BIOCONDUCTOR . ORG {
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Title:
Bioconductor - anota2seq
Description:
anota2seq provides analysis of translational efficiency and differential expression analysis for polysome-profiling and ribosome-profiling studies (two or more sample classes) quantified by RNA sequencing or DNA-microarray. Polysome-profiling and ribosome-profiling typically generate data for two RNA sources; translated mRNA and total mRNA. Analysis of differential expression is used to estimate changes within each RNA source (i.e. translated mRNA or total mRNA). Analysis of translational efficiency aims to identify changes in translation efficiency leading to altered protein levels that are independent of total mRNA levels (i.e. changes in translated mRNA that are independent of levels of total mRNA) or buffering, a mechanism regulating translational efficiency so that protein levels remain constant despite fluctuating total mRNA levels (i.e. changes in total mRNA that are independent of levels of translated mRNA). anota2seq applies analysis of partial variance and the random variance model to fulfill these tasks.
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Keywords {🔍}
bioconductor, package, mrna, anotaseq, analysis, packages, version, efficiency, total, levels, translational, source, kise, release, translated, generally, applicable, transcriptomewide, rna, independent, oertlin, larsson, enter, install, binary, learn, developers, started, software, differential, expression, polysomeprofiling, ribosomeprofiling, sequencing, translation, protein, variance, christian, christianoertlin, lorent, ola, olalarsson, installation, start, documentation, system, pdf, details, bioc, stats,
Topics {✒️}
org/packages/anota2seq source repository bioconductor release tgz source repository source package european bioconductor conference release ribosome-profiling studies //code bioconductor support site altered protein levels script reference manual gz windows binary zip macos binary tgz macos binary package installed anota2seq applies analysis random variance model /nar/article/47/12/e70/5423604 translational efficiency aims rna source git clone https differential expression analysis details biocviews summarizedexperiment system requirements translation efficiency leading total mrna levels package packages started install translational efficiency polysome-profiling differential expression software version total mrna bioconductor //bioconductor partial variance 1093/nar/gkz223 translated mrna anota2seq doi org registration open sample classes rna sources quietly = true older versions gpl-3 depends methods imports developer access released version
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