We are analyzing https://link.springer.com/protocol/10.1007/978-1-4939-9706-0_2.

Title:
Guidelines for CSF Processing and Biobanking: Impact on the Identification and Development of Optimal CSF Protein Biomarkers | SpringerLink
Description:
The field of neurological diseases strongly needs biomarkers for early diagnosis and optimal stratification of patients in clinical trials or to monitor disease progression. Cerebrospinal fluid (CSF) is one of the main sources for the identification of novel protein...
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Automotive

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

pubmed, google, scholar, article, cas, fluid, cerebrospinal, alzheimers, csf, teunissen, biomarkers, central, van, disease, preanalytical, blennow, clin, zetterberg, clinical, biomarker, neurol, dement, parnetti, analysis, proteomics, protein, willemse, proteome, med, vanderstichele, molinuevo, httpsdoiorgjjalz, verbeek, protocol, guidelines, diseases, stability, storage, scheltens, lewczuk, engelborghs, research, biobanking, impact, studies, factors, mollenhauer, shaw, flier, httpsdoiorg,

Topics {✒️}

month download article/chapter high-resolution mass spectrometry nia-aa research framework maldi-tof mass spectrometry pre-analytical quality indicators pre-analytical confounding factors teunissen & marta del campo pre-analytical factors influencing protocol hok-a-hin blood-based biomarker studies jarrige-le prado ac koel-simmelink mj alpha-synuclein biomarker studies csf alpha-synuclein concentrations de oliveira cr van der flier device instant download privacy choices/manage cookies magnetic bead separation technical [corrected] artefact o'bryant editor information editors disease-specific csf investigations standard operating procedures van der voort o'brien rj flight mass spectrometry preanalytical confounding factors pre-analytical confounders pre-analytical confounders human cerebrospinal fluid fernández-irigoyen hok-a-hin standardized operating procedures central biobank protocol cerebrospinal fluid neuron-specific enolase van elk ej van gool aj van berckel bn springer nature pre-analytical variables endogeneous peptide profiling amyloid-beta 42 adsorption cerebrospinal fluid proteins cerebrospinal fluid examined paired cerebrospinal fluid high variability observed postsynaptic protein neurogranin freeze/thaw conditions

Questions {❓}

Carrette O, Burkhard PR, Hughes S, Hochstrasser DF, Sanchez JC (2005) Truncated cystatin C in cerebrospiral fluid: technical [corrected] artefact or biological process?
Kraut A, Marcellin M, Adrait A, Kuhn L, Louwagie M, Kieffer-Jaquinod S, Lebert D, Masselon CD, Dupuis A, Bruley C, Jaquinod M, Garin J, Gallagher-Gambarelli M (2009) Peptide storage: are you getting the best return on your investment?
Willemse E, van Uffelen K, Brix B, Engelborghs S, Vanderstichele H, Teunissen C (2017) How to handle adsorption of cerebrospinal fluid amyloid beta (1-42) in laboratory practice?

Schema {🗺️}

ScholarlyArticle:
      headline:Guidelines for CSF Processing and Biobanking: Impact on the Identification and Development of Optimal CSF Protein Biomarkers
      pageEnd:50
      pageStart:27
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-9706-0.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Cerebrospinal Fluid (CSF) Proteomics
         isbn:
            978-1-4939-9706-0
            978-1-4939-9705-3
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yanaika S. Hok-A-Hin
            affiliation:
                  name:Amsterdam UMC
                  address:
                     name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Eline A. J. Willemse
            affiliation:
                  name:Amsterdam UMC
                  address:
                     name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Charlotte E. Teunissen
            affiliation:
                  name:Amsterdam UMC
                  address:
                     name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marta Del Campo
            affiliation:
                  name:Amsterdam UMC
                  address:
                     name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:CSF, Proteomics, Biomarkers, Neurology, Guidelines, Biobanking, Pre-analytical confounding factors, Stability, Reproducibility
      description:The field of neurological diseases strongly needs biomarkers for early diagnosis and optimal stratification of patients in clinical trials or to monitor disease progression. Cerebrospinal fluid (CSF) is one of the main sources for the identification of novel protein biomarkers for neurological diseases. Despite the enormous efforts employed to identify novel CSF biomarkers, the high variability observed across different studies has hampered their validation and implementation in clinical practice. Such variability is partly caused by the effect of different pre-analytical confounding factors on protein stability, highlighting the importance to develop and comply with standardized operating procedures. In this chapter, we describe the international consensus pre-analytical guidelines for CSF processing and biobanking that have been established during the last decade, with a special focus on the influence of pre-analytical confounders on the global CSF proteome. In addition, we provide novel results on the influence of different delayed storage and freeze/thaw conditions on the CSF proteome using two novel large multiplex protein arrays (SOMAscan and Olink). Compliance to consensus guidelines will likely facilitate the successful development and implementation of CSF protein biomarkers in both research and clinical settings, ultimately facilitating the successful development of disease-modifying therapies.
      datePublished:2019
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
      context:https://schema.org
Book:
      name:Cerebrospinal Fluid (CSF) Proteomics
      isbn:
         978-1-4939-9706-0
         978-1-4939-9705-3
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Amsterdam UMC
      address:
         name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
         type:PostalAddress
      name:Amsterdam UMC
      address:
         name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
         type:PostalAddress
      name:Amsterdam UMC
      address:
         name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
         type:PostalAddress
      name:Amsterdam UMC
      address:
         name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yanaika S. Hok-A-Hin
      affiliation:
            name:Amsterdam UMC
            address:
               name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Eline A. J. Willemse
      affiliation:
            name:Amsterdam UMC
            address:
               name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Charlotte E. Teunissen
      affiliation:
            name:Amsterdam UMC
            address:
               name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Marta Del Campo
      affiliation:
            name:Amsterdam UMC
            address:
               name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
      name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
      name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
      name:Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(334)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js

CDN Services {📦}

Pbgrd

4.5s.

LINK . SPRINGER . COM {}