
BIOCONDUCTOR . ORG {
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Title:
Bioconductor - hummingbird
Description:
A package for detecting differential methylation. It exploits a Bayesian hidden Markov model that incorporates location dependence among genomic loci, unlike most existing methods that assume independence among observations. Bayesian priors are applied to permit information sharing across an entire chromosome for improved power of detection. The direct output of our software package is the best sequence of methylation states, eliminating the use of a subjective, and most of the time an arbitrary, threshold of p-value for determining significance. At last, our methodology does not require replication in either or both of the two comparison groups.
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Keywords {π}
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Topics {βοΈ}
org/packages/hummingbird source repository joint galaxy/bioconductor conference bioconductor release tgz source repository source package org/packages/hummingbird differentially methylated regions release //code bioconductor support site incorporates location dependence permit information sharing script reference manual gz windows binary zip macos binary tgz macos binary eleni adam [aut detecting differential methylation software package tieming ji [aut] git clone https details biocviews iranges system requirements package installed package version 1 started install packages package bayesian priors //bioconductor bioconductor software version methylation states registration open genomic loci existing methods assume independence entire chromosome improved power direct output determining significance comparison groups quietly = true older versions pdf news developer access org download stats released version devel version
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