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Modified nucleosides and bizarre 5′-termini in mouse myeloma mRNA | Nature
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Messenger RNAs from mouse myeloma cells contain N6-methyl adenosine and novel 5′ termini having 7-methylguanosine in a 5′, 5′triphosphate linkage with ribose-methylated nucleosides. Ten common 5′-terminal sequences of the forms m7G5′ppp5′NmpNp and m7G5′ppp5′NmpNmpNp are reported. Structures like this may be a general feature of mRN A in eukaryotes.
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