
NATURE . COM {
}
Title:
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex | Cell Death & Differentiation
Description:
Caspase-11 is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis. Caspase-11 is not expressed in most tissues under normal condition, but highly inducible upon pathological stimulation such as in the presence of lipopolysaccharide (LPS). Here, we describe the identification and characterization of wedelolactone, a natural compound that inhibits LPS-induced caspase-11 expression in cultured cells by inhibiting NF-κB-mediated transcription. We demonstrate that wedelolactone is an inhibitor of IKK, a kinase critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Science
- Education
- Photography
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌆 Monumental Traffic: 20M - 50M visitors per month
Based on our best estimate, this website will receive around 42,797,153 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$539,300 per month
Estimations show Nature.com's display ad online revenue falls between $359,538 and $988,730 per month.
Keywords {🔍}
wedelolactone, caspase, cells, activity, ikk, nfκb, figure, lps, iκbα, article, expression, balbc, inhibited, kinase, google, scholar, treated, min, cas, cell, activation, effect, nature, induction, prostrata, pga, fraction, western, inhibits, ikkβ, levels, tnfα, data, inhibiting, phosphorylation, antibody, degradation, incubated, protein, assay, analysis, lpsinduced, yuan, ilβ, treatment, μgml, ethyl, acetate, active, inhibit,
Topics {✒️}
nature portfolio permissions reprints privacy policy p65/p50 nf-κb heterodimer author information authors advertising nature 386 nature 403 nature blood research open circle open box social media anti-inflammatory cyclopentenone prostaglandins inhibiting nf-κb-mediated transcription forms nf-κb−iκb complex research nf-κb p65 bound india nf-κb-luciferase construct full size image nf-κb reporter activity interleukin-1β converting enzyme nf-κb transcriptional activity enzyme-linked-immuno-assay il-1β-converting enzyme inhibit nf-κb activity treating particle-induced osteolysis p65 binding site inhibiting nf-κb activation processes pro-il-1β tumor necrosis factor iκb–nf-κb structures nf-κb p65 proinflammatory cytokine il-1β inhibits nf-κb activation producing mature il-1β esi-ms spectra showed rabbit polyclonal antibody regulatory subunit ikkγ/nemo 5 μci/ml [3h] tyrosine permissions inhibiting lps-induced expression anti-phospho-s32 antibody nf-κb activity bind nf-κb lps-induced caspase-11 expression china short-lived proteins degradation cell death differ
Schema {🗺️}
WebPage:
mainEntity:
headline:Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex
description:Caspase-11 is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis. Caspase-11 is not expressed in most tissues under normal condition, but highly inducible upon pathological stimulation such as in the presence of lipopolysaccharide (LPS). Here, we describe the identification and characterization of wedelolactone, a natural compound that inhibits LPS-induced caspase-11 expression in cultured cells by inhibiting NF-κB-mediated transcription. We demonstrate that wedelolactone is an inhibitor of IKK, a kinase critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα.
datePublished:2003-10-03T00:00:00Z
dateModified:2003-10-03T00:00:00Z
pageStart:123
pageEnd:130
sameAs:https://doi.org/10.1038/sj.cdd.4401325
keywords:
wedelolactone
caspase-11
LPS
NF-κB
IKK
Life Sciences
general
Biochemistry
Cell Biology
Stem Cells
Apoptosis
Cell Cycle Analysis
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig4_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig6_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig7_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig8_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig9_HTML.jpg
isPartOf:
name:Cell Death & Differentiation
issn:
1476-5403
1350-9047
volumeNumber:11
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:M Kobori
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:National Food Research Institute
address:
name:National Food Research Institute, Tsukuba, Japan
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Z Yang
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:D Gong
affiliation:
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu
address:
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, China
type:PostalAddress
type:Organization
type:Person
name:V Heissmeyer
affiliation:
name:Center for Blood Research
address:
name:Center for Blood Research, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:H Zhu
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:Y-K Jung
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:M Angelica M Gakidis
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:A Rao
affiliation:
name:Center for Blood Research
address:
name:Center for Blood Research, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:T Sekine
affiliation:
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku
address:
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, Japan
type:PostalAddress
type:Organization
type:Person
name:F Ikegami
affiliation:
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku
address:
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, Japan
type:PostalAddress
type:Organization
type:Person
name:C Yuan
affiliation:
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu
address:
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, China
type:PostalAddress
type:Organization
type:Person
name:J Yuan
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex
description:Caspase-11 is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis. Caspase-11 is not expressed in most tissues under normal condition, but highly inducible upon pathological stimulation such as in the presence of lipopolysaccharide (LPS). Here, we describe the identification and characterization of wedelolactone, a natural compound that inhibits LPS-induced caspase-11 expression in cultured cells by inhibiting NF-κB-mediated transcription. We demonstrate that wedelolactone is an inhibitor of IKK, a kinase critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα.
datePublished:2003-10-03T00:00:00Z
dateModified:2003-10-03T00:00:00Z
pageStart:123
pageEnd:130
sameAs:https://doi.org/10.1038/sj.cdd.4401325
keywords:
wedelolactone
caspase-11
LPS
NF-κB
IKK
Life Sciences
general
Biochemistry
Cell Biology
Stem Cells
Apoptosis
Cell Cycle Analysis
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig4_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig6_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig7_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig8_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.cdd.4401325/MediaObjects/41418_2004_Article_BF4401325_Fig9_HTML.jpg
isPartOf:
name:Cell Death & Differentiation
issn:
1476-5403
1350-9047
volumeNumber:11
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:M Kobori
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:National Food Research Institute
address:
name:National Food Research Institute, Tsukuba, Japan
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Z Yang
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:D Gong
affiliation:
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu
address:
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, China
type:PostalAddress
type:Organization
type:Person
name:V Heissmeyer
affiliation:
name:Center for Blood Research
address:
name:Center for Blood Research, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:H Zhu
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:Y-K Jung
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:M Angelica M Gakidis
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:A Rao
affiliation:
name:Center for Blood Research
address:
name:Center for Blood Research, Boston, USA
type:PostalAddress
type:Organization
type:Person
name:T Sekine
affiliation:
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku
address:
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, Japan
type:PostalAddress
type:Organization
type:Person
name:F Ikegami
affiliation:
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku
address:
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, Japan
type:PostalAddress
type:Organization
type:Person
name:C Yuan
affiliation:
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu
address:
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, China
type:PostalAddress
type:Organization
type:Person
name:J Yuan
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
["Periodical","PublicationVolume"]:
name:Cell Death & Differentiation
issn:
1476-5403
1350-9047
volumeNumber:11
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
name:National Food Research Institute
address:
name:National Food Research Institute, Tsukuba, Japan
type:PostalAddress
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu
address:
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, China
type:PostalAddress
name:Center for Blood Research
address:
name:Center for Blood Research, Boston, USA
type:PostalAddress
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
name:Center for Blood Research
address:
name:Center for Blood Research, Boston, USA
type:PostalAddress
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku
address:
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, Japan
type:PostalAddress
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku
address:
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, Japan
type:PostalAddress
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu
address:
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, China
type:PostalAddress
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:M Kobori
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:National Food Research Institute
address:
name:National Food Research Institute, Tsukuba, Japan
type:PostalAddress
type:Organization
email:[email protected]
name:Z Yang
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:D Gong
affiliation:
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu
address:
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, China
type:PostalAddress
type:Organization
name:V Heissmeyer
affiliation:
name:Center for Blood Research
address:
name:Center for Blood Research, Boston, USA
type:PostalAddress
type:Organization
name:H Zhu
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Y-K Jung
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:M Angelica M Gakidis
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:A Rao
affiliation:
name:Center for Blood Research
address:
name:Center for Blood Research, Boston, USA
type:PostalAddress
type:Organization
name:T Sekine
affiliation:
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku
address:
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, Japan
type:PostalAddress
type:Organization
name:F Ikegami
affiliation:
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku
address:
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, Japan
type:PostalAddress
type:Organization
name:C Yuan
affiliation:
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu
address:
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, China
type:PostalAddress
type:Organization
name:J Yuan
affiliation:
name:Harvard Medical School
address:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Cell Biology, Harvard Medical School, Boston, USA
name:National Food Research Institute, Tsukuba, Japan
name:Department of Cell Biology, Harvard Medical School, Boston, USA
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, China
name:Center for Blood Research, Boston, USA
name:Department of Cell Biology, Harvard Medical School, Boston, USA
name:Department of Cell Biology, Harvard Medical School, Boston, USA
name:Department of Cell Biology, Harvard Medical School, Boston, USA
name:Center for Blood Research, Boston, USA
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, Japan
name:Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, Japan
name:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, China
name:Department of Cell Biology, Harvard Medical School, Boston, USA
External Links {🔗}(88)
- Discover the revenue of https://doi.org/10.1074%2Fjbc.271.34.20580
- How much does http://scholar.google.com/scholar_lookup?&title=Identification%20and%20characterization%20of%20Ich-3%2C%20a%20member%20of%20the%20interleukin-1%CE%B2%20converting%20enzyme%20%28ICE%29%2FCed-3%20family%20and%20an%20upstream%20regulator%20of%20ICE&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.271.34.20580&volume=271&pages=20580-20587&publication_year=1996&author=Wang%2CS&author=Miura%2CM&author=Jung%2CYK&author=Zhu%2CH&author=Gagliardini%2CV&author=Shi%2CL&author=Greenberg%2CAH&author=Yuan%2CJ pull in monthly?
- What's the profit of https://doi.org/10.1016%2FS0092-8674%2800%2980943-5?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Murine%20caspase-11%2C%20an%20ICE-interacting%20protease%2C%20is%20essential%20for%20the%20activation%20of%20ICE&journal=Cell&doi=10.1016%2FS0092-8674%2800%2980943-5&volume=92&pages=501-509&publication_year=1998&author=Wang%2CS&author=Miura%2CM&author=Jung%2CYK&author=Zhu%2CH&author=Li%2CE&author=Yuan%2CJ generate?
- How much does https://doi.org/10.1083%2Fjcb.149.3.613 earn?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Dual%20role%20of%20caspase-11%20in%20mediating%20activation%20of%20caspase-1%20and%20caspase-3%20under%20pathological%20conditions&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.149.3.613&volume=149&pages=613-622&publication_year=2000&author=Kang%2CSJ&author=Wang%2CS&author=Hara%2CH&author=Peterson%2CEP&author=Namura%2CS&author=Amin-Hanjani%2CS&author=Huang%2CZ&author=Srinivasan%2CA&author=Tomaselli%2CKJ&author=Thornberry%2CNA&author=Moskowitz%2CMA&author=Yuan%2CJ?
- How much cash flow does https://doi.org/10.1016%2F0092-8674%2895%2990490-5 have monthly?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Mice%20deficient%20in%20IL-1%CE%B2-converting%20enzyme%20are%20defective%20in%20production%20of%20mature%20IL-1%CE%B2%20and%20resistant%20to%20endotoxic%20shock&journal=Cell&doi=10.1016%2F0092-8674%2895%2990490-5&volume=80&pages=401-411&publication_year=1995&author=Li%2CP&author=Allen%2CH&author=Banerjee%2CS&author=Franklin%2CS&author=Herzog%2CL&author=Johnston%2CC&author=McDowell%2CJ&author=Paskind%2CM&author=Rodman%2CL&author=Salfeld%2CJ&author=Towne%2CE&author=Tracey%2CD&author=Wardwell%2CS&author=Wei%2CFY&author=Wong%2CW&author=Kamen%2CR&author=Seshadri%2CT?
- What's the total monthly financial gain of https://doi.org/10.1038%2F386619a0?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Caspase-1%20processes%20IFN-%CE%B3-inducing%20factor%20and%20regulates%20LPS-induced%20IFN-%CE%B3%20production&journal=Nature&doi=10.1038%2F386619a0&volume=386&pages=619-623&publication_year=1997&author=Ghayur%2CT&author=Banerjee%2CS&author=Hugunin%2CM&author=Butler%2CD&author=Herzog%2CL&author=Carter%2CA&author=Quintal%2CL&author=Sekut%2CL&author=Talanian%2CR&author=Paskind%2CM&author=Wong%2CW&author=Kamen%2CR&author=Tracey%2CD&author=Allen%2CH generate?
- How much money does https://doi.org/10.1038%2Fsj.cdd.4401087 make?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Distinct%20downstream%20pathways%20of%20caspase-11%20in%20regulating%20apoptosis%20and%20cytokine%20maturation%20during%20septic%20shock%20response&journal=Cell%20Death%20Differ.&doi=10.1038%2Fsj.cdd.4401087&volume=9&pages=1115-1125&publication_year=2002&author=Kang%2CSJ&author=Wang%2CS&author=Kuida%2CK&author=Yuan%2CJ produce monthly?
- How much does https://doi.org/10.1084%2Fjem.193.1.111 make?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Caspase-11%20mediates%20oligodendrocyte%20cell%20death%20and%20pathogenesis%20of%20autoimmune-mediated%20demyelination&journal=J.%20Exp.%20Med.&doi=10.1084%2Fjem.193.1.111&volume=193&pages=111-122&publication_year=2001&author=Hisahara%2CS&author=Yuan%2CJ&author=Momoi%2CT&author=Okano%2CH&author=Miura%2CM
- What's the financial gain of https://doi.org/10.1074%2Fjbc.M007255200?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=Expression%20analysis%20of%20the%20human%20caspase-1%20subfamily%20reveals%20specific%20regulation%20of%20the%20CASP5%20gene%20by%20lipopolysaccharide%20and%20interferon-%CE%B3&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M007255200&volume=275&pages=39920-39926&publication_year=2000&author=Lin%2CXY&author=Choi%2CMSK&author=Porter%2CAG
- What's the total monthly financial gain of https://doi.org/10.1055%2Fs-2007-969188?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Coumestans%20as%20the%20main%20active%20principles%20of%20the%20liver%20drugs%20Eclipta%20alba%20and%20Wedelia%20calendulacea&journal=Planta%20Med.&doi=10.1055%2Fs-2007-969188&volume=52&pages=370-374&publication_year=1986&author=Wangner%2CH&author=Geyer%2CB&author=Kiso%2CY&author=Hikino%2CH&author=Rao%2CGS have monthly?
- What's the financial gain of https://doi.org/10.1016%2F0041-0101%2894%2990207-0?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20the%20mytotoxic%20and%20hemorrhagic%20activities%20of%20crotalid%20venoms%20by%20Eclipta%20prostrata%20%28Asteraceae%29%20extracts%20and%20constituents&journal=Toxicon&doi=10.1016%2F0041-0101%2894%2990207-0&volume=32&pages=595-603&publication_year=1994&author=Melo%2CPA&author=Nascimento%2CMC&author=Mors%2CWB&author=Suarez-Kurtz%2CG generate?
- Get to know what's the income of https://doi.org/10.1016%2FS0092-8674%2800%2981694-3
- How much does http://scholar.google.com/scholar_lookup?&title=I%CE%BAB%E2%80%93NF-%CE%BAB%20structures%3A%20at%20the%20interface%20of%20inflammation%20control&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981694-3&volume=95&pages=729-731&publication_year=1998&author=Baeuerle%2CPA bring in each month?
- How much does https://doi.org/10.1074%2Fjbc.M205165200 rake in every month?
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=IKK%CE%B1%2C%20IKK%CE%B2%2C%20and%20NEMO%2FIKK%CE%B3%20are%20each%20required%20for%20the%20NF-%CE%BAB%20mediated%20inflammatory%20response%20program&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M205165200&volume=277&pages=45129-45140&publication_year=2002&author=Li%2CX&author=Massa%2CPE&author=Hanidu%2CA&author=Peet%2CGW&author=Aro%2CP&author=Savitt%2CA&author=Mishe%2CS&author=Li%2CJ&author=Marcu%2CKB
- What's the monthly income of https://doi.org/10.1074%2Fjbc.M207852200?
- How much does http://scholar.google.com/scholar_lookup?&title=Caspase-11%20gene%20expression%20in%20response%20to%20lipopolysaccharide%20and%20interferon-%CE%B3%20requires%20nuclear%20factor-%CE%BAB%20and%20signal%20transducer%20and%20activator%20of%20transcription%20%28STAT%29%201&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M207852200&volume=277&pages=41624-41630&publication_year=2002&author=Schauvliege%2CR&author=Vanrobaeys%2CJ&author=Schotte%2CP&author=Beyaert%2CR gross monthly?
- How much money does https://doi.org/10.1093%2Femboj%2F18.23.6682 make?
- Find out how much http://scholar.google.com/scholar_lookup?&title=An%20N-terminal%20nuclear%20export%20signal%20is%20required%20for%20the%20nucleocytoplasmic%20shuttling%20of%20I%CE%BAB%CE%B1&journal=EMBO%20J.&doi=10.1093%2Femboj%2F18.23.6682&volume=18&pages=6682-6693&publication_year=1999&author=Johnson%2CC&author=Van%20Antwerp%2CD&author=Hope%2CTJ earns monthly
- How much profit does https://doi.org/10.1074%2Fjbc.274.35.24625 generate?
- Get to know http://scholar.google.com/scholar_lookup?&title=Differential%20effects%20of%20lipopolysaccharide%20and%20tumor%20necrosis%20factor%20on%20monocytic%20I%CE%BAB%20kinase%20signalsome%20activation%20and%20I%CE%BAB%20proteolysis&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.274.35.24625&volume=274&pages=24625-24632&publication_year=1999&author=Fisher%2CC&author=Page%2CS&author=Weber%2CM&author=Eisele%2CT&author=Neumeier%2CD&author=Brand%2CK's earnings
- Financial intake of https://doi.org/10.1016%2FS0092-8674%2800%2981064-8
- Find out how much http://scholar.google.com/scholar_lookup?&title=Site-specific%20phosphorylation%20of%20I%CE%BAB%CE%B1%20by%20a%20novel%20ubiquitination-dependent%20protein%20kinase%20activity&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981064-8&volume=84&pages=853-862&publication_year=1996&author=Chen%2CZJ&author=Parent%2CL&author=Maniatis%2CT earns monthly
- How much money does https://doi.org/10.1038%2F47520 generate?
- Income figures for http://scholar.google.com/scholar_lookup?&title=Anti-inflammatory%20cyclopentenone%20prostaglandins%20are%20direct%20inhibitors%20of%20I%CE%BAB%20kinase&journal=Nature&doi=10.1038%2F47520&volume=403&pages=103-118&publication_year=2000&author=Rossi%2CA&author=Kapahi%2CP&author=Natoli%2CG&author=Takahashi%2CT&author=Chen%2CY&author=Karin%2CM&author=Santoro%2CMG
- See how much https://doi.org/10.1073%2Fpnas.92.24.11259 makes per month
- Income figures for http://scholar.google.com/scholar_lookup?&title=Signal-induced%20degradation%20of%20I%CE%BAB%CE%B1%20requires%20site-specific%20ubiquitination&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.92.24.11259&volume=92&pages=11259-11263&publication_year=1995&author=Scherer%2CDC&author=Brockman%2CJA&author=Chen%2CZ&author=Maniatis%2CT&author=Ballard%2CDW
- What are the earnings of https://doi.org/10.1126%2Fscience.278.5339.860?
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=IKK-1%20and%20IKK-2%3A%20cytokine-activated%20I%CE%BAB%20kinase%20essential%20for%20NF-%CE%BAB%20activation&journal=Science&doi=10.1126%2Fscience.278.5339.860&volume=278&pages=860-866&publication_year=1997&author=Mercurio%2CF&author=Zhu%2CH&author=Murray%2CBW&author=Shevchenko%2CA&author=Bennett%2CBL&author=Li%2CJW&author=Young%2CDB&author=Barbosa%2CM&author=Mann%2CM&author=Manning%2CA&author=Rao%2CA?
- What's https://doi.org/10.1074%2Fjbc.273.46.30410's gross income?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Role%20of%20IKK1%20and%20IKK2%20in%20lipopolysaccharide%20signaling%20in%20human%20monocytic%20cells&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.273.46.30410&volume=273&pages=30410-30414&publication_year=1998&author=O%27Connel%2CMA&author=Bennet%2CBL&author=Mercurio%2CF&author=Manning%2CAM&author=Mackman%2CN
- Learn how profitable https://doi.org/10.1126%2Fscience.284.5412.309 is on a monthly basis
- What's http://scholar.google.com/scholar_lookup?&title=Positive%20and%20negative%20regulation%20of%20I%CE%BAB%20kinase%20activity%20through%20IKK%CE%B2%20subunit%20phosphorylation&journal=Science&doi=10.1126%2Fscience.284.5412.309&volume=284&pages=309-313&publication_year=1999&author=Delhase%2CM&author=Hayakawa%2CM&author=Chen%2CY&author=Karin%2CM's gross income?
- https://doi.org/10.1016%2FS1074-5521%2801%2900049-7's total income per month
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=The%20anti-inflammatory%20natural%20product%20parthenolide%20from%20the%20medicinal%20herb%20feverfew%20directly%20binds%20to%20and%20inhibits%20I%CE%BAB%20kinase&journal=Chem.%20Biol.&doi=10.1016%2FS1074-5521%2801%2900049-7&volume=8&pages=759-766&publication_year=2001&author=Kwok%2CBH&author=Koh%2CB&author=Ndubusi%2CMI&author=Elofsson%2CM&author=Crews%2CCM
- What's the revenue for https://doi.org/10.4049%2Fjimmunol.165.12.7180?
- How much income does http://scholar.google.com/scholar_lookup?&title=Vitamin%20C%20inhibits%20NF-%CE%BAB%20activation%20by%20TNF%20via%20the%20activation%20of%20p38%20mitogen-activated%20protein%20kianse&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.165.12.7180&volume=165&pages=7180-7188&publication_year=2000&author=Bowie%2CAG&author=O%27Nell%2CLAJ have?
- Profit of https://doi.org/10.1016%2FS0092-8674%2800%2981590-1
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Cleavage%20of%20BID%20by%20caspase%208%20mediates%20the%20mitochondrial%20damage%20in%20the%20Fas%20pathway%20of%20apoptosis&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981590-1&volume=94&pages=491-501&publication_year=1998&author=Li%2CH&author=Zhu%2CH&author=Xu%2CCJ&author=Yuan%2CJ?
- How much does https://doi.org/10.1016%2FS0040-4020%2801%2989154-7 make?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Mushroom%20tyrosinase%20catalysed%20synthesis%20of%20coumestans%2C%20benzofuran%20derivatives%20and%20related%20heterocyclic%20compounds&journal=Tetrahedron&doi=10.1016%2FS0040-4020%2801%2989154-7&volume=45&pages=6867-6874&publication_year=1989&author=Pandey%2CG&author=Muralikrishna%2CC&author=Bhalerao%2CUT each month?
- Learn about the earnings of https://doi.org/10.1074%2Fjbc.M001039200
- How much profit is http://scholar.google.com/scholar_lookup?&title=Analysis%20of%20domains%20in%20the%20IKK%CE%B1%20and%20IKK%CE%B2%20proteins%20that%20regulate%20their%20kinase%20activity&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M001039200&volume=275&pages=14752-14759&publication_year=2000&author=Kwak%2CYT&author=Guo%2CJ&author=Shen%2CJ&author=Gaynor%2CRB making per month?
- What's the financial outcome of https://citation-needed.springer.com/v2/references/10.1038/sj.cdd.4401325?format=refman&flavour=references?
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=M%20Kobori generate?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22M%20Kobori%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- What's the revenue for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Z%20Yang?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Z%20Yang%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earn?
- How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=D%20Gong generate?
- Learn how profitable https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22D%20Gong%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en is on a monthly basis
- Monthly income for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=V%20Heissmeyer
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22V%20Heissmeyer%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- What's https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=H%20Zhu's gross income?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22H%20Zhu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in monthly?
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Y-K%20Jung generate?
- What's the financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Y-K%20Jung%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=M%20Angelica%20M%20Gakidis
- Learn about the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22M%20Angelica%20M%20Gakidis%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=A%20Rao
- Learn how profitable https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22A%20Rao%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en is on a monthly basis
- What's the total monthly financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=T%20Sekine?
- How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22T%20Sekine%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- What's the financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=F%20Ikegami?
- What's the financial outcome of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22F%20Ikegami%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=C%20Yuan income
- What is the monthly revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22C%20Yuan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How profitable is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=J%20Yuan?
- What's the monthly money flow for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22J%20Yuan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://s100.copyright.com/AppDispatchServlet?title=Wedelolactone%20suppresses%20LPS-induced%20caspase-11%20expression%20by%20directly%20inhibiting%20the%20IKK%20Complex&author=M%20Kobori%20et%20al&contentID=10.1038%2Fsj.cdd.4401325©right=Springer%20Nature%20Limited&publication=1350-9047&publicationDate=2003-10-03&publisherName=SpringerNature&orderBeanReset=true bring in each month?
- How much profit does https://citation-needed.springer.com/v2/references/10.1038/sj.cdd.4401325?format=refman&flavour=citation generate?
- How much does https://doi.org/10.1038/s41467-023-37459-z bring in each month?
- What's https://doi.org/10.1007/s10565-023-09820-x's gross income?
- Income figures for https://doi.org/10.1007/s11030-022-10425-5
- What's the total monthly financial gain of https://doi.org/10.1186/s13045-022-01312-5?
- What is the monthly revenue of https://doi.org/10.1186/s13018-022-03228-9?
- https://www.protocols.io/'s total income per month
- What's the monthly money flow for https://www.natureindex.com/?
- Financial intake of http://www.naturechina.com
- https://www.natureasia.com/ja-jp's total income per month
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref