NATURE . COM {}

Matching Content Categories {📚}

• Education
• Technology & Computing
• Social Networks

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,554,915 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$536,300 per month
Our estimates place Nature.com's monthly online earnings from display ads at $357,503 to $983,134.

Keywords {🔍}

article, nature, google, scholar, cas, access, content, cookies, nude, privacy, mouse, nehls, boehm, genes, data, member, wingedhelix, mutations, michael, pfeifer, hedrich, mice, open, ads, research, advertising, information, journal, subscribe, protein, family, disrupted, rat, schorpp, hans, rats, development, whn, domain, gene, institution, buy, editing, vivo, press, germany, eur, immun, cell, proc,

Topics {✒️}

nature portfolio permissions reprints privacy policy character-istic dna-binding domain distort cell-fate deci-sions advertising nature genet subscribe nature nature 372 nature social media vulval development winged-helix domain family winged-helix domain genes personal data springerlink instant access data protection permissions rat nude mutations t-cell differentiation privacy causing nude mice chimeric mice generated rat rnun alleles explore content subscription content article nehls european economic area specific developmental defect institutional subscriptions read retroelement lx9 puts nucleic acids res patient-derived xenograft accepting optional cookies journals search log issue learn medizinische hochschule hannover konstanty-gutschow-strasse 8 transcription factors gcm2 manage preferences content mouse nude locus article purchase jr genes dev access article cite 03 november 1994 https 1038/372103a0 journal publish

Schema {🗺️}

WebPage:
      mainEntity:
         headline:New member of the winged-helix protein family disrupted in mouse and rat nude mutations
         description:MUTATIONS at the nude locus of mice and rats disrupt normal hair growth and thymus development1,2, causing nude mice and rats to be immune-deficient. The mouse nude locus has been localized on chromosome 11 (refs 3, 4) within a region of < 1 megabase5. Here we show that one of the genes from this critical region, designated whn, encodes a new member of the winged-helix domain family of transcription factors6,7, and that it is disrupted on mouse nu and rat rnuN alleles. Mutant transcripts do not encode the character-istic DNA-binding domain, strongly suggesting that the whn gene is the nude gene. Mutations in winged-helix domain genes cause homeotic transformations in Drosophila8 and distort cell-fate deci-sions during vulval development in Caenorhabditis elegans9. The whn gene is thus the first member of this class of genes to be implicated in a specific developmental defect in vertebrates.
         datePublished:
         dateModified:
         pageStart:103
         pageEnd:107
         sameAs:https://doi.org/10.1038/372103a0
         keywords:
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:372
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Michael Nehls
               affiliation:
                     name:University of Freiburg
                     address:
                        name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Dietmar Pfeifer
               affiliation:
                     name:University of Freiburg
                     address:
                        name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Michael Schorpp
               affiliation:
                     name:University of Freiburg
                     address:
                        name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hans Hedrich
               affiliation:
                     name:University of Freiburg
                     address:
                        name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Zentrale Tierversuchsanlage, Medizinische Hochschule Hannover
                     address:
                        name:Zentrale Tierversuchsanlage, Medizinische Hochschule Hannover, Hannover-Krefeld, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Thomas Boehm
               affiliation:
                     name:University of Freiburg
                     address:
                        name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:New member of the winged-helix protein family disrupted in mouse and rat nude mutations
      description:MUTATIONS at the nude locus of mice and rats disrupt normal hair growth and thymus development1,2, causing nude mice and rats to be immune-deficient. The mouse nude locus has been localized on chromosome 11 (refs 3, 4) within a region of < 1 megabase5. Here we show that one of the genes from this critical region, designated whn, encodes a new member of the winged-helix domain family of transcription factors6,7, and that it is disrupted on mouse nu and rat rnuN alleles. Mutant transcripts do not encode the character-istic DNA-binding domain, strongly suggesting that the whn gene is the nude gene. Mutations in winged-helix domain genes cause homeotic transformations in Drosophila8 and distort cell-fate deci-sions during vulval development in Caenorhabditis elegans9. The whn gene is thus the first member of this class of genes to be implicated in a specific developmental defect in vertebrates.
      datePublished:
      dateModified:
      pageStart:103
      pageEnd:107
      sameAs:https://doi.org/10.1038/372103a0
      keywords:
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:372
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Michael Nehls
            affiliation:
                  name:University of Freiburg
                  address:
                     name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dietmar Pfeifer
            affiliation:
                  name:University of Freiburg
                  address:
                     name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michael Schorpp
            affiliation:
                  name:University of Freiburg
                  address:
                     name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hans Hedrich
            affiliation:
                  name:University of Freiburg
                  address:
                     name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Zentrale Tierversuchsanlage, Medizinische Hochschule Hannover
                  address:
                     name:Zentrale Tierversuchsanlage, Medizinische Hochschule Hannover, Hannover-Krefeld, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thomas Boehm
            affiliation:
                  name:University of Freiburg
                  address:
                     name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:372
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Freiburg
      address:
         name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:Zentrale Tierversuchsanlage, Medizinische Hochschule Hannover
      address:
         name:Zentrale Tierversuchsanlage, Medizinische Hochschule Hannover, Hannover-Krefeld, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Michael Nehls
      affiliation:
            name:University of Freiburg
            address:
               name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Dietmar Pfeifer
      affiliation:
            name:University of Freiburg
            address:
               name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Michael Schorpp
      affiliation:
            name:University of Freiburg
            address:
               name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Hans Hedrich
      affiliation:
            name:University of Freiburg
            address:
               name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
            name:Zentrale Tierversuchsanlage, Medizinische Hochschule Hannover
            address:
               name:Zentrale Tierversuchsanlage, Medizinische Hochschule Hannover, Hannover-Krefeld, Germany
               type:PostalAddress
            type:Organization
      name:Thomas Boehm
      affiliation:
            name:University of Freiburg
            address:
               name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
      name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
      name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
      name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
      name:Zentrale Tierversuchsanlage, Medizinische Hochschule Hannover, Hannover-Krefeld, Germany
      name:Molecular Medicine Group, Department of Medicine I, University of Freiburg, Freiburg, Germany
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/Nature
• https://twitter.com/nature

External Links {🔗}(66)

• https://link.springer.com/article/10.1038/372103a0?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle's revenue stream
• What is the earnings of http://scholar.google.com/scholar_lookup?&title=Genetic%20Variants%20and%20Strains%20of%20the%20Laboratory%20Mouse&publication_year=1989&author=Lyon%2CMF&author=Searle%2CAG?
• What's the total monthly financial gain of https://doi.org/10.1084%2Fjem.175.3.873?
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=J.%20exp.%20Med.&doi=10.1084%2Fjem.175.3.873&volume=175&pages=873-876&publication_year=1992&author=Takahashi%2CY net monthly?
• What's the total monthly financial gain of https://doi.org/10.1038%2Fng0194-57?
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Nature%20Genet.&doi=10.1038%2Fng0194-57&volume=6&pages=57-63&publication_year=1994&author=Lisitsyn%2CAN bring in each month?
• Revenue of https://doi.org/10.1002%2Feji.1830240742
• http://scholar.google.com/scholar_lookup?&title=&journal=Eur.%20J.%20Immun.&doi=10.1002%2Feji.1830240742&volume=24&pages=1721-1723&publication_year=1994&author=Nehls%2CM's revenue stream
• How much does https://doi.org/10.1016%2F0092-8674%2890%2990439-L make?
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=&journal=Cell&doi=10.1016%2F0092-8674%2890%2990439-L&volume=63&pages=455-456&publication_year=1990&author=Weigel%2CD&author=J%C3%A4ckle%2CH?
• What's the financial intake of https://doi.org/10.1073%2Fpnas.90.22.10421?
• Explore the financials of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1993PNAS...9010421L
• How much revenue does http://scholar.google.com/scholar_lookup?&title=&journal=Proc.%20natn.%20Acad.%20Sci.%20U.S.A.&doi=10.1073%2Fpnas.90.22.10421&volume=90&pages=10421-10423&publication_year=1993&author=Lai%2CE&author=Clark%2CKL&author=Burley%2CSK&author=Darnell%2CJE generate?
• What's the financial gain of https://doi.org/10.1016%2F0092-8674%2889%2990133-5?
• How much income is http://scholar.google.com/scholar_lookup?&title=&journal=Cell&doi=10.1016%2F0092-8674%2889%2990133-5&volume=57&pages=645-658&publication_year=1989&author=Weigel%2CD&author=J%C3%BCrgens%2CG&author=K%C3%BCttner%2CF&author=Seifer%2CE&author=J%C3%A4ckle%2CH earning monthly?
• How much does https://doi.org/10.1101%2Fgad.7.6.933 gross monthly?
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Genes%20Dev.&doi=10.1101%2Fgad.7.6.933&volume=7&pages=933-947&publication_year=1993&author=Miller%2CLM&author=Gallegos%2CME&author=Morisseau%2CBA&author=Kim%2CSK gross monthly?
• How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8036002 make?
• How much income does http://scholar.google.com/scholar_lookup?&title=&journal=Oncogene&volume=9&pages=2169-2176&publication_year=1994&author=Nehls%2CM&author=Pfeifer%2CD&author=Boehm%2CT have?
• How much revenue does https://doi.org/10.1002%2Faja.1001570303 bring in?
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=&journal=Am.%20J.%20Anat.&doi=10.1002%2Faja.1001570303&volume=157&pages=227-263&publication_year=1980&author=Cordier%2CAC&author=Haumont%2CSM
• https://doi.org/10.1159%2F000146996 income
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Acta%20anat.&doi=10.1159%2F000146996&volume=139&pages=178-190&publication_year=1990&author=K%C3%B6pf-Maier%2CP&author=Mbonenko%2CVF&author=Merker%2CHJ gross monthly?
• https://doi.org/10.1002%2Feji.1830150707 income
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Eur.%20J.%20Immun.&doi=10.1002%2Feji.1830150707&volume=15&pages=675-681&publication_year=1985&author=van%20Vliet%2CE net monthly?
• What's https://doi.org/10.1002%2Feji.1830210117's gross income?
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Eur.%20J.%20Immun.&doi=10.1002%2Feji.1830210117&volume=21&pages=109-113&publication_year=1991&author=Palacios%2CR&author=Samaridis%2CJ pull in monthly?
• Financial intake of https://doi.org/10.1016%2F0888-7543%2892%2990138-I
• What are the earnings of http://scholar.google.com/scholar_lookup?&title=&journal=Genomics&doi=10.1016%2F0888-7543%2892%2990138-I&volume=13&pages=658-664&publication_year=1992&author=Li%2CC&author=Lusis%2CAJ&author=Sparkes%2CT&author=Tran%2CSM&author=Gaynor%2CR?
• How much profit does https://doi.org/10.1126%2Fscience.2667136 generate?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1989Sci...245..371M net monthly?
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=&journal=Science&doi=10.1126%2Fscience.2667136&volume=245&pages=371-378&publication_year=1989&author=Mitchell%2CPJ&author=Tijan%2CR
• What's the monthly income of https://link.springer.com/doi/10.1007/BF00364661?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=&journal=Mammal.%20Genome&doi=10.1007%2FBF00364661&volume=4&pages=37-42&publication_year=1993&author=Cash%2CJM produce monthly?
• https://doi.org/10.1093%2Fnar%2F15.20.8125's revenue stream
• What are the earnings of http://scholar.google.com/scholar_lookup?&title=&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2F15.20.8125&volume=15&pages=8125-8148&publication_year=1987&author=Kozak%2CM?
• How much does https://doi.org/10.1101%2Fgad.5.3.416 pull in monthly?
• How much money does http://scholar.google.com/scholar_lookup?&title=&journal=Genes%20Dev.&doi=10.1101%2Fgad.5.3.416&volume=5&pages=416-427&publication_year=1991&author=Lai%2CE&author=Prezioso%2CVR&author=Tao%2CW&author=Chen%2CWS&author=Darnell%2CJE make?
• https://doi.org/10.1073%2Fpnas.88.10.4367's revenue stream
• How much profit does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1991PNAS...88.4367B make?
• How much profit does http://scholar.google.com/scholar_lookup?&title=&journal=Proc.%20natn.%20Acad.%20Sci.%20U.S.A.&doi=10.1073%2Fpnas.88.10.4367&volume=88&pages=4367-4371&publication_year=1991&author=Boehm%2CT generate?
• How much does https://doi.org/10.1073%2Fpnas.74.12.5463 pull in?
• Income figures for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1977PNAS...74.5463S
• What are the total earnings of http://scholar.google.com/scholar_lookup?&title=&journal=Proc.%20natn.%20Acad.%20Sci.%20U.S.A.&doi=10.1073%2Fpnas.74.12.5463&volume=74&pages=5463-5467&publication_year=1977&author=Sanger%2CF&author=Nicklen%2CS&author=Coulson%2CA?
• How much profit does https://citation-needed.springer.com/v2/references/10.1038/372103a0?format=refman&flavour=references generate?
• Learn how profitable https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Michael%20Nehls is on a monthly basis
• What's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Michael%20Nehls%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dietmar%20Pfeifer
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Dietmar%20Pfeifer%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en gross monthly?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Michael%20Schorpp net monthly?
• Learn about the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Michael%20Schorpp%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• Check the income stats for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hans%20Hedrich
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hans%20Hedrich%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• What's https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Thomas%20Boehm's gross income?
• What are the total earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Thomas%20Boehm%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What's the financial outcome of https://s100.copyright.com/AppDispatchServlet?title=New%20member%20of%20the%20winged-helix%20protein%20family%20disrupted%20in%20mouse%20and%20rat%20nude%20mutations&author=Michael%20Nehls%20et%20al&contentID=10.1038%2F372103a0©right=Springer%20Nature%20Limited&publication=0028-0836&publicationDate=1994-11-03&publisherName=SpringerNature&orderBeanReset=true?
• What is the earnings of https://citation-needed.springer.com/v2/references/10.1038/372103a0?format=refman&flavour=citation?
• What's https://doi.org/10.1038/s41467-023-43456-z's gross income?
• How much does https://doi.org/10.1186/s12967-022-03405-8 earn?
• How much revenue does https://doi.org/10.1038/s41598-022-07159-7 bring in?
• How much income does https://doi.org/10.1038/s41598-022-17844-2 have?
• https://doi.org/10.1007/s12565-022-00663-w's total income per month
• What's the monthly money flow for https://www.protocols.io/?
• What are the total earnings of https://www.natureindex.com/?
• What's http://www.naturechina.com's gross income?
• How much profit is https://www.natureasia.com/ja-jp making per month?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref