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• Health & Fitness
• Science
• Education

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

cancer, breast, google, scholar, article, ferroptosis, cas, cell, cells, death, iron, ros, expression, apoptosis, lipid, acid, fatty, human, gpx, pufas, pathway, wang, chen, found, res, nrf, induced, acsl, acids, induce, growth, autophagy, role, receptor, zhang, ferritin, levels, biol, yang, protein, activity, studies, increased, induces, peroxidation, genes, intracellular, resistance, necroptosis, liu,

Topics {✒️}

cso-ss-cy7-hex/spion/srfn phorbol-12-myristate-13-acetate-induced protein 1 g6pd/hif-1alpha/notch1 axis ros-mediated rip1/rip3/parp-1 pathways gcn2/eif2α/atf4/chac1 pathway gcn2-eif2α-atf4-chac1 pathway [79] gcn2-eif2α-atf4-chac1 pathway rna-binding protein elavl1/hur �oncogenic-ras-selective lethal” property oncogenic-ras-harboring cancer cells glucose-deficient/glutamine-replete conditions ripk1/ripk3/mlkl/chac1 pathway p62-keap1-nrf2 pathway protects ferritin-rich cd68-positive macrophages gcn2/eif2α/atf4 pathway therapy-resistant mesenchymal-high state oestrogen-related receptor alpha long-chain acyl-coenzyme pi3k/akt/nrf2 signaling pathway gcn2-eif2alpha-atf4 pathway nanoparticle ferritin-bound erastin triple-negative cell lines african-centric s47 variant p62/keap1/nrf2/ho-1 pathway vacuolaor-atpase inhibitor archazolid triple-negative breast cancer pufa-induced cell death dna-binding domain leading vital anti-ferroptotic factor autophagy-mediated cell death article download pdf 3-hydroxy-3-methyl-glutaryl-coenzyme tagging single-nucleotide polymorphisms doxorubicin-induced cell death nutrient/serum-deprived condition ripk1/ripk3/mlkl pathway stimulate hormone-responsive cells ros/ask1/jnk pathway nutrient-deprived cancer cells neutral sphingomyelinase-mediated pathway r-ooh forms r-oo· noncanonical perk-nrf2 signaling surmount therapy-resistant cancer e2-induced transient increase withaferin a-induced apoptosis dha-induced cell death autophagy-dependent cell death fish oil-fed rats dmba-induced mammary carcinogenesis induce cell–cycle arrest

Questions {❓}

• Does iron have a role in breast cancer?
• For example, what is the marker of ferroptosis?
• The crosstalk between autophagy and ferroptosis: what can we learn to target drug resistance in cancer?
• Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
• What is ferroptosis?
• What is the biological marker of ferroptosis similar to caspases in apoptosis?

Schema {🗺️}

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         headline:Targeting ferroptosis in breast cancer
         description:Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, making it a promising therapeutic target to manage cancer. Here, we describe the current status of ferroptosis studies in breast cancer and trace the key regulators of ferroptosis back to previous studies. We also compare ferroptosis to common regulated cell death patterns and discuss the sensitivity to ferroptosis in different subtypes of breast cancer. We propose that viewing ferroptosis-related studies from a historical angle will accelerate the development of ferroptosis-based biomarkers and therapeutic strategies in breast cancer.
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      description:Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, making it a promising therapeutic target to manage cancer. Here, we describe the current status of ferroptosis studies in breast cancer and trace the key regulators of ferroptosis back to previous studies. We also compare ferroptosis to common regulated cell death patterns and discuss the sensitivity to ferroptosis in different subtypes of breast cancer. We propose that viewing ferroptosis-related studies from a historical angle will accelerate the development of ferroptosis-based biomarkers and therapeutic strategies in breast cancer.
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      dateModified:2020-11-05T00:00:00Z
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         Breast cancer
         Regulated cell death
         Crosstalk
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         Historical perspective
         Biomedicine
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         Cancer Research
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      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
      address:
         name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
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      name:Cixi People’s Hospital Medical and Health Group
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         name:Cixi People’s Hospital Medical and Health Group, Ningbo, China
         type:PostalAddress
      name:Zhejiang University
      address:
         name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
         type:PostalAddress
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
      address:
         name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
         type:PostalAddress
      name:Zhejiang University
      address:
         name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
         type:PostalAddress
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      address:
         name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
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      name:Zhejiang University
      address:
         name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
         type:PostalAddress
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
      address:
         name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
         type:PostalAddress
      name:Zhejiang University
      address:
         name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
         type:PostalAddress
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
      address:
         name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
         type:PostalAddress
      name:Zhejiang University
      address:
         name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
         type:PostalAddress
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
      address:
         name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
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Person:
      name:Zhaoqing Li
      affiliation:
            name:Zhejiang University
            address:
               name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Zhejiang University
            address:
               name:Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
            address:
               name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Lini Chen
      affiliation:
            name:Zhejiang University
            address:
               name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
            address:
               name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Cong Chen
      affiliation:
            name:Zhejiang University
            address:
               name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
            address:
               name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Yulu Zhou
      affiliation:
            name:Zhejiang University
            address:
               name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
            address:
               name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Dengdi Hu
      affiliation:
            name:Cixi People’s Hospital Medical and Health Group
            address:
               name:Cixi People’s Hospital Medical and Health Group, Ningbo, China
               type:PostalAddress
            type:Organization
      name:Jingjing Yang
      affiliation:
            name:Zhejiang University
            address:
               name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
            address:
               name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Yongxia Chen
      affiliation:
            name:Zhejiang University
            address:
               name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
            address:
               name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Wenying Zhuo
      affiliation:
            name:Cixi People’s Hospital Medical and Health Group
            address:
               name:Cixi People’s Hospital Medical and Health Group, Ningbo, China
               type:PostalAddress
            type:Organization
      name:Misha Mao
      affiliation:
            name:Zhejiang University
            address:
               name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
            address:
               name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Xun Zhang
      affiliation:
            name:Zhejiang University
            address:
               name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
            address:
               name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Ling Xu
      affiliation:
            name:Zhejiang University
            address:
               name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
            address:
               name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Linbo Wang
      affiliation:
            name:Zhejiang University
            address:
               name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
            address:
               name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jichun Zhou
      url:http://orcid.org/0000-0002-0727-4034
      affiliation:
            name:Zhejiang University
            address:
               name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province
            address:
               name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
      name:Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
      name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
      name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
      name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
      name:Cixi People’s Hospital Medical and Health Group, Ningbo, China
      name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
      name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
      name:Cixi People’s Hospital Medical and Health Group, Ningbo, China
      name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
      name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
      name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
      name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China
      name:Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
      name:Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China

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