Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Schema
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers
  15. CDN Services

We are analyzing https://www.nature.com/articles/22780.

Title:
Creation of human tumour cells with defined genetic elements | Nature
Description:
During malignant transformation, cancer cells acquire genetic mutations that override the normal mechanisms controlling cellular proliferation. Primary rodent cells are efficiently converted into tumorigenic cells by the coexpression of cooperating oncogenes1,2. However, similar experiments with human cells have consistently failed to yield tumorigenic transformants3,4,5, indicating a fundamental difference in the biology of human and rodent cells. The few reported successes in the creation of human tumour cells have depended on the use of chemical or physical agents to achieve immortalization6, the selection of rare, spontaneously arising immortalized cells7,8,9,10, or the use of an entire viral genome11. We show here that the ectopic expression of the telomerase catalytic subunit (hTERT)12 in combination with two oncogenes (the simian virus 40 large-T oncoprotein and an oncogenic allele of H-ras) results in direct tumorigenic conversion of normal human epithelial and fibroblast cells. These results demonstrate that disruption of the intracellular pathways regulated by large-T, oncogenic ras and telomerase suffices to create a human tumor cell.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {πŸ“š}

  • Science
  • Education
  • Non-Profit & Charity

Content Management System {πŸ“}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {πŸ“ˆ}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {πŸ’Έ}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {πŸ’°}


Display Ads {🎯}

$63,100 per month
Our estimates place Nature.com's monthly online earnings from display ads at $42,042 to $115,616.

Keywords {πŸ”}

article, scholar, google, cas, human, nature, cells, cancer, telomerase, ads, cell, access, usa, research, content, cookies, hahn, counter, weinberg, activity, privacy, william, lundberg, transformation, normal, expression, epithelial, fibroblasts, proc, natl, acad, sci, mol, biol, data, tumour, christopher, ante, robert, primary, tumorigenic, oncogenes, simian, virus, ras, tumor, senescence, oncogene, science, large,

Topics {βœ’οΈ}

nature portfolio permissions reprints privacy policy advertising social media mouse development biomedical research nature genet subscribe nature middle nature 304 nature 394 nature 396 nature 400 nature human tfiib-related factor dana-farber cancer institute personal data author correspondence springerlink instant access data protection permissions normal human epithelial defined genetic elements entire viral genome11 privacy human fibroblasts caused human fibroblasts immortalized normal human cells harvard medical school human tumor cell transform primary cells cellular transforming genes prostate epithelial cells human epidermal keratinocytes normal epithelium outcompete human somatic cells explore content subscription content human tumour cells european economic area intracellular pathways regulated institutional subscriptions read activated v-myc kirsten sarcoma viruses cold spring harb rb/p16ink4a inactivation polymerase iii promoter nucleic acids res histone deacetylase inhibitors

Schema {πŸ—ΊοΈ}

WebPage:
      mainEntity:
         headline:Creation of human tumour cells with defined genetic elements
         description:During malignant transformation, cancer cells acquire genetic mutations that override the normal mechanisms controlling cellular proliferation. Primary rodent cells are efficiently converted into tumorigenic cells by the coexpression of cooperating oncogenes1,2. However, similar experiments with human cells have consistently failed to yield tumorigenic transformants3,4,5, indicating a fundamental difference in the biology of human and rodent cells. The few reported successes in the creation of human tumour cells have depended on the use of chemical or physical agents to achieve immortalization6, the selection of rare, spontaneously arising immortalized cells7,8,9,10, or the use of an entire viral genome11. We show here that the ectopic expression of the telomerase catalytic subunit (hTERT)12 in combination with two oncogenes (the simian virus 40 large-T oncoprotein and an oncogenic allele of H-ras) results in direct tumorigenic conversion of normal human epithelial and fibroblast cells. These results demonstrate that disruption of the intracellular pathways regulated by large-T, oncogenic ras and telomerase suffices to create a human tumor cell.
         datePublished:
         dateModified:
         pageStart:464
         pageEnd:468
         sameAs:https://doi.org/10.1038/22780
         keywords:
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig4_HTML.gif
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:400
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:William C. Hahn
               affiliation:
                     name:Whitehead Institute for Biomedical Research
                     address:
                        name:Whitehead Institute for Biomedical Research
                        type:PostalAddress
                     type:Organization
                     name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
                     address:
                        name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Massachusetts Institute of Technology
                     address:
                        name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Christopher M. Counter
               affiliation:
                     name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
                     address:
                        name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
                        type:PostalAddress
                     type:Organization
                     name:Duke University Medical Center
                     address:
                        name:Duke University Medical Center, Durham, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ante S. Lundberg
               affiliation:
                     name:Whitehead Institute for Biomedical Research
                     address:
                        name:Whitehead Institute for Biomedical Research
                        type:PostalAddress
                     type:Organization
                     name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
                     address:
                        name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Massachusetts Institute of Technology
                     address:
                        name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Roderick L. Beijersbergen
               affiliation:
                     name:Whitehead Institute for Biomedical Research
                     address:
                        name:Whitehead Institute for Biomedical Research
                        type:PostalAddress
                     type:Organization
                     name:Massachusetts Institute of Technology
                     address:
                        name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mary W. Brooks
               affiliation:
                     name:Whitehead Institute for Biomedical Research
                     address:
                        name:Whitehead Institute for Biomedical Research
                        type:PostalAddress
                     type:Organization
                     name:Massachusetts Institute of Technology
                     address:
                        name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Robert A. Weinberg
               affiliation:
                     name:Whitehead Institute for Biomedical Research
                     address:
                        name:Whitehead Institute for Biomedical Research
                        type:PostalAddress
                     type:Organization
                     name:Massachusetts Institute of Technology
                     address:
                        name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Creation of human tumour cells with defined genetic elements
      description:During malignant transformation, cancer cells acquire genetic mutations that override the normal mechanisms controlling cellular proliferation. Primary rodent cells are efficiently converted into tumorigenic cells by the coexpression of cooperating oncogenes1,2. However, similar experiments with human cells have consistently failed to yield tumorigenic transformants3,4,5, indicating a fundamental difference in the biology of human and rodent cells. The few reported successes in the creation of human tumour cells have depended on the use of chemical or physical agents to achieve immortalization6, the selection of rare, spontaneously arising immortalized cells7,8,9,10, or the use of an entire viral genome11. We show here that the ectopic expression of the telomerase catalytic subunit (hTERT)12 in combination with two oncogenes (the simian virus 40 large-T oncoprotein and an oncogenic allele of H-ras) results in direct tumorigenic conversion of normal human epithelial and fibroblast cells. These results demonstrate that disruption of the intracellular pathways regulated by large-T, oncogenic ras and telomerase suffices to create a human tumor cell.
      datePublished:
      dateModified:
      pageStart:464
      pageEnd:468
      sameAs:https://doi.org/10.1038/22780
      keywords:
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig4_HTML.gif
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:400
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:William C. Hahn
            affiliation:
                  name:Whitehead Institute for Biomedical Research
                  address:
                     name:Whitehead Institute for Biomedical Research
                     type:PostalAddress
                  type:Organization
                  name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
                  address:
                     name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Massachusetts Institute of Technology
                  address:
                     name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christopher M. Counter
            affiliation:
                  name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
                  address:
                     name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
                     type:PostalAddress
                  type:Organization
                  name:Duke University Medical Center
                  address:
                     name:Duke University Medical Center, Durham, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ante S. Lundberg
            affiliation:
                  name:Whitehead Institute for Biomedical Research
                  address:
                     name:Whitehead Institute for Biomedical Research
                     type:PostalAddress
                  type:Organization
                  name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
                  address:
                     name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Massachusetts Institute of Technology
                  address:
                     name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Roderick L. Beijersbergen
            affiliation:
                  name:Whitehead Institute for Biomedical Research
                  address:
                     name:Whitehead Institute for Biomedical Research
                     type:PostalAddress
                  type:Organization
                  name:Massachusetts Institute of Technology
                  address:
                     name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mary W. Brooks
            affiliation:
                  name:Whitehead Institute for Biomedical Research
                  address:
                     name:Whitehead Institute for Biomedical Research
                     type:PostalAddress
                  type:Organization
                  name:Massachusetts Institute of Technology
                  address:
                     name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Robert A. Weinberg
            affiliation:
                  name:Whitehead Institute for Biomedical Research
                  address:
                     name:Whitehead Institute for Biomedical Research
                     type:PostalAddress
                  type:Organization
                  name:Massachusetts Institute of Technology
                  address:
                     name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:400
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Whitehead Institute for Biomedical Research
      address:
         name:Whitehead Institute for Biomedical Research
         type:PostalAddress
      name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
      address:
         name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts Institute of Technology
      address:
         name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
      address:
         name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
         type:PostalAddress
      name:Duke University Medical Center
      address:
         name:Duke University Medical Center, Durham, USA
         type:PostalAddress
      name:Whitehead Institute for Biomedical Research
      address:
         name:Whitehead Institute for Biomedical Research
         type:PostalAddress
      name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
      address:
         name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Massachusetts Institute of Technology
      address:
         name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:Whitehead Institute for Biomedical Research
      address:
         name:Whitehead Institute for Biomedical Research
         type:PostalAddress
      name:Massachusetts Institute of Technology
      address:
         name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:Whitehead Institute for Biomedical Research
      address:
         name:Whitehead Institute for Biomedical Research
         type:PostalAddress
      name:Massachusetts Institute of Technology
      address:
         name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:Whitehead Institute for Biomedical Research
      address:
         name:Whitehead Institute for Biomedical Research
         type:PostalAddress
      name:Massachusetts Institute of Technology
      address:
         name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:William C. Hahn
      affiliation:
            name:Whitehead Institute for Biomedical Research
            address:
               name:Whitehead Institute for Biomedical Research
               type:PostalAddress
            type:Organization
            name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
            address:
               name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Massachusetts Institute of Technology
            address:
               name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Christopher M. Counter
      affiliation:
            name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
            address:
               name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
               type:PostalAddress
            type:Organization
            name:Duke University Medical Center
            address:
               name:Duke University Medical Center, Durham, USA
               type:PostalAddress
            type:Organization
      name:Ante S. Lundberg
      affiliation:
            name:Whitehead Institute for Biomedical Research
            address:
               name:Whitehead Institute for Biomedical Research
               type:PostalAddress
            type:Organization
            name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
            address:
               name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Massachusetts Institute of Technology
            address:
               name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Roderick L. Beijersbergen
      affiliation:
            name:Whitehead Institute for Biomedical Research
            address:
               name:Whitehead Institute for Biomedical Research
               type:PostalAddress
            type:Organization
            name:Massachusetts Institute of Technology
            address:
               name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Mary W. Brooks
      affiliation:
            name:Whitehead Institute for Biomedical Research
            address:
               name:Whitehead Institute for Biomedical Research
               type:PostalAddress
            type:Organization
            name:Massachusetts Institute of Technology
            address:
               name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Robert A. Weinberg
      affiliation:
            name:Whitehead Institute for Biomedical Research
            address:
               name:Whitehead Institute for Biomedical Research
               type:PostalAddress
            type:Organization
            name:Massachusetts Institute of Technology
            address:
               name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Whitehead Institute for Biomedical Research
      name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
      name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
      name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
      name:Duke University Medical Center, Durham, USA
      name:Whitehead Institute for Biomedical Research
      name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
      name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
      name:Whitehead Institute for Biomedical Research
      name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
      name:Whitehead Institute for Biomedical Research
      name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
      name:Whitehead Institute for Biomedical Research
      name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {πŸ”—}(99)

Analytics and Tracking {πŸ“Š}

  • Google Tag Manager

Libraries {πŸ“š}

  • Prism.js
  • Zoom.js

Emails and Hosting {βœ‰οΈ}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {πŸ“¦}

  • Crossref

5.66s.