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Title:
Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury - PubMed
Description:
Mitochondria play an important role in cell death and cardioprotection. During ischemia, when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium (Ca(2+)), which further accelerates ATP depletion. The rise in Ca(2+) during ischemia and reperfusion leads to mitocho …
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Keywords {🔍}
mitochondrial, doi, pmid, pmc, pubmed, cell, mitochondria, free, article, review, injury, death, oxygen, figure, epub, cardiac, atp, ros, permeability, signaling, heart, metabolism, articles, mesh, ischemiareperfusion, calcium, reperfusion, reactive, species, overload, transition, central, reduce, preconditioning, nih, main, states, ncbi, figures, similar, cited, references, resources, physiol, mechanisms, protection, murphy, ischemia, pore, akt,
Topics {✒️}
reactive oxygen species united states government main page content similar articles cited vitro ischemia/reperfusion injury funding linkout antioxid redox signal randomised placebo-controlled trial reduce ischemic injury literature sources mesh keyword intracellular calcium reduce cell death calcium cell death cell mol med mol cell biochem pubmed ala-rami hhs cardioprotective mechanisms converge compromises cellular energetics garcía-rivas gj biochim biophys acta multiple biological effects 536 high-risk individuals f1f0-atpase inhibition hydrophobic motif site ischemia reperfusion ischemia-reperfusion increased mitochondrial generation cardiac protection methodist debakey cardiovasc rictor-mtor phosphorylates basic res cardiol antioxidant vitamin supplementation produce cardioprotection accompanied accelerates atp depletion resultant low atp central players signaling pathways oxygen figures reperfusion leads ischaemia-reperfusion cited cell metab mitochondrial ca cardiac myocytes pubmed ahmad pubmed show
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