
NATURE . COM {
}
Title:
Creation of human tumour cells with defined genetic elements | Nature
Description:
During malignant transformation, cancer cells acquire genetic mutations that override the normal mechanisms controlling cellular proliferation. Primary rodent cells are efficiently converted into tumorigenic cells by the coexpression of cooperating oncogenes1,2. However, similar experiments with human cells have consistently failed to yield tumorigenic transformants3,4,5, indicating a fundamental difference in the biology of human and rodent cells. The few reported successes in the creation of human tumour cells have depended on the use of chemical or physical agents to achieve immortalization6, the selection of rare, spontaneously arising immortalized cells7,8,9,10, or the use of an entire viral genome11. We show here that the ectopic expression of the telomerase catalytic subunit (hTERT)12 in combination with two oncogenes (the simian virus 40 large-T oncoprotein and an oncogenic allele of H-ras) results in direct tumorigenic conversion of normal human epithelial and fibroblast cells. These results demonstrate that disruption of the intracellular pathways regulated by large-T, oncogenic ras and telomerase suffices to create a human tumor cell.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {π}
- Science
- Education
- Non-Profit & Charity
Content Management System {π}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {π}
What is the average monthly size of nature.com audience?
π Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {πΈ}
Display Ads {π―}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {π°}
Display Ads {π―}
$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.
Keywords {π}
article, scholar, google, cas, human, nature, cells, cancer, telomerase, ads, cell, access, usa, research, content, cookies, hahn, counter, weinberg, activity, privacy, william, lundberg, transformation, normal, expression, epithelial, fibroblasts, proc, natl, acad, sci, mol, biol, data, tumour, christopher, ante, robert, primary, tumorigenic, oncogenes, simian, virus, ras, tumor, senescence, oncogene, science, large,
Topics {βοΈ}
nature portfolio permissions reprints privacy policy advertising social media mouse development biomedical research nature genet subscribe nature middle nature 304 nature 394 nature 396 nature 400 nature human tfiib-related factor dana-farber cancer institute personal data author correspondence springerlink instant access data protection permissions normal human epithelial defined genetic elements entire viral genome11 privacy human fibroblasts caused human fibroblasts immortalized normal human cells harvard medical school human tumor cell transform primary cells cellular transforming genes prostate epithelial cells human epidermal keratinocytes normal epithelium outcompete human somatic cells explore content subscription content human tumour cells european economic area intracellular pathways regulated institutional subscriptions read activated v-myc kirsten sarcoma viruses cold spring harb rb/p16ink4a inactivation polymerase iii promoter nucleic acids res histone deacetylase inhibitors
Schema {πΊοΈ}
WebPage:
mainEntity:
headline:Creation of human tumour cells with defined genetic elements
description:During malignant transformation, cancer cells acquire genetic mutations that override the normal mechanisms controlling cellular proliferation. Primary rodent cells are efficiently converted into tumorigenic cells by the coexpression of cooperating oncogenes1,2. However, similar experiments with human cells have consistently failed to yield tumorigenic transformants3,4,5, indicating a fundamental difference in the biology of human and rodent cells. The few reported successes in the creation of human tumour cells have depended on the use of chemical or physical agents to achieve immortalization6, the selection of rare, spontaneously arising immortalized cells7,8,9,10, or the use of an entire viral genome11. We show here that the ectopic expression of the telomerase catalytic subunit (hTERT)12 in combination with two oncogenes (the simian virus 40 large-T oncoprotein and an oncogenic allele of H-ras) results in direct tumorigenic conversion of normal human epithelial and fibroblast cells. These results demonstrate that disruption of the intracellular pathways regulated by large-T, oncogenic ras and telomerase suffices to create a human tumor cell.
datePublished:
dateModified:
pageStart:464
pageEnd:468
sameAs:https://doi.org/10.1038/22780
keywords:
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig4_HTML.gif
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:400
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:William C. Hahn
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Christopher M. Counter
affiliation:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
address:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
type:PostalAddress
type:Organization
name:Duke University Medical Center
address:
name:Duke University Medical Center, Durham, USA
type:PostalAddress
type:Organization
type:Person
name:Ante S. Lundberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Roderick L. Beijersbergen
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Mary W. Brooks
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Robert A. Weinberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Creation of human tumour cells with defined genetic elements
description:During malignant transformation, cancer cells acquire genetic mutations that override the normal mechanisms controlling cellular proliferation. Primary rodent cells are efficiently converted into tumorigenic cells by the coexpression of cooperating oncogenes1,2. However, similar experiments with human cells have consistently failed to yield tumorigenic transformants3,4,5, indicating a fundamental difference in the biology of human and rodent cells. The few reported successes in the creation of human tumour cells have depended on the use of chemical or physical agents to achieve immortalization6, the selection of rare, spontaneously arising immortalized cells7,8,9,10, or the use of an entire viral genome11. We show here that the ectopic expression of the telomerase catalytic subunit (hTERT)12 in combination with two oncogenes (the simian virus 40 large-T oncoprotein and an oncogenic allele of H-ras) results in direct tumorigenic conversion of normal human epithelial and fibroblast cells. These results demonstrate that disruption of the intracellular pathways regulated by large-T, oncogenic ras and telomerase suffices to create a human tumor cell.
datePublished:
dateModified:
pageStart:464
pageEnd:468
sameAs:https://doi.org/10.1038/22780
keywords:
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F22780/MediaObjects/41586_1999_Article_BF22780_Fig4_HTML.gif
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:400
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:William C. Hahn
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Christopher M. Counter
affiliation:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
address:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
type:PostalAddress
type:Organization
name:Duke University Medical Center
address:
name:Duke University Medical Center, Durham, USA
type:PostalAddress
type:Organization
type:Person
name:Ante S. Lundberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Roderick L. Beijersbergen
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Mary W. Brooks
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
type:Person
name:Robert A. Weinberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:400
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
address:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
type:PostalAddress
name:Duke University Medical Center
address:
name:Duke University Medical Center, Durham, USA
type:PostalAddress
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:William C. Hahn
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
name:Christopher M. Counter
affiliation:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
address:
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
type:PostalAddress
type:Organization
name:Duke University Medical Center
address:
name:Duke University Medical Center, Durham, USA
type:PostalAddress
type:Organization
name:Ante S. Lundberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School
address:
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
name:Roderick L. Beijersbergen
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
name:Mary W. Brooks
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
name:Robert A. Weinberg
affiliation:
name:Whitehead Institute for Biomedical Research
address:
name:Whitehead Institute for Biomedical Research
type:PostalAddress
type:Organization
name:Massachusetts Institute of Technology
address:
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Whitehead Institute for Biomedical Research
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
name:Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
name:Duke University Medical Center, Durham, USA
name:Whitehead Institute for Biomedical Research
name:Department of Adult Oncology, Departments of Medicine, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
name:Whitehead Institute for Biomedical Research
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
name:Whitehead Institute for Biomedical Research
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
name:Whitehead Institute for Biomedical Research
name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {π}(99)
- What are the total earnings of https://link.springer.com/article/10.1038/22780?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle?
- Profit of https://doi.org/10.1038%2F304596a0
- What's the income of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1983Natur.304..596L?
- http://scholar.google.com/scholar_lookup?&title=Tumorigenic%20conversion%20of%20primary%20embryo%20fibroblasts%20requires%20at%20least%20two%20cooperating%20oncogenes.&journal=Nature&doi=10.1038%2F304596a0&volume=304&pages=596-602&publication_year=1983&author=Land%2CH&author=Parada%2CLF&author=Weinberg%2CRA's revenue stream
- How much does https://doi.org/10.1038%2F304602a0 gross monthly?
- Learn how profitable http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1983Natur.304..602R is on a monthly basis
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Adenovirus%20early%20region%201A%20enables%20viral%20and%20cellular%20transforming%20genes%20to%20transform%20primary%20cells%20in%20culture.&journal=Nature&doi=10.1038%2F304602a0&volume=304&pages=602-606&publication_year=1983&author=Ruley%2CH have monthly?
- What's the income generated by https://doi.org/10.1289%2Fehp.919359 each month?
- Get to know http://scholar.google.com/scholar_lookup?&title=Senescence%20as%20a%20mode%20of%20tumor%20suppression.&journal=Environ.%20Health%20Perspect.&doi=10.1289%2Fehp.919359&volume=93&pages=59-62&publication_year=1991&author=Sager%2CR's earnings
- How much money does https://doi.org/10.1073%2Fpnas.83.22.8659 make?
- Financial intake of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1986PNAS...83.8659O
- How much profit is http://scholar.google.com/scholar_lookup?&title=Suppression%20of%20tumor%20growth%20by%20senescence%20in%20virally%20transformed%20human%20fibroblasts.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.83.22.8659&volume=83&pages=8659-8663&publication_year=1986&author=O%27Brien%2CW&author=Stenman%2CG&author=Sager%2CR making per month?
- How much revenue does https://doi.org/10.1128%2FMCB.6.10.3410 bring in?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Activated%20v-myc%20and%20v-ras%20oncogenes%20do%20not%20transform%20normal%20human%20lymphocytes.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.6.10.3410&volume=6&pages=3410-3417&publication_year=1986&author=Stevenson%2CM&author=Volsky%2CDJ?
- Check the income stats for https://doi.org/10.1002%2F%28SICI%291098-2744%28199804%2921%3A4%3C225%3A%3AAID-MC1%3E3.0.CO%3B2-J
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Involvement%20of%20tyrosine%20phosphorylation%20of%20p185c-erb%2Fneu%20in%20tumorigenicity%20induced%20by%20X-rays%20and%20the%20neu%20oncogene%20in%20human%20breast%20epithelial%20cells.&journal=Mol.%20Carcinogen.&doi=10.1002%2F%28SICI%291098-2744%28199804%2921%3A4%3C225%3A%3AAID-MC1%3E3.0.CO%3B2-J&volume=21&pages=225-233&publication_year=1998&author=Kang%2CJ-S bring in?
- What are the earnings of https://doi.org/10.1126%2Fscience.3975607?
- What is the earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1985Sci...227.1174Y?
- How much money does http://scholar.google.com/scholar_lookup?&title=Transformation%20of%20human%20bronchial%20epithelial%20cells%20transfected%20by%20the%20Harvey%20ras%20oncogene.&journal=Science&doi=10.1126%2Fscience.3975607&volume=227&pages=1174-1179&publication_year=1985&author=Yakum%2CGH make?
- How much income does https://doi.org/10.1126%2Fscience.2579430 have?
- How much money does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1985Sci...227.1250R make?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Neoplastic%20transformation%20of%20human%20epidermal%20keratinocytes%20by%20AD12-SV40%20and%20Kirsten%20sarcoma%20viruses.&journal=Science&doi=10.1126%2Fscience.2579430&volume=227&pages=1250-1252&publication_year=1985&author=Rhim%2CJS
- How much revenue does https://doi.org/10.1073%2Fpnas.86.1.187 bring in?
- Profit of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1989PNAS...86..187H
- http://scholar.google.com/scholar_lookup?&title=Malignant%20transformation%20of%20human%20fibroblasts%20caused%20by%20expression%20of%20a%20transfected%20T24%20HRAS%20oncogene.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.86.1.187&volume=86&pages=187-181&publication_year=1989&author=Hurlin%2CPJ&author=Maher%2CVM&author=McCormick%2CJJ's total income per month
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9772298 generate?
- How much does http://scholar.google.com/scholar_lookup?&title=Effect%20of%20oncogene%20expression%20on%20telomerase%20activation%20and%20telomere%20length%20in%20human%20endothelial%2C%20fibroblast%20and%20prostate%20epithelial%20cells.&journal=Int.%20J.%20Oncol.&volume=13&pages=1043-1048&publication_year=1998&author=Burger%2CAM rake in every month?
- https://doi.org/10.1038%2F29093 income
- What's the income of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1998Natur.394..588F?
- How much does http://scholar.google.com/scholar_lookup?&title=Transformation%20of%20primary%20human%20endothelial%20cells%20by%20Kaposi%27s%20sarcoma-associated%20herpesvirus.&journal=Nature&doi=10.1038%2F29093&volume=394&pages=588-592&publication_year=1998&author=Flore%2CA bring in each month?
- What's the profit of https://doi.org/10.1016%2FS0092-8674%2800%2981123-X?
- See how much http://scholar.google.com/scholar_lookup?&title=Reversing%20time%3A%20origin%20of%20telomerase.&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981123-X&volume=92&pages=587-590&publication_year=1998&author=Nakamura%2CTM&author=Cech%2CTR makes per month
- Check the income stats for https://doi.org/10.1016%2FS0959-8049%2897%2900060-9
- http://scholar.google.com/scholar_lookup?&title=Telomere%20structure%20and%20telomerase%20expression%20during%20mouse%20development%20and%20tumorigenesis.&journal=Eur.%20J.%20Cancer&doi=10.1016%2FS0959-8049%2897%2900060-9&volume=33&pages=792-800&publication_year=1997&author=Kipling%2CD's financial summary
- Revenue of https://doi.org/10.1126%2Fscience.7605428
- Revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1994Sci...266.2011K
- How much profit does http://scholar.google.com/scholar_lookup?&title=Specific%20association%20of%20human%20telomerase%20activity%20with%20immortal%20cells%20and%20cancer.&journal=Science&doi=10.1126%2Fscience.7605428&volume=266&pages=2011-2015&publication_year=1994&author=Kim%2CNW generate?
- What's the financial intake of https://doi.org/10.1016%2FS0959-8049%2897%2900062-2?
- How much does http://scholar.google.com/scholar_lookup?&title=Asurvey%20of%20telomerase%20activity%20in%20human%20cancer.&journal=Eur.%20J.%20Cancer&doi=10.1016%2FS0959-8049%2897%2900062-2&volume=33&pages=787-791&publication_year=1997&author=Shay%2CJW&author=Bacchetti%2CS generate monthly?
- https://doi.org/10.1101%2FSQB.1994.059.01.035 income
- What's http://scholar.google.com/scholar_lookup?&title=Telomerase%2C%20cell%20immortality%2C%20and%20cancer.&journal=Cold%20Spring%20Harb.%20Symp.%20Quant.%20Biol.&doi=10.1101%2FSQB.1994.059.01.035&volume=59&pages=307-315&publication_year=1994&author=Harley%2CCB's gross income?
- Learn how profitable https://doi.org/10.1126%2Fscience.279.5349.349 is on a monthly basis
- What's the financial gain of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1998Sci...279..349B?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Extension%20of%20life-span%20by%20introduction%20of%20telomerase%20into%20normal%20human%20cells.&journal=Science&doi=10.1126%2Fscience.279.5349.349&volume=279&pages=349-352&publication_year=1998&author=Bodnar%2CAG?
- How much income does https://doi.org/10.1038%2F23962 have?
- Financial intake of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1998Natur.396...84K
- How much income is http://scholar.google.com/scholar_lookup?&title=Both%20Rb%2Fp16INK4a%20inactivation%20and%20telomerase%20activity%20are%20required%20to%20immortalize%20human%20epithelial%20cells.&journal=Nature&doi=10.1038%2F23962&volume=396&pages=84-88&publication_year=1998&author=Kiyono%2CT earning monthly?
- How much profit does https://doi.org/10.1073%2Fpnas.96.7.3339 make?
- What's the financial outcome of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1999PNAS...96.3339L?
- How much does http://scholar.google.com/scholar_lookup?&title=Crisis%20intervention%3A%20the%20role%20of%20telomerase.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.96.7.3339&volume=96&pages=3339-3341&publication_year=1999&author=Lustig%2CAJ generate monthly?
- How much profit is https://doi.org/10.1016%2FS0092-8674%2800%2981902-9 making per month?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Oncogenic%20ras%20provokes%20premature%20cell%20senescence%20associated%20with%20accumulation%20of%20p53%20nd%20p16ink4a.&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981902-9&volume=88&pages=593-602&publication_year=1997&author=Serrano%2CM&author=Lin%2CAW&author=McCurrach%2CME&author=Beach%2CD&author=Lowe%2CSW generate?
- What's the profit of https://doi.org/10.1073%2Fpnas.95.25.14723?
- How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1998PNAS...9514723C pull in monthly?
- Get to know http://scholar.google.com/scholar_lookup?&title=Dissociation%20among%20in%20vitro%20telomerase%20activity%2C%20telomere%20maintenance%2C%20and%20cellular%20immortalization.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.95.25.14723&volume=95&pages=14723-14728&publication_year=1998&author=Counter%2CCM's earnings
- https://doi.org/10.1038%2F5063's financial summary
- What's http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1999Natur.399..115M's gross income?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Absence%20of%20cancer-associated%20changes%20in%20human%20fibroblasts%20immortalized%20with%20telomerase.&journal=Nature%20Genet.&doi=10.1038%2F5063&volume=21&pages=115-118&publication_year=1999&author=Morales%2CCP?
- Learn how profitable https://doi.org/10.1128%2FMCB.18.3.1408 is on a monthly basis
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=The%20J%20domain%20of%20simian%20virus%2040%20large%20T%20antigen%20is%20required%20to%20functionally%20inactivate%20RB%20family%20proteins.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.18.3.1408&volume=18&pages=1408-1415&publication_year=1998&author=Zalvide%2CJ&author=Stubdal%2CH&author=DeCaprio%2CJA?
- Learn how profitable https://doi.org/10.1128%2FMCB.18.3.1331 is on a monthly basis
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Simian%20virus%2040%20large%20T%20antigen%20interacts%20with%20human%20TFIIB-related%20factor%20and%20small%20nuclear%20RNA-activating%20protein%20complex%20for%20transcriptional%20activation%20of%20TATA-containing%20polymerase%20III%20promoter.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.18.3.1331&volume=18&pages=1331-1338&publication_year=1998&author=Damania%2CB&author=Mital%2CR&author=Alwine%2CJC?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Immortalized%20cells%20with%20no%20detectable%20telomerase%20activity.%20A%20review.&journal=Biochemistry%20%28Mosc.%29&volume=62&pages=1254-1262&publication_year=1997&author=Reddel%2CRR&author=Bryan%2CTM&author=Murnane%2CJP each month?
- Find out how much https://doi.org/10.1038%2F5056 earns monthly
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Telomerase%20expression%20in%20human%20somatic%20cells%20does%20not%20induce%20changes%20associated%20with%20a%20transformed%20phenotype.&journal=Nature%20Genet.&doi=10.1038%2F5056&volume=21&pages=111-114&publication_year=1999&author=Jiang%2CX-R?
- What is the monthly revenue of https://doi.org/10.1128%2FMCB.6.4.1204?
- How much income does http://scholar.google.com/scholar_lookup?&title=Recombinant%20retroviruses%20encoding%20simian%20virus%2040%20large%20T%20antigen%20and%20polyomavirus%20large%20and%20middle%20T%20antigens.&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.6.4.1204&volume=6&pages=1204-1217&publication_year=1986&author=Jat%2CPS&author=Cepko%2CCL&author=Mulligan%2CRC&author=Sharp%2CPA have?
- What's the profit of https://doi.org/10.1093%2Fnar%2F25.13.2595?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Advances%20in%20quantification%20and%20characterization%20of%20telomerase%20activity%20by%20the%20telomeric%20repeat%20amplification%20protocol%20%28TRAP%29.&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2F25.13.2595&volume=25&pages=2595-2597&publication_year=1997&author=Kim%2CNW&author=Wu%2CF have monthly?
- How much cash flow does https://doi.org/10.1073%2Fpnas.77.2.1039 have monthly?
- Income figures for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1980PNAS...77.1039C
- How much does http://scholar.google.com/scholar_lookup?&title=Correlation%20of%20patterns%20of%20anchorage-independent%20growth%20with%20in%20vivo%20behavior%20of%20cells%20from%20a%20murine%20fibrosarcoma.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.77.2.1039&volume=77&pages=1039-1043&publication_year=1980&author=Cifone%2CMA&author=Fidler%2CIJ pull in?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7815516 bring in?
- Get to know http://www.ncbi.nlm.nih.gov/pmc/articles/PMC188715's earnings
- How much profit is http://scholar.google.com/scholar_lookup?&title=Potential%20role%20of%20natural%20killer%20cells%20in%20controlling%20tumorigenesis%20by%20human%20T-cell%20leukemia%20viruses.&journal=J.%20Virol.&volume=69&pages=1328-1333&publication_year=1995&author=Feuer%2CG making per month?
- Monthly income for https://citation-needed.springer.com/v2/references/10.1038/22780?format=refman&flavour=references
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=William%20C.%20Hahn earn?
- What's the total monthly financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22William%20C.%20Hahn%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Christopher%20M.%20Counter's revenue stream
- Income figures for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Christopher%20M.%20Counter%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Monthly income for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ante%20S.%20Lundberg
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ante%20S.%20Lundberg%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in monthly?
- What is the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Roderick%20L.%20Beijersbergen?
- Learn how profitable https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Roderick%20L.%20Beijersbergen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en is on a monthly basis
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Mary%20W.%20Brooks earn?
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Mary%20W.%20Brooks%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Robert%20A.%20Weinberg bring in each month?
- How profitable is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Robert%20A.%20Weinberg%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://s100.copyright.com/AppDispatchServlet?title=Creation%20of%20human%20tumour%20cells%20with%20defined%20genetic%20elements&author=William%20C.%20Hahn%20et%20al&contentID=10.1038%2F22780©right=Macmillan%20Magazines%20Ltd.&publication=0028-0836&publicationDate=1999-07-29&publisherName=SpringerNature&orderBeanReset=true net monthly?
- Revenue of https://citation-needed.springer.com/v2/references/10.1038/22780?format=refman&flavour=citation
- What's the revenue for https://doi.org/10.1186/s12935-023-03041-2?
- Learn how profitable https://doi.org/10.1007/s13577-023-00925-3 is on a monthly basis
- How much money does https://doi.org/10.1186/s13058-022-01538-8 generate?
- What's the financial gain of https://doi.org/10.1186/s12859-022-04788-7?
- What are the total earnings of https://doi.org/10.1186/s13148-022-01370-z?
- https://www.protocols.io/'s revenue stream
- What's the financial outcome of https://www.natureindex.com/?
- How much profit is http://www.naturechina.com making per month?
- How much does https://www.natureasia.com/ja-jp pull in?
Analytics and Tracking {π}
- Google Tag Manager
Libraries {π}
- Prism.js
- Zoom.js
Emails and Hosting {βοΈ}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {π¦}
- Crossref