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Title:
Carbohydrate restriction ameliorates nephropathy by reducing oxidative stress and upregulating HIF-1α levels in type-1 diabetic rats | Journal of Diabetes & Metabolic Disorders
Description:
Background Carbohydrate restricted diet regimen is widely accepted as therapeutic approach for the treatment of kidney disease associated with type-2 diabetes, obesity and hypertensive disorders. The present study tested the influence of carbohydrate-energy restricted diet (CR) on type-1 diabetes induced renal dysfunction, hypoxia and structural alterations against diabetic rat group fed control diet (ad libitium). Methods Male wistar rats weighing between 180 and 190 g were subjected to 30% carbohydrate energy restricted diet (CR) and diabetes was induced by administration of streptozotocin (45 mg/kg., i.p). Assessment of renal function was done after 4 weeks by determining the serum levels of creatinine, BUN, proteinuria. Oxidative stress was determined by estimating the reduced glutathione, malonaldehyde levels, catalase activity and extent of renal hypoxia by estimating the HIF-1α levels in kidney tissue homogenates. Histological studies were conducted on kidney sections using hematoxylin and eosin, periodic acid-schiff staining. Results Diabetic rats exhibited marked hyperglycemia and renal dysfunction developed in diabetic rats fed control diet (ad libitium) as shown by significantly elevated levels of serum creatinine, BUN and massive proteinuria after 4 weeks period. CR diet treatment in diabetic rats significantly lowered hyperglycemia, reversed the above renal functional abnormalities, reduced oxidative stress and enhanced HIF-1α levels. Furthermore histological examination of kidney sections from CR diet treated diabetic rat group showed absence of glomerular hypertrophy, mesangial expansion and tubular vacoulations. Conclusion Our results demonstrated that CR diet treatment in diabetic rats attenuated renal damage by reducing oxidative stress and preventing the development of hypoxia by up-regulating HIF-1α levels.
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Keywords {🔍}

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Topics {✒️}

insulin-treated diabetic rats kidney/body weight ratio periodic acid-schiff staining producing blood cells long-term caloric restriction carbohydrate-energy restricted diet carbohydrate-energy-restricted diet hif-1α upregulation abolished hypoxia inducible factor-1α streptozotocin-induced diabetic rats i-mark microplate reader nad-dependent histone deacetylase bt/pr-4548/inf/22/146/2012 granted upregulating hif-1α levels long-term consumption significantly elevated levels angiotensin-converting enzyme inhibitors enhanced hif-1α levels article download pdf cr + stz rat groups low insulin levels ain-76a rodent diet significantly lower compared assess reno-protective effects regulating hif-1α levels periodic acid schiff streptozotocin treated rats body weight occurs sirt1-dependent mitochondrial autophagy induced type-1 diabetes type-1 diabetic rats carbohydrate restricted diet carbohydrate-restricted diet improved renal dysfunction diabetic rat kidney thiobarbituric acid reaction reduced glutathione levels carbohydrate restriction exposure hypoxia inducible factor blood urea nitrogen diabetic rat kidneys carbohydrate-energy-restricted stz treated rats onkar bedi carried diabetic kidney disease carbohydrate diet restriction normal rats cr + stz constitutively expressed β-subunit reduced oxidative stress full access

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Is there a role for carbohydrate restriction in the treatment and prevention of cancer?

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         description:Carbohydrate restricted diet regimen is widely accepted as therapeutic approach for the treatment of kidney disease associated with type-2 diabetes, obesity and hypertensive disorders. The present study tested the influence of carbohydrate-energy restricted diet (CR) on type-1 diabetes induced renal dysfunction, hypoxia and structural alterations against diabetic rat group fed control diet (ad libitium). Male wistar rats weighing between 180 and 190 g were subjected to 30% carbohydrate energy restricted diet (CR) and diabetes was induced by administration of streptozotocin (45 mg/kg., i.p). Assessment of renal function was done after 4 weeks by determining the serum levels of creatinine, BUN, proteinuria. Oxidative stress was determined by estimating the reduced glutathione, malonaldehyde levels, catalase activity and extent of renal hypoxia by estimating the HIF-1α levels in kidney tissue homogenates. Histological studies were conducted on kidney sections using hematoxylin and eosin, periodic acid-schiff staining. Diabetic rats exhibited marked hyperglycemia and renal dysfunction developed in diabetic rats fed control diet (ad libitium) as shown by significantly elevated levels of serum creatinine, BUN and massive proteinuria after 4 weeks period. CR diet treatment in diabetic rats significantly lowered hyperglycemia, reversed the above renal functional abnormalities, reduced oxidative stress and enhanced HIF-1α levels. Furthermore histological examination of kidney sections from CR diet treated diabetic rat group showed absence of glomerular hypertrophy, mesangial expansion and tubular vacoulations. Our results demonstrated that CR diet treatment in diabetic rats attenuated renal damage by reducing oxidative stress and preventing the development of hypoxia by up-regulating HIF-1α levels.
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      headline:Carbohydrate restriction ameliorates nephropathy by reducing oxidative stress and upregulating HIF-1α levels in type-1 diabetic rats
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