We are analyzing https://link.springer.com/article/10.1186/s40164-015-0001-6.

Title:
New frontiers for platelet CD154 | Experimental Hematology & Oncology
Description:
The role of platelets extends beyond hemostasis. The pivotal role of platelets in inflammation has shed new light on the natural history of conditions associated with acute or chronic inflammation. Beyond the preservation of vascular integrity, platelets are essential to tissue homeostasis and platelet-derived products are already used in the clinics. Unanticipated was the role of platelets in the adaptative immune response, allowing a renewed conceptual approach of auto-immune diseases. Platelets are also important players in cancer growth and dissemination. Platelets fulfill most of their functions through the expression of still incompletely characterized membrane-bound or soluble mediators. Among them, CD154 holds a peculiar position, as platelets represent a major source of CD154 and as CD154 contributes to most of these new platelet attributes. Here, we provide an overview of some of the new frontiers that the study of platelet CD154 is opening, in inflammation, tissue homeostasis, immune response, hematopoiesis and cancer.
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Keywords {🔍}

pubmed, google, scholar, article, cas, platelet, platelets, cells, central, cell, activation, soluble, role, inflammation, ligand, immune, scd, tissue, blood, thromb, expression, activated, cancer, vascular, cdl, response, immunol, inflammatory, including, biol, tumor, human, res, mediators, endothelial, release, signaling, haemost, growth, plateletderived, injury, factor, disease, clin, mechanisms, repair, microparticles, cdcd, patients, plasma,

Topics {✒️}

x-linked hyper-igm syndrome c-jun n-terminal kinase phosphatidylinositol-3 kinase/akt pathway signal-dependent pre-mrna splicing beta3 integrin–dependent mechanism cd40/cd154 receptor/ligand dyad article download pdf translational-dependent pathway triggered vegf-induced ec migration t-cell independent antigens mhc class ii thrombin receptor-agonist peptide t-cell dependent antigens stimulate post-ischemic revascularization platelet-derived growth factor glycoprotein iib/iiia antagonists platelet-lymphocyte cross-talk cd40-ligand stimulates myelopoiesis cd40-directed experimental therapy cytokine signature profiles cd40 ligand-dependent maturation cd34+/stromal cell cocultures platelet-mediated vascular dysfunction von willebrand factor renal ischaemia-reperfusion injury suggesting feed-back amplification cd40 protein-dependent manner plasmacytoid dendritic cells cd40/cd40 ligand pathway platelet-mediated lymphocyte delivery blocking cd40-traf6 signaling l-selectin-deficient mice promoting endothelial repair cd40l-cd40-mediated signals cd154-cd40 t-cell cd40/cd154 costimulatory pathway express mhc class cd40/cd40 ligand system mesenteric ischemia/reperfusion injury including nuclear factor-κb collagen-dependent microparticle production article dewitte scd154-induced increased number scd154-mediated increased granulocyte open access license cd40-dependent inflammatory response cd40/cd40 ligand signaling membrane-bound cd40 ligand high endothelial venules incompletely characterized membrane-bound

Questions {❓}

Bench-to-bedside review: Platelets and active immune functions - new clues for immunopathology?
CD40 signaling in vascular cells: a key role in atherosclerosis?
Cellular microparticles: new players in the field of vascular disease?
Could platelets deliver a CD154 signal, through sCD154, platelet- or PMP-associated CD154 that regulates hematopoiesis?
Involvement of platelets in tumour angiogenesis?
Liver inflammation and regeneration: two distinct biological phenomena or parallel pathophysiologic processes?
Platelet CD154: a new hematopoietic regulator?
Platelets and cancer metastasis: a causal relationship?
Platelets in Rheumatic Diseases: Friend or Foe?
Secrets of platelet exocytosis - what do we really know about platelet secretion mechanisms?

Schema {🗺️}

WebPage:
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         headline:New frontiers for platelet CD154
         description:The role of platelets extends beyond hemostasis. The pivotal role of platelets in inflammation has shed new light on the natural history of conditions associated with acute or chronic inflammation. Beyond the preservation of vascular integrity, platelets are essential to tissue homeostasis and platelet-derived products are already used in the clinics. Unanticipated was the role of platelets in the adaptative immune response, allowing a renewed conceptual approach of auto-immune diseases. Platelets are also important players in cancer growth and dissemination. Platelets fulfill most of their functions through the expression of still incompletely characterized membrane-bound or soluble mediators. Among them, CD154 holds a peculiar position, as platelets represent a major source of CD154 and as CD154 contributes to most of these new platelet attributes. Here, we provide an overview of some of the new frontiers that the study of platelet CD154 is opening, in inflammation, tissue homeostasis, immune response, hematopoiesis and cancer.
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ScholarlyArticle:
      headline:New frontiers for platelet CD154
      description:The role of platelets extends beyond hemostasis. The pivotal role of platelets in inflammation has shed new light on the natural history of conditions associated with acute or chronic inflammation. Beyond the preservation of vascular integrity, platelets are essential to tissue homeostasis and platelet-derived products are already used in the clinics. Unanticipated was the role of platelets in the adaptative immune response, allowing a renewed conceptual approach of auto-immune diseases. Platelets are also important players in cancer growth and dissemination. Platelets fulfill most of their functions through the expression of still incompletely characterized membrane-bound or soluble mediators. Among them, CD154 holds a peculiar position, as platelets represent a major source of CD154 and as CD154 contributes to most of these new platelet attributes. Here, we provide an overview of some of the new frontiers that the study of platelet CD154 is opening, in inflammation, tissue homeostasis, immune response, hematopoiesis and cancer.
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         CD154
         Hematology
         Oncology
         Cancer Research
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               type:PostalAddress
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            address:
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PostalAddress:
      name:INSERM U1026, and Université de Bordeaux, Bordeaux, France
      name:Service d’Anesthésie-Réanimation II, CHU de Bordeaux, Pessac, France
      name:INSERM U1026, and Université de Bordeaux, Bordeaux, France
      name:Cell and Developmental Biology Programme, Centre for Genomic Regulation, Barcelona, Spain
      name:Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA
      name:INSERM U1026, and Université de Bordeaux, Bordeaux, France
      name:Service d’Anesthésie-Réanimation II, CHU de Bordeaux, Pessac, France
      name:EA 6309, University of Limoges, Limoges, France
      name:INSERM U1026, and Université de Bordeaux, Bordeaux, France
      name:Service de Néphrologie Transplantation Dialyse, CHU de Bordeaux, Bordeaux, France
      name:INSERM U1026, and Université de Bordeaux, Bordeaux, France

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