
PUBMED . NCBI . NLM . NIH . GOV {
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Title:
Depressing mitochondria-reticulum interactions protects cardiomyocytes from lethal hypoxia-reoxygenation injury - PubMed
Description:
Our data (1) point to a new role of CypD at the ER-mitochondria interface and (2) suggest that decreasing ER-mitochondria interaction at reperfusion can protect cardiomyocytes against lethal reperfusion injury through the reduction of mitochondrial Ca(2+) overload via the CypD/VDAC1/Grp75/IP3R1 comp …
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Keywords {🔍}
doi, pmid, physiology, injury, cypd, epub, hypoxiareoxygenation, cell, zhang, cardiomyocytes, mitochondria, complex, pmc, transfer, reticulum, mitochondrial, interaction, calcium, wang, free, article, proteins, similar, articles, mesh, ipr, protein, mice, ermitochondria, reperfusion, liu, cyclophilins, myocytes, cardiac, main, content, ncbi, cited, resources, protects, teixeira, ovize, endoplasmic, role, death, inhibition, cells, pubmed, mar, membrane,
Topics {✒️}
main page content similar articles cited mitochondria-endoplasmic reticulum interactions mouse vdac1 protein cypd/vdac1/grp75/ip3r1 complex vdac1/grp75/ip3r1 complex mitochondria links alterations inbred c57bl mice er membrane integrity endoplasmic reticulum adult mice cardiomyocytes decreasing er-mitochondria interaction lethal reperfusion injury similar effect mol cell cardiol literature sources cell death meet cell death dis ischemic postconditioning protects ischemia/reperfusion injury ischemia-reperfusion injury hypoxia-reoxygenation injury hypoxia/reoxygenation injury mesh keyword mitochondrial chaperone cyclophilin cell calcium adult cardiomyocytes decreased united states government resources circulation mfn2 similarly reduced hepatic insulin resistance front cardiovasc med attenuated mitochondrial ca local calcium transfer pierre-alain thiebaut protected cells er-mitochondria interface er-mitochondria interaction sarcoplasmic reticulum reperfusion injury ip3r1 complex cited hypoxia-reoxygenation human services mitochondrial matrix pubmed wordmark pubmed logo mitochondrial ca calcium transfer heart
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