
NATURE . COM {
}
Title:
Creation of human tumour cells with defined genetic elements | Nature
Description:
During malignant transformation, cancer cells acquire genetic mutations that override the normal mechanisms controlling cellular proliferation. Primary rodent cells are efficiently converted into tumorigenic cells by the coexpression of cooperating oncogenes1,2. However, similar experiments with human cells have consistently failed to yield tumorigenic transformants3,4,5, indicating a fundamental difference in the biology of human and rodent cells. The few reported successes in the creation of human tumour cells have depended on the use of chemical or physical agents to achieve immortalization6, the selection of rare, spontaneously arising immortalized cells7,8,9,10, or the use of an entire viral genome11. We show here that the ectopic expression of the telomerase catalytic subunit (hTERT)12 in combination with two oncogenes (the simian virus 40 large-T oncoprotein and an oncogenic allele of H-ras) results in direct tumorigenic conversion of normal human epithelial and fibroblast cells. These results demonstrate that disruption of the intracellular pathways regulated by large-T, oncogenic ras and telomerase suffices to create a human tumor cell.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {π}
- Science
- Education
- Non-Profit & Charity
Content Management System {π}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {π}
What is the average monthly size of nature.com audience?
π Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {πΈ}
Display Ads {π―}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {π°}
Display Ads {π―}
$63,100 per month
Our estimates place Nature.com's monthly online earnings from display ads at $42,042 to $115,616.
Keywords {π}
article, scholar, google, cas, human, nature, cells, cancer, telomerase, ads, cell, access, usa, research, content, cookies, hahn, counter, weinberg, activity, privacy, william, lundberg, transformation, normal, expression, epithelial, fibroblasts, proc, natl, acad, sci, mol, biol, data, tumour, christopher, ante, robert, primary, tumorigenic, oncogenes, simian, virus, ras, tumor, senescence, oncogene, science, large,
Topics {βοΈ}
nature portfolio permissions reprints privacy policy advertising social media mouse development biomedical research nature genet subscribe nature middle nature 304 nature 394 nature 396 nature 400 nature human tfiib-related factor dana-farber cancer institute personal data author correspondence springerlink instant access data protection permissions normal human epithelial defined genetic elements entire viral genome11 privacy human fibroblasts caused human fibroblasts immortalized normal human cells harvard medical school human tumor cell transform primary cells cellular transforming genes prostate epithelial cells human epidermal keratinocytes normal epithelium outcompete human somatic cells explore content subscription content human tumour cells european economic area intracellular pathways regulated institutional subscriptions read activated v-myc kirsten sarcoma viruses cold spring harb rb/p16ink4a inactivation polymerase iii promoter nucleic acids res histone deacetylase inhibitors
Schema {πΊοΈ}
WebPage:
mainEntity:
headline:Creation of human tumour cells with defined genetic elements
description:During malignant transformation, cancer cells acquire genetic mutations that override the normal mechanisms controlling cellular proliferation. Primary rodent cells are efficiently converted into tumorigenic cells by the coexpression of cooperating oncogenes1,2. However, similar experiments with human cells have consistently failed to yield tumorigenic transformants3,4,5, indicating a fundamental difference in the biology of human and rodent cells. The few reported successes in the creation of human tumour cells have depended on the use of chemical or physical agents to achieve immortalization6, the selection of rare, spontaneously arising immortalized cells7,8,9,10, or the use of an entire viral genome11. We show here that the ectopic expression of the telomerase catalytic subunit (hTERT)12 in combination with two oncogenes (the simian virus 40 large-T oncoprotein and an oncogenic allele of H-ras) results in direct tumorigenic conversion of normal human epithelial and fibroblast cells. These results demonstrate that disruption of the intracellular pathways regulated by large-T, oncogenic ras and telomerase suffices to create a human tumor cell.
datePublished:
dateModified:
pageStart:464
pageEnd:468
sameAs:https://doi.org/10.1038/22780
keywords:
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig4_HTML.gif
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:400
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:William C. Hahn
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Christopher M. Counter
affiliation:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
address:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
type:PostalAddress
type:Organization
name:Duke University Medical Center
address:
name:Duke University Medical Center, Durham, USA
type:PostalAddress
type:Organization
type:Person
name:Ante S. Lundberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Roderick L. Beijersbergen
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Mary W. Brooks
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Robert A. Weinberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Creation of human tumour cells with defined genetic elements
description:During malignant transformation, cancer cells acquire genetic mutations that override the normal mechanisms controlling cellular proliferation. Primary rodent cells are efficiently converted into tumorigenic cells by the coexpression of cooperating oncogenes1,2. However, similar experiments with human cells have consistently failed to yield tumorigenic transformants3,4,5, indicating a fundamental difference in the biology of human and rodent cells. The few reported successes in the creation of human tumour cells have depended on the use of chemical or physical agents to achieve immortalization6, the selection of rare, spontaneously arising immortalized cells7,8,9,10, or the use of an entire viral genome11. We show here that the ectopic expression of the telomerase catalytic subunit (hTERT)12 in combination with two oncogenes (the simian virus 40 large-T oncoprotein and an oncogenic allele of H-ras) results in direct tumorigenic conversion of normal human epithelial and fibroblast cells. These results demonstrate that disruption of the intracellular pathways regulated by large-T, oncogenic ras and telomerase suffices to create a human tumor cell.
datePublished:
dateModified:
pageStart:464
pageEnd:468
sameAs:https://doi.org/10.1038/22780
keywords:
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig4_HTML.gif
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:400
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:William C. Hahn
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Christopher M. Counter
affiliation:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
address:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
type:PostalAddress
type:Organization
name:Duke University Medical Center
address:
name:Duke University Medical Center, Durham, USA
type:PostalAddress
type:Organization
type:Person
name:Ante S. Lundberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Roderick L. Beijersbergen
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Mary W. Brooks
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Robert A. Weinberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:400
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
address:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
type:PostalAddress
name:Duke University Medical Center
address:
name:Duke University Medical Center, Durham, USA
type:PostalAddress
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:William C. Hahn
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
name:Christopher M. Counter
affiliation:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
address:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
type:PostalAddress
type:Organization
name:Duke University Medical Center
address:
name:Duke University Medical Center, Durham, USA
type:PostalAddress
type:Organization
name:Ante S. Lundberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
name:Roderick L. Beijersbergen
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
name:Mary W. Brooks
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
name:Robert A. Weinberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Whitehead Institute for Biomedical Research
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
name:Duke University Medical Center, Durham, USA
name:Whitehead Institute for Biomedical Research
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
name:Whitehead Institute for Biomedical Research
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
name:Whitehead Institute for Biomedical Research
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
name:Whitehead Institute for Biomedical Research
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {π}(99)
- Discover the revenue of https://link.springer.com/article/10.1038/22780?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle
- How much income does https://doi.org/10.1038%2F304596a0 have?
- How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1983Natur.304..596L bring in each month?
- Revenue of http://scholar.google.com/scholar_lookup?&title=Tumorigenic%20conversion%20of%20primary%20embryo%20fibroblasts%20requires%20at%20least%20two%20cooperating%20oncogenes.&journal=Nature&doi=10.1038%2F304596a0&volume=304&pages=596-602&publication_year=1983&author=Land%2CH&author=Parada%2CLF&author=Weinberg%2CRA
- https://doi.org/10.1038%2F304602a0 income
- What are the earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1983Natur.304..602R?
- How much does http://scholar.google.com/scholar_lookup?&title=Adenovirus%20early%20region%201A%20enables%20viral%20and%20cellular%20transforming%20genes%20to%20transform%20primary%20cells%20in%20culture.&journal=Nature&doi=10.1038%2F304602a0&volume=304&pages=602-606&publication_year=1983&author=Ruley%2CH earn?
- Check the income stats for https://doi.org/10.1289%2Fehp.919359
- http://scholar.google.com/scholar_lookup?&title=Senescence%20as%20a%20mode%20of%20tumor%20suppression.&journal=Environ.%20Health%20Perspect.&doi=10.1289%2Fehp.919359&volume=93&pages=59-62&publication_year=1991&author=Sager%2CR's financial summary
- How much profit is https://doi.org/10.1073%2Fpnas.83.22.8659 making per month?
- Learn about the earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1986PNAS...83.8659O
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Suppression%20of%20tumor%20growth%20by%20senescence%20in%20virally%20transformed%20human%20fibroblasts.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.83.22.8659&volume=83&pages=8659-8663&publication_year=1986&author=O%27Brien%2CW&author=Stenman%2CG&author=Sager%2CR?
- What is the monthly revenue of https://doi.org/10.1128%2FMCB.6.10.3410?
- How much income is http://scholar.google.com/scholar_lookup?&title=Activated%20v-myc%20and%20v-ras%20oncogenes%20do%20not%20transform%20normal%20human%20lymphocytes.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.6.10.3410&volume=6&pages=3410-3417&publication_year=1986&author=Stevenson%2CM&author=Volsky%2CDJ earning monthly?
- What's the financial outcome of https://doi.org/10.1002%2F%28SICI%291098-2744%28199804%2921%3A4%3C225%3A%3AAID-MC1%3E3.0.CO%3B2-J?
- How much does http://scholar.google.com/scholar_lookup?&title=Involvement%20of%20tyrosine%20phosphorylation%20of%20p185c-erb%2Fneu%20in%20tumorigenicity%20induced%20by%20X-rays%20and%20the%20neu%20oncogene%20in%20human%20breast%20epithelial%20cells.&journal=Mol.%20Carcinogen.&doi=10.1002%2F%28SICI%291098-2744%28199804%2921%3A4%3C225%3A%3AAID-MC1%3E3.0.CO%3B2-J&volume=21&pages=225-233&publication_year=1998&author=Kang%2CJ-S earn?
- What's https://doi.org/10.1126%2Fscience.3975607's gross income?
- How much income is http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1985Sci...227.1174Y earning monthly?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Transformation%20of%20human%20bronchial%20epithelial%20cells%20transfected%20by%20the%20Harvey%20ras%20oncogene.&journal=Science&doi=10.1126%2Fscience.3975607&volume=227&pages=1174-1179&publication_year=1985&author=Yakum%2CGH
- How much does https://doi.org/10.1126%2Fscience.2579430 rake in every month?
- http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1985Sci...227.1250R's total income per month
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Neoplastic%20transformation%20of%20human%20epidermal%20keratinocytes%20by%20AD12-SV40%20and%20Kirsten%20sarcoma%20viruses.&journal=Science&doi=10.1126%2Fscience.2579430&volume=227&pages=1250-1252&publication_year=1985&author=Rhim%2CJS produce monthly?
- https://doi.org/10.1073%2Fpnas.86.1.187 income
- Get to know what's the income of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1989PNAS...86..187H
- How much does http://scholar.google.com/scholar_lookup?&title=Malignant%20transformation%20of%20human%20fibroblasts%20caused%20by%20expression%20of%20a%20transfected%20T24%20HRAS%20oncogene.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.86.1.187&volume=86&pages=187-181&publication_year=1989&author=Hurlin%2CPJ&author=Maher%2CVM&author=McCormick%2CJJ earn?
- What's http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9772298's gross income?
- How much profit is http://scholar.google.com/scholar_lookup?&title=Effect%20of%20oncogene%20expression%20on%20telomerase%20activation%20and%20telomere%20length%20in%20human%20endothelial%2C%20fibroblast%20and%20prostate%20epithelial%20cells.&journal=Int.%20J.%20Oncol.&volume=13&pages=1043-1048&publication_year=1998&author=Burger%2CAM making per month?
- Income figures for https://doi.org/10.1038%2F29093
- Check the income stats for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1998Natur.394..588F
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Transformation%20of%20primary%20human%20endothelial%20cells%20by%20Kaposi%27s%20sarcoma-associated%20herpesvirus.&journal=Nature&doi=10.1038%2F29093&volume=394&pages=588-592&publication_year=1998&author=Flore%2CA each month?
- Check the income stats for https://doi.org/10.1016%2FS0092-8674%2800%2981123-X
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Reversing%20time%3A%20origin%20of%20telomerase.&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981123-X&volume=92&pages=587-590&publication_year=1998&author=Nakamura%2CTM&author=Cech%2CTR
- What's the profit of https://doi.org/10.1016%2FS0959-8049%2897%2900060-9?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Telomere%20structure%20and%20telomerase%20expression%20during%20mouse%20development%20and%20tumorigenesis.&journal=Eur.%20J.%20Cancer&doi=10.1016%2FS0959-8049%2897%2900060-9&volume=33&pages=792-800&publication_year=1997&author=Kipling%2CD?
- What's the financial gain of https://doi.org/10.1126%2Fscience.7605428?
- What is the earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1994Sci...266.2011K?
- How much income does http://scholar.google.com/scholar_lookup?&title=Specific%20association%20of%20human%20telomerase%20activity%20with%20immortal%20cells%20and%20cancer.&journal=Science&doi=10.1126%2Fscience.7605428&volume=266&pages=2011-2015&publication_year=1994&author=Kim%2CNW have?
- How much profit does https://doi.org/10.1016%2FS0959-8049%2897%2900062-2 generate?
- http://scholar.google.com/scholar_lookup?&title=Asurvey%20of%20telomerase%20activity%20in%20human%20cancer.&journal=Eur.%20J.%20Cancer&doi=10.1016%2FS0959-8049%2897%2900062-2&volume=33&pages=787-791&publication_year=1997&author=Shay%2CJW&author=Bacchetti%2CS income
- How much does https://doi.org/10.1101%2FSQB.1994.059.01.035 earn?
- What's http://scholar.google.com/scholar_lookup?&title=Telomerase%2C%20cell%20immortality%2C%20and%20cancer.&journal=Cold%20Spring%20Harb.%20Symp.%20Quant.%20Biol.&doi=10.1101%2FSQB.1994.059.01.035&volume=59&pages=307-315&publication_year=1994&author=Harley%2CCB's gross income?
- How profitable is https://doi.org/10.1126%2Fscience.279.5349.349?
- How much money does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1998Sci...279..349B make?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Extension%20of%20life-span%20by%20introduction%20of%20telomerase%20into%20normal%20human%20cells.&journal=Science&doi=10.1126%2Fscience.279.5349.349&volume=279&pages=349-352&publication_year=1998&author=Bodnar%2CAG generate?
- How much money does https://doi.org/10.1038%2F23962 generate?
- How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1998Natur.396...84K earn?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Both%20Rb%2Fp16INK4a%20inactivation%20and%20telomerase%20activity%20are%20required%20to%20immortalize%20human%20epithelial%20cells.&journal=Nature&doi=10.1038%2F23962&volume=396&pages=84-88&publication_year=1998&author=Kiyono%2CT bring in?
- How much does https://doi.org/10.1073%2Fpnas.96.7.3339 pull in monthly?
- Get to know http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1999PNAS...96.3339L's earnings
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Crisis%20intervention%3A%20the%20role%20of%20telomerase.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.96.7.3339&volume=96&pages=3339-3341&publication_year=1999&author=Lustig%2CAJ bring in?
- How much money does https://doi.org/10.1016%2FS0092-8674%2800%2981902-9 make?
- How much does http://scholar.google.com/scholar_lookup?&title=Oncogenic%20ras%20provokes%20premature%20cell%20senescence%20associated%20with%20accumulation%20of%20p53%20nd%20p16ink4a.&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981902-9&volume=88&pages=593-602&publication_year=1997&author=Serrano%2CM&author=Lin%2CAW&author=McCurrach%2CME&author=Beach%2CD&author=Lowe%2CSW generate monthly?
- What's the income generated by https://doi.org/10.1073%2Fpnas.95.25.14723 each month?
- How much money does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1998PNAS...9514723C generate?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Dissociation%20among%20in%20vitro%20telomerase%20activity%2C%20telomere%20maintenance%2C%20and%20cellular%20immortalization.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.95.25.14723&volume=95&pages=14723-14728&publication_year=1998&author=Counter%2CCM?
- What's the financial gain of https://doi.org/10.1038%2F5063?
- What are the earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1999Natur.399..115M?
- How much money does http://scholar.google.com/scholar_lookup?&title=Absence%20of%20cancer-associated%20changes%20in%20human%20fibroblasts%20immortalized%20with%20telomerase.&journal=Nature%20Genet.&doi=10.1038%2F5063&volume=21&pages=115-118&publication_year=1999&author=Morales%2CCP make?
- What's the financial gain of https://doi.org/10.1128%2FMCB.18.3.1408?
- How much does http://scholar.google.com/scholar_lookup?&title=The%20J%20domain%20of%20simian%20virus%2040%20large%20T%20antigen%20is%20required%20to%20functionally%20inactivate%20RB%20family%20proteins.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.18.3.1408&volume=18&pages=1408-1415&publication_year=1998&author=Zalvide%2CJ&author=Stubdal%2CH&author=DeCaprio%2CJA pull in?
- How much does https://doi.org/10.1128%2FMCB.18.3.1331 make?
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Simian%20virus%2040%20large%20T%20antigen%20interacts%20with%20human%20TFIIB-related%20factor%20and%20small%20nuclear%20RNA-activating%20protein%20complex%20for%20transcriptional%20activation%20of%20TATA-containing%20polymerase%20III%20promoter.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.18.3.1331&volume=18&pages=1331-1338&publication_year=1998&author=Damania%2CB&author=Mital%2CR&author=Alwine%2CJC
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Immortalized%20cells%20with%20no%20detectable%20telomerase%20activity.%20A%20review.&journal=Biochemistry%20%28Mosc.%29&volume=62&pages=1254-1262&publication_year=1997&author=Reddel%2CRR&author=Bryan%2CTM&author=Murnane%2CJP?
- What are the earnings of https://doi.org/10.1038%2F5056?
- Get to know http://scholar.google.com/scholar_lookup?&title=Telomerase%20expression%20in%20human%20somatic%20cells%20does%20not%20induce%20changes%20associated%20with%20a%20transformed%20phenotype.&journal=Nature%20Genet.&doi=10.1038%2F5056&volume=21&pages=111-114&publication_year=1999&author=Jiang%2CX-R's earnings
- Profit of https://doi.org/10.1128%2FMCB.6.4.1204
- http://scholar.google.com/scholar_lookup?&title=Recombinant%20retroviruses%20encoding%20simian%20virus%2040%20large%20T%20antigen%20and%20polyomavirus%20large%20and%20middle%20T%20antigens.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.6.4.1204&volume=6&pages=1204-1217&publication_year=1986&author=Jat%2CPS&author=Cepko%2CCL&author=Mulligan%2CRC&author=Sharp%2CPA's revenue stream
- What's the monthly money flow for https://doi.org/10.1093%2Fnar%2F25.13.2595?
- http://scholar.google.com/scholar_lookup?&title=Advances%20in%20quantification%20and%20characterization%20of%20telomerase%20activity%20by%20the%20telomeric%20repeat%20amplification%20protocol%20%28TRAP%29.&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2F25.13.2595&volume=25&pages=2595-2597&publication_year=1997&author=Kim%2CNW&author=Wu%2CF's financial summary
- How much cash flow does https://doi.org/10.1073%2Fpnas.77.2.1039 have monthly?
- What are the total earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1980PNAS...77.1039C?
- See how much http://scholar.google.com/scholar_lookup?&title=Correlation%20of%20patterns%20of%20anchorage-independent%20growth%20with%20in%20vivo%20behavior%20of%20cells%20from%20a%20murine%20fibrosarcoma.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.77.2.1039&volume=77&pages=1039-1043&publication_year=1980&author=Cifone%2CMA&author=Fidler%2CIJ makes per month
- Learn about the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7815516
- How much income is http://www.ncbi.nlm.nih.gov/pmc/articles/PMC188715 earning monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Potential%20role%20of%20natural%20killer%20cells%20in%20controlling%20tumorigenesis%20by%20human%20T-cell%20leukemia%20viruses.&journal=J.%20Virol.&volume=69&pages=1328-1333&publication_year=1995&author=Feuer%2CG bring in each month?
- What's the monthly income of https://citation-needed.springer.com/v2/references/10.1038/22780?format=refman&flavour=references?
- Get to know what's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=William%20C.%20Hahn
- How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22William%20C.%20Hahn%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
- Profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Christopher%20M.%20Counter
- Explore the financials of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Christopher%20M.%20Counter%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ante%20S.%20Lundberg
- How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ante%20S.%20Lundberg%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Roderick%20L.%20Beijersbergen earn?
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Roderick%20L.%20Beijersbergen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's total income per month
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Mary%20W.%20Brooks make?
- Get to know what's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Mary%20W.%20Brooks%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Robert%20A.%20Weinberg's financial summary
- What's the profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Robert%20A.%20Weinberg%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Discover the revenue of https://s100.copyright.com/AppDispatchServlet?title=Creation%20of%20human%20tumour%20cells%20with%20defined%20genetic%20elements&author=William%20C.%20Hahn%20et%20al&contentID=10.1038%2F22780©right=Macmillan%20Magazines%20Ltd.&publication=0028-0836&publicationDate=1999-07-29&publisherName=SpringerNature&orderBeanReset=true
- How much money does https://citation-needed.springer.com/v2/references/10.1038/22780?format=refman&flavour=citation generate?
- How much does https://doi.org/10.1186/s12935-023-03041-2 bring in each month?
- Get to know what's the income of https://doi.org/10.1007/s13577-023-00925-3
- Monthly income for https://doi.org/10.1186/s13058-022-01538-8
- How profitable is https://doi.org/10.1186/s12859-022-04788-7?
- Income figures for https://doi.org/10.1186/s13148-022-01370-z
- Explore the financials of https://www.protocols.io/
- How much money does https://www.natureindex.com/ generate?
- What is the earnings of http://www.naturechina.com?
- How much revenue does https://www.natureasia.com/ja-jp generate?
Analytics and Tracking {π}
- Google Tag Manager
Libraries {π}
- Prism.js
- Zoom.js
Emails and Hosting {βοΈ}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {π¦}
- Crossref