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Title:
Bioconductor - awst
Description:
We propose an Asymmetric Within-Sample Transformation (AWST) to regularize RNA-seq read counts and reduce the effect of noise on the classification of samples. AWST comprises two main steps: standardization and smoothing. These steps transform gene expression data to reduce the noise of the lowly expressed features, which suffer from background effects and low signal-to-noise ratio, and the influence of the highly expressed features, which may be the result of amplification bias and other experimental artifacts.
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Keywords {🔍}
bioconductor, package, awst, packages, version, release, source, asymmetric, rnaseq, risso, enter, install, license, reports, binary, learn, developers, started, software, withinsample, transformation, reduce, noise, steps, standardization, expression, expressed, features, davide, aut, cph, orcid, pagnotta, installation, start, documentation, system, text, details, bioc, stats, url, macos, awsttgz, repository, git, clone, code, registration, open,
Topics {✒️}
org/packages/awst source repository /drisso/awst bug reports rna-seq expression profiles joint galaxy/bioconductor conference bioconductor release tgz source repository source package release //code bioconductor support site /drisso/awst/issues lowly expressed features highly expressed features script reference manual gz windows binary zip macos binary tgz macos binary package installed stefano pagnotta [aut git clone https details biocviews summarizedexperiment system requirements davide risso [aut asymmetric winsorization lead package packages started install main steps awst comprises sample transformation bioconductor //bioconductor pagnotta sm org registration open background effects low signal amplification bias experimental artifacts cph] orcid accurate clustering quietly = true older versions pdf news developer access sample standardization text license released version devel version transcriptomics version
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