
NATURE . COM {
}
Title:
Creation of human tumour cells with defined genetic elements | Nature
Description:
During malignant transformation, cancer cells acquire genetic mutations that override the normal mechanisms controlling cellular proliferation. Primary rodent cells are efficiently converted into tumorigenic cells by the coexpression of cooperating oncogenes1,2. However, similar experiments with human cells have consistently failed to yield tumorigenic transformants3,4,5, indicating a fundamental difference in the biology of human and rodent cells. The few reported successes in the creation of human tumour cells have depended on the use of chemical or physical agents to achieve immortalization6, the selection of rare, spontaneously arising immortalized cells7,8,9,10, or the use of an entire viral genome11. We show here that the ectopic expression of the telomerase catalytic subunit (hTERT)12 in combination with two oncogenes (the simian virus 40 large-T oncoprotein and an oncogenic allele of H-ras) results in direct tumorigenic conversion of normal human epithelial and fibroblast cells. These results demonstrate that disruption of the intracellular pathways regulated by large-T, oncogenic ras and telomerase suffices to create a human tumor cell.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {π}
- Science
- Education
- Non-Profit & Charity
Content Management System {π}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {π}
What is the average monthly size of nature.com audience?
π Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {πΈ}
Display Ads {π―}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {π°}
Display Ads {π―}
$63,100 per month
Estimations show Nature.com's display ad online revenue falls between $42,042 and $115,616 per month.
Keywords {π}
article, scholar, google, cas, human, nature, cells, cancer, telomerase, ads, cell, access, usa, research, content, cookies, hahn, counter, weinberg, activity, privacy, william, lundberg, transformation, normal, expression, epithelial, fibroblasts, proc, natl, acad, sci, mol, biol, data, tumour, christopher, ante, robert, primary, tumorigenic, oncogenes, simian, virus, ras, tumor, senescence, oncogene, science, large,
Topics {βοΈ}
nature portfolio permissions reprints privacy policy advertising social media mouse development biomedical research nature genet subscribe nature middle nature 304 nature 394 nature 396 nature 400 nature human tfiib-related factor dana-farber cancer institute personal data author correspondence springerlink instant access data protection permissions normal human epithelial defined genetic elements entire viral genome11 privacy human fibroblasts caused human fibroblasts immortalized normal human cells harvard medical school human tumor cell transform primary cells cellular transforming genes prostate epithelial cells human epidermal keratinocytes normal epithelium outcompete human somatic cells explore content subscription content human tumour cells european economic area intracellular pathways regulated institutional subscriptions read activated v-myc kirsten sarcoma viruses cold spring harb rb/p16ink4a inactivation polymerase iii promoter nucleic acids res histone deacetylase inhibitors
Schema {πΊοΈ}
WebPage:
mainEntity:
headline:Creation of human tumour cells with defined genetic elements
description:During malignant transformation, cancer cells acquire genetic mutations that override the normal mechanisms controlling cellular proliferation. Primary rodent cells are efficiently converted into tumorigenic cells by the coexpression of cooperating oncogenes1,2. However, similar experiments with human cells have consistently failed to yield tumorigenic transformants3,4,5, indicating a fundamental difference in the biology of human and rodent cells. The few reported successes in the creation of human tumour cells have depended on the use of chemical or physical agents to achieve immortalization6, the selection of rare, spontaneously arising immortalized cells7,8,9,10, or the use of an entire viral genome11. We show here that the ectopic expression of the telomerase catalytic subunit (hTERT)12 in combination with two oncogenes (the simian virus 40 large-T oncoprotein and an oncogenic allele of H-ras) results in direct tumorigenic conversion of normal human epithelial and fibroblast cells. These results demonstrate that disruption of the intracellular pathways regulated by large-T, oncogenic ras and telomerase suffices to create a human tumor cell.
datePublished:
dateModified:
pageStart:464
pageEnd:468
sameAs:https://doi.org/10.1038/22780
keywords:
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig4_HTML.gif
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:400
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:William C. Hahn
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Christopher M. Counter
affiliation:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
address:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
type:PostalAddress
type:Organization
name:Duke University Medical Center
address:
name:Duke University Medical Center, Durham, USA
type:PostalAddress
type:Organization
type:Person
name:Ante S. Lundberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Roderick L. Beijersbergen
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Mary W. Brooks
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Robert A. Weinberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Creation of human tumour cells with defined genetic elements
description:During malignant transformation, cancer cells acquire genetic mutations that override the normal mechanisms controlling cellular proliferation. Primary rodent cells are efficiently converted into tumorigenic cells by the coexpression of cooperating oncogenes1,2. However, similar experiments with human cells have consistently failed to yield tumorigenic transformants3,4,5, indicating a fundamental difference in the biology of human and rodent cells. The few reported successes in the creation of human tumour cells have depended on the use of chemical or physical agents to achieve immortalization6, the selection of rare, spontaneously arising immortalized cells7,8,9,10, or the use of an entire viral genome11. We show here that the ectopic expression of the telomerase catalytic subunit (hTERT)12 in combination with two oncogenes (the simian virus 40 large-T oncoprotein and an oncogenic allele of H-ras) results in direct tumorigenic conversion of normal human epithelial and fibroblast cells. These results demonstrate that disruption of the intracellular pathways regulated by large-T, oncogenic ras and telomerase suffices to create a human tumor cell.
datePublished:
dateModified:
pageStart:464
pageEnd:468
sameAs:https://doi.org/10.1038/22780
keywords:
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig4_HTML.gif
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:400
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:William C. Hahn
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Christopher M. Counter
affiliation:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
address:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
type:PostalAddress
type:Organization
name:Duke University Medical Center
address:
name:Duke University Medical Center, Durham, USA
type:PostalAddress
type:Organization
type:Person
name:Ante S. Lundberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Roderick L. Beijersbergen
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Mary W. Brooks
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Robert A. Weinberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:400
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
address:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
type:PostalAddress
name:Duke University Medical Center
address:
name:Duke University Medical Center, Durham, USA
type:PostalAddress
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:William C. Hahn
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
name:Christopher M. Counter
affiliation:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
address:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
type:PostalAddress
type:Organization
name:Duke University Medical Center
address:
name:Duke University Medical Center, Durham, USA
type:PostalAddress
type:Organization
name:Ante S. Lundberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
name:Roderick L. Beijersbergen
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
name:Mary W. Brooks
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
name:Robert A. Weinberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Whitehead Institute for Biomedical Research
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
name:Duke University Medical Center, Durham, USA
name:Whitehead Institute for Biomedical Research
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
name:Whitehead Institute for Biomedical Research
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
name:Whitehead Institute for Biomedical Research
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
name:Whitehead Institute for Biomedical Research
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {π}(99)
- How much does https://link.springer.com/article/10.1038/22780?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle gross monthly?
- Get to know https://doi.org/10.1038%2F304596a0's earnings
- What's the income generated by http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1983Natur.304..596L each month?
- http://scholar.google.com/scholar_lookup?&title=Tumorigenic%20conversion%20of%20primary%20embryo%20fibroblasts%20requires%20at%20least%20two%20cooperating%20oncogenes.&journal=Nature&doi=10.1038%2F304596a0&volume=304&pages=596-602&publication_year=1983&author=Land%2CH&author=Parada%2CLF&author=Weinberg%2CRA's total income per month
- How much does https://doi.org/10.1038%2F304602a0 bring in each month?
- How much profit does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1983Natur.304..602R make?
- Get to know http://scholar.google.com/scholar_lookup?&title=Adenovirus%20early%20region%201A%20enables%20viral%20and%20cellular%20transforming%20genes%20to%20transform%20primary%20cells%20in%20culture.&journal=Nature&doi=10.1038%2F304602a0&volume=304&pages=602-606&publication_year=1983&author=Ruley%2CH's earnings
- What's the financial gain of https://doi.org/10.1289%2Fehp.919359?
- How much does http://scholar.google.com/scholar_lookup?&title=Senescence%20as%20a%20mode%20of%20tumor%20suppression.&journal=Environ.%20Health%20Perspect.&doi=10.1289%2Fehp.919359&volume=93&pages=59-62&publication_year=1991&author=Sager%2CR net monthly?
- How much does https://doi.org/10.1073%2Fpnas.83.22.8659 make?
- Financial intake of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1986PNAS...83.8659O
- http://scholar.google.com/scholar_lookup?&title=Suppression%20of%20tumor%20growth%20by%20senescence%20in%20virally%20transformed%20human%20fibroblasts.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.83.22.8659&volume=83&pages=8659-8663&publication_year=1986&author=O%27Brien%2CW&author=Stenman%2CG&author=Sager%2CR's financial summary
- What's the income of https://doi.org/10.1128%2FMCB.6.10.3410?
- How much does http://scholar.google.com/scholar_lookup?&title=Activated%20v-myc%20and%20v-ras%20oncogenes%20do%20not%20transform%20normal%20human%20lymphocytes.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.6.10.3410&volume=6&pages=3410-3417&publication_year=1986&author=Stevenson%2CM&author=Volsky%2CDJ rake in every month?
- What's the income of https://doi.org/10.1002%2F%28SICI%291098-2744%28199804%2921%3A4%3C225%3A%3AAID-MC1%3E3.0.CO%3B2-J?
- Income figures for http://scholar.google.com/scholar_lookup?&title=Involvement%20of%20tyrosine%20phosphorylation%20of%20p185c-erb%2Fneu%20in%20tumorigenicity%20induced%20by%20X-rays%20and%20the%20neu%20oncogene%20in%20human%20breast%20epithelial%20cells.&journal=Mol.%20Carcinogen.&doi=10.1002%2F%28SICI%291098-2744%28199804%2921%3A4%3C225%3A%3AAID-MC1%3E3.0.CO%3B2-J&volume=21&pages=225-233&publication_year=1998&author=Kang%2CJ-S
- What's the financial outcome of https://doi.org/10.1126%2Fscience.3975607?
- What's the revenue for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1985Sci...227.1174Y?
- How much does http://scholar.google.com/scholar_lookup?&title=Transformation%20of%20human%20bronchial%20epithelial%20cells%20transfected%20by%20the%20Harvey%20ras%20oncogene.&journal=Science&doi=10.1126%2Fscience.3975607&volume=227&pages=1174-1179&publication_year=1985&author=Yakum%2CGH earn?
- What's https://doi.org/10.1126%2Fscience.2579430's gross income?
- How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1985Sci...227.1250R pull in monthly?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Neoplastic%20transformation%20of%20human%20epidermal%20keratinocytes%20by%20AD12-SV40%20and%20Kirsten%20sarcoma%20viruses.&journal=Science&doi=10.1126%2Fscience.2579430&volume=227&pages=1250-1252&publication_year=1985&author=Rhim%2CJS bring in?
- How much profit does https://doi.org/10.1073%2Fpnas.86.1.187 generate?
- How profitable is http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1989PNAS...86..187H?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Malignant%20transformation%20of%20human%20fibroblasts%20caused%20by%20expression%20of%20a%20transfected%20T24%20HRAS%20oncogene.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.86.1.187&volume=86&pages=187-181&publication_year=1989&author=Hurlin%2CPJ&author=Maher%2CVM&author=McCormick%2CJJ?
- Financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9772298
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Effect%20of%20oncogene%20expression%20on%20telomerase%20activation%20and%20telomere%20length%20in%20human%20endothelial%2C%20fibroblast%20and%20prostate%20epithelial%20cells.&journal=Int.%20J.%20Oncol.&volume=13&pages=1043-1048&publication_year=1998&author=Burger%2CAM
- Revenue of https://doi.org/10.1038%2F29093
- How much money does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1998Natur.394..588F make?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Transformation%20of%20primary%20human%20endothelial%20cells%20by%20Kaposi%27s%20sarcoma-associated%20herpesvirus.&journal=Nature&doi=10.1038%2F29093&volume=394&pages=588-592&publication_year=1998&author=Flore%2CA
- Get to know what's the income of https://doi.org/10.1016%2FS0092-8674%2800%2981123-X
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Reversing%20time%3A%20origin%20of%20telomerase.&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981123-X&volume=92&pages=587-590&publication_year=1998&author=Nakamura%2CTM&author=Cech%2CTR generate?
- Explore the financials of https://doi.org/10.1016%2FS0959-8049%2897%2900060-9
- Income figures for http://scholar.google.com/scholar_lookup?&title=Telomere%20structure%20and%20telomerase%20expression%20during%20mouse%20development%20and%20tumorigenesis.&journal=Eur.%20J.%20Cancer&doi=10.1016%2FS0959-8049%2897%2900060-9&volume=33&pages=792-800&publication_year=1997&author=Kipling%2CD
- What's the financial intake of https://doi.org/10.1126%2Fscience.7605428?
- How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1994Sci...266.2011K rake in every month?
- How much does http://scholar.google.com/scholar_lookup?&title=Specific%20association%20of%20human%20telomerase%20activity%20with%20immortal%20cells%20and%20cancer.&journal=Science&doi=10.1126%2Fscience.7605428&volume=266&pages=2011-2015&publication_year=1994&author=Kim%2CNW make?
- What's the financial intake of https://doi.org/10.1016%2FS0959-8049%2897%2900062-2?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Asurvey%20of%20telomerase%20activity%20in%20human%20cancer.&journal=Eur.%20J.%20Cancer&doi=10.1016%2FS0959-8049%2897%2900062-2&volume=33&pages=787-791&publication_year=1997&author=Shay%2CJW&author=Bacchetti%2CS?
- How much does https://doi.org/10.1101%2FSQB.1994.059.01.035 earn?
- How much does http://scholar.google.com/scholar_lookup?&title=Telomerase%2C%20cell%20immortality%2C%20and%20cancer.&journal=Cold%20Spring%20Harb.%20Symp.%20Quant.%20Biol.&doi=10.1101%2FSQB.1994.059.01.035&volume=59&pages=307-315&publication_year=1994&author=Harley%2CCB rake in every month?
- Revenue of https://doi.org/10.1126%2Fscience.279.5349.349
- How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1998Sci...279..349B pull in?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Extension%20of%20life-span%20by%20introduction%20of%20telomerase%20into%20normal%20human%20cells.&journal=Science&doi=10.1126%2Fscience.279.5349.349&volume=279&pages=349-352&publication_year=1998&author=Bodnar%2CAG bring in?
- Income figures for https://doi.org/10.1038%2F23962
- How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1998Natur.396...84K earn?
- Earnings of http://scholar.google.com/scholar_lookup?&title=Both%20Rb%2Fp16INK4a%20inactivation%20and%20telomerase%20activity%20are%20required%20to%20immortalize%20human%20epithelial%20cells.&journal=Nature&doi=10.1038%2F23962&volume=396&pages=84-88&publication_year=1998&author=Kiyono%2CT
- How much revenue does https://doi.org/10.1073%2Fpnas.96.7.3339 bring in?
- How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1999PNAS...96.3339L generate monthly?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Crisis%20intervention%3A%20the%20role%20of%20telomerase.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.96.7.3339&volume=96&pages=3339-3341&publication_year=1999&author=Lustig%2CAJ?
- How much does https://doi.org/10.1016%2FS0092-8674%2800%2981902-9 generate monthly?
- Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Oncogenic%20ras%20provokes%20premature%20cell%20senescence%20associated%20with%20accumulation%20of%20p53%20nd%20p16ink4a.&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981902-9&volume=88&pages=593-602&publication_year=1997&author=Serrano%2CM&author=Lin%2CAW&author=McCurrach%2CME&author=Beach%2CD&author=Lowe%2CSW
- How much money does https://doi.org/10.1073%2Fpnas.95.25.14723 generate?
- How much income is http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1998PNAS...9514723C earning monthly?
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Dissociation%20among%20in%20vitro%20telomerase%20activity%2C%20telomere%20maintenance%2C%20and%20cellular%20immortalization.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.95.25.14723&volume=95&pages=14723-14728&publication_year=1998&author=Counter%2CCM?
- https://doi.org/10.1038%2F5063's total income per month
- http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1999Natur.399..115M's financial summary
- http://scholar.google.com/scholar_lookup?&title=Absence%20of%20cancer-associated%20changes%20in%20human%20fibroblasts%20immortalized%20with%20telomerase.&journal=Nature%20Genet.&doi=10.1038%2F5063&volume=21&pages=115-118&publication_year=1999&author=Morales%2CCP's financial summary
- https://doi.org/10.1128%2FMCB.18.3.1408 income
- How much revenue does http://scholar.google.com/scholar_lookup?&title=The%20J%20domain%20of%20simian%20virus%2040%20large%20T%20antigen%20is%20required%20to%20functionally%20inactivate%20RB%20family%20proteins.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.18.3.1408&volume=18&pages=1408-1415&publication_year=1998&author=Zalvide%2CJ&author=Stubdal%2CH&author=DeCaprio%2CJA bring in?
- What's the monthly money flow for https://doi.org/10.1128%2FMCB.18.3.1331?
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=Simian%20virus%2040%20large%20T%20antigen%20interacts%20with%20human%20TFIIB-related%20factor%20and%20small%20nuclear%20RNA-activating%20protein%20complex%20for%20transcriptional%20activation%20of%20TATA-containing%20polymerase%20III%20promoter.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.18.3.1331&volume=18&pages=1331-1338&publication_year=1998&author=Damania%2CB&author=Mital%2CR&author=Alwine%2CJC
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Immortalized%20cells%20with%20no%20detectable%20telomerase%20activity.%20A%20review.&journal=Biochemistry%20%28Mosc.%29&volume=62&pages=1254-1262&publication_year=1997&author=Reddel%2CRR&author=Bryan%2CTM&author=Murnane%2CJP?
- What are the earnings of https://doi.org/10.1038%2F5056?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Telomerase%20expression%20in%20human%20somatic%20cells%20does%20not%20induce%20changes%20associated%20with%20a%20transformed%20phenotype.&journal=Nature%20Genet.&doi=10.1038%2F5056&volume=21&pages=111-114&publication_year=1999&author=Jiang%2CX-R
- How much does https://doi.org/10.1128%2FMCB.6.4.1204 earn?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Recombinant%20retroviruses%20encoding%20simian%20virus%2040%20large%20T%20antigen%20and%20polyomavirus%20large%20and%20middle%20T%20antigens.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.6.4.1204&volume=6&pages=1204-1217&publication_year=1986&author=Jat%2CPS&author=Cepko%2CCL&author=Mulligan%2CRC&author=Sharp%2CPA?
- Check the income stats for https://doi.org/10.1093%2Fnar%2F25.13.2595
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Advances%20in%20quantification%20and%20characterization%20of%20telomerase%20activity%20by%20the%20telomeric%20repeat%20amplification%20protocol%20%28TRAP%29.&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2F25.13.2595&volume=25&pages=2595-2597&publication_year=1997&author=Kim%2CNW&author=Wu%2CF?
- How much does https://doi.org/10.1073%2Fpnas.77.2.1039 make?
- What's the profit of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1980PNAS...77.1039C?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Correlation%20of%20patterns%20of%20anchorage-independent%20growth%20with%20in%20vivo%20behavior%20of%20cells%20from%20a%20murine%20fibrosarcoma.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.77.2.1039&volume=77&pages=1039-1043&publication_year=1980&author=Cifone%2CMA&author=Fidler%2CIJ
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7815516 bring in?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC188715 earn?
- How much profit is http://scholar.google.com/scholar_lookup?&title=Potential%20role%20of%20natural%20killer%20cells%20in%20controlling%20tumorigenesis%20by%20human%20T-cell%20leukemia%20viruses.&journal=J.%20Virol.&volume=69&pages=1328-1333&publication_year=1995&author=Feuer%2CG making per month?
- How much profit does https://citation-needed.springer.com/v2/references/10.1038/22780?format=refman&flavour=references make?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=William%20C.%20Hahn income
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22William%20C.%20Hahn%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- Find out how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Christopher%20M.%20Counter earns monthly
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Christopher%20M.%20Counter%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's total income per month
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ante%20S.%20Lundberg bring in each month?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ante%20S.%20Lundberg%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en gross monthly?
- Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Roderick%20L.%20Beijersbergen
- Revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Roderick%20L.%20Beijersbergen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Monthly income for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Mary%20W.%20Brooks
- What's the financial outcome of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Mary%20W.%20Brooks%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What's the financial outcome of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Robert%20A.%20Weinberg?
- What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Robert%20A.%20Weinberg%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://s100.copyright.com/AppDispatchServlet?title=Creation%20of%20human%20tumour%20cells%20with%20defined%20genetic%20elements&author=William%20C.%20Hahn%20et%20al&contentID=10.1038%2F22780©right=Macmillan%20Magazines%20Ltd.&publication=0028-0836&publicationDate=1999-07-29&publisherName=SpringerNature&orderBeanReset=true pull in?
- What's the monthly money flow for https://citation-needed.springer.com/v2/references/10.1038/22780?format=refman&flavour=citation?
- How much does https://doi.org/10.1186/s12935-023-03041-2 gross monthly?
- https://doi.org/10.1007/s13577-023-00925-3's financial summary
- How much does https://doi.org/10.1186/s13058-022-01538-8 pull in monthly?
- What's the financial gain of https://doi.org/10.1186/s12859-022-04788-7?
- What's the monthly money flow for https://doi.org/10.1186/s13148-022-01370-z?
- What's the financial outcome of https://www.protocols.io/?
- Earnings of https://www.natureindex.com/
- Get to know http://www.naturechina.com's earnings
- What's the income of https://www.natureasia.com/ja-jp?
Analytics and Tracking {π}
- Google Tag Manager
Libraries {π}
- Prism.js
- Zoom.js
Emails and Hosting {βοΈ}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {π¦}
- Crossref