We are analyzing https://link.springer.com/article/10.1186/s40169-019-0237-6.

Title:
The role of liver microenvironment in hepatic metastasis | Clinical and Translational Medicine
Description:
Metastasis is still poorly understood and thus further research must be conducted to provide insight into the driving factors. Novel research has revealed the significance of the microenvironment in the delegation of metastasis, expanding the field of cancer metastasis to cells and cell environments surrounding the migrated tumor cells. Research on hepatic metastasis is an ever-growing domain of this field, as several primary tumors can metastasize to the liver. The two features within the liver that promote metastasis—cellular and acellular—are found in the current interpretation of liver microenvironment. Novel findings of both are included in this review. Different hypotheses detailing the methods by which metastasis can occur must be included to understand the significance of the microenvironment, as well as a brief overview of the methods that can be used during research. This review aims to highlight the importance of liver microenvironment on the development or potential regression of hepatic metastasis through discussing both acellular and cellular components of liver microenvironment and their interaction with metastasis.
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Keywords {🔍}

metastasis, cells, liver, pubmed, cancer, article, tumor, google, scholar, microenvironment, cas, cell, growth, hepatic, central, metastatic, role, proteins, factor, components, collagen, colorectal, study, cellular, matrix, ecm, metastases, kcs, immune, pancreatic, acellular, emt, research, review, promote, contribute, patients, macrophages, transition, factors, kupffer, endothelial, vegf, niche, signaling, formation, models, stem, data, provide,

Topics {✒️}

nuclear factor kappa-light-chain-enhancer article download pdf serum-derived carcinoembryonic antigen myeloid-derived suppressor cells α-smooth muscle actin bone-marrow-derived macrophages organ-specific metastases obtained targeting igf-ir therapy hepatic stellate cells cea-expressing tumor cells tissue-specific decellularized scaffolds metastatic niche formation privacy choices/manage cookies regulate tumor metastasis hepatocyte growth factor hypoxia-inducing factor-1 cell adhesion molecules cells tgf-β pancreatic ductal adenocarcinoma direct proliferative measures colon cancer cells pdac-derived exosomes highly vascular nature hsc-derived factors natural killer cells cancer stem cells disseminated tumor cells regulatory transcription factor cancer cell cultures organ systems external pretumoral pancreatic lesions colorectal cancer metastasis promotes cell migration major cellular components igf-ir signaling individual cells detected article williamson cell environments surrounding tumour cell lines related subjects colorectal liver metastasis major acellular components primary breast tumor tumor-activated forms pro-metastatic functions circulating tumour cells spermine pullulan play opposing roles migrated tumor cells circulating tumor cells

Schema {🗺️}

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         headline:The role of liver microenvironment in hepatic metastasis
         description:Metastasis is still poorly understood and thus further research must be conducted to provide insight into the driving factors. Novel research has revealed the significance of the microenvironment in the delegation of metastasis, expanding the field of cancer metastasis to cells and cell environments surrounding the migrated tumor cells. Research on hepatic metastasis is an ever-growing domain of this field, as several primary tumors can metastasize to the liver. The two features within the liver that promote metastasis—cellular and acellular—are found in the current interpretation of liver microenvironment. Novel findings of both are included in this review. Different hypotheses detailing the methods by which metastasis can occur must be included to understand the significance of the microenvironment, as well as a brief overview of the methods that can be used during research. This review aims to highlight the importance of liver microenvironment on the development or potential regression of hepatic metastasis through discussing both acellular and cellular components of liver microenvironment and their interaction with metastasis.
         datePublished:2019-07-01T00:00:00Z
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      headline:The role of liver microenvironment in hepatic metastasis
      description:Metastasis is still poorly understood and thus further research must be conducted to provide insight into the driving factors. Novel research has revealed the significance of the microenvironment in the delegation of metastasis, expanding the field of cancer metastasis to cells and cell environments surrounding the migrated tumor cells. Research on hepatic metastasis is an ever-growing domain of this field, as several primary tumors can metastasize to the liver. The two features within the liver that promote metastasis—cellular and acellular—are found in the current interpretation of liver microenvironment. Novel findings of both are included in this review. Different hypotheses detailing the methods by which metastasis can occur must be included to understand the significance of the microenvironment, as well as a brief overview of the methods that can be used during research. This review aims to highlight the importance of liver microenvironment on the development or potential regression of hepatic metastasis through discussing both acellular and cellular components of liver microenvironment and their interaction with metastasis.
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