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Title:
Bioconductor - dar
Description:
Differential abundance testing in microbiome data challenges both parametric and non-parametric statistical methods, due to its sparsity, high variability and compositional nature. Microbiome-specific statistical methods often assume classical distribution models or take into account compositional specifics. These produce results that range within the specificity vs sensitivity space in such a way that type I and type II error that are difficult to ascertain in real microbiome data when a single method is used. Recently, a consensus approach based on multiple differential abundance (DA) methods was recently suggested in order to increase robustness. With dar, you can use dplyr-like pipeable sequences of DA methods and then apply different consensus strategies. In this way we can obtain more reliable results in a fast, consistent and reproducible way.
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Keywords {π}
bioconductor, package, packages, dar, version, data, html, script, methods, release, microbiome, source, differential, abundance, consensus, real, install, license, reports, binary, learn, developers, started, software, analysis, statistical, compositional, results, type, recently, francesc, catalamoll, installation, start, enter, documentation, system, workflow, text, details, bioc, url, macos, dartgz, repository, git, clone, code, registration, open,
Topics {βοΈ}
org/packages/dar source repository io/dar/ bug reports joint galaxy/bioconductor conference francesc catala-moll [aut bioconductor release tgz source repository source package /microbialgenomics-irsicaixaorg/dar/issues microbiome-specific statistical methods /microbialgenomics-irsicaixaorg/dar https release //code bioconductor support site differential abundance analysis differential abundance testing multiple differential abundance gz windows binary zip macos binary tgz macos binary package installed git clone https account compositional specifics consensus approach based microbiome data challenges microbiome data analysis script reference manual type ii error details biocviews waldo system requirements parametric statistical methods real microbiome data package //microbialgenomics-irsicaixaorg packages started install real data software version bioconductor //bioconductor compositional nature data import consensus doi consensus strategies org script filtering script introduction script reproducibility script workflow registration open high variability
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