We are analyzing https://link.springer.com/protocol/10.1007/978-1-60761-416-6_3.

Title:
Studying Drug Resistance Using Genetically Engineered Mouse Models for Breast Cancer | SpringerLink
Description:
The generation of genetically engineered mouse models (GEMMs) that mimic breast cancer in humans provides new tools to investigate mechanisms of drug resistance in vivo. The advantages are manifold: inbred mice do not have the genomic heterogeneity seen in patients;...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

De Visser KE (2008) Spontaneous immune responses to sporadic tumors: tumor-promoting, tumor-protective or both?

Schema {🗺️}

ScholarlyArticle:
      headline:Studying Drug Resistance Using Genetically Engineered Mouse Models for Breast Cancer
      pageEnd:45
      pageStart:33
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-60761-416-6.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Multi-Drug Resistance in Cancer
         isbn:
            978-1-60761-416-6
            978-1-60761-415-9
         type:Book
      publisher:
         name:Humana Press
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Sven Rottenberg
            affiliation:
                  name:The Netherlands Cancer Institute
                  address:
                     name:Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Marina Pajic
            affiliation:
                  name:The Netherlands Cancer Institute
                  address:
                     name:Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jos Jonkers
            affiliation:
                  name:The Netherlands Cancer Institute
                  address:
                     name:Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:GEMM, Breast cancer, Orthotopic transplantation, BRCA1, BRCA2, E-cadherin, ATP-binding cassette (ABC) transporter, FACS sorting, Tumor-initiating cells
      description:The generation of genetically engineered mouse models (GEMMs) that mimic breast cancer in humans provides new tools to investigate mechanisms of drug resistance in vivo. The advantages are manifold: inbred mice do not have the genomic heterogeneity seen in patients; mammary tumors are superficial and therefore easily accessible for measurement and sampling pre- and posttreatment; tumors can be transplanted orthotopically into syngeneic, immunocompetent animals; and tumor cells can be modified in vitro (e.g., gene overexpression, shRNA knockdown, insertional mutagenesis) prior to transplantation. Here, we provide an overview with experimental details of various approaches to study mechanisms of drug resistance in GEMMs for breast cancer.
      datePublished:2010
      isAccessibleForFree:
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         type:WebPageElement
      context:https://schema.org
Book:
      name:Multi-Drug Resistance in Cancer
      isbn:
         978-1-60761-416-6
         978-1-60761-415-9
Organization:
      name:Humana Press
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The Netherlands Cancer Institute
      address:
         name:Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
         type:PostalAddress
      name:The Netherlands Cancer Institute
      address:
         name:Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
         type:PostalAddress
      name:The Netherlands Cancer Institute
      address:
         name:Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Sven Rottenberg
      affiliation:
            name:The Netherlands Cancer Institute
            address:
               name:Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Marina Pajic
      affiliation:
            name:The Netherlands Cancer Institute
            address:
               name:Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Jos Jonkers
      affiliation:
            name:The Netherlands Cancer Institute
            address:
               name:Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
      name:Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
      name:Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

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