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Keywords {🔍}

wedelolactone, caspase, cells, activity, ikk, nfκb, figure, lps, iκbα, article, expression, balbc, inhibited, kinase, google, scholar, treated, min, cas, cell, activation, effect, nature, induction, prostrata, pga, fraction, western, inhibits, ikkβ, levels, tnfα, data, inhibiting, phosphorylation, antibody, degradation, incubated, protein, assay, analysis, lpsinduced, yuan, ilβ, treatment, μgml, ethyl, acetate, active, inhibit,

Topics {✒️}

nature portfolio permissions reprints privacy policy p65/p50 nf-κb heterodimer author information authors advertising nature 386 nature 403 nature blood research open circle open box social media anti-inflammatory cyclopentenone prostaglandins inhibiting nf-κb-mediated transcription forms nf-κb−iκb complex research nf-κb p65 bound india nf-κb-luciferase construct full size image nf-κb reporter activity interleukin-1β converting enzyme nf-κb transcriptional activity enzyme-linked-immuno-assay il-1β-converting enzyme inhibit nf-κb activity treating particle-induced osteolysis p65 binding site inhibiting nf-κb activation processes pro-il-1β tumor necrosis factor iκb–nf-κb structures nf-κb p65 proinflammatory cytokine il-1β inhibits nf-κb activation producing mature il-1β esi-ms spectra showed rabbit polyclonal antibody regulatory subunit ikkγ/nemo 5 μci/ml [3h] tyrosine permissions inhibiting lps-induced expression anti-phospho-s32 antibody nf-κb activity bind nf-κb lps-induced caspase-11 expression china short-lived proteins degradation cell death differ

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         description:Caspase-11 is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis. Caspase-11 is not expressed in most tissues under normal condition, but highly inducible upon pathological stimulation such as in the presence of lipopolysaccharide (LPS). Here, we describe the identification and characterization of wedelolactone, a natural compound that inhibits LPS-induced caspase-11 expression in cultured cells by inhibiting NF-κB-mediated transcription. We demonstrate that wedelolactone is an inhibitor of IKK, a kinase critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα.
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