NATURE . COM {}

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We are analyzing https://www.nature.com/articles/6691257.

Title:
Down-regulation of TGF-β 1 production restores immunogenicity in prostate cancer cells | British Journal of Cancer
Description:
British Journal of Cancer - Down-regulation of TGF-β 1 production restores immunogenicity in prostate cancer cells
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

Education
Science
Social Networks

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What CMS is nature.com built with?

Custom-built

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🌠 Phenomenal Traffic: 5M - 10M visitors per month

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conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}

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$63,100 per month
Estimations show Nature.com's display ad online revenue falls between $42,042 and $115,616 per month.

Keywords {🔍}

cancer, article, google, scholar, pubmed, cells, tgfβ, cas, nature, prostate, growth, cell, transforming, content, cookies, rat, matlylu, tumour, usa, privacy, expression, antisense, transfected, proliferation, dunning, prostatic, data, information, journal, production, yang, control, research, references, factor, res, metastatic, adenocarcinoma, effects, permissions, advertising, change, british, open, immunogenicity, matthews, janulis, karpus, construct, rats,

Topics {✒️}

nature portfolio privacy policy tumour development transforming growth factor-β1-induced nature advertising avi publishing altered tgf-β expression transforming growth factor-α social media 0/ reprints tumour incidence personal data tgf-β linked dunning rat model data protection targeting signaling pathways tgf-β1 antisense tgf-β1 reduced privacy tgf-β karpus rights prostate cancer cells explore content cellular content tumour cells matlylu tumour prostate-specific immunity renal cell carcinoma cell proliferation kinetics journals search log updated abstract permissions highly metastatic variety predicting metastatic abilities european economic area bowen-pope df estrogen-progesterone treatment experimental autoimmune encephalomyelitis retinoblastoma protein phosphorylation leukocytic subset distributions mcgraw-hill book chicken chorioallantoic membrane accepting optional cookies connective tissue cells syngeneic male hosts paracrine effects stephen athymic nude rats manage preferences 25 july 2000

Schema {🗺️}

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         description:The objective of this study is to determine if a non-immunogenic Dunning's rat prostate cancer cell line, MATLyLu, can become immunogenic by reducing the endogenous production of TGF-Î²1. An expression construct containing a DNA sequence in an antisense orientation to TGF-Î²1 (TGF-Î²1 antisense) was stably transfected into MATLyLu cells. Following transfection, cellular content of TGF-Î²1 reduced from 70 to10 pg per 2 Ã 104cells and the rate of in vitro3H-thymidine incorporation increased 3â5-fold. After subcutaneous injection of tumour cells into syngeneic male hosts (Copenhagen rats), the tumour incidence was 100% (15/15) for the wild type MATLyLu cells and cells transfected with the control construct, but only 43% (9/21, Pâ¤ 0.05) for cells transfected with TGF-Î²1 antisense. However, when cells were injected into immunodeficient hosts (athymic nude rats), the incidence of tumour development was 100% (10/10) for both the wild type MATLyLu cells and cells transfected with the control construct and 90% (9/10) for cells transfected with TGF-Î²1 antisense. These observations support the concept that MATLyLu cells are immunogenic, when the endogenous production of TGF-Î²1 is down-regulated. Â© 2000 Cancer Research Campaign
         datePublished:2000-07-25T00:00:00Z
         dateModified:2011-11-16T00:00:00Z
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ScholarlyArticle:
      headline:Down-regulation of TGF-Î² 1 production restores immunogenicity in prostate cancer cells
      description:The objective of this study is to determine if a non-immunogenic Dunning's rat prostate cancer cell line, MATLyLu, can become immunogenic by reducing the endogenous production of TGF-Î²1. An expression construct containing a DNA sequence in an antisense orientation to TGF-Î²1 (TGF-Î²1 antisense) was stably transfected into MATLyLu cells. Following transfection, cellular content of TGF-Î²1 reduced from 70 to10 pg per 2 Ã 104cells and the rate of in vitro3H-thymidine incorporation increased 3â5-fold. After subcutaneous injection of tumour cells into syngeneic male hosts (Copenhagen rats), the tumour incidence was 100% (15/15) for the wild type MATLyLu cells and cells transfected with the control construct, but only 43% (9/21, Pâ¤ 0.05) for cells transfected with TGF-Î²1 antisense. However, when cells were injected into immunodeficient hosts (athymic nude rats), the incidence of tumour development was 100% (10/10) for both the wild type MATLyLu cells and cells transfected with the control construct and 90% (9/10) for cells transfected with TGF-Î²1 antisense. These observations support the concept that MATLyLu cells are immunogenic, when the endogenous production of TGF-Î²1 is down-regulated. Â© 2000 Cancer Research Campaign
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         Drug Resistance
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