
BIOCONDUCTOR . ORG {
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Title:
Bioconductor - musicatk
Description:
Mutational signatures are carcinogenic exposures or aberrant cellular processes that can cause alterations to the genome. We created musicatk (MUtational SIgnature Comprehensive Analysis ToolKit) to address shortcomings in versatility and ease of use in other pre-existing computational tools. Although many different types of mutational data have been generated, current software packages do not have a flexible framework to allow users to mix and match different types of mutations in the mutational signature inference process. Musicatk enables users to count and combine multiple mutation types, including SBS, DBS, and indels. Musicatk calculates replication strand, transcription strand and combinations of these features along with discovery from unique and proprietary genomic feature associated with any mutation type. Musicatk also implements several methods for discovery of new signatures as well as methods to infer exposure given an existing set of signatures. Musicatk provides functions for visualization and downstream exploratory analysis including the ability to compare signatures between cohorts and find matching signatures in COSMIC V2 or COSMIC V3.
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Keywords {🔍}
bioconductor, package, musicatk, packages, version, mutational, signature, analysis, signatures, comprehensive, toolkit, release, aut, source, software, types, methods, orchid, campbell, enter, install, reports, binary, learn, developers, started, users, mutation, including, strand, discovery, find, cosmic, chevalier, gurevich, guo, joshua, httpsbioconductororgpackagesmusicatk, installation, start, documentation, system, details, variantannotation, bioc, base, txdbhsapiensucschgknowngene, bsgenomehsapiensucschg, bsgenomemmusculusucscmm, url,
Topics {✒️}
org/packages/musicatk source repository joint galaxy/bioconductor conference pre-existing computational tools bioconductor release tgz source repository source package org/packages/musicatk bug reports find matching signatures current software packages release base //code bioconductor support site aberrant cellular processes proprietary genomic feature script reference manual gz windows binary zip macos binary tgz macos binary /campbio/musicatk/issues package installed package version 2 git clone https details biocviews conclust system requirements aaron chevalier [aut] natasha gurevich [aut] tao guo [aut] musicatk enables users package started install mutational signatures packages mutational data including sbs transcription strand mutation type existing set campbell [aut created musicatk //bioconductor bioconductor registration open carcinogenic exposures address shortcomings flexible framework infer exposure cosmic v2 cosmic v3
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