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Complex patterns of ETS gene alteration arise during cancer development in the human prostate | Oncogene
Description:
An ERG gene ‘break-apart’ fluorescence in situ hybridization (FISH) assay has been used to screen whole-mount prostatectomy specimens for rearrangements at the ERG locus. In cancers containing ERG alterations the observed pattern of changes was often complex. Different categories of ERG gene alteration were found either together in a single cancerous region or within separate foci of cancer in the same prostate slice. In some cases the juxtaposition of particular patterns of ERG alterations suggested possible mechanisms of tumour progression. Prostates harbouring ERG alterations commonly also contained cancer that lacked rearrangements of the ERG gene. A single trans-urethral resection of the prostate specimen examined harboured both ERG and ETV1 gene rearrangements demonstrating that the observed complexity may, at least in part, be explained by multiple ETS gene alterations arising independently in a single prostate. In a search for possible precursor lesions clonal ERG rearrangements were found both in high grade prostatic intraepithelial neoplasia (PIN) and in atypical in situ epithelial lesions consistent with the diagnosis of low grade PIN. Our observations support the view that ERG gene alterations represent an initiating event that promotes clonal expansion initially to form regions of epithelial atypia. The complex patterns of ERG alteration found in prostatectomy specimens have important implications for the design of experiments investigating the clinical significance and mechanism of development of individual prostate cancers.
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Keywords {🔍}
cancer, prostate, pubmed, article, google, scholar, cas, gene, erg, nature, oncogene, prostatic, supplementary, access, fusion, tmprsserg, central, research, figure, jpg, neoplasia, pathol, expression, content, human, foster, prostatectomy, alterations, res, cookies, data, information, clark, intraepithelial, clinical, factor, heterogeneity, tmprss, carcinoma, privacy, patterns, ets, development, attard, jhavar, scardino, fisher, specimens, rearrangements, radical,
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nature portfolio permissions reprints privacy policy nature advertising social media author information authors cancer research uk tmprss2–erg fusion transcripts cancer research androgen-dependent prostate cancer single trans-urethral resection author correspondence docetaxel-resistant prostate cancer oncogenic ets factors erg gene fusion springerlink instant access permissions gene expression profiling c-myc oncogene amplification breast tumor subtypes erg gene alteration erg gene ‘break tmprss2/erg fusions cancer development personal data gene expression alterations erg alterations suggested long-term outcome gene expression correlates privacy prostate cancers arising human prostate cancer data protection single cancerous region issue learn paired hgpin lesions preceding development transcription factor srf localized prostate cancer lethal prostate cancer prostate cancer precursors early prostate cancer prostate cancer cells aggressive prostate cancer human prostate carcinoma gene expression patterns erg alteration found etv4 splice variants prostate needle biopsy
Questions {❓}
- C-MYC, HIF-1α, ERG, TKT, and GSTP1: an Axis in Prostate Cancer?
- Zonal origin of prostatic adenocarcinoma: are there biologic differences between transition zone and peripheral zone adenocarcinomas of the prostate gland?
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name:Institute of Cancer Research, Male Urological Cancer Research Centre, Sutton, UK
name:The Royal Marsden NHS Trust Foundation Hospital, Sutton, UK
name:Institute of Cancer Research, Male Urological Cancer Research Centre, Sutton, UK
name:The Royal Marsden NHS Trust Foundation Hospital, Sutton, UK
name:Department of Urology, Memorial Sloan-Kettering Cancer Centre, New York, USA
name:Wolfson Institute of Preventive Medicine, University of London, London, UK
name:Wolfson Institute of Preventive Medicine, University of London, London, UK
name:Institute of Cancer Research, Male Urological Cancer Research Centre, Sutton, UK
name:Department of Pathology, The University of Liverpool, Royal Liverpool University Hospital, Liverpool, UK
name:The Orchid Tissue Laboratory, St Bartholomew's Hospital, London, UK
name:Laboratory of Molecular Oncology, Medical Faculty, Ruprecht-Karls-University, Heidelberg, Germany
name:Institute of Cancer Research, Male Urological Cancer Research Centre, Sutton, UK
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