
PUBMED . NCBI . NLM . NIH . GOV {
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Title:
Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1alpha Pro-564 hydroxylation - PubMed
Description:
The mechanism by which hypoxia induces gene transcription involves the inhibition of hypoxia-inducible factor (HIF)-1alpha prolyl hydroxylase activity, which prevents von Hippel-Lindau (vHL)-dependent targeting of HIF-1alpha to the ubiquitin-proteasome pathway. HIF-1alpha is stabilized, translocates …
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Keywords {🔍}
doi, pmid, hypoxiainducible, factor, hifalpha, csa, free, article, pmc, transcription, protein, hypoxic, hypoxia, gene, effects, drug, review, metabolism, articles, mesh, jbcm, epub, adaptation, hif, research, main, ncbi, similar, cited, resources, biol, chem, prevents, hydroxylation, dangelo, duplan, vigne, frelin, mechanism, activity, pathway, promotes, degradation, proline, pubmed, biochem, oct, factors, cell, liu,
Topics {✒️}
main page content similar articles cited hypoxia-inducible factors hif-alpha-prolyl-4-hydroxylases mesh terms adaptation hypoxia-inducible factor 12876291 hypoxia-inducible factor-1 hypoxia-inducible factor 1 hypoxia-inducible factor-1 differentiating 3t3-l1 preadipocytes natural product-based inhibitors proline residue prevents von hippel-lindau csa destabilizes hif-1alpha green fluorescent protein metabolism odd fusion protein gfp fusion protein curr drug targets mesh keyword reporter gene assay hypoxia-responsive elements oxygen-dependent manner gene expression hypoxia-sensing pathway resources promoting hydroxylation prostaglandin f2alpha induces biomedical research d'angelo united states government c6 glioma cells glutathione s-transferase protect normal cells genetically encoded tools csa-induced nephrotoxicity 2-oxoglutarate-dependent dioxygenases blocking rack1 dimerization csa effects prevent hypoxic adaptation ubiquitin-proteasome pathway limits hif-1 responses research hif-1alpha sequence hypoxic signaling cascade adverse effects brain hypoxia cited protein hif-1alpha
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