BIOCONDUCTOR . ORG {
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Title:
Bioconductor - mslp
Description:
An integrated pipeline to predict the potential synthetic lethality partners (SLPs) of tumour mutations, based on gene expression, mutation profiling and cell line genetic screens data. It has builtd-in support for data from cBioPortal. The primary SLPs correlating with muations in WT and compensating for the loss of function of mutations are predicted by random forest based methods (GENIE3) and Rank Products, respectively. Genetic screens are employed to identfy consensus SLPs leads to reduced cell viability when perturbed.
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Keywords {🔍}
bioconductor, package, packages, mslp, version, mutations, release, source, synthetic, partners, slps, chunxuan, shao, enter, install, binary, learn, developers, started, software, predict, lethal, tumour, doi, pipeline, based, cell, genetic, screens, data, support, installation, start, documentation, system, details, bioc, stats, url, macos, repository, git, clone, reports, code, registration, open, gbcc, joint, galaxybioconductor,
Topics {✒️}
org/packages/mslp source repository joint galaxy/bioconductor conference bioconductor release source package source repository release reduced cell viability //code bioconductor support site script reference manual gz windows binary zip macos binary tgz macos binary package installed primary slps correlating chunxuan shao [aut git clone https details biocviews utils system requirements genetic screens package packages started install tumour mutations org/content/10 software version bioconductor //bioconductor registration open integrated pipeline gene expression mutation profiling rank products cre] maintainer comprehensive pipeline quietly = true older versions pdf news gpl-3 depends developer access released version devel version view documentation url download stats org install mutations //git installation
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