Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Questions
  10. Schema
  11. Social Networks
  12. External Links
  13. Analytics And Tracking
  14. Libraries
  15. Hosting Providers
  16. CDN Services

We are analyzing https://www.nature.com/articles/cdd2013139.

Title:
Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis | Cell Death & Differentiation
Description:
The central role of the Bcl-2 family in regulating apoptotic cell death was first identified in the 1980s. Since then, significant in-roads have been made in identifying the multiple members of this family, characterizing their form and function and understanding how their interactions determine whether a cell lives or dies. In this review we focus on the recent progress made in characterizing the proapoptotic Bcl-2 family members, Bax and Bak. This progress has resolved longstanding controversies, but has also challenged established theories in the apoptosis field. We will discuss different models of how these two proteins become activated and different ‘modes’ by which they are inhibited by other Bcl-2 family members. We will also discuss novel conformation changes leading to Bak and Bax oligomerization and speculate how these oligomers might permeabilize the mitochondrial outer membrane.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Science
  • Education
  • Fitness & Wellness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
Our estimates place Nature.com's monthly online earnings from display ads at $42,042 to $115,616.

Keywords {🔍}

bax, pubmed, bak, article, proteins, google, scholar, cas, cell, central, activation, bcl, bhonly, prosurvival, groove, apoptosis, binding, membrane, domain, biol, proapoptotic, mode, family, conformation, mitochondrial, death, figure, apoptotic, protein, activated, helices, oligomerization, structure, mitochondria, function, model, mom, peptide, nature, members, inhibition, chem, pore, residues, cells, activate, peptides, hydrophobic, change, dewson,

Topics {✒️}

nature portfolio permissions reprints privacy policy nature reviews advertising medical research nature 2005 nature 1996 nature 2008 nature social media normal development open questions research author information authors high-molecular weight oligomer bcl-xl/bim fragment complex c-terminal α6–α8 helices n-terminal α1–α5 helices intrinsic caspase-independent pathway author correspondence voltage-dependent-anion-channel2 bcl-xl-bak peptide complex parent full-length proteins core/latch dissociation exposes amino-acid sequence similarity full-length bax monomer full-length bax calculated anti-apoptotic context md e3 ligase ibrdc2 n-terminal 6a7 epitope full-length proapoptotic bak c-terminal α9 helix membrane-targeted death ligand cell damage-induced conformational �retro-translocation’ remains obscure bax channel-forming activity pro-apoptotic protein bak improves long-term function willis sn permissions α1/α2 loop displacement regulating protein–protein interactions groove interaction central opoku-nsiah ka operational infrastructure grants pro-survival proteins solid-state nmr investigation structural data supporting bak c-terminus mutant

Questions {❓}

  • Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
  • Are both proposed binding sites on Bax essential for its activation by BH3-only proteins?
  • Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check?
  • Does Bax and Bak pore formation involve insertion of their α5/α6 helices as a membrane-spanning hairpin?
  • Pharmacological manipulation of cell death: clinical applications in sight?
  • What molecular features present in Bax and Bak but not in the prosurvival proteins allow conformation change, oligomerization and pore formation?
  • What protein:protein interfaces allow Bax and Bak to form high molecular weight oligomeric pores?
  • What’s Next?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis
         description:The central role of the Bcl-2 family in regulating apoptotic cell death was first identified in the 1980s. Since then, significant in-roads have been made in identifying the multiple members of this family, characterizing their form and function and understanding how their interactions determine whether a cell lives or dies. In this review we focus on the recent progress made in characterizing the proapoptotic Bcl-2 family members, Bax and Bak. This progress has resolved longstanding controversies, but has also challenged established theories in the apoptosis field. We will discuss different models of how these two proteins become activated and different ‘modes’ by which they are inhibited by other Bcl-2 family members. We will also discuss novel conformation changes leading to Bak and Bax oligomerization and speculate how these oligomers might permeabilize the mitochondrial outer membrane.
         datePublished:2013-10-25T00:00:00Z
         dateModified:2013-10-25T00:00:00Z
         pageStart:196
         pageEnd:205
         sameAs:https://doi.org/10.1038/cdd.2013.139
         keywords:
            Apoptosis
            Molecular conformation
            apoptosis
            Bak
            Bax
            conformation change
            oligomerization
            Life Sciences
            general
            Biochemistry
            Cell Biology
            Stem Cells
            Cell Cycle Analysis
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcdd.2013.139/MediaObjects/41418_2014_Article_BFcdd2013139_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcdd.2013.139/MediaObjects/41418_2014_Article_BFcdd2013139_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcdd.2013.139/MediaObjects/41418_2014_Article_BFcdd2013139_Figa_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcdd.2013.139/MediaObjects/41418_2014_Article_BFcdd2013139_Fig3_HTML.jpg
         isPartOf:
            name:Cell Death & Differentiation
            issn:
               1476-5403
               1350-9047
            volumeNumber:21
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:D Westphal
               affiliation:
                     name:The Walter and Eliza Hall Institute of Medical Research
                     address:
                        name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
                        type:PostalAddress
                     type:Organization
                     name:The University of Melbourne
                     address:
                        name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:R M Kluck
               affiliation:
                     name:The Walter and Eliza Hall Institute of Medical Research
                     address:
                        name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
                        type:PostalAddress
                     type:Organization
                     name:The University of Melbourne
                     address:
                        name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:G Dewson
               affiliation:
                     name:The Walter and Eliza Hall Institute of Medical Research
                     address:
                        name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
                        type:PostalAddress
                     type:Organization
                     name:The University of Melbourne
                     address:
                        name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis
      description:The central role of the Bcl-2 family in regulating apoptotic cell death was first identified in the 1980s. Since then, significant in-roads have been made in identifying the multiple members of this family, characterizing their form and function and understanding how their interactions determine whether a cell lives or dies. In this review we focus on the recent progress made in characterizing the proapoptotic Bcl-2 family members, Bax and Bak. This progress has resolved longstanding controversies, but has also challenged established theories in the apoptosis field. We will discuss different models of how these two proteins become activated and different ‘modes’ by which they are inhibited by other Bcl-2 family members. We will also discuss novel conformation changes leading to Bak and Bax oligomerization and speculate how these oligomers might permeabilize the mitochondrial outer membrane.
      datePublished:2013-10-25T00:00:00Z
      dateModified:2013-10-25T00:00:00Z
      pageStart:196
      pageEnd:205
      sameAs:https://doi.org/10.1038/cdd.2013.139
      keywords:
         Apoptosis
         Molecular conformation
         apoptosis
         Bak
         Bax
         conformation change
         oligomerization
         Life Sciences
         general
         Biochemistry
         Cell Biology
         Stem Cells
         Cell Cycle Analysis
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcdd.2013.139/MediaObjects/41418_2014_Article_BFcdd2013139_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcdd.2013.139/MediaObjects/41418_2014_Article_BFcdd2013139_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcdd.2013.139/MediaObjects/41418_2014_Article_BFcdd2013139_Figa_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fcdd.2013.139/MediaObjects/41418_2014_Article_BFcdd2013139_Fig3_HTML.jpg
      isPartOf:
         name:Cell Death & Differentiation
         issn:
            1476-5403
            1350-9047
         volumeNumber:21
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:D Westphal
            affiliation:
                  name:The Walter and Eliza Hall Institute of Medical Research
                  address:
                     name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
                     type:PostalAddress
                  type:Organization
                  name:The University of Melbourne
                  address:
                     name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:R M Kluck
            affiliation:
                  name:The Walter and Eliza Hall Institute of Medical Research
                  address:
                     name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
                     type:PostalAddress
                  type:Organization
                  name:The University of Melbourne
                  address:
                     name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:G Dewson
            affiliation:
                  name:The Walter and Eliza Hall Institute of Medical Research
                  address:
                     name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
                     type:PostalAddress
                  type:Organization
                  name:The University of Melbourne
                  address:
                     name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Cell Death & Differentiation
      issn:
         1476-5403
         1350-9047
      volumeNumber:21
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The Walter and Eliza Hall Institute of Medical Research
      address:
         name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
         type:PostalAddress
      name:The University of Melbourne
      address:
         name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
         type:PostalAddress
      name:The Walter and Eliza Hall Institute of Medical Research
      address:
         name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
         type:PostalAddress
      name:The University of Melbourne
      address:
         name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
         type:PostalAddress
      name:The Walter and Eliza Hall Institute of Medical Research
      address:
         name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
         type:PostalAddress
      name:The University of Melbourne
      address:
         name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:D Westphal
      affiliation:
            name:The Walter and Eliza Hall Institute of Medical Research
            address:
               name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
               type:PostalAddress
            type:Organization
            name:The University of Melbourne
            address:
               name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
               type:PostalAddress
            type:Organization
      name:R M Kluck
      affiliation:
            name:The Walter and Eliza Hall Institute of Medical Research
            address:
               name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
               type:PostalAddress
            type:Organization
            name:The University of Melbourne
            address:
               name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
               type:PostalAddress
            type:Organization
      name:G Dewson
      affiliation:
            name:The Walter and Eliza Hall Institute of Medical Research
            address:
               name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
               type:PostalAddress
            type:Organization
            name:The University of Melbourne
            address:
               name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
      name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
      name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
      name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
      name:The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
      name:Department of Medical Biology, The University of Melbourne, Parkville, Australia

Social Networks {👍}(1)

External Links {🔗}(436)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

5.19s.