PUBMED . NCBI . NLM . NIH . GOV {
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Title:
Inhibition of Drp1-dependent mitochondrial fragmentation and apoptosis by a polypeptide antagonist of calcineurin - PubMed
Description:
During apoptosis, mitochondria lose their membrane potential and undergo fragmentation around the time of release of cytochrome c. Apoptotic fission is at least in part sustained by the translocation of dynamin-related protein 1 (Drp1), normally located in the cytosol, to mitochondria. This process …
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Keywords {🔍}
mitochondrial, apoptosis, cell, doi, mitochondria, ppd, metabolism, pmid, pmc, protein, pubmed, calcineurin, proteins, epub, free, article, drp, death, fragmentation, fission, cells, figure, membrane, human, binding, inhibitors, articles, mesh, dynaminrelated, biol, jul, tacrolimus, main, ncbi, similar, cited, references, resources, inhibition, scorrano, potential, release, cytochrome, translocation, inhibitor, staurosporine, liu, drug, effects, gtp,
Topics {✒️}
/ metabolism cytochromes membrane binding main page content calcineurin-dependent mitochondrial fragmentation similar articles cited drp1-dependent mitochondrial fragmentation dynamin-related protein drp1 promoting er-mitochondria contact human dynamins cyclophilin literature sources pubchem substance grants dynamin-related protein 1 staurosporine bcl-2 homolog autophagy mitochondria elongate ngf-deprived sympathetic neurons ppd1 delays apoptosis articles references wang death protein cytochromes mesh keyword membrane potential mitochondrial fission astrocytic cells subjected mitochondrial dysfunction mitochondrial neuroglobin mitochondrial network mitochondria lose ir-783-induced apoptosis calcineurin regulates translocation apoptosis protein mitochondria protein bad bax/bak-dependent 61 abstract microrna-dependent inhibition united states government genetic analysis revealed martins de brito biochim biophys acta critical control points sustain cell viability drp1-independent targeting bergmann-leitner es cell mol med funding linkout protection induced nat cell biol phosphatase calcineurin x-linked inhibitor membrane permeabilization
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