We are analyzing https://link.springer.com/article/10.1186/s13195-018-0338-2.

Title:
Novel botanical drug DA-9803 prevents deficits in Alzheimer’s mouse models | Alzheimer's Research & Therapy
Description:
Background Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by deposition of amyloid plaques and disruption of neural circuitry, leading to cognitive decline. Animal models of AD deposit senile plaques and exhibit structural and functional deficits in neurons and neural networks. An effective treatment would prevent or restore these deficits, including calcium dyshomeostasis observed with in-vivo imaging. Methods We examined the effects of DA-9803, a multimodal botanical drug, in 5XFAD and APP/PS1 transgenic mice which underwent daily oral treatment with 30 or 100 mg/kg DA-9803 or vehicle alone. Behavioral testing and longitudinal imaging of amyloid deposits and intracellular calcium in neurons with multiphoton microscopy was performed. Results Chronic administration of DA-9803 restored behavioral deficits in 5XFAD mice and reduced amyloid-β levels. DA-9803 also prevented progressive amyloid plaque deposition in APP/PS1 mice. Elevated calcium, detected in a subset of neurons before the treatment, was restored and served as a functional indicator of treatment efficacy in addition to the behavioral readout. In contrast, mice treated with vehicle alone continued to progressively accumulate amyloid plaques and calcium overload. Conclusions In summary, treatment with DA-9803 prevented structural and functional outcome measures in mouse models of AD. Thus, DA-9803 shows promise as a novel therapeutic approach for Alzheimer’s disease.
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Keywords {🔍}

mice, treatment, amyloid, calcium, plaque, plaques, pubmed, article, vehicle, fig, animals, google, scholar, imaging, alzheimers, levels, treated, number, disease, neurites, cas, data, appps, mouse, xfad, mgkg, microglia, burden, overload, astrocytes, images, vehicletreated, deposition, conditions, behavioral, methoxyxo, compared, daily, neuronal, sections, clearance, datreated, fluorescent, test, research, deficits, central, cortex, drug, chronic,

Topics {✒️}

newman–keuls post-hoc test methoxy-xo4-labeled amyloid burden student–newman–keuls method vehicle-treated app/ps1 mice article download pdf texas red-labeled dextran anti-rabbit igg hrp app/ps1 mice overexpress 100 mg/kg-treated animals performed methoxy-xo4 labeling colocalized 4 mg/kg methoxy-xo4 reduced amyloid-β levels transgenic appswe/ps1de9 mice 100 mg/kg condition recovered oligomeric beta-amyloid peptide app/ps1 transgenic mice il-4-induced selective clearance app/ps1 mice treated develop aβ-related pathologies 30 mg/kg treatment failed intraneuronal β-amyloid aggregates song-hyen choi shapiro–wilk normality test ca2+-binding proteins contributes methoxy-xo4-labeled plaques 30 mg/kg-treated mice appswe/ps1de9 mouse model high-magnification fluorescent images 100 mg/kg-treated animals methoxy-xo4-positive plaques methoxy-xo4 amyloid plaques da-9803-treated mice developed cyan fluorescent protein 100 mg/kg da-9803 treatment methoxy-positive amyloid plaques da-9803-treated animals exhibiting nonparametric mann–whitney test massachusetts general hospital vehicle-treated mice presented da-9803-treated mice exhibited methoxy-xo4 injected intraperitoneally drug-treated animals compared rabbit anti-mouse aβ40 privacy choices/manage cookies yellow fluorescent protein yfp/cfp ratio greater yellow arrows pointing app/ps1 mice app/ps1 mice [12 methoxy-xo4-labeled

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Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

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         headline:Novel botanical drug DA-9803 prevents deficits in Alzheimer’s mouse models
         description:Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by deposition of amyloid plaques and disruption of neural circuitry, leading to cognitive decline. Animal models of AD deposit senile plaques and exhibit structural and functional deficits in neurons and neural networks. An effective treatment would prevent or restore these deficits, including calcium dyshomeostasis observed with in-vivo imaging. We examined the effects of DA-9803, a multimodal botanical drug, in 5XFAD and APP/PS1 transgenic mice which underwent daily oral treatment with 30 or 100 mg/kg DA-9803 or vehicle alone. Behavioral testing and longitudinal imaging of amyloid deposits and intracellular calcium in neurons with multiphoton microscopy was performed. Chronic administration of DA-9803 restored behavioral deficits in 5XFAD mice and reduced amyloid-β levels. DA-9803 also prevented progressive amyloid plaque deposition in APP/PS1 mice. Elevated calcium, detected in a subset of neurons before the treatment, was restored and served as a functional indicator of treatment efficacy in addition to the behavioral readout. In contrast, mice treated with vehicle alone continued to progressively accumulate amyloid plaques and calcium overload. In summary, treatment with DA-9803 prevented structural and functional outcome measures in mouse models of AD. Thus, DA-9803 shows promise as a novel therapeutic approach for Alzheimer’s disease.
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            In vivo
            Calcium imaging
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            Geriatric Psychiatry
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      headline:Novel botanical drug DA-9803 prevents deficits in Alzheimer’s mouse models
      description:Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by deposition of amyloid plaques and disruption of neural circuitry, leading to cognitive decline. Animal models of AD deposit senile plaques and exhibit structural and functional deficits in neurons and neural networks. An effective treatment would prevent or restore these deficits, including calcium dyshomeostasis observed with in-vivo imaging. We examined the effects of DA-9803, a multimodal botanical drug, in 5XFAD and APP/PS1 transgenic mice which underwent daily oral treatment with 30 or 100 mg/kg DA-9803 or vehicle alone. Behavioral testing and longitudinal imaging of amyloid deposits and intracellular calcium in neurons with multiphoton microscopy was performed. Chronic administration of DA-9803 restored behavioral deficits in 5XFAD mice and reduced amyloid-β levels. DA-9803 also prevented progressive amyloid plaque deposition in APP/PS1 mice. Elevated calcium, detected in a subset of neurons before the treatment, was restored and served as a functional indicator of treatment efficacy in addition to the behavioral readout. In contrast, mice treated with vehicle alone continued to progressively accumulate amyloid plaques and calcium overload. In summary, treatment with DA-9803 prevented structural and functional outcome measures in mouse models of AD. Thus, DA-9803 shows promise as a novel therapeutic approach for Alzheimer’s disease.
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      dateModified:2018-01-29T00:00:00Z
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         Alzheimer’s disease
         Multiphoton microscopy
         Therapeutic
         In vivo
         Calcium imaging
         Neurosciences
         Neurology
         Geriatrics/Gerontology
         Geriatric Psychiatry
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