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Title:
Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo - PubMed
Description:
In this account, we report the development of a series of substituted cinnamic anilides that represents a novel class of mitochondrial permeability transition pore (mPTP) inhibitors. Initial class expansion led to the establishment of the basic structural requirements for activity and to the identif β¦
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Keywords {π}
mitochondrial, doi, permeability, transition, pore, pmid, epub, anilides, inhibitors, injury, pmc, metabolism, opening, myocardial, review, free, article, naphthylamine, chemical, articles, cited, mesh, jun, mptp, calcium, reperfusion, res, synthesis, chemistry, pharmacology, acrylamides, cinnamates, main, ncbi, similar, resources, med, cinnamic, bernardi, lisa, infarction, pubmed, mice, nov, jul, cardiol, mol, cell, mar, membrane,
Topics {βοΈ}
acute myocardial infarction n-naphthalen-1-yl-acrylamide 22 hepatic ischemia/reperfusion injury limit reperfusion injury augmented reperfusion injury similar articles cited mitochondrial calcium substituted cinnamic anilides cinnamic anilides main page content mitochondrial ion channels derivatives mesh keyword protect mice neonatal hypoxic-ischemic encephalopathy activity mice literature sources 1021/jm500547c abstract inhibitors neonatal hypoxia ischemia cited united states government pier giuseppe pelicci basic structural requirements inhibitory potency higher thiol cross-linkers thiol redox state mol cell cardiol inbred c57bl mitochondria cyclophilins block opening vivo daniele fancelliΒ 1 4-fluoro-3-hydroxy-phenyl de armas-ricard cell mol med inhibit mptp opening basic res cardiol standard inhibitor cyclosporine fabio di lisa resources pubmed wordmark pubmed logo attenuate opening di lisa hhs vivo data diabetic heart de stefani 4-fluoro-3-hydroxyphenyl med chem
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