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nature portfolio permissions reprints privacy policy character-istic dna-binding domain distort cell-fate deci-sions advertising nature genet subscribe nature nature 372 nature social media vulval development winged-helix domain family winged-helix domain genes personal data springerlink instant access data protection permissions rat nude mutations t-cell differentiation privacy causing nude mice chimeric mice generated rat rnun alleles explore content subscription content article nehls european economic area specific developmental defect institutional subscriptions read retroelement lx9 puts nucleic acids res patient-derived xenograft accepting optional cookies journals search log issue learn medizinische hochschule hannover konstanty-gutschow-strasse 8 transcription factors gcm2 manage preferences content mouse nude locus article purchase jr genes dev access article cite 03 november 1994 https 1038/372103a0 journal publish

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         headline:New member of the winged-helix protein family disrupted in mouse and rat nude mutations
         description:MUTATIONS at the nude locus of mice and rats disrupt normal hair growth and thymus development1,2, causing nude mice and rats to be immune-deficient. The mouse nude locus has been localized on chromosome 11 (refs 3, 4) within a region of < 1 megabase5. Here we show that one of the genes from this critical region, designated whn, encodes a new member of the winged-helix domain family of transcription factors6,7, and that it is disrupted on mouse nu and rat rnuN alleles. Mutant transcripts do not encode the character-istic DNA-binding domain, strongly suggesting that the whn gene is the nude gene. Mutations in winged-helix domain genes cause homeotic transformations in Drosophila8 and distort cell-fate deci-sions during vulval development in Caenorhabditis elegans9. The whn gene is thus the first member of this class of genes to be implicated in a specific developmental defect in vertebrates.
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      headline:New member of the winged-helix protein family disrupted in mouse and rat nude mutations
      description:MUTATIONS at the nude locus of mice and rats disrupt normal hair growth and thymus development1,2, causing nude mice and rats to be immune-deficient. The mouse nude locus has been localized on chromosome 11 (refs 3, 4) within a region of < 1 megabase5. Here we show that one of the genes from this critical region, designated whn, encodes a new member of the winged-helix domain family of transcription factors6,7, and that it is disrupted on mouse nu and rat rnuN alleles. Mutant transcripts do not encode the character-istic DNA-binding domain, strongly suggesting that the whn gene is the nude gene. Mutations in winged-helix domain genes cause homeotic transformations in Drosophila8 and distort cell-fate deci-sions during vulval development in Caenorhabditis elegans9. The whn gene is thus the first member of this class of genes to be implicated in a specific developmental defect in vertebrates.
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