal=Annu.%20Rev.%20Cell%20Dev.%20Biol.&doi=10.1146%2Fannurev.cellbio.14.1.167&volume=14&pages=167-196&publication_year=1998&author=Black%2CBL&author=Olson%2CEN make?
• Get to know what's the income of https://doi.org/10.1128%2FMCB.20.17.6600-6611.2000
• How much revenue does http://scholar.google.com/scholar_lookup?&title=A%20calcineurin-NFATc3-dependent%20pathway%20regulates%20skeletal%20muscle%20differentiation%20and%20slow%20myosin%20heavy-chain%20expression&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.20.17.6600-6611.2000&volume=20&pages=6600-6611&publication_year=2000&author=Delling%2CU generate?
• Financial intake of https://doi.org/10.1073%2Fpnas.061035098
• Earnings of http://scholar.google.com/scholar_lookup?&title=Restoration%20of%20insulin-sensitive%20glucose%20transporter%20%28Glut4%29%20gene%20expression%20in%20muscle%20cells%20by%20the%20transcriptional%20coactivator%20PGC-1&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.061035098&volume=98&pages=3820-3825&publication_year=2001&author=Michael%2CLF
• What's the monthly income of https://doi.org/10.1128%2FMCB.16.5.2408?
• How much income is http://scholar.google.com/scholar_lookup?&title=Common%20core%20sequences%20are%20found%20in%20skeletal%20muscle%20slow-%20and%20fast-fibre-type-specific%20regulatory%20elements&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.16.5.2408&volume=16&pages=2408-2417&publication_year=1996&author=Nakayama%2CM earning monthly?
• What's the total monthly financial gain of https://doi.org/10.1006%2Fbbrc.2000.3134?
• http://scholar.google.com/scholar_lookup?&title=cDNA%20cloning%20and%20mRNA%20analysis%20of%20PGC-1%20in%20epitrochlearis%20muscle%20in%20swimming-exercised%20rats&journal=Biochem.%20Biophys.%20Res.%20Comm.&doi=10.1006%2Fbbrc.2000.3134&volume=274&pages=350-354&publication_year=2000&author=Goto%2CM's financial summary
• How profitable is https://citation-needed.springer.com/v2/references/10.1038/nature00904?format=refman&flavour=references?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jiandie%20Lin pull in monthly?
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jiandie%20Lin%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's revenue stream
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hai%20Wu make?
• What are the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hai%20Wu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What's the revenue for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Paul%20T.%20Tarr?
• Learn how profitable https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Paul%20T.%20Tarr%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en is on a monthly basis
• What's the monthly money flow for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chen-Yu%20Zhang?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chen-Yu%20Zhang%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Zhidan%20Wu
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Zhidan%20Wu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• Check the income stats for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Olivier%20Boss
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Olivier%20Boss%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Laura%20F.%20Michael make?
• How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Laura%20F.%20Michael%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• What's the monthly income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Pere%20Puigserver?
• Check the income stats for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Pere%20Puigserver%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Eiji%20Isotani pull in?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Eiji%20Isotani%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en gross monthly?
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Eric%20N.%20Olson generate?
• Discover the revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Eric%20N.%20Olson%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Bradford%20B.%20Lowell's revenue stream
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Bradford%20B.%20Lowell%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en gross monthly?
• See how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Rhonda%20Bassel-Duby makes per month
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Rhonda%20Bassel-Duby%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in?
• How profitable is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Bruce%20M.%20Spiegelman?
• What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Bruce%20M.%20Spiegelman%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much revenue does https://s100.copyright.com/AppDispatchServlet?title=Transcriptional%20co-activator%20PGC-1%CE%B1%20drives%20the%20formation%20of%20slow-twitch%20muscle%20fibres&author=Jiandie%20Lin%20et%20al&contentID=10.1038%2Fnature00904©right=Macmillan%20Magazines%20Ltd.&publication=0028-0836&publicationDate=2002-08-15&publisherName=SpringerNature&orderBeanReset=true generate?
• See how much https://citation-needed.springer.com/v2/references/10.1038/nature00904?format=refman&flavour=citation makes per month
• Find out how much https://doi.org/10.1186/s40104-023-00968-4 earns monthly
• Monthly income for https://doi.org/10.1038/s41598-024-52198-x
• What are the total earnings of https://doi.org/10.1038/s41598-023-50464-y?
• What is the earnings of https://doi.org/10.1007/s40279-024-02007-2?
• How much does https://doi.org/10.1186/s13395-023-00327-x make?
• What's the financial intake of https://www.protocols.io/?
• Income figures for https://www.natureindex.com/
• How much income is http://www.naturechina.com earning monthly?
• How much profit does https://www.natureasia.com/ja-jp make?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref