We are analyzing https://link.springer.com/article/10.1186/s13568-016-0226-8.

Title:
Angiogenic inhibitors delivered by the type III secretion system of tumor-targeting Salmonella typhimurium safely shrink tumors in mice | AMB Express
Description:
Despite of a growing number of bacterial species that apparently exhibit intrinsic tumor-targeting properties, no bacterium is able to inhibit tumor growth completely in the immunocompetent hosts, due to its poor dissemination inside the tumors. Oxygen and inflammatory reaction form two barriers and restrain the spread of the bacteria inside the tumors. Here, we engineered a Salmonella typhimurium strain named ST8 which is safe and has limited ability to spread beyond the anaerobic regions of tumors. When injected systemically to tumor-bearing immunocompetent mice, ST8 accumulated in tumors at levels at least 100-fold greater than parental obligate anaerobic strain ST4. ST8/pSEndo harboring therapeutic plasmids encoding Endostatin fused with a secreted protein SopA could target vasculature at the tumor periphery, can stably maintain and safely deliver a therapeutic vector, release angiogenic inhibitors through a type III secretion system (T3SS) to interfere with the pro-angiogenic action of growth factors in tumors. Mice with murine CT26 colon cancer that had been injected with ST8/pSEndo showed efficient tumor suppression by inducing more severe necrosis and inhibiting blooding vessel density within tumors. Our findings provide a therapeutic platform for indirectly acting therapeutic strategies such as anti-angiogenesis and immune therapy.
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Keywords {🔍}

tumors, tumor, salmonella, article, pubmed, stpsendo, therapeutic, google, scholar, cells, mice, bacteria, cancer, bacterial, typhimurium, fig, cas, strain, angiogenesis, hong, endostatin, therapy, research, secretion, expression, huang, gene, cell, angiogenic, growth, plasmid, kong, inhibitors, system, regions, control, effects, medium, stpsgfp, iii, shi, anaerobic, protein, solid, university, type, tumortargeting, number, injected, infection,

Topics {✒️}

pubmed google scholar genetically-modified salmonella typhimurium sl7207/pcdna-infa infected tumors article download pdf aromatic-dependent salmonella typhimurium st8/pcdna-infa inside tumors sopa n-terminal sequence scale bar 100 μm jian-dong huang tumor-bearing nude mice full size image robust anti-tumoral effect tumor-bearing immunocompetent mice attenuated salmonella typhimurium heat-induced antigen retrieval quantitative rt-pcr analysis st8/pcdna-infa isolated st8/psendo conditioned medium direct anti-angiogenic effect drives pbad-promoted expression orthotopic nude-mouse models viable region heavily immune-suppressed microenvironment st8/psendo treated tumors st8/psendo treated mice cancer gene therapy salmonella typhimurium a1 e-stained paraffin section plasmid-carrying bacterial cells st8/psgfp conditioned medium st8/psendo treatment group previous studies salmonella st8 secretion explore therapeutic strategies author information authors exogenous plasmid pcdna-infa standard cancer therapy typhimurium strain st8 subcutaneous tumor size st8/psendo group compared st8-mediated secretion replication-competent strains st7 bacterial-mediated secretion anti-cancer toxins human endothelial cells explicit hypoxia targeting viable tumor cells cultured ct26 cells condensed culture medium deliver endostatin fused

Schema {🗺️}

WebPage:
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         headline:Angiogenic inhibitors delivered by the type III secretion system of tumor-targeting Salmonella typhimurium safely shrink tumors in mice
         description:Despite of a growing number of bacterial species that apparently exhibit intrinsic tumor-targeting properties, no bacterium is able to inhibit tumor growth completely in the immunocompetent hosts, due to its poor dissemination inside the tumors. Oxygen and inflammatory reaction form two barriers and restrain the spread of the bacteria inside the tumors. Here, we engineered a Salmonella typhimurium strain named ST8 which is safe and has limited ability to spread beyond the anaerobic regions of tumors. When injected systemically to tumor-bearing immunocompetent mice, ST8 accumulated in tumors at levels at least 100-fold greater than parental obligate anaerobic strain ST4. ST8/pSEndo harboring therapeutic plasmids encoding Endostatin fused with a secreted protein SopA could target vasculature at the tumor periphery, can stably maintain and safely deliver a therapeutic vector, release angiogenic inhibitors through a type III secretion system (T3SS) to interfere with the pro-angiogenic action of growth factors in tumors. Mice with murine CT26 colon cancer that had been injected with ST8/pSEndo showed efficient tumor suppression by inducing more severe necrosis and inhibiting blooding vessel density within tumors. Our findings provide a therapeutic platform for indirectly acting therapeutic strategies such as anti-angiogenesis and immune therapy.
         datePublished:2016-08-24T00:00:00Z
         dateModified:2016-08-24T00:00:00Z
         pageStart:1
         pageEnd:10
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1186/s13568-016-0226-8
         keywords:
            Bacterial cancer therapy
            Tumor-targeting
             Salmonella typhimurium
            Viable region
            Type III secretion system
            Anti-angiogenesis
            Microbiology
            Microbial Genetics and Genomics
            Biotechnology
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                     address:
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                     address:
                        name:Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, People’s Republic of China
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                        name:The Centre for Synthetic Biology Engineering Research, Shenzhen Institutes of Advanced Technology, Shenzhen, People’s Republic of China
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ScholarlyArticle:
      headline:Angiogenic inhibitors delivered by the type III secretion system of tumor-targeting Salmonella typhimurium safely shrink tumors in mice
      description:Despite of a growing number of bacterial species that apparently exhibit intrinsic tumor-targeting properties, no bacterium is able to inhibit tumor growth completely in the immunocompetent hosts, due to its poor dissemination inside the tumors. Oxygen and inflammatory reaction form two barriers and restrain the spread of the bacteria inside the tumors. Here, we engineered a Salmonella typhimurium strain named ST8 which is safe and has limited ability to spread beyond the anaerobic regions of tumors. When injected systemically to tumor-bearing immunocompetent mice, ST8 accumulated in tumors at levels at least 100-fold greater than parental obligate anaerobic strain ST4. ST8/pSEndo harboring therapeutic plasmids encoding Endostatin fused with a secreted protein SopA could target vasculature at the tumor periphery, can stably maintain and safely deliver a therapeutic vector, release angiogenic inhibitors through a type III secretion system (T3SS) to interfere with the pro-angiogenic action of growth factors in tumors. Mice with murine CT26 colon cancer that had been injected with ST8/pSEndo showed efficient tumor suppression by inducing more severe necrosis and inhibiting blooding vessel density within tumors. Our findings provide a therapeutic platform for indirectly acting therapeutic strategies such as anti-angiogenesis and immune therapy.
      datePublished:2016-08-24T00:00:00Z
      dateModified:2016-08-24T00:00:00Z
      pageStart:1
      pageEnd:10
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1186/s13568-016-0226-8
      keywords:
         Bacterial cancer therapy
         Tumor-targeting
          Salmonella typhimurium
         Viable region
         Type III secretion system
         Anti-angiogenesis
         Microbiology
         Microbial Genetics and Genomics
         Biotechnology
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                  address:
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                     type:PostalAddress
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                  address:
                     name:Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, People’s Republic of China
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                     name:Advanced Institute of Translational Medicine, Tongji University School of Medicine, Shanghai, People’s Republic of China
                     type:PostalAddress
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            affiliation:
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                     type:PostalAddress
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                  address:
                     name:Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, People’s Republic of China
                     type:PostalAddress
                  type:Organization
                  name:Shenzhen Institutes of Advanced Technology
                  address:
                     name:The Centre for Synthetic Biology Engineering Research, Shenzhen Institutes of Advanced Technology, Shenzhen, People’s Republic of China
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         type:PostalAddress
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         name:Advanced Institute of Translational Medicine, Tongji University School of Medicine, Shanghai, People’s Republic of China
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         name:Faculty of Medicine, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong
         type:PostalAddress
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         type:PostalAddress
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               type:PostalAddress
            type:Organization
            name:The University of Hong Kong
            address:
               name:Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, People’s Republic of China
               type:PostalAddress
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      name:Bin Yu
      affiliation:
            name:The University of Hong Kong
            address:
               name:Faculty of Medicine, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong
               type:PostalAddress
            type:Organization
            name:The University of Hong Kong
            address:
               name:Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, People’s Republic of China
               type:PostalAddress
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            name:Shenzhen University
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               name:Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Chun-Hui Cai
      affiliation:
            name:The University of Hong Kong
            address:
               name:Department of Obstetrics and Gynaecology, The University of Hong Kong, Pokfulam, Hong Kong
               type:PostalAddress
            type:Organization
            name:Tongji University School of Medicine
            address:
               name:Advanced Institute of Translational Medicine, Tongji University School of Medicine, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Jian-Dong Huang
      affiliation:
            name:The University of Hong Kong
            address:
               name:Faculty of Medicine, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong
               type:PostalAddress
            type:Organization
            name:The University of Hong Kong
            address:
               name:Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:Shenzhen Institutes of Advanced Technology
            address:
               name:The Centre for Synthetic Biology Engineering Research, Shenzhen Institutes of Advanced Technology, Shenzhen, People’s Republic of China
               type:PostalAddress
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      email:[email protected]
PostalAddress:
      name:Faculty of Medicine, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong
      name:Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, People’s Republic of China
      name:Faculty of Medicine, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong
      name:Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, People’s Republic of China
      name:Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, People’s Republic of China
      name:Department of Obstetrics and Gynaecology, The University of Hong Kong, Pokfulam, Hong Kong
      name:Advanced Institute of Translational Medicine, Tongji University School of Medicine, Shanghai, People’s Republic of China
      name:Faculty of Medicine, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong
      name:Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, People’s Republic of China
      name:The Centre for Synthetic Biology Engineering Research, Shenzhen Institutes of Advanced Technology, Shenzhen, People’s Republic of China

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