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Title:
Collection Of Human And Mouse TF Regulons • dorothea
Description:
DoRothEA is a gene regulatory network containing signed transcription factor (TF) - target gene interactions. DoRothEA regulons, the collection of a TF and its transcriptional targets, were curated and collected from different types of evidence for both human and mouse. A confidence level was assigned to each TF-target interaction based on the number of supporting evidence.
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Keywords {🔍}
dorothea, activities, mouse, regulons, holland, human, data, infer, package, version, badiaimompel, transcription, factor, decoupler, bioconductor, install, extension, developed, collectri, license, resources, cite, garciaalonso, saezrodriguez, doi, dimitrov, author, collection, gene, grn, curated, evidence, based, singlecell, development, github, benchmark, showed, databases, coverage, nonacademic, citation, resource, estimation, müllerdott, ramirez, flores, pau, daniel, christian,
Topics {✒️}
pau badia-i-mompel badia-i-mompel single-cell rna-seq data daniel dimitrov license dorothea high-confidence prior knowledge tf-target interaction based luz garcia-alonso single-cell transcriptomics scrna-seq data signed transcription factor transcription factor activities citation christian gene regulatory network identifying perturbed tfs infer biological activities infer tf activities literature based grn run mouse version garcia-alonso dimitrov confidence level obtain activities mouse data human data omics data installation dorothea saezlab/dorothea originally dorothea dorothea resource dorothea regulons development version mouse orthologs transcriptional targets statistical method github repository quietly = true github repo original release human genes encourage users licenses don permit commercial holland ch ibrahim mm saez-rodriguez genome research vélez santiago müller-dott
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