NATURE . COM {}

Matching Content Categories {📚}

• Social Networks
• Education
• Science

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$63,100 per month
According to our algorithms, Nature.com's monthly online income from display advertising ranges from $42,042 to $115,616.

Keywords {🔍}

cancer, breast, res, nature, mol, growth, elizalde, access, baserga, article, biol, oncogene, receptor, cell, content, vivo, igfir, research, assodns, natl, sci, cookies, antisense, charreau, tumor, proc, acad, usa, endocrinology, privacy, progesterone, salatino, tumors, experimental, open, rubin, lee, lange, data, inhibition, signaling, pathways, proietti, mice, chem, ilan, endocrinol, coppola, sell, horwitz,

Topics {✒️}

nature portfolio permissions reprints privacy policy nature advertising scientific promotion social media author information authors research igf-1r antibody cixutumumab author correspondence igf-ir mrna resulted erbb-2-positive breast cancer insulin receptor substrate-1 growth factor receptor personal data springerlink instant access instituto de biología progesterone receptor expression progesterone receptor activity data protection permissions breast cancer growth cancer gene ther isabel frahm induced mammary adenocarcinomas breast cancer cells privacy igf-ir expression c4hd tumor growth tumor-suppressor mir-16 breast cancer res explore content subscription content kull jr fc specific antisense mechanism european economic area present study addresses institutional subscriptions read e3 ligase nedd4 sanatorio mater dei accepting optional cookies myers jr mg roberts jr ct journals search log phosphorothioate antisense oligodeoxynucleotides ignar-trowbridge dm overcomes trastuzumab resistance cordo russow béguelinp article salatino

Questions {❓}

• Nuclear ErbB-2: a Novel Therapeutic Target in ErbB-2-Positive Breast Cancer?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity
         description:The present study addresses the effect of targeting type I insulin-like growth factor receptor (IGF-IR) with antisense strategies in in vivo growth of breast cancer cells. Our research was carried out on C4HD tumors from an experimental model of hormonal carcinogenesis in which the synthetic progestin medroxyprogesterone acetate (MPA) induced mammary adenocarcinomas in Balb/c mice. We employed two different experimental strategies. With the first one we demonstrated that direct intratumor injection of phosphorothioate antisense oligodeoxynucleotides (AS[S]ODNs) to IGF-IR mRNA resulted in a significant inhibition of C4HD tumor growth. In the second experimental strategy, we assessed the effect of intravenous (i.v.) injection of AS [S]ODN on C4HD tumor growth. This systemic treatment also resulted in significant reduction in tumor growth. The antitumor effect of IGF-IR AS[S]ODNs in both experimental protocols was due to a specific antisense mechanism, since growth inhibition was dose-dependent and no abrogation of tumor proliferation was observed in mice treated with phosphorothioate sense ODNs (S[S]ODNs). In addition, IGF-IR expression was inhibited in tumors from mice receiving AS[S]ODNs, as compared to tumors from control groups. We then investigated signal transduction pathways modulated in vivo by AS[S]ODNs treatment. Tumors from AS[S]ODN-treated mice of both intratumoral and intravenous protocols showed a significant decrease in the degree of insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation. Activation of two of the main IGF-IR signaling pathways, phosphatidylinositol 3-kinase (PI-3K)/Akt and p42/p44 mitogen-activated protein kinases (MAPK) was abolished in tumors growing in AS[S]ODN-treated animals. Moreover, ErbB-2 tyrosine phosphorylation was blocked by in vivo administration of AS[S]ODNs. On the other hand, we found no regulation of either progesterone receptor expression or activity by in vivo AS[S]ODNs administration. Our results for the first time demonstrated that breast cancer growth can be inhibited by direct in vivo administration of IGF-IR AS[S]ODNs.
         datePublished:2004-05-03T00:00:00Z
         dateModified:2004-05-03T00:00:00Z
         pageStart:5161
         pageEnd:5174
         sameAs:https://doi.org/10.1038/sj.onc.1207659
         keywords:
            breast cancer
            IGF-IR
            antisense strategies
            Medicine/Public Health
            general
            Internal Medicine
            Cell Biology
            Human Genetics
            Oncology
            Apoptosis
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig5_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig6_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig7_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig8_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig9_HTML.jpg
         isPartOf:
            name:Oncogene
            issn:
               1476-5594
               0950-9232
            volumeNumber:23
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Mariana Salatino
               affiliation:
                     name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
                     address:
                        name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Roxana Schillaci
               affiliation:
                     name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
                     address:
                        name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Cecilia J Proietti
               affiliation:
                     name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
                     address:
                        name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Romina Carnevale
               affiliation:
                     name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
                     address:
                        name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Isabel Frahm
               affiliation:
                     name:Servicio de Patología, Sanatorio Mater Dei
                     address:
                        name:Servicio de Patología, Sanatorio Mater Dei, Buenos Aires, Argentina
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alfredo A Molinolo
               affiliation:
                     name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
                     address:
                        name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Adolfo Iribarren
               affiliation:
                     name:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI)
                     address:
                        name:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI), Argentina
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eduardo H Charreau
               affiliation:
                     name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
                     address:
                        name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Patricia V Elizalde
               affiliation:
                     name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
                     address:
                        name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity
      description:The present study addresses the effect of targeting type I insulin-like growth factor receptor (IGF-IR) with antisense strategies in in vivo growth of breast cancer cells. Our research was carried out on C4HD tumors from an experimental model of hormonal carcinogenesis in which the synthetic progestin medroxyprogesterone acetate (MPA) induced mammary adenocarcinomas in Balb/c mice. We employed two different experimental strategies. With the first one we demonstrated that direct intratumor injection of phosphorothioate antisense oligodeoxynucleotides (AS[S]ODNs) to IGF-IR mRNA resulted in a significant inhibition of C4HD tumor growth. In the second experimental strategy, we assessed the effect of intravenous (i.v.) injection of AS [S]ODN on C4HD tumor growth. This systemic treatment also resulted in significant reduction in tumor growth. The antitumor effect of IGF-IR AS[S]ODNs in both experimental protocols was due to a specific antisense mechanism, since growth inhibition was dose-dependent and no abrogation of tumor proliferation was observed in mice treated with phosphorothioate sense ODNs (S[S]ODNs). In addition, IGF-IR expression was inhibited in tumors from mice receiving AS[S]ODNs, as compared to tumors from control groups. We then investigated signal transduction pathways modulated in vivo by AS[S]ODNs treatment. Tumors from AS[S]ODN-treated mice of both intratumoral and intravenous protocols showed a significant decrease in the degree of insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation. Activation of two of the main IGF-IR signaling pathways, phosphatidylinositol 3-kinase (PI-3K)/Akt and p42/p44 mitogen-activated protein kinases (MAPK) was abolished in tumors growing in AS[S]ODN-treated animals. Moreover, ErbB-2 tyrosine phosphorylation was blocked by in vivo administration of AS[S]ODNs. On the other hand, we found no regulation of either progesterone receptor expression or activity by in vivo AS[S]ODNs administration. Our results for the first time demonstrated that breast cancer growth can be inhibited by direct in vivo administration of IGF-IR AS[S]ODNs.
      datePublished:2004-05-03T00:00:00Z
      dateModified:2004-05-03T00:00:00Z
      pageStart:5161
      pageEnd:5174
      sameAs:https://doi.org/10.1038/sj.onc.1207659
      keywords:
         breast cancer
         IGF-IR
         antisense strategies
         Medicine/Public Health
         general
         Internal Medicine
         Cell Biology
         Human Genetics
         Oncology
         Apoptosis
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig5_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig6_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig7_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig8_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1207659/MediaObjects/41388_2004_Article_BF1207659_Fig9_HTML.jpg
      isPartOf:
         name:Oncogene
         issn:
            1476-5594
            0950-9232
         volumeNumber:23
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Mariana Salatino
            affiliation:
                  name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
                  address:
                     name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Roxana Schillaci
            affiliation:
                  name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
                  address:
                     name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Cecilia J Proietti
            affiliation:
                  name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
                  address:
                     name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Romina Carnevale
            affiliation:
                  name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
                  address:
                     name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Isabel Frahm
            affiliation:
                  name:Servicio de Patología, Sanatorio Mater Dei
                  address:
                     name:Servicio de Patología, Sanatorio Mater Dei, Buenos Aires, Argentina
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alfredo A Molinolo
            affiliation:
                  name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
                  address:
                     name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Adolfo Iribarren
            affiliation:
                  name:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI)
                  address:
                     name:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI), Argentina
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eduardo H Charreau
            affiliation:
                  name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
                  address:
                     name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Patricia V Elizalde
            affiliation:
                  name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
                  address:
                     name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Oncogene
      issn:
         1476-5594
         0950-9232
      volumeNumber:23
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
      address:
         name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
         type:PostalAddress
      name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
      address:
         name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
         type:PostalAddress
      name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
      address:
         name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
         type:PostalAddress
      name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
      address:
         name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
         type:PostalAddress
      name:Servicio de Patología, Sanatorio Mater Dei
      address:
         name:Servicio de Patología, Sanatorio Mater Dei, Buenos Aires, Argentina
         type:PostalAddress
      name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
      address:
         name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
         type:PostalAddress
      name:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI)
      address:
         name:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI), Argentina
         type:PostalAddress
      name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
      address:
         name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
         type:PostalAddress
      name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
      address:
         name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Mariana Salatino
      affiliation:
            name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
            address:
               name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
               type:PostalAddress
            type:Organization
      name:Roxana Schillaci
      affiliation:
            name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
            address:
               name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
               type:PostalAddress
            type:Organization
      name:Cecilia J Proietti
      affiliation:
            name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
            address:
               name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
               type:PostalAddress
            type:Organization
      name:Romina Carnevale
      affiliation:
            name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
            address:
               name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
               type:PostalAddress
            type:Organization
      name:Isabel Frahm
      affiliation:
            name:Servicio de Patología, Sanatorio Mater Dei
            address:
               name:Servicio de Patología, Sanatorio Mater Dei, Buenos Aires, Argentina
               type:PostalAddress
            type:Organization
      name:Alfredo A Molinolo
      affiliation:
            name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
            address:
               name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
               type:PostalAddress
            type:Organization
      name:Adolfo Iribarren
      affiliation:
            name:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI)
            address:
               name:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI), Argentina
               type:PostalAddress
            type:Organization
      name:Eduardo H Charreau
      affiliation:
            name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
            address:
               name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
               type:PostalAddress
            type:Organization
      name:Patricia V Elizalde
      affiliation:
            name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490
            address:
               name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
      name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
      name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
      name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
      name:Servicio de Patología, Sanatorio Mater Dei, Buenos Aires, Argentina
      name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
      name:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI), Argentina
      name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
      name:Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Obligado 2490, Buenos Aires, Argentina
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(1)

• https://twitter.com/oncogenejournal

External Links {🔗}(31)

• How much income does https://link.springer.com/article/10.1038/sj.onc.1207659?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle have?
• What's the financial gain of https://citation-needed.springer.com/v2/references/10.1038/sj.onc.1207659?format=refman&flavour=references?
• What are the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Mariana%20Salatino?
• Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Mariana%20Salatino%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Roxana%20Schillaci
• Monthly income for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Roxana%20Schillaci%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Cecilia%20J%20Proietti
• Get to know what's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Cecilia%20J%20Proietti%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• What's the financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Romina%20Carnevale?
• Monthly income for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Romina%20Carnevale%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Isabel%20Frahm income
• What's the monthly money flow for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Isabel%20Frahm%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Alfredo%20A%20Molinolo earn?
• What are the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Alfredo%20A%20Molinolo%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Adolfo%20Iribarren pull in monthly?
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Adolfo%20Iribarren%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Eduardo%20H%20Charreau earn?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Eduardo%20H%20Charreau%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in each month?
• What's the monthly money flow for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Patricia%20V%20Elizalde?
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Patricia%20V%20Elizalde%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• https://s100.copyright.com/AppDispatchServlet?title=Inhibition%20of%20in%20vivo%20breast%20cancer%20growth%20by%20antisense%20oligodeoxynucleotides%20to%20type%20I%20insulin-like%20growth%20factor%20receptor%20mRNA%20involves%20inactivation%20of%20ErbBs%2C%20PI-3K%2FAkt%20and%20p42%2Fp44%20MAPK%20signaling%20pathways%20but%20not%20modulation%20of%20progesterone%20receptor%20activity&author=Mariana%20Salatino%20et%20al&contentID=10.1038%2Fsj.onc.1207659©right=Springer%20Nature%20Limited&publication=0950-9232&publicationDate=2004-05-03&publisherName=SpringerNature&orderBeanReset=true income
• Financial intake of https://citation-needed.springer.com/v2/references/10.1038/sj.onc.1207659?format=refman&flavour=citation
• How much revenue does https://doi.org/10.1007/s12672-018-0356-3 bring in?
• Learn how profitable https://doi.org/10.1038/onc.2014.272 is on a monthly basis
• How much money does https://doi.org/10.1007/s10549-013-2528-8 make?
• How much income does https://doi.org/10.1186/bcr3211 have?
• How much money does https://doi.org/10.1186/bcr3187 make?
• How much does https://www.protocols.io/ pull in monthly?
• What's the income of https://www.natureindex.com/?
• What's the financial outcome of http://www.naturechina.com?
• How much does https://www.natureasia.com/ja-jp gross monthly?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref