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We are analyzing https://www.nature.com/articles/6691257.

Title:
Down-regulation of TGF-β 1 production restores immunogenicity in prostate cancer cells | British Journal of Cancer
Description:
British Journal of Cancer - Down-regulation of TGF-β 1 production restores immunogenicity in prostate cancer cells
Website Age:
30 years and 10 months (reg. 1994-08-11).

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Education
Science
Social Networks

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Custom-built

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🌆 Monumental Traffic: 20M - 50M visitors per month

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$536,300 per month
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Keywords {🔍}

cancer, article, google, scholar, pubmed, cells, tgfβ, cas, nature, prostate, growth, cell, transforming, content, cookies, rat, matlylu, tumour, usa, privacy, expression, antisense, transfected, proliferation, dunning, prostatic, data, journal, production, yang, control, research, factor, res, metastatic, adenocarcinoma, effects, advertising, information, british, open, immunogenicity, matthews, janulis, karpus, construct, rats, incidence, immune, publication,

Topics {✒️}

nature portfolio privacy policy tumour development transforming growth factor-β1-induced nature advertising avi publishing altered tgf-β expression transforming growth factor-α social media 0/ reprints tumour incidence personal data tgf-β linked dunning rat model data protection permissions targeting signaling pathways tgf-β1 antisense tgf-β1 reduced privacy tgf-β prostate cancer cells explore content cellular content tumour cells matlylu tumour prostate-specific immunity renal cell carcinoma cell proliferation kinetics journals search log highly metastatic variety predicting metastatic abilities european economic area bowen-pope df estrogen-progesterone treatment experimental autoimmune encephalomyelitis retinoblastoma protein phosphorylation leukocytic subset distributions mcgraw-hill book chicken chorioallantoic membrane accepting optional cookies connective tissue cells syngeneic male hosts paracrine effects stephen athymic nude rats manage preferences 25 july 2000 autocrine pdgf loop https

Schema {🗺️}

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         description:The objective of this study is to determine if a non-immunogenic Dunning's rat prostate cancer cell line, MATLyLu, can become immunogenic by reducing the endogenous production of TGF-Î²1. An expression construct containing a DNA sequence in an antisense orientation to TGF-Î²1 (TGF-Î²1 antisense) was stably transfected into MATLyLu cells. Following transfection, cellular content of TGF-Î²1 reduced from 70 to10 pg per 2 Ã 104cells and the rate of in vitro3H-thymidine incorporation increased 3â5-fold. After subcutaneous injection of tumour cells into syngeneic male hosts (Copenhagen rats), the tumour incidence was 100% (15/15) for the wild type MATLyLu cells and cells transfected with the control construct, but only 43% (9/21, Pâ¤ 0.05) for cells transfected with TGF-Î²1 antisense. However, when cells were injected into immunodeficient hosts (athymic nude rats), the incidence of tumour development was 100% (10/10) for both the wild type MATLyLu cells and cells transfected with the control construct and 90% (9/10) for cells transfected with TGF-Î²1 antisense. These observations support the concept that MATLyLu cells are immunogenic, when the endogenous production of TGF-Î²1 is down-regulated. Â© 2000 Cancer Research Campaign
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ScholarlyArticle:
      headline:Down-regulation of TGF-Î² 1 production restores immunogenicity in prostate cancer cells
      description:The objective of this study is to determine if a non-immunogenic Dunning's rat prostate cancer cell line, MATLyLu, can become immunogenic by reducing the endogenous production of TGF-Î²1. An expression construct containing a DNA sequence in an antisense orientation to TGF-Î²1 (TGF-Î²1 antisense) was stably transfected into MATLyLu cells. Following transfection, cellular content of TGF-Î²1 reduced from 70 to10 pg per 2 Ã 104cells and the rate of in vitro3H-thymidine incorporation increased 3â5-fold. After subcutaneous injection of tumour cells into syngeneic male hosts (Copenhagen rats), the tumour incidence was 100% (15/15) for the wild type MATLyLu cells and cells transfected with the control construct, but only 43% (9/21, Pâ¤ 0.05) for cells transfected with TGF-Î²1 antisense. However, when cells were injected into immunodeficient hosts (athymic nude rats), the incidence of tumour development was 100% (10/10) for both the wild type MATLyLu cells and cells transfected with the control construct and 90% (9/10) for cells transfected with TGF-Î²1 antisense. These observations support the concept that MATLyLu cells are immunogenic, when the endogenous production of TGF-Î²1 is down-regulated. Â© 2000 Cancer Research Campaign
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