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Title:
Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue - PubMed
Description:
Strong evidence is emerging that mitochondrial permeability transition (MPT) may be important in certain physiological conditions and, above all, in the processes of cell damage and death. Reversible MPT, triggered by inducing agents in the presence of calcium ions, has resulted in the opening of a …
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Keywords {🔍}
doi, pmid, mitochondria, receptor, mitochondrial, benzodiazepine, ligands, permeability, transition, cardiac, effects, free, drug, pmc, swelling, apoptosis, article, similar, articles, mesh, rat, calcium, peripheral, role, epub, gabaa, heart, main, ncbi, cited, resources, peripheraltype, mpt, cell, membrane, pbr, ultrastructural, pubmed, receptors, review, pharmacology, pubchem, hhs, page, content, homepage, navigation, search, full, text,
Topics {✒️}
main page content similar articles cited peripheral-type benzodiazepine receptor host-defense response resources biochem pharmacol 2-chlorophenyl-n-methyl-1-methylpropyl mitochondrial permeability transition cell damage dose-dependent cardiovascular system peripheral benzodiazepine receptor mesh keyword synaptic mitochondrial vulnerability pk 11195-induced swelling free radical generation rat cardiac tissue 18-kda translocator protein damaging effects isolated cardiac mitochondria calcium ions isolated cardiac nuclei 3-dihydro-1-methyl-2h-1 drug development drug gaba mitochondrial swelling mitochondria-mediated neurodegeneration united states government highest concentration tested cultured neural cells curr pharm des f1fo atp synthase alcoholic liver disease mitochondrial membrane calcium apoptosis inducers neuronal apoptosis cited similar norenberg md pbr ligands vitro studies wistar receptors mitochondria exposed nonsynaptic mitochondria apoptosis pubmed wordmark pubmed logo apoptotic role mpt pore hhs
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