
BIOCONDUCTOR . ORG {
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Title:
Bioconductor - octad
Description:
OCTAD provides a platform for virtually screening compounds targeting precise cancer patient groups. The essential idea is to identify drugs that reverse the gene expression signature of disease by tamping down over-expressed genes and stimulating weakly expressed ones. The package offers deep-learning based reference tissue selection, disease gene expression signature creation, pathway enrichment analysis, drug reversal potency scoring, cancer cell line selection, drug enrichment analysis and in silico hit validation. It currently covers ~20,000 patient tissue samples covering 50 cancer types, and expression profiles for ~12,000 distinct compounds.
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23 years and 7 months (reg. 2001-11-19).
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Keywords {🔍}
bioconductor, package, octad, packages, version, ctb, cancer, release, expression, aut, source, open, patient, gene, chekalin, enter, install, binary, learn, developers, started, software, virtually, screening, compounds, targeting, precise, groups, signature, disease, reference, tissue, selection, enrichment, analysis, drug, paithankar, zeng, glicksberg, newbury, xing, liu, joseph, chen, installation, start, documentation, system, details, bioc,
Topics {✒️}
org/packages/octad source repository joint galaxy/bioconductor conference bioconductor release source package script reference manual gene expression signature source repository release //code gene expression features bioconductor support site drug enrichment analysis pathway enrichment analysis silico hit validation package installed stimulating weakly expressed git clone https gz windows binary details biocviews utils system requirements 000 distinct compounds package packages started install expression profiles software version bioconductor //bioconductor registration open open workspace expressed genes macos binary essential idea identify drugs � nature protocols quietly = true older versions pdf news s4vectors imports developer access released version devel version chekalin [aut paithankar [aut] zeng [aut] org/ org glicksberg [ctb] newbury [ctb] xing [ctb]
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