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Title:
A new member of the immunoglobulin superfamily—CTLA-4 | Nature
Description:
The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains1,2. It includes such functionally important members as the immunoglobulins themselves, major histocompatibility complex (MHC) class I and class II and T-cell receptor (TCR) molecules. Several members of this superfamily are expressed on lymphocytes where they are membrane-bound and capable of interactions with other members of the family, thus taking part in cell–cell recognition. In screening mouse cytolytic-T-cell-derived cDNA libraries, we came across cDNA clones defining a sequence, CTLA-4, which could encode a 223-amino-acid protein clearly belonging to the immunoglobulin superfamily. It consists of one V-like domain flanked by two hydrophobic regions, one of which has a structure suggestive of membrane anchoring. CTLA-4 is mainly expressed in activated lymphocytes and is coinduced with T-cell-mediated cytotoxicity in inducible models of this process. The mouse ctla-4 gene maps to band C of chromosome 1.
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nature portfolio permissions reprints privacy policy advertising social media t-cell-mediated cytotoxicity cells nature magali roux-dosseto al nature 322 molecular tumor markers nature 298 nature 323 nature 324 nature 316 nature 308 nature 312 nature 328 nature major histocompatibility complex personal data springerlink instant access data protection permissions t-cell receptor cdna clones defining immune checkpoint inhibitors cancer stem cells privacy cell–cell recognition immunoglobulin superfamily—ctla-4 article brunet marie-françoise luciani european economic area 223-amino-acid protein institutional subscriptions read multi-epitope vaccine nucleic acids res boulevard leï roure potential therapeutic targets accepting optional cookies explore content subscription content content milestone journals search log clinical practice guidelines clinical oncology manage preferences taking part functionally important members membrane-bound
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