NATURE . COM {}

Matching Content Categories {📚}

• Social Networks
• Photography
• Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$63,100 per month
Estimations show Nature.com's display ad online revenue falls between $42,042 and $115,616 per month.

Keywords {🔍}

nature, access, article, content, cookies, science, privacy, immunoglobulin, ctla, cells, open, cell, data, magali, rouxdosseto, immune, proc, natn, acad, sci, usa, marseille, france, research, advertising, information, journal, subscribe, brunet, denizot, luciani, mariegeneviève, mattei, golstein, superfamily, members, institution, buy, cancer, hood, hunkapiller, immunogenetics, immun, press, genet, author, cedex, permissions, essential, optional,

Topics {✒️}

nature portfolio permissions reprints privacy policy advertising social media t-cell-mediated cytotoxicity cells nature magali roux-dosseto al nature 322 molecular tumor markers nature 298 nature 323 nature 324 nature 316 nature 308 nature 312 nature 328 nature major histocompatibility complex personal data springerlink instant access data protection permissions t-cell receptor cdna clones defining immune checkpoint inhibitors cancer stem cells privacy cell–cell recognition immunoglobulin superfamily—ctla-4 article brunet marie-françoise luciani european economic area 223-amino-acid protein institutional subscriptions read multi-epitope vaccine nucleic acids res boulevard leï roure potential therapeutic targets accepting optional cookies explore content subscription content content milestone journals search log clinical practice guidelines clinical oncology manage preferences taking part functionally important members membrane-bound

Schema {🗺️}

WebPage:
      mainEntity:
         headline:A new member of the immunoglobulin superfamily—CTLA-4
         description:The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains1,2. It includes such functionally important members as the immunoglobulins themselves, major histocompatibility complex (MHC) class I and class II and T-cell receptor (TCR) molecules. Several members of this superfamily are expressed on lymphocytes where they are membrane-bound and capable of interactions with other members of the family, thus taking part in cell–cell recognition. In screening mouse cytolytic-T-cell-derived cDNA libraries, we came across cDNA clones defining a sequence, CTLA-4, which could encode a 223-amino-acid protein clearly belonging to the immunoglobulin superfamily. It consists of one V-like domain flanked by two hydrophobic regions, one of which has a structure suggestive of membrane anchoring. CTLA-4 is mainly expressed in activated lymphocytes and is coinduced with T-cell-mediated cytotoxicity in inducible models of this process. The mouse ctla-4 gene maps to band C of chromosome 1.
         datePublished:
         dateModified:
         pageStart:267
         pageEnd:270
         sameAs:https://doi.org/10.1038/328267a0
         keywords:
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:328
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Jean-François Brunet
               affiliation:
                     name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
                     address:
                        name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:François Denizot
               affiliation:
                     name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
                     address:
                        name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marie-Françoise Luciani
               affiliation:
                     name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
                     address:
                        name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Magali Roux-Dosseto
               affiliation:
                     name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
                     address:
                        name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
                        type:PostalAddress
                     type:Organization
                     name:UA CNRS 1175, Faculté de Médicine Secteur Nord
                     address:
                        name:UA CNRS 1175, Faculté de Médicine Secteur Nord, Marseille, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marie Suzan
               affiliation:
                     name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
                     address:
                        name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marie-Geneviève Mattei
               affiliation:
                     name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
                     address:
                        name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pierre Golstein
               affiliation:
                     name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
                     address:
                        name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A new member of the immunoglobulin superfamily—CTLA-4
      description:The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains1,2. It includes such functionally important members as the immunoglobulins themselves, major histocompatibility complex (MHC) class I and class II and T-cell receptor (TCR) molecules. Several members of this superfamily are expressed on lymphocytes where they are membrane-bound and capable of interactions with other members of the family, thus taking part in cell–cell recognition. In screening mouse cytolytic-T-cell-derived cDNA libraries, we came across cDNA clones defining a sequence, CTLA-4, which could encode a 223-amino-acid protein clearly belonging to the immunoglobulin superfamily. It consists of one V-like domain flanked by two hydrophobic regions, one of which has a structure suggestive of membrane anchoring. CTLA-4 is mainly expressed in activated lymphocytes and is coinduced with T-cell-mediated cytotoxicity in inducible models of this process. The mouse ctla-4 gene maps to band C of chromosome 1.
      datePublished:
      dateModified:
      pageStart:267
      pageEnd:270
      sameAs:https://doi.org/10.1038/328267a0
      keywords:
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:328
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jean-François Brunet
            affiliation:
                  name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
                  address:
                     name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:François Denizot
            affiliation:
                  name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
                  address:
                     name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marie-Françoise Luciani
            affiliation:
                  name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
                  address:
                     name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Magali Roux-Dosseto
            affiliation:
                  name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
                  address:
                     name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
                     type:PostalAddress
                  type:Organization
                  name:UA CNRS 1175, Faculté de Médicine Secteur Nord
                  address:
                     name:UA CNRS 1175, Faculté de Médicine Secteur Nord, Marseille, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marie Suzan
            affiliation:
                  name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
                  address:
                     name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marie-Geneviève Mattei
            affiliation:
                  name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
                  address:
                     name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pierre Golstein
            affiliation:
                  name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
                  address:
                     name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:328
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
      address:
         name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
         type:PostalAddress
      name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
      address:
         name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
         type:PostalAddress
      name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
      address:
         name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
         type:PostalAddress
      name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
      address:
         name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
         type:PostalAddress
      name:UA CNRS 1175, Faculté de Médicine Secteur Nord
      address:
         name:UA CNRS 1175, Faculté de Médicine Secteur Nord, Marseille, France
         type:PostalAddress
      name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
      address:
         name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
         type:PostalAddress
      name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
      address:
         name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
         type:PostalAddress
      name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
      address:
         name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Jean-François Brunet
      affiliation:
            name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
            address:
               name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
               type:PostalAddress
            type:Organization
      name:François Denizot
      affiliation:
            name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
            address:
               name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
               type:PostalAddress
            type:Organization
      name:Marie-Françoise Luciani
      affiliation:
            name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
            address:
               name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
               type:PostalAddress
            type:Organization
      name:Magali Roux-Dosseto
      affiliation:
            name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
            address:
               name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
               type:PostalAddress
            type:Organization
            name:UA CNRS 1175, Faculté de Médicine Secteur Nord
            address:
               name:UA CNRS 1175, Faculté de Médicine Secteur Nord, Marseille, France
               type:PostalAddress
            type:Organization
      name:Marie Suzan
      affiliation:
            name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
            address:
               name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
               type:PostalAddress
            type:Organization
      name:Marie-Geneviève Mattei
      affiliation:
            name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
            address:
               name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
               type:PostalAddress
            type:Organization
      name:Pierre Golstein
      affiliation:
            name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906
            address:
               name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
      name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
      name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
      name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
      name:UA CNRS 1175, Faculté de Médicine Secteur Nord, Marseille, France
      name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
      name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
      name:Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, France
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/Nature
• https://twitter.com/nature

External Links {🔗}(27)

• What are the total earnings of https://link.springer.com/article/10.1038/328267a0?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle?
• https://citation-needed.springer.com/v2/references/10.1038/328267a0?format=refman&flavour=references's total income per month
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jean-Fran%C3%A7ois%20Brunet bring in?
• How profitable is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jean-Fran%C3%A7ois%20Brunet%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What's the revenue for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Fran%C3%A7ois%20Denizot?
• Discover the revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Fran%C3%A7ois%20Denizot%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Marie-Fran%C3%A7oise%20Luciani earn?
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Marie-Fran%C3%A7oise%20Luciani%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Magali%20Roux-Dosseto
• Monthly income for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Magali%20Roux-Dosseto%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• Profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Marie%20Suzan
• How profitable is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Marie%20Suzan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Marie-Genevi%C3%A8ve%20Mattei
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Marie-Genevi%C3%A8ve%20Mattei%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Pierre%20Golstein
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Pierre%20Golstein%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's total income per month
• How much revenue does https://s100.copyright.com/AppDispatchServlet?title=A%20new%20member%20of%20the%20immunoglobulin%20superfamily%E2%80%94CTLA-4&author=Jean-Fran%C3%A7ois%20Brunet%20et%20al&contentID=10.1038%2F328267a0©right=Springer%20Nature%20Limited&publication=0028-0836&publicationDate=1987-07-16&publisherName=SpringerNature&orderBeanReset=true bring in?
• How much does https://citation-needed.springer.com/v2/references/10.1038/328267a0?format=refman&flavour=citation earn?
• What's the monthly money flow for https://doi.org/10.1007/s11064-024-04121-z?
• Financial intake of https://doi.org/10.1007/s10147-023-02430-x
• Financial intake of https://doi.org/10.1186/s12964-023-01354-3
• What's the income generated by https://doi.org/10.1186/s40164-023-00456-5 each month?
• What is the earnings of https://doi.org/10.1186/s12943-023-01748-4?
• Discover the revenue of https://www.protocols.io/
• How much does https://www.natureindex.com/ gross monthly?
• Income figures for http://www.naturechina.com
• How much income does https://www.natureasia.com/ja-jp have?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref