
BIOCONDUCTOR . ORG {
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Title:
Bioconductor - retrofit
Description:
RETROFIT is a Bayesian non-negative matrix factorization framework to decompose cell type mixtures in ST data without using external single-cell expression references. RETROFIT outperforms existing reference-based methods in estimating cell type proportions and reconstructing gene expressions in simulations with varying spot size and sample heterogeneity, irrespective of the quality or availability of the single-cell reference. RETROFIT recapitulates known cell-type localization patterns in a Slide-seq dataset of mouse cerebellum without using any single-cell data.
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Keywords {🔍}
bioconductor, retrofit, package, packages, version, cell, release, singlecell, aut, source, mixtures, spatial, transcriptomics, park, orcid, enter, install, reports, binary, learn, developers, started, software, referencefree, deconvolution, bayesian, type, data, reference, adam, singh, zhu, installation, start, documentation, system, vignette, html, script, details, bioc, url, macos, retrofittgz, repository, git, clone, code, registration, open,
Topics {✒️}
org/packages/retrofit source repository /qunhualilab/retrofit bug reports joint galaxy/bioconductor conference cell-type localization patterns bioconductor release tgz source repository source package single-cell reference release script reference manual //code bioconductor support site reference-free deconvolution single-cell data retrofit colon vignette /qunhualilab/retrofit/issues adam park [aut reconstructing gene expressions varying spot size slide-seq dataset package installed gz windows binary tgz macos binary git clone https details biocviews package packages started install cell mixtures macos binary retrofit recapitulates bioconductor //bioconductor park ak st data org registration open sample heterogeneity mouse cerebellum hardison rc spatial transcriptomics quietly = true older versions pdf news gpl-3 depends rcpp imports developer access download stats released version devel version
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